Selective inhibitors for JNK signalling: a potential targeted therapy in cancer

JNK signaling in cancer cell survival

(2019) Qinghua Wu et al.   MEDICINAL RESEARCH REVIEWS

In silico-in vitro discovery of untargeted kinase–inhibitor interactions from kinase-targeted therapies: A case study on the cancer MAPK signaling pathway

(2018) Li Meng et al.   COMPUTATIONAL BIOLOGY AND CHEMISTRY

TRPM2 channel–mediated regulation of autophagy maintains mitochondrial function and promotes gastric cancer cell survival via the JNK-signaling pathway

(2018) Shekoufeh Almasi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tumor necrosis factor receptor-associated factor 6 mediated the promotion of salivary adenoid cystic carcinoma progression through Smad-p38-JNK signaling pathway induced by TGF-β

(2018) Yancan Liang et al.   JOURNAL OF ORAL PATHOLOGY & MEDICINE

Chemotherapy-Induced Tunneling Nanotubes Mediate Intercellular Drug Efflux in Pancreatic Cancer

(2018) Snider Desir et al.   Scientific Reports

37LRP induces invasion in hypoxic lung adenocarcinoma cancer cells A549 through the JNK/ERK/c-Jun signaling cascade

(2017) Yongan Zhou et al.   TUMOR BIOLOGY

Role of JNK signaling in oral cancer: A mini review

(2017) Ioannis Gkouveris et al.   TUMOR BIOLOGY

A c-Jun N-terminal kinase inhibitor, JNK-IN-8, sensitizes triple negative breast cancer cells to lapatinib

(2017) Nancy D. Ebelt et al.   Oncotarget

JNK, p38, ERK, and SGK1 Inhibitors in Cancer

(2017) Jonas Cicenas et al.   Cancers

A multicenter, single-arm, open-label, phase 2 study of apitolisib (GDC-0980) for the treatment of recurrent or persistent endometrial carcinoma (MAGGIE study)

(2016) Vicky Makker et al.   CANCER

PI3K p110β isoform synergizes with JNK in the regulation of glioblastoma cell proliferation and migration through Akt and FAK inhibition

(2016) Hua-Fu Zhao et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

TGF-β Down-regulates Apolipoprotein M Expression through the TAK-1-JNK-c-Jun Pathway in HepG2 Cells

(2016) Kun Ren et al.   LIPIDS

JNK Signaling: Regulation and Functions Based on Complex Protein-Protein Partnerships

(2016) András Zeke et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Elevated STC-1 augments the invasiveness of triple-negative breast cancer cells through activation of the JNK/c-Jun signaling pathway

(2016) Jeonghun Han et al.   ONCOLOGY REPORTS

Identification of p62/SQSTM1 as a component of non-canonical Wnt VANGL2–JNK signalling in breast cancer

(2016) Tania M. Puvirajesinghe et al.   Nature Communications

The novel JNK inhibitor AS602801 inhibits cancer stem cells in vitro and in vivo

(2016) Masashi Okada et al.   Oncotarget

Co-Targeting of JNK and HUNK in Resistant HER2-Positive Breast Cancer

(2016) Kendall Phelps-Polirer et al.   PLoS One

ROS activates JNK-mediated autophagy to counteract apoptosis in mouse mesenchymal stem cells in vitro

(2015) Guan-yu Liu et al.   ACTA PHARMACOLOGICA SINICA

Crosstalk between JNK and NF-κB signaling pathways via HSP27 phosphorylation in HepG2 cells

(2015) Jie Ruan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

CIP2A overexpression induces autoimmune response and enhances JNK signaling pathway in human lung cancer

(2015) Bo Peng et al.   BMC CANCER

Phase I study of OPB-51602, an oral inhibitor of signal transducer and activator of transcription 3, in patients with relapsed/refractory hematological malignancies

(2015) Michinori Ogura et al.   CANCER SCIENCE

JNK pathway signaling: a novel and smarter therapeutic targets for various biological diseases

(2015) Ankit Kumar et al.   Future Medicinal Chemistry

Phase 1 and pharmacological trial of OPB-31121, a signal transducer and activator of transcription-3 inhibitor, in patients with advanced hepatocellular carcinoma

(2015) Takuji Okusaka et al.   HEPATOLOGY RESEARCH

Phosphorylation of GlutathioneS-Transferase P1 (GSTP1) by Epidermal Growth Factor Receptor (EGFR) Promotes Formation of the GSTP1-c-Jun N-terminal kinase (JNK) Complex and Suppresses JNK Downstream Signaling and Apoptosis in Brain Tumor Cells

(2015) Tatsunori Okamura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DUSP4 deficiency caused by promoter hypermethylation drives JNK signaling and tumor cell survival in diffuse large B cell lymphoma

(2015) Corina A. Schmid et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The c-Jun N-terminal kinase inhibitor SP600125 inhibits human cytomegalovirus replication

(2015) Huiping Zhang et al.   JOURNAL OF MEDICAL VIROLOGY

Subconjunctival Injection of XG-102, a JNK Inhibitor Peptide, in Patients with Intraocular Inflammation: A Safety and Tolerability Study

(2015) Talal Beydoun et al.   JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS

Interleukin-33 predicts poor prognosis and promotes ovarian cancer cell growth and metastasis through regulating ERK and JNK signaling pathways

(2015) Xiaoguang Tong et al.   Molecular Oncology

Ginsenoside Rg1 Ameliorates Motor Function in an Animal Model of Parkinson's Disease

(2015) Wenda Jiang et al.   PHARMACOLOGY

Ginsenoside Rg1, a potential JNK inhibitor, protects against ischemia/reperfusion-induced liver damage

(2015) Xiao-Jing Zhang et al.   Journal of Functional Foods

Pyridopyrimidinone Derivatives as Potent and Selective c-Jun N-Terminal Kinase (JNK) Inhibitors

(2015) Ke Zheng et al.   ACS Medicinal Chemistry Letters

SP600125 has a remarkable anticancer potential against undifferentiated thyroid cancer through selective action on ROCK and p53 pathways

(2015) Elisa Stellaria Grassi et al.   Oncotarget

Targeting JNK-interacting-protein-1 (JIP1) sensitises osteosarcoma to doxorubicin

(2015) Jantine PosthumadeBoer et al.   Oncotarget

Inhibition of JNK2 and JNK3 by JNK inhibitor IX induces prometaphase arrest-dependent apoptotic cell death in human Jurkat T cells

(2014) Won Young Jang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Crosstalk of JNK1-STAT3 is critical for RAW264.7 cell survival

(2014) Qinghua Wu et al.   CELLULAR SIGNALLING

Recent Progress in the Design, Study, and Development of c-Jun N-Terminal Kinase Inhibitors as Anticancer Agents

(2014) Abdellah Messoussi et al.   CHEMISTRY & BIOLOGY

Acentrosomal Drosophila Epithelial Cells Exhibit Abnormal Cell Division, Leading to Cell Death and Compensatory Proliferation

(2014) John S. Poulton et al.   DEVELOPMENTAL CELL

The Role of Hepatic Ischemia–Reperfusion Injury and Liver Parenchymal Quality on Cancer Recurrence

(2014) Lorenzo A. Orci et al.   DIGESTIVE DISEASES AND SCIENCES

GRP78 promotes the invasion of pancreatic cancer cells by FAK and JNK

(2014) X. P. Yuan et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Alkyl chain substituted 1,9-pyrazoloanthrones exhibit prominent inhibitory effect on c-Jun N-terminal kinase (JNK)

(2014) Karothu Durga Prasad et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Immune-mediated tumor evolution: Nanog links the emergence of a stem like cancer cell state and immune evasion

(2014) Chih-Ping Mao et al.   OncoImmunology

Synthesis and SAR of novel isoxazoles as potent c-jun N-terminal kinase (JNK) inhibitors

(2013) Yuanjun He et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

JNK signalling in cancer: in need of new, smarter therapeutic targets

(2013) Concetta Bubici et al.   BRITISH JOURNAL OF PHARMACOLOGY

JNK activation is required for TNFα-induced apoptosis in human hepatocarcinoma cells

(2013) Valerio Giacomo Minero et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Specific role of JNK in the maintenance of the tumor-initiating capacity of A549 human non-small cell lung cancer cells

(2013) MASASHI OKADA et al.   ONCOLOGY REPORTS

JNK and Macroautophagy Activation by Bortezomib Has a Pro-Survival Effect in Primary Effusion Lymphoma Cells

(2013) Marisa Granato et al.   PLoS One

RIP3 Inhibits Inflammatory Hepatocarcinogenesis but Promotes Cholestasis by Controlling Caspase-8- and JNK-Dependent Compensatory Cell Proliferation

(2013) Mihael Vucur et al.   Cell Reports

Discovery of a novel series of 4-quinolone JNK inhibitors

(2012) Leyi Gong et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of Potent and Selective Covalent Inhibitors of JNK

(2012) Tinghu Zhang et al.   CHEMISTRY & BIOLOGY

Phase I pharmacokinetic and pharmacodynamic study of the pan-PI3K/mTORC vascular targeted pro-drug SF1126 in patients with advanced solid tumours and B-cell malignancies

(2012) D. Mahadevan et al.   EUROPEAN JOURNAL OF CANCER

Activation of JNK/c-Jun is required for the proliferation, survival, and angiogenesis induced by EET in pulmonary artery endothelial cells

(2012) Jun Ma et al.   JOURNAL OF LIPID RESEARCH

Rosiglitazone and AS601245 Decrease Cell Adhesion and Migration through Modulation of Specific Gene Expression in Human Colon Cancer Cells

(2012) Angelo Cerbone et al.   PLoS One

AS601245, an Anti-Inflammatory JNK Inhibitor, and Clofibrate Have a Synergistic Effect in Inducing Cell Responses and in Affecting the Gene Expression Profile in CaCo-2 Colon Cancer Cells

(2012) Angelo Cerbone et al.   PPAR Research

Identification of an Adamantyl Azaquinolone JNK Selective Inhibitor

(2012) Nancy-Ellen Haynes et al.   ACS Medicinal Chemistry Letters

Pro-survival effects of JNK and p38 MAPK pathways in LPS-induced activation of BV-2 cells

(2011) Christina Svensson et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Characterization of a novel JNK (c-Jun N-terminal kinase) inhibitory peptide

(2011) Kevin R. W. Ngoei et al.   BIOCHEMICAL JOURNAL

Highly selective c-Jun N-terminal kinase (JNK) 3 inhibitors with in vitro CNS-like pharmacokinetic properties II. Central core replacement

(2011) R. Jeffrey Neitz et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and SAR of novel quinazolines as potent and brain-penetrant c-jun N-terminal kinase (JNK) Inhibitors

(2011) Yuanjun He et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of CC-930, an orally active anti-fibrotic JNK inhibitor

(2011) Véronique Plantevin Krenitsky et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The JNK inhibitor D-JNKI-1 blocks apoptotic JNK signaling in brain mitochondria

(2011) Yi Zhao et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Contribution of persistent C-Jun N-terminal kinase activity to the survival of human vestibular schwannoma cells by suppression of accumulation of mitochondrial superoxides

(2011) Wei Ying Yue et al.   NEURO-ONCOLOGY

Evading tumor evasion: Current concepts and perspectives of anti-angiogenic cancer therapy

(2010) Amir Abdollahi et al.   DRUG RESISTANCE UPDATES

Targeting the RAF–MEK–ERK pathway in cancer therapy

(2009) Clara Montagut et al.   CANCER LETTERS

Selective inhibition of JNK with a peptide inhibitor attenuates pain hypersensitivity and tumor growth in a mouse skin cancer pain model

(2009) Yong-Jing Gao et al.   EXPERIMENTAL NEUROLOGY

A selective small-molecule inhibitor of c-JunN-terminal kinase 1

(2009) Ke Yao et al.   FEBS LETTERS

Discovery, synthesis and biological evaluation of isoquinolones as novel and highly selective JNK inhibitors (1)

(2008) Yasutomi Asano et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Identification of a new JNK inhibitor targeting the JNK-JIP interaction site

(2008) J. L. Stebbins et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA