6,6-Difluorobicyclo[3.1.0]hexane as a Rigidified 4,4-Difluorocyclohexane Mimetic: Multigram Synthesis, Physicochemical Characterization, and Incorporation into Maraviroc Analogs
出版年份 2023 全文链接
标题
6,6-Difluorobicyclo[3.1.0]hexane as a Rigidified 4,4-Difluorocyclohexane Mimetic: Multigram Synthesis, Physicochemical Characterization, and Incorporation into Maraviroc Analogs
作者
关键词
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出版物
JOURNAL OF FLUORINE CHEMISTRY
Volume -, Issue -, Pages 110215
出版商
Elsevier BV
发表日期
2023-11-04
DOI
10.1016/j.jfluchem.2023.110215
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- (2023) Chong Huang et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
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- (2022) Oleksandr O. Grygorenko et al. ChemMedChem
- Fluoroalkyl‐Containing 1,2‐Disubstituted Cyclobutanes: Advanced Building Blocks for Medicinal Chemistry
- (2021) Oleksandr P. Demchuk et al. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
- Fluorine‐Labelled Spiro[3.3]heptane‐Derived Building Blocks: Is Single Fluorine the Best?
- (2021) Andrii Malashchuk et al. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
- Polar organofluorine substituents: Multivicinal fluorines on alkyl chains and alicyclic rings
- (2020) David O'Hagan CHEMISTRY-A EUROPEAN JOURNAL
- Contribution of Organofluorine Compounds to Pharmaceuticals
- (2020) Munenori Inoue et al. ACS Omega
- Fluoroalkyl-Substituted Cyclopropane Derivatives: Synthesis and Physicochemical Properties
- (2020) Anton V. Chernykh et al. JOURNAL OF ORGANIC CHEMISTRY
- Last of the gem-Difluorocycloalkanes: Synthesis and Characterization of 2,2-Difluorocyclobutyl-Substituted Building Blocks
- (2019) Anton V. Chernykh et al. JOURNAL OF ORGANIC CHEMISTRY
- 3-[(1S,2S,3R)-2,3-Difluoro-1-hydroxy-7-methylsulfonylindan-4-yl]oxy-5-fluorobenzonitrile (PT2977), a Hypoxia-Inducible Factor 2α (HIF-2α) Inhibitor for the Treatment of Clear Cell Renal Cell Carcinoma
- (2019) Rui Xu et al. JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis of Functionalized Difluorocyclopropanes: Unique Building Blocks for Drug Discovery
- (2018) Roman M. Bychek et al. CHEMISTRY-A EUROPEAN JOURNAL
- Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design
- (2018) Nicholas A. Meanwell JOURNAL OF MEDICINAL CHEMISTRY
- Metabolism and hydrophilicity of the polarised ‘Janus face’ all-cis tetrafluorocyclohexyl ring, a candidate motif for drug discovery
- (2018) Andrea Rodil et al. Chemical Science
- Discovery of AG-120 (Ivosidenib): A First-in-Class Mutant IDH1 Inhibitor for the Treatment of IDH1 Mutant Cancers
- (2018) Janeta Popovici-Muller et al. ACS Medicinal Chemistry Letters
- Transition Metal-free gem -difluorocyclopropanation of Alkenes with CF3 SiMe3 −NaI System: a Recipe for Electron-deficient Substrates
- (2018) Pavel S. Nosik et al. ADVANCED SYNTHESIS & CATALYSIS
- Lowering Lipophilicity by Adding Carbon: One-Carbon Bridges of Morpholines and Piperazines
- (2018) Sébastien L. Degorce et al. JOURNAL OF MEDICINAL CHEMISTRY
- DrugBank 5.0: a major update to the DrugBank database for 2018
- (2017) David S Wishart et al. NUCLEIC ACIDS RESEARCH
- Introduction: Fluorine Chemistry
- (2015) Veronique Gouverneur et al. CHEMICAL REVIEWS
- Chemokine Receptor CCR5 Antagonist Maraviroc: Medicinal Chemistry and Clinical Applications
- (2014) Guoyan Xu et al. CURRENT TOPICS IN MEDICINAL CHEMISTRY
- Structure of the CCR5 Chemokine Receptor-HIV Entry Inhibitor Maraviroc Complex
- (2013) Q. Tan et al. SCIENCE
- Synthesis of gem-Difluorinated Cyclopropanes and Cyclopropenes: Trifluoromethyltrimethylsilane as a Difluorocarbene Source
- (2011) Fei Wang et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
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