6,6-Difluorobicyclo[3.1.0]hexane as a Rigidified 4,4-Difluorocyclohexane Mimetic: Multigram Synthesis, Physicochemical Characterization, and Incorporation into Maraviroc Analogs

Discovery and structure-activity relationship studies of novel α-ketoamide derivatives targeting the SARS-CoV-2 main protease

(2023) Chong Huang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Fluorinated Cycloalkyl Building Blocks for Drug Discovery

(2022) Oleksandr O. Grygorenko et al.   ChemMedChem

Fluoroalkyl‐Containing 1,2‐Disubstituted Cyclobutanes: Advanced Building Blocks for Medicinal Chemistry

(2021) Oleksandr P. Demchuk et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Fluorine‐Labelled Spiro[3.3]heptane‐Derived Building Blocks: Is Single Fluorine the Best?

(2021) Andrii Malashchuk et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Polar organofluorine substituents: Multivicinal fluorines on alkyl chains and alicyclic rings

(2020) David O'Hagan   CHEMISTRY-A EUROPEAN JOURNAL

Contribution of Organofluorine Compounds to Pharmaceuticals

(2020) Munenori Inoue et al.   ACS Omega

Fluoroalkyl-Substituted Cyclopropane Derivatives: Synthesis and Physicochemical Properties

(2020) Anton V. Chernykh et al.   JOURNAL OF ORGANIC CHEMISTRY

Last of the gem-Difluorocycloalkanes: Synthesis and Characterization of 2,2-Difluorocyclobutyl-Substituted Building Blocks

(2019) Anton V. Chernykh et al.   JOURNAL OF ORGANIC CHEMISTRY

3-[(1S,2S,3R)-2,3-Difluoro-1-hydroxy-7-methylsulfonylindan-4-yl]oxy-5-fluorobenzonitrile (PT2977), a Hypoxia-Inducible Factor 2α (HIF-2α) Inhibitor for the Treatment of Clear Cell Renal Cell Carcinoma

(2019) Rui Xu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of Functionalized Difluorocyclopropanes: Unique Building Blocks for Drug Discovery

(2018) Roman M. Bychek et al.   CHEMISTRY-A EUROPEAN JOURNAL

Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design

(2018) Nicholas A. Meanwell   JOURNAL OF MEDICINAL CHEMISTRY

Metabolism and hydrophilicity of the polarised ‘Janus face’ all-cis tetrafluorocyclohexyl ring, a candidate motif for drug discovery

(2018) Andrea Rodil et al.   Chemical Science

Discovery of AG-120 (Ivosidenib): A First-in-Class Mutant IDH1 Inhibitor for the Treatment of IDH1 Mutant Cancers

(2018) Janeta Popovici-Muller et al.   ACS Medicinal Chemistry Letters

Transition Metal-free gem -difluorocyclopropanation of Alkenes with CF3 SiMe3 −NaI System: a Recipe for Electron-deficient Substrates

(2018) Pavel S. Nosik et al.   ADVANCED SYNTHESIS & CATALYSIS

Lowering Lipophilicity by Adding Carbon: One-Carbon Bridges of Morpholines and Piperazines

(2018) Sébastien L. Degorce et al.   JOURNAL OF MEDICINAL CHEMISTRY

DrugBank 5.0: a major update to the DrugBank database for 2018

(2017) David S Wishart et al.   NUCLEIC ACIDS RESEARCH

Introduction: Fluorine Chemistry

(2015) Veronique Gouverneur et al.   CHEMICAL REVIEWS

Chemokine Receptor CCR5 Antagonist Maraviroc: Medicinal Chemistry and Clinical Applications

(2014) Guoyan Xu et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Structure of the CCR5 Chemokine Receptor-HIV Entry Inhibitor Maraviroc Complex

(2013) Q. Tan et al.   SCIENCE

Synthesis of gem-Difluorinated Cyclopropanes and Cyclopropenes: Trifluoromethyltrimethylsilane as a Difluorocarbene Source

(2011) Fei Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION