AMPK/mTOR pathway significance in healthy liver and non‐alcoholic fatty liver disease and its progression

Clustering NAFLD: phenotypes of nonalcoholic fatty liver disease and their differing trajectories

(2023) Konstantinos Kantartzis et al.   Hepatology Communications

Rab2A regulates the progression of nonalcoholic fatty liver disease downstream of AMPK-TBC1D1 axis by stabilizing PPARγ

(2022) Zi-Yue Chen et al.   PLOS BIOLOGY

The mTORC1/AMPK pathway plays a role in the beneficial effects of semaglutide (GLP-1 receptor agonist) on the liver of obese mice

(2022) Pedro Henrique Reis-Barbosa et al.   Clinics and Research in Hepatology and Gastroenterology

Beneficial Effect of Taraxacum coreanum Nakai via the Activation of LKB1-AMPK Signaling Pathway on Obesity

(2021) Mi-Rae Shin et al.   Evidence-based Complementary and Alternative Medicine

Lauric Triglyceride Ameliorates High-Fat-Diet-Induced Obesity in Rats by Reducing Lipogenesis and Increasing Lipolysis and β-Oxidation

(2021) Jiaheng Xia et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Regulation and metabolic functions of mTORC1 and mTORC2

(2021) Angelia Szwed et al.   PHYSIOLOGICAL REVIEWS

The ménage à trois of autophagy, lipid droplets and liver disease

(2021) Yasmina Filali-Mouncef et al.   Autophagy

Mechanisms and disease consequences of nonalcoholic fatty liver disease

(2021) Rohit Loomba et al.   CELL

Salidroside activates the AMP‐activated protein kinase pathway to suppress non‐alcoholic steatohepatitis

(2021) Manli Hu et al.   HEPATOLOGY

IL37 overexpression inhibits autophagy and apoptosis induced by hepatic ischemia reperfusion injury via modulating AMPK/mTOR/ULLK1 signalling pathways

(2021) Qing-song Chen et al.   LIFE SCIENCES

Autophagy in liver diseases: A review

(2021) Hui Qian et al.   MOLECULAR ASPECTS OF MEDICINE

Gut microbiota in obesity

(2021) Bing-Nan Liu et al.   WORLD JOURNAL OF GASTROENTEROLOGY

The mTOR–Autophagy Axis and the Control of Metabolism

(2021) Nerea Deleyto-Seldas et al.   Frontiers in Cell and Developmental Biology

Role of AMPK mediated pathways in autophagy and aging

(2021) Yuchen Ge et al.   BIOCHIMIE

PPARs as Metabolic Regulators in the Liver: Lessons from Liver-Specific PPAR-Null Mice

(2020) Yaping Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

SIRT3 deficiency is resistant to autophagy‐dependent ferroptosis by inhibiting the AMPK/mTOR pathway and promoting GPX4 levels

(2020) Dandan Han et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Role and Mechanisms of Mitophagy in Liver Diseases

(2020) Xiaowen Ma et al.   Cells

From NAFLD to MAFLD: Implications of a premature change in terminology

(2020) Zobair M Younossi et al.   HEPATOLOGY

Autophagy and liver cancer

(2020) Xiaojuan Chao et al.   Clinical and Molecular Hepatology

Suppression of p16 Induces mTORC1-Mediated Nucleotide Metabolic Reprogramming

(2019) Raquel Buj et al.   Cell Reports

Starvation induces rapid degradation of selective autophagy receptors by endosomal microautophagy

(2018) Jakob Mejlvang et al.   JOURNAL OF CELL BIOLOGY

Gut microbiota and mTOR signaling: Insight on a new pathophysiological interaction

(2018) Mohamed H. Noureldein et al.   MICROBIAL PATHOGENESIS

Nonalcoholic fatty liver disease

(2018) Dunya Tomic et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Improvements in Histologic Features and Diagnosis associated with Improvement in Fibrosis in NASH : Results from the NASH Clinical Research Network Treatment Trials

(2018) Elizabeth M Brunt et al.   HEPATOLOGY

Medium-chain triglyceride reinforce the hepatic damage caused by fructose intake in mice

(2018) Janaina Guimarães et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Comparison of laboratory tests, ultrasound, or magnetic resonance elastography to detect fibrosis in patients with nonalcoholic fatty liver disease: A meta-analysis

(2017) Guangqin Xiao et al.   HEPATOLOGY

Irbesartan ameliorates hyperlipidemia and liver steatosis in type 2 diabetic db/db mice via stimulating PPAR-γ, AMPK/Akt/mTOR signaling and autophagy

(2017) Juan Zhong et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Epigenetics in non-alcoholic fatty liver disease

(2017) Jooho Lee et al.   MOLECULAR ASPECTS OF MEDICINE

mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT

(2017) Yuchao Gu et al.   MOLECULAR CELL

mTORC1 Balances Cellular Amino Acid Supply with Demand for Protein Synthesis through Post-transcriptional Control of ATF4

(2017) Yeonwoo Park et al.   Cell Reports

Treatment of nonalcoholic fatty liver disease: role of AMPK

(2016) Brennan K. Smith et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Nuclear receptors and nonalcoholic fatty liver disease 1 1This article is part of a Special Issue entitled: Xenobiotic nuclear receptors: New Tricks for An Old Dog, edited by Dr. Wen Xie.

(2016) Matthew C. Cave et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

4E-BP1, a multifactor regulated multifunctional protein

(2016) Xiaoyu Qin et al.   CELL CYCLE

Rubicon inhibits autophagy and accelerates hepatocyte apoptosis and lipid accumulation in nonalcoholic fatty liver disease in mice

(2016) Satoshi Tanaka et al.   HEPATOLOGY

Sirt1 and the Mitochondria

(2016)   MOLECULES AND CELLS

Upregulation of Mitochondrial Content in Cytochrome c Oxidase Deficient Fibroblasts

(2016) Aviram Kogot-Levin et al.   PLoS One

Adipose tissue mTORC2 regulates ChREBP-driven de novo lipogenesis and hepatic glucose metabolism

(2016) Yuefeng Tang et al.   Nature Communications

Effects of Excess Energy Intake on Glucose and Lipid Metabolism in C57BL/6 Mice

(2016) Jing Pang et al.   PLoS One

Nonalcoholic Fatty Liver Disease

(2015) Mary E. Rinella   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Both mTORC1 and mTORC2 are involved in the regulation of cell adhesion

(2015) Long Chen et al.   Oncotarget

Nonalcoholic fatty liver disease

(2015) Elizabeth M. Brunt et al.   Nature Reviews Disease Primers

Antagonistic crosstalk between NF-κB and SIRT1 in the regulation of inflammation and metabolic disorders

(2013) Anu Kauppinen et al.   CELLULAR SIGNALLING

From NAFLD to NASH and HCC: Pathogenetic Mechanisms and Therapeutic Insights

(2013) Samuele De Minicis et al.   CURRENT PHARMACEUTICAL DESIGN

Role of PRAS40 in Akt and mTOR signaling in health and disease

(2012) Claudia Wiza et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Therapeutic targets in liver fibrosis

(2011) Jonathan A. Fallowfield   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Autophagy: cellular and molecular mechanisms

(2010) Danielle Glick et al.   JOURNAL OF PATHOLOGY

Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1

(2010) Katrin Düvel et al.   MOLECULAR CELL

AMPK activation attenuates S6K1, 4E-BP1, and eEF2 signaling responses to high-frequency electrically stimulated skeletal muscle contractions

(2008) David M. Thomson et al.   JOURNAL OF APPLIED PHYSIOLOGY