Implications of intrinsic disorder and functional proteomics in the merkel cell polyomavirus life cycle

Liaisons dangereuses: Intrinsic Disorder in Cellular Proteins Recruited to Viral Infection-Related Biocondensates

(2023) Greta Bianchi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Prediction of liquid–liquid phase separating proteins using machine learning

(2022) Xiaoquan Chu et al.   BMC BIOINFORMATICS

FuzDrop on AlphaFold: visualizing the sequence-dependent propensity of liquid–liquid phase separation and aggregation of proteins

(2022) Andras Hatos et al.   NUCLEIC ACIDS RESEARCH

Long-read sequencing reveals complex patterns of wraparound transcription in polyomaviruses

(2022) Jason Nomburg et al.   PLoS Pathogens

I-TASSER-MTD: a deep-learning-based platform for multi-domain protein structure and function prediction

(2022) Xiaogen Zhou et al.   Nature Protocols

Exosome biogenesis: machinery, regulation, and therapeutic implications in cancer

(2022) Qing-Fang Han et al.   Molecular Cancer

Intrinsically disordered regions that drive phase separation form a robustly distinct protein class

(2022) Ayyam Y. Ibrahim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

UniProt: the Universal Protein Knowledgebase in 2023

(2022) et al.   NUCLEIC ACIDS RESEARCH

Rapid prediction and analysis of protein intrinsic disorder

(2022) Guy W. Dayhoff et al.   PROTEIN SCIENCE

Merkel cell polyomavirus small T antigen is a viral transcription activator that is essential for viral genome maintenance

(2022) Kyle Rapchak et al.   PLoS Pathogens

Epidemiology of Merkel Cell Polyomavirus Infection and Merkel Cell Carcinoma

(2022) Steffi Silling et al.   Cancers

Merkel Cell Carcinoma—Update on Diagnosis, Management and Future Perspectives

(2022) Eleni Zaggana et al.   Cancers

Comprehensive Intrinsic Disorder Analysis of 6108 Viral Proteomes: From the Extent of Intrinsic Disorder Penetrance to Functional Annotation of Disordered Viral Proteins

(2021) Naveen Kumar et al.   JOURNAL OF PROTEOME RESEARCH

Characterization of ALTO-encoding circular RNAs expressed by Merkel cell polyomavirus and trichodysplasia spinulosa polyomavirus

(2021) Rong Yang et al.   PLoS Pathogens

Emerging role of human polyomaviruses 6 and 7 in human cancers

(2021) Faisal Klufah et al.   Infectious Agents and Cancer

Sequence Determinants of the Aggregation of Proteins Within Condensates Generated by Liquid-liquid Phase Separation

(2021) Michele Vendruscolo et al.   JOURNAL OF MOLECULAR BIOLOGY

Highly accurate protein structure prediction with AlphaFold

(2021) John Jumper et al.   NATURE

Accurate prediction of protein structures and interactions using a three-track neural network

(2021) Minkyung Baek et al.   SCIENCE

From Merkel Cell Polyomavirus Infection to Merkel Cell Carcinoma Oncogenesis

(2021) Nathan A. Krump et al.   Frontiers in Microbiology

The Eukaryotic Linear Motif resource: 2022 release

(2021) Manjeet Kumar et al.   NUCLEIC ACIDS RESEARCH

Selective sorting of microRNAs into exosomes by phase-separated YBX1 condensates

(2021) Xiao-Man Liu et al.   eLife

Surface charge of Merkel cell polyomavirus small T antigen determines cell transformation through allosteric FBW7 WD40 domain targeting

(2020) Nnenna Nwogu et al.   Oncogenesis

Structure of Merkel cell polyomavirus capsid and interaction with its glycosaminoglycan attachment receptor

(2020) Niklas J. Bayer et al.   JOURNAL OF VIROLOGY

Merkel Cell Polyomavirus Large T Antigen Unique Domain Regulates Its Own Protein Stability and Cell Growth

(2020) Nnenna Nwogu et al.   Viruses-Basel

Liquid–Liquid Phase Separation by Intrinsically Disordered Protein Regions of Viruses: Roles in Viral Life Cycle and Control of Virus–Host Interactions

(2020) Stefania Brocca et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Widespread occurrence of the droplet state of proteins in the human proteome

(2020) Maarten Hardenberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Merkel cell polyomavirus Tumor antigens expressed in Merkel cell carcinoma function independently of the ubiquitin ligases Fbw7 and β-TrCP

(2019) Kristine N. Dye et al.   PLoS Pathogens

Considerations and Challenges in Studying Liquid-Liquid Phase Separation and Biomolecular Condensates

(2019) Simon Alberti et al.   CELL

Computational identification of prion-like RNA-binding proteins that form liquid phase-separated condensates

(2019) Gabriele Orlando et al.   BIOINFORMATICS

Effect of the Large and Small T-Antigens of Human Polyomaviruses on Signaling Pathways

(2019) Ugo Moens et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Merkel cell carcinoma: Current US incidence and projected increases based on changing demographics

(2018) Kelly G. Paulson et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

The Structure of an Infectious Human Polyomavirus and Its Interactions with Cellular Receptors

(2018) Daniel L. Hurdiss et al.   STRUCTURE

Pi-Pi contacts are an overlooked protein feature relevant to phase separation

(2018) Robert McCoy Vernon et al.   eLife

Physical Chemistry of Cellular Liquid Phase Separation

(2018) Emily P. Bentley et al.   CHEMISTRY-A EUROPEAN JOURNAL

Biology, evolution, and medical importance of polyomaviruses: An update

(2017) Ugo Moens et al.   INFECTION GENETICS AND EVOLUTION

Protein-mediated viral latency is a novel mechanism for Merkel cell polyomavirus persistence

(2017) Hyun Jin Kwun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Merkel cell polyomavirus recruits MYCL to the EP400 complex to promote oncogenesis

(2017) Jingwei Cheng et al.   PLoS Pathogens

A Concentration-Dependent Liquid Phase Separation Can Cause Toxicity upon Increased Protein Expression

(2016) Benedetta Bolognesi et al.   Cell Reports

High-throughput prediction of RNA, DNA and protein binding regions mediated by intrinsic disorder

(2015) Zhenling Peng et al.   NUCLEIC ACIDS RESEARCH

Intrinsically disordered proteins and multicellular organisms

(2015) A. Keith Dunker et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

PLAAC: a web and command-line application to identify proteins with prion-like amino acid composition

(2014) A. K. Lancaster et al.   BIOINFORMATICS

Structural Disorder in Viral Proteins

(2014) Bin Xue et al.   CHEMICAL REVIEWS

Short Linear Motifs: Ubiquitous and Functionally Diverse Protein Interaction Modules Directing Cell Regulation

(2014) Kim Van Roey et al.   CHEMICAL REVIEWS

Disordered Interactome of Human Papillomavirus

(2014) Bin Xue et al.   CURRENT PHARMACEUTICAL DESIGN

Merkel Cell Polyomavirus Small T Antigen Mediates Microtubule Destabilization To Promote Cell Motility and Migration

(2014) Laura M. Knight et al.   JOURNAL OF VIROLOGY

Merkel Cell Polyomavirus Small T Antigen Controls Viral Replication and Oncoprotein Expression by Targeting the Cellular Ubiquitin Ligase SCFFbw7

(2013) Hyun Jin Kwun et al.   Cell Host & Microbe

The Merkel Cell Polyomavirus Minor Capsid Protein

(2013) Rachel M. Schowalter et al.   PLoS Pathogens

Structures of Merkel Cell Polyomavirus VP1 Complexes Define a Sialic Acid Binding Site Required for Infection

(2012) Ursula Neu et al.   PLoS Pathogens

Comparative analysis of SV40 17kT and LT function in vivo demonstrates that LT’s C-terminus re-programs hepatic gene expression and is necessary for tumorigenesis in the liver

(2012) S A Comerford et al.   Oncogenesis

Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega

(2011) F. Sievers et al.   Molecular Systems Biology

PONDR-FIT: A meta-predictor of intrinsically disordered amino acids

(2010) Bin Xue et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Lessons in Signaling and Tumorigenesis from Polyomavirus Middle T Antigen

(2009) M. M. Fluck et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Clonal Integration of a Polyomavirus in Human Merkel Cell Carcinoma

(2008) H. Feng et al.   SCIENCE