JNK regulates ciliogenesis through the interflagellar transport complex and actin networks

JNK Activation in Alzheimer’s Disease Is Driven by Amyloid β and Is Associated with Tau Pathology

(2023) Maite Solas et al.   ACS Chemical Neuroscience

Lrrcc1 and Ccdc61 are conserved effectors of multiciliated cell function

(2022) Aude Nommick et al.   JOURNAL OF CELL SCIENCE

Impact of Motile Ciliopathies on Human Development and Clinical Consequences in the Newborn

(2022) Rachael M. Hyland et al.   Cells

CC-90001, a c-Jun N-terminal kinase (JNK) inhibitor, in patients with pulmonary fibrosis: design of a phase 2, randomised, placebo-controlled trial

(2022) Zoran Popmihajlov et al.   BMJ Open Respiratory Research

Sequential action of JNK genes establishes the embryonic left-right axis

(2022) Christopher J. Derrick et al.   DEVELOPMENT

Microridge-like structures anchor motile cilia

(2022) Takayuki Yasunaga et al.   Nature Communications

The apical ciliary adhesion complex is established at the basal foot of motile cilia and depends on the microtubule network

(2022) Maria Chatzifrangkeskou et al.   Scientific Reports

Primary Cilia and Atherosclerosis

(2021) Zhi-Mei Wang et al.   Frontiers in Physiology

Cytoskeleton and Associated Proteins: Pleiotropic JNK Substrates and Regulators

(2021) Béatrice Benoit et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

c-Jun N-terminal kinase (JNK) signaling contributes to cystic burden in polycystic kidney disease

(2021) Abigail O. Smith et al.   PLoS Genetics

Selective inhibitors for JNK signalling: a potential targeted therapy in cancer

(2020) Qinghua Wu et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Cilia and polycystic kidney disease

(2020) Ming Ma   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Role of c-Jun N-terminal Kinase (JNK) in Obesity and Type 2 Diabetes

(2020) Justin Hou Ming Yung et al.   Cells

Human IFT52 mutations uncover a novel role for the protein in microtubule dynamics and centrosome cohesion

(2019) Marie Alice Dupont et al.   HUMAN MOLECULAR GENETICS

Biology of multiciliated cells

(2019) Camille Boutin et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Phosphorylation sites of microtubule-associated protein 1B (MAP 1B) are involved in axon growth and regeneration

(2019) Yuya Ishikawa et al.   Molecular Brain

Cav-1 promotes atherosclerosis by activating JNK-associated signaling

(2018) Dong-Xia Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

WDR5 Stabilizes Actin Architecture to Promote Multiciliated Cell Formation

(2018) Saurabh S. Kulkarni et al.   DEVELOPMENTAL CELL

Expanding the genetic architecture and phenotypic spectrum in the skeletal ciliopathies

(2017) Wenjuan Zhang et al.   HUMAN MUTATION

Intraflagellar transport protein IFT52 recruits IFT46 to the basal body and flagella

(2017) Bo Lv et al.   JOURNAL OF CELL SCIENCE

RhoA regulates actin network dynamics during apical surface emergence in multiciliated epithelial cells

(2017) Jakub Sedzinski et al.   JOURNAL OF CELL SCIENCE

The Ciliary Transition Zone: Finding the Pieces and Assembling the Gate

(2017) João Gonçalves et al.   MOLECULES AND CELLS

The development and functions of multiciliated epithelia

(2017) Nathalie Spassky et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cilia and Obesity

(2017) Christian Vaisse et al.   Cold Spring Harbor Perspectives in Biology

The signalling receptor MCAM coordinates apical-basal polarity and planar cell polarity during morphogenesis

(2017) Qian Gao et al.   Nature Communications

The JNK Signaling Pathway in Renal Fibrosis

(2017) Keren Grynberg et al.   Frontiers in Physiology

The role of primary cilia in obesity and diabetes

(2016) Francesco Volta et al.   Annals of the New York Academy of Sciences

Emergence of an Apical Epithelial Cell Surface In Vivo

(2016) Jakub Sedzinski et al.   DEVELOPMENTAL CELL

IFT52mutations destabilize anterograde complex assembly, disrupt ciliogenesis and result in short rib polydactyly syndrome

(2016) Wenjuan Zhang et al.   HUMAN MOLECULAR GENETICS

Ciliary transcription factors and miRNAs precisely regulate Cp110 levels required for ciliary adhesions and ciliogenesis

(2016) Peter Walentek et al.   eLife

c-Jun N-terminal Kinase (JNK) Signaling as a Therapeutic Target for Alzheimer’s Disease

(2016) Ramon Yarza et al.   Frontiers in Pharmacology

The essential roles of transition fibers in the context of cilia

(2015) Qing Wei et al.   CURRENT OPINION IN CELL BIOLOGY

The ciliary transition zone functions in cell adhesion but is dispensable for axoneme assembly inC. elegans

(2015) Clementine Schouteden et al.   JOURNAL OF CELL BIOLOGY

miR-34/449 control apical actin network formation during multiciliogenesis through small GTPase pathways

(2015) Benoît Chevalier et al.   Nature Communications

Superresolution Pattern Recognition Reveals the Architectural Map of the Ciliary Transition Zone

(2015) T. Tony Yang et al.   Scientific Reports

Multiciliated Cells

(2014) Eric R. Brooks et al.   CURRENT BIOLOGY

The Rac1 regulator ELMO controls basal body migration and docking in multiciliated cells through interaction with Ezrin

(2014) D. Epting et al.   DEVELOPMENT

Making the Connection: Ciliary Adhesion Complexes Anchor Basal Bodies to the Actin Cytoskeleton

(2014) Ioanna Antoniades et al.   DEVELOPMENTAL CELL

Crystal structures of IFT70/52 and IFT52/46 provide insight into intraflagellar transport B core complex assembly

(2014) Michael Taschner et al.   JOURNAL OF CELL BIOLOGY

Chibby promotes ciliary vesicle formation and basal body docking during airway cell differentiation

(2014) Michael C. Burke et al.   JOURNAL OF CELL BIOLOGY

NPHP4 controls ciliary trafficking of membrane proteins and large soluble proteins at the transition zone

(2014) J. Awata et al.   JOURNAL OF CELL SCIENCE

C2cd3 is critical for centriolar distal appendage assembly and ciliary vesicle docking in mammals

(2014) Xuan Ye et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cep164 triggers ciliogenesis by recruiting Tau tubulin kinase 2 to the mother centriole

(2014) L.  ajanek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

JNK1 controls dendritic field size in L2/3 and L5 of the motor cortex, constrains soma size, and influences fine motor coordination

(2014) Emilia Komulainen et al.   Frontiers in Cellular Neuroscience

JNK signalling in cancer: in need of new, smarter therapeutic targets

(2013) Concetta Bubici et al.   BRITISH JOURNAL OF PHARMACOLOGY

Combining docking site and phosphosite predictions to find new substrates: Identification of smoothelin-like-2 (SMTNL2) as a c-Jun N-terminal kinase (JNK) substrate

(2013) Elizabeth A. Gordon et al.   CELLULAR SIGNALLING

Xenopus laevis nucleotide binding protein 1 (xNubp1) is important for convergent extension movements and controls ciliogenesis via regulation of the actin cytoskeleton

(2013) Andriani Ioannou et al.   DEVELOPMENTAL BIOLOGY

Centriole distal appendages promote membrane docking, leading to cilia initiation

(2013) B. E. Tanos et al.   GENES & DEVELOPMENT

Two appendages homologous between basal bodies and centrioles are formed using distinctOdf2domains

(2013) Kazuhiro Tateishi et al.   JOURNAL OF CELL BIOLOGY

Involvement of JNK in the Embryonic Development and Organogenesis in Zebrafish

(2013) Yamei Xiao et al.   MARINE BIOTECHNOLOGY

CCDC41 is required for ciliary vesicle docking to the mother centriole

(2013) K. Joo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cilia functions in development

(2012) Iain A Drummond   CURRENT OPINION IN CELL BIOLOGY

The base of the cilium: roles for transition fibres and the transition zone in ciliary formation, maintenance and compartmentalization

(2012) Jeremy F Reiter et al.   EMBO REPORTS

Cep164 mediates vesicular docking to the mother centriole during early steps of ciliogenesis

(2012) Kerstin N. Schmidt et al.   JOURNAL OF CELL BIOLOGY

Actin realignment and cofilin regulation are essential for barrier integrity during shear stress

(2012) Joshua B. Slee et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

c-Jun N-Terminal Kinase Phosphorylation of MARCKSL1 Determines Actin Stability and Migration in Neurons and in Cancer Cells

(2012) B. Bjorkblom et al.   MOLECULAR AND CELLULAR BIOLOGY

Mapping the NPHP-JBTS-MKS Protein Network Reveals Ciliopathy Disease Genes and Pathways

(2011) Liyun Sang et al.   CELL

C-Jun N-Terminal kinase mediates disassembly of apical junctions in model intestinal epithelia

(2011) Nayden G. Naydenov et al.   CELL CYCLE

Lack of Primary Cilia Primes Shear-Induced Endothelial-to-Mesenchymal Transition

(2011) Anastasia D. Egorova et al.   CIRCULATION RESEARCH

Assessing the localization of centrosomal proteins by PALM/STORM nanoscopy

(2011) James E. Sillibourne et al.   Cytoskeleton

Understanding ciliated epithelia: The power ofXenopus

(2011) M.E. Werner et al.   GENESIS

MKS and NPHP modules cooperate to establish basal body/transition zone membrane associations and ciliary gate function during ciliogenesis

(2011) Corey L. Williams et al.   JOURNAL OF CELL BIOLOGY

A ciliopathy complex at the transition zone protects the cilia as a privileged membrane domain

(2011) Ben Chih et al.   NATURE CELL BIOLOGY

A transition zone complex regulates mammalian ciliogenesis and ciliary membrane composition

(2011) Francesc R Garcia-Gonzalo et al.   NATURE GENETICS

Imaging protein activity in live embryos using fluorescence resonance energy transfer biosensors

(2011) Elena Kardash et al.   Nature Protocols

Planar cell polarity signaling, cilia and polarized ciliary beating

(2010) John B Wallingford   CURRENT OPINION IN CELL BIOLOGY

Fluid shear stress-induced JNK activity leads to actin remodeling for cell alignment

(2010) Meron Mengistu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Visualization of JNK activity dynamics with a genetically encoded fluorescent biosensor

(2010) M. Fosbrink et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Septin Diffusion Barrier at the Base of the Primary Cilium Maintains Ciliary Membrane Protein Distribution

(2010) Q. Hu et al.   SCIENCE

Assembly of primary cilia

(2008) Lotte B. Pedersen et al.   DEVELOPMENTAL DYNAMICS

Dishevelled controls apical docking and planar polarization of basal bodies in ciliated epithelial cells

(2008) Tae Joo Park et al.   NATURE GENETICS

Identification of a new JNK inhibitor targeting the JNK-JIP interaction site

(2008) J. L. Stebbins et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dishevelled links basal body docking and orientation in ciliated epithelial cells

(2008) Eszter K. Vladar et al.   TRENDS IN CELL BIOLOGY