Surface charge of Merkel cell polyomavirus small T antigen determines cell transformation through allosteric FBW7 WD40 domain targeting

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The WD40 domain of FBXW7 is a poly(ADP-ribose)-binding domain that mediates the early DNA damage response

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The additive mutational effects from surface charge engineering: A compromise between enzyme activity, thermostability and ionic liquid tolerance

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Cellular sheddases are induced by Merkel cell polyomavirus small tumour antigen to mediate cell dissociation and invasiveness

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FBXW7 mutations reduce binding of NOTCH1, leading to cleaved NOTCH1 accumulation and target gene activation in CLL

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The ClusPro web server for protein–protein docking

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Merkel cell polyomavirus small T antigen induces genome instability by E3 ubiquitin ligase targeting

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Protein-mediated viral latency is a novel mechanism for Merkel cell polyomavirus persistence

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An allosteric conduit facilitates dynamic multisite substrate recognition by the SCFCdc4 ubiquitin ligase

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Merkel cell polyomavirus recruits MYCL to the EP400 complex to promote oncogenesis

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Systematic approaches to identify E3 ligase substrates

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Oncogenic mutations in the FBXW7 gene of adult T-cell leukemia patients

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Merkel Cell Polyomavirus Small T Antigen Promotes Pro-Glycolytic Metabolic Perturbations Required for Transformation

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Merkel Cell Polyomavirus Small T Antigen Is Oncogenic in Transgenic Mice

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Restricted Protein Phosphatase 2A Targeting by Merkel Cell Polyomavirus Small T Antigen

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CDK1 substitutes for mTOR kinase to activate mitotic cap-dependent protein translation

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FBXW7 Mutations in Melanoma and a New Therapeutic Paradigm

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Merkel Cell Polyomavirus Small T Antigen Mediates Microtubule Destabilization To Promote Cell Motility and Migration

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Synergistic blockade of mitotic exit by two chemical inhibitors of the APC/C

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Merkel Cell Polyomavirus Small T Antigen Controls Viral Replication and Oncoprotein Expression by Targeting the Cellular Ubiquitin Ligase SCFFbw7

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Fbw7 dimerization determines the specificity and robustness of substrate degradation

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Merkel Cell Polyomavirus Large T Antigen Disrupts Host Genomic Integrity and Inhibits Cellular Proliferation

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Merkel Cell Polyomavirus Large T Antigen Has Growth-Promoting and Inhibitory Activities

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Immunoaffinity Enrichment and Mass Spectrometry Analysis of Protein Methylation

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Mechanisms and function of substrate recruitment by F-box proteins

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Human Merkel cell polyomavirus small T antigen is an oncoprotein targeting the 4E-BP1 translation regulator

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SCF ubiquitin ligases in the maintenance of genome stability

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Surface Charge: A Key Determinant of Protein Localization and Function

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Inhibitors for E3 ubiquitin ligases

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I-TASSER: a unified platform for automated protein structure and function prediction

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WD40 proteins propel cellular networks

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The Minimum Replication Origin of Merkel Cell Polyomavirus Has a Unique Large T-Antigen Loading Architecture and Requires Small T-Antigen Expression for Optimal Replication

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T antigen mutations are a human tumor-specific signature for Merkel cell polyomavirus

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Clonal Integration of a Polyomavirus in Human Merkel Cell Carcinoma

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