The Mass Production of Redundant, Misleading, and Conflicted Systematic Reviews and Meta-analyses

Field-wide meta-analyses of observational associations can map selective availability of risk factors and the impact of model specifications

(2016) Stylianos Serghiou et al.   JOURNAL OF CLINICAL EPIDEMIOLOGY

Meta-analyses with industry involvement are massively published and report no caveats for antidepressants

(2016) Shanil Ebrahim et al.   JOURNAL OF CLINICAL EPIDEMIOLOGY

Reproducible Research Practices and Transparency across the Biomedical Literature

(2016) Shareen A. Iqbal et al.   PLOS BIOLOGY

Epidemiology and Reporting Characteristics of Systematic Reviews of Biomedical Research: A Cross-Sectional Study

(2016) Matthew J. Page et al.   PLOS MEDICINE

The PRISMA Extension Statement for Reporting of Systematic Reviews Incorporating Network Meta-analyses of Health Care Interventions: Checklist and Explanations

(2015) Brian Hutton et al.   ANNALS OF INTERNAL MEDICINE

The Proposed Rule for U.S. Clinical Trial Registration and Results Submission

(2015) Deborah A. Zarin et al.   NEW ENGLAND JOURNAL OF MEDICINE

The COMET initiative database: progress and activities update (2014)

(2015) Elizabeth Gargon et al.   Trials

Why data sharing should be the expected norm

(2015) H. M. Krumholz   BMJ-British Medical Journal

Completeness of main outcomes across randomized trials in entire discipline: survey of chronic lung disease outcomes in preterm infants

(2015) J. P. A. Ioannidis et al.   BMJ-British Medical Journal

Restoring Study 329: efficacy and harms of paroxetine and imipramine in treatment of major depression in adolescence

(2015) Joanna Le Noury et al.   BMJ-British Medical Journal

Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: elaboration and explanation

(2015) L. Shamseer et al.   BMJ-British Medical Journal

Why data sharing should be the expected norm

(2015) H. M. Krumholz   BMJ-British Medical Journal

Completeness of main outcomes across randomized trials in entire discipline: survey of chronic lung disease outcomes in preterm infants

(2015) J. P. A. Ioannidis et al.   BMJ-British Medical Journal

Restoring Study 329: efficacy and harms of paroxetine and imipramine in treatment of major depression in adolescence

(2015) Joanna Le Noury et al.   BMJ-British Medical Journal

Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: elaboration and explanation

(2015) L. Shamseer et al.   BMJ-British Medical Journal

Financial Conflicts of Interest and Conclusions About Neuraminidase Inhibitors for Influenza

(2014) Adam G. Dunn et al.   ANNALS OF INTERNAL MEDICINE

Sea Change in Open Science and Data Sharing: Leadership by Industry

(2014) H. M. Krumholz et al.  

Reanalyses of Randomized Clinical Trial Data

(2014) Shanil Ebrahim et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

How evidence-based medicine is failing due to biased trials and selective publication

(2014) Susanna Every-Palmer et al.   JOURNAL OF EVALUATION IN CLINICAL PRACTICE

Biomedical research: increasing value, reducing waste

(2014) Malcolm R Macleod et al.   LANCET

Increasing value and reducing waste in research design, conduct, and analysis

(2014) John P A Ioannidis et al.   LANCET

Bibliometrics: Is your most cited work your best?

(2014) John P. A. Ioannidis et al.   NATURE

Systematic Reviews of Animal Studies; Missing Link in Translational Research?

(2014) Judith van Luijk et al.   PLoS One

The Need for Randomization in Animal Trials: An Overview of Systematic Reviews

(2014) Jennifer A. Hirst et al.   PLoS One

Evaluating the Quality of Evidence from a Network Meta-Analysis

(2014) Georgia Salanti et al.   PLoS One

Dissemination Bias in Systematic Reviews of Animal Research: A Systematic Review

(2014) Katharina F. Mueller et al.   PLoS One

Quality of reporting in systematic reviews of adverse events: systematic review

(2014) L. Zorzela et al.   BMJ-British Medical Journal

Multisystem failure: the story of anti-influenza drugs

(2014) T. Jefferson et al.   BMJ-British Medical Journal

Evidence based medicine: a movement in crisis?

(2014) T. Greenhalgh et al.   BMJ-British Medical Journal

Oseltamivir for influenza in adults and children: systematic review of clinical study reports and summary of regulatory comments

(2014) T. Jefferson et al.   BMJ-British Medical Journal

How to Make More Published Research True

(2014) John P. A. Ioannidis   PLOS MEDICINE

Seeding Trials: Just Say “No”

(2013) Harold C. Sox et al.   ANNALS OF INTERNAL MEDICINE

The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration

(2013) Alessandro Liberati   ANNALS OF INTERNAL MEDICINE

Comparative Benefits and Harms of Second-Generation Antidepressants for Treating Major Depressive Disorder

(2013) Gerald Gartlehner et al.   ANNALS OF INTERNAL MEDICINE

Trust but Verify: Trial Registration and Determining Fidelity to the Protocol

(2013) Deborah A. Zarin et al.   ANNALS OF INTERNAL MEDICINE

The Power of Meta-Analysis in Genome-Wide Association Studies

(2013) Orestis A. Panagiotou et al.   Annual Review of Genomics and Human Genetics

Ushering in a New Era of Open Science Through Data Sharing

(2013) Joseph S. Ross et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Most meta-analyses of drug interventions have narrow scopes and many focus on specific agents

(2013) Anna-Bettina Haidich et al.   JOURNAL OF CLINICAL EPIDEMIOLOGY

Publication of Trials Funded by the National Heart, Lung, and Blood Institute

(2013) David Gordon et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Geometric Increase in Meta-Analyses from China in the Genomic Era

(2013) John P. A. Ioannidis et al.   PLoS One

The case for duplication of meta-analyses and systematic reviews

(2013) H. Krumholz   BMJ-British Medical Journal

Trusting researchers to use open trial registers such as PROSPERO responsibly

(2013) A. Booth et al.   BMJ-British Medical Journal

Ensuring the integrity of clinical practice guidelines: a tool for protecting patients

(2013) Jeanne Lenzer et al.   BMJ-British Medical Journal

The automation of systematic reviews

(2013) G. Tsafnat et al.   BMJ-British Medical Journal

Overlapping meta-analyses on the same topic: survey of published studies

(2013) K. C. Siontis et al.   BMJ-British Medical Journal

Why we can't trust clinical guidelines

(2013) J. Lenzer   BMJ-British Medical Journal

Evaluation of Excess Significance Bias in Animal Studies of Neurological Diseases

(2013) Konstantinos K. Tsilidis et al.   PLOS BIOLOGY

Cochrane and non-Cochrane systematic reviews in leading orthodontic journals: a quality paradigm?

(2012) P. S. Fleming et al.   EUROPEAN JOURNAL OF ORTHODONTICS

Systematic analysis of hydroxyethyl starch (HES) reviews: proliferation of low-quality reviews overwhelms the results of well-performed meta-analyses

(2012) Christiane S. Hartog et al.   INTENSIVE CARE MEDICINE

Raise standards for preclinical cancer research

(2012) C. Glenn Begley et al.   NATURE

High reprint orders in medical journals and pharmaceutical industry funding: case-control study

(2012) A. E. Handel et al.   BMJ-British Medical Journal

Content area experts as authors: helpful or harmful for systematic reviews and meta-analyses?

(2012) P. C. Gotzsche et al.   BMJ-British Medical Journal

The False-positive to False-negative Ratio in Epidemiologic Studies

(2011) John P. A. Ioannidis et al.   EPIDEMIOLOGY

An Evidence-Based Medicine Methodology To Bridge The Gap Between Clinical And Environmental Health Sciences

(2011) Tracey J. Woodruff et al.   HEALTH AFFAIRS

Believe it or not: how much can we rely on published data on potential drug targets?

(2011) Florian Prinz et al.   NATURE REVIEWS DRUG DISCOVERY

The methodology for developing a prospective meta-analysis in the family planning community

(2011) David K Turok et al.   Trials

Promotional Tone in Reviews of Menopausal Hormone Therapy After the Women's Health Initiative: An Analysis of Published Articles

(2011) Adriane Fugh-Berman et al.   PLOS MEDICINE

Meta-research: The art of getting it wrong

(2011) John P. A. Ioannidis   Research Synthesis Methods

Twenty Years of Meta-Analyses in Orthopaedic Surgery: Has Quality Kept Up with Quantity?

(2010) Bernadette G Dijkman et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

Partisan Perspectives in the Medical Literature: A Study of High Frequency Editorialists Favoring Hormone Replacement Therapy

(2010) Athina Tatsioni et al.   JOURNAL OF GENERAL INTERNAL MEDICINE

Publication Bias in Reports of Animal Stroke Studies Leads to Major Overstatement of Efficacy

(2010) Emily S. Sena et al.   PLOS BIOLOGY

Seventy-Five Trials and Eleven Systematic Reviews a Day: How Will We Ever Keep Up?

(2010) Hilda Bastian et al.   PLOS MEDICINE

Development of a combined database for meta-epidemiological research

(2010) Jelena Savović et al.   Research Synthesis Methods

An international survey indicated that unpublished systematic reviews exist

(2009) Andrea C. Tricco et al.   JOURNAL OF CLINICAL EPIDEMIOLOGY

AHRQ Series Paper 5: Grading the strength of a body of evidence when comparing medical interventions—Agency for Healthcare Research and Quality and the Effective Health-Care Program

(2009) Douglas K. Owens et al.   JOURNAL OF CLINICAL EPIDEMIOLOGY

Ranking antidepressants

(2009) John PA Ioannidis   LANCET

Comparative efficacy and acceptability of 12 new-generation antidepressants: a multiple-treatments meta-analysis

(2009) Andrea Cipriani et al.   LANCET

Industry-supported meta-analyses compared with meta-analyses with non-profit or no support: Differences in methodological quality and conclusions

(2008) Anders W Jørgensen et al.   BMC Medical Research Methodology

Selective Publication of Antidepressant Trials and Its Influence on Apparent Efficacy

(2008) Erick H. Turner et al.   NEW ENGLAND JOURNAL OF MEDICINE

Evaluation of meta-analyses in the otolaryngological literature

(2008) Luke R. Rudmik et al.   OTOLARYNGOLOGY-HEAD AND NECK SURGERY

Following 411 Cochrane Protocols to Completion: A Retrospective Cohort Study

(2008) Andrea C. Tricco et al.   PLoS One

Empirical Evidence of Bias in the Design of Experimental Stroke Studies

(2008) Nicolas A. Crossley et al.   STROKE

Primer: strengths and weaknesses of meta-analysis

(2008) Axel Finckh et al.   Nature clinical practice. Rheumatology

How useful are systematic reviews for informing palliative care practice? Survey of 25 Cochrane systematic reviews

(2008) Bee Wee et al.   BMC Palliative Care

Effectiveness of antidepressants: an evidence myth constructed from a thousand randomized trials?

(2008) John PA Ioannidis   Philosophy Ethics and Humanities in Medicine