CD8+ lymphocytes are critical for early control of tuberculosis in macaques

Multimodal profiling of lung granulomas in macaques reveals cellular correlates of tuberculosis control

(2022) Hannah P. Gideon et al.   IMMUNITY

T cell transcription factor expression evolves over time in granulomas from Mycobacterium tuberculosis-infected cynomolgus macaques

(2022) Nicole L. Grant et al.   Cell Reports

Macrophages and neutrophils express IFNλs in granulomas from Mycobacterium tuberculosis-infected nonhuman primates

(2022) Priyanka Talukdar et al.   Frontiers in Immunology

The role of donor‐unrestricted T‐cells, innate lymphoid cells, and NK cells in anti‐mycobacterial immunity

(2021) Paula Ruibal et al.   IMMUNOLOGICAL REVIEWS

Prevention of tuberculosis in macaques after intravenous BCG immunization

(2020) Patricia A. Darrah et al.   NATURE

Second-Strand Synthesis-Based Massively Parallel scRNA-Seq Reveals Cellular States and Molecular Features of Human Inflammatory Skin Pathologies

(2020) Travis K. Hughes et al.   IMMUNITY

muscat detects subpopulation-specific state transitions from multi-sample multi-condition single-cell transcriptomics data

(2020) Helena L. Crowell et al.   Nature Communications

Prevention of tuberculosis infection and disease by local BCG in repeatedly exposed rhesus macaques

(2019) Karin Dijkman et al.   NATURE MEDICINE

Immunization of Vγ2Vδ2 T cells programs sustained effector memory responses that control tuberculosis in nonhuman primates

(2019) Ling Shen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recognition of CD8+ T cell Epitopes to Identify Adults with Pulmonary Tuberculosis

(2019) Christina Lancioni et al.   EUROPEAN RESPIRATORY JOURNAL

Harnessing donor unrestricted T-cells for new vaccines against tuberculosis

(2019) Simone A. Joosten et al.   VACCINE

Scrublet: Computational Identification of Cell Doublets in Single-Cell Transcriptomic Data

(2019) Samuel L. Wolock et al.   Cell Systems

Insights and challenges in tuberculosis vaccine development

(2019) Helen McShane   Lancet Respiratory Medicine

Differential skewing of donor-unrestricted and γδ T cell repertoires in tuberculosis-infected human lungs

(2019) Paul Ogongo et al.   JOURNAL OF CLINICAL INVESTIGATION

Fast, sensitive and accurate integration of single-cell data with Harmony

(2019) Ilya Korsunsky et al.   NATURE METHODS

Single-cell transcriptomics of human T cells reveals tissue and activation signatures in health and disease

(2019) Peter A. Szabo et al.   Nature Communications

IL-10 Impairs Local Immune Response in Lung Granulomas and Lymph Nodes during Early Mycobacterium tuberculosis Infection

(2019) Eileen A. Wong et al.   JOURNAL OF IMMUNOLOGY

Orchestrating single-cell analysis with Bioconductor

(2019) Robert A. Amezquita et al.   NATURE METHODS

NicheNet: modeling intercellular communication by linking ligands to target genes

(2019) Robin Browaeys et al.   NATURE METHODS

Bhlhe40 is an essential repressor of IL-10 duringMycobacterium tuberculosisinfection

(2018) Jeremy P. Huynh et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Prevention of tuberculosis in rhesus macaques by a cytomegalovirus-based vaccine

(2018) Scott G Hansen et al.   NATURE MEDICINE

A multi-cohort study of the immune factors associated with M. tuberculosis infection outcomes

(2018) Roshni Roy Chowdhury et al.   NATURE

IL-15 is a component of the inflammatory milieu in the tumor microenvironment promoting antitumor responses

(2018) Rosa M. Santana Carrero et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Concurrent infection with Mycobacterium tuberculosis confers robust protection against secondary infection in macaques

(2018) Anthony M. Cadena et al.   PLoS Pathogens

Seq-Well: portable, low-cost RNA sequencing of single cells at high throughput

(2017) Todd M Gierahn et al.   NATURE METHODS

Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors

(2017) Alexandra-Chloé Villani et al.   SCIENCE

Digitally Barcoding Mycobacterium tuberculosis Reveals In Vivo Infection Dynamics in the Macaque Model of Tuberculosis

(2017) Constance J. Martin et al.   mBio

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates

(2017) Alexander G. White et al.   Jove-Journal of Visualized Experiments

Polyfunctional CD4+ T Cells As Targets for Tuberculosis Vaccination

(2017) Deborah A. Lewinsohn et al.   Frontiers in Immunology

Comprehensive definition of human immunodominant CD8 antigens in tuberculosis

(2017) Deborah A. Lewinsohn et al.   npj Vaccines

Batch effects and the effective design of single-cell gene expression studies

(2017) Po-Yuan Tung et al.   Scientific Reports

Lipoarabinomannan-Responsive Polycytotoxic T Cells Are Associated with Protection in Human Tuberculosis

(2016) Martin Busch et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Human CD8 T lymphocytes recognize Mycobacterium tuberculosis antigens presented by HLA-E during active tuberculosis and express type 2 cytokines

(2015) Nadia Caccamo et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

CD8 T cells and Mycobacterium tuberculosis infection

(2015) Philana Ling Lin et al.   Seminars in Immunopathology

Variability in Tuberculosis Granuloma T Cell Responses Exists, but a Balance of Pro- and Anti-inflammatory Cytokines Is Associated with Sterilization

(2015) Hannah Priyadarshini Gideon et al.   PLoS Pathogens

Early Changes by 18Fluorodeoxyglucose Positron Emission Tomography Coregistered with Computed Tomography Predict Outcome after Mycobacterium tuberculosis Infection in Cynomolgus Macaques

(2014) M. T. Coleman et al.   INFECTION AND IMMUNITY

Sterilization of granulomas is common in active and latent tuberculosis despite within-host variability in bacterial killing

(2013) Philana Ling Lin et al.   NATURE MEDICINE

CD4 T Cell Depletion Exacerbates Acute Mycobacterium tuberculosis While Reactivation of Latent Infection Is Dependent on Severity of Tissue Depletion in Cynomolgus Macaques

(2012) Philana Ling Lin et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15

(2012) Aaron M Ring et al.   NATURE IMMUNOLOGY

Differential expression analysis of multifactor RNA-Seq experiments with respect to biological variation

(2012) Davis J. McCarthy et al.   NUCLEIC ACIDS RESEARCH

Circos: An information aesthetic for comparative genomics

(2009) M. Krzywinski et al.   GENOME RESEARCH

A Critical Role for CD8 T Cells in a Nonhuman Primate Model of Tuberculosis

(2009) Crystal Y. Chen et al.   PLoS Pathogens

IL-15 trans-presentation promotes human NK cell development and differentiation in vivo

(2008) Nicholas D. Huntington et al.   JOURNAL OF EXPERIMENTAL MEDICINE