Identifying Rare Genetic Determinants for Improved Polygenic Risk Prediction of Bone Mineral Density and Fracture Risk

Polygenic risk score as a possible tool for identifying familial monogenic causes of complex diseases

(2022) Tianyuan Lu et al.   GENETICS IN MEDICINE

Identifying Causes of Fracture Beyond Bone Mineral Density: Evidence From Human Genetics

(2022) Tianyuan Lu et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Wnt signaling in colorectal cancer: pathogenic role and therapeutic target

(2022) Hui Zhao et al.   Molecular Cancer

Capturing additional genetic risk from family history for improved polygenic risk prediction

(2022) Tianyuan Lu et al.   Communications Biology

Genetic determinants of polygenic prediction accuracy within a population

(2022) Tianyuan Lu et al.   GENETICS

Improved prediction of fracture risk leveraging a genome-wide polygenic risk score

(2021) Tianyuan Lu et al.   Genome Medicine

A polygenic risk score to predict future adult short stature amongst children

(2021) Tianyuan Lu et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Computationally efficient whole-genome regression for quantitative and binary traits

(2021) Joelle Mbatchou et al.   NATURE GENETICS

Exome sequencing and analysis of 454,787 UK Biobank participants

(2021) Joshua D. Backman et al.   NATURE

Development of a polygenic risk score to improve screening for fracture risk: A genetic risk prediction study

(2020) Vincenzo Forgetta et al.   PLOS MEDICINE

Lysine demethylase 5B suppresses CC chemokine ligand 14 to promote progression of colorectal cancer through the Wnt/β-catenin pathway

(2020) Guoqiang Yan et al.   LIFE SCIENCES

Clinical use of current polygenic risk scores may exacerbate health disparities

(2019) Alicia R. Martin et al.   NATURE GENETICS

Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations

(2018) Amit V. Khera et al.   NATURE GENETICS

Genomic Risk Prediction of Coronary Artery Disease in 480,000 Adults

(2018) Michael Inouye et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The UK Biobank resource with deep phenotyping and genomic data

(2018) Clare Bycroft et al.   NATURE

An atlas of genetic influences on osteoporosis in humans and mice

(2018) John A. Morris et al.   NATURE GENETICS

CADD: predicting the deleteriousness of variants throughout the human genome

(2018) Philipp Rentzsch et al.   NUCLEIC ACIDS RESEARCH

Wnt1 is an Lrp5-independent bone-anabolic Wnt ligand

(2018) Julia Luther et al.   Science Translational Medicine

Overview of Fracture Prediction Tools

(2017) John A. Kanis et al.   JOURNAL OF CLINICAL DENSITOMETRY

Osteocyte-specific WNT1 regulates osteoblast function during bone homeostasis

(2017) Kyu Sang Joeng et al.   JOURNAL OF CLINICAL INVESTIGATION

DNA sequencing at 40: past, present and future

(2017) Jay Shendure et al.   NATURE

Identification of 153 new loci associated with heel bone mineral density and functional involvement of GPC6 in osteoporosis

(2017) John P Kemp et al.   NATURE GENETICS

A reference panel of 64,976 haplotypes for genotype imputation

(2016)   NATURE GENETICS

LGR4 is a receptor for RANKL and negatively regulates osteoclast differentiation and bone resorption

(2016) Jian Luo et al.   NATURE MEDICINE

Whole‐genome sequencing identifies EN1 as a determinant of bone density and fracture

(2015) Hou‐Feng Zheng et al.   NATURE

A comprehensive 1000 Genomes–based genome-wide association meta-analysis of coronary artery disease

(2015) Majid Nikpay et al.   NATURE GENETICS

WNT signaling in bone homeostasis and disease: from human mutations to treatments

(2013) Roland Baron et al.   NATURE MEDICINE

A program for annotating and predicting the effects of single nucleotide polymorphisms, SnpEff

(2012) Pablo Cingolani et al.   FLY

Tissue inhibitor of metalloproteinase-1 (TIMP-1) regulates mesenchymal stem cells through let-7f microRNA and Wnt/ -catenin signaling

(2012) V. Egea et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Smad6 is essential to limit BMP signaling during cartilage development

(2011) Kristine D Estrada et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Lrp5 functions in bone to regulate bone mass

(2011) Yajun Cui et al.   NATURE MEDICINE

LocusZoom: regional visualization of genome-wide association scan results

(2010) R. J. Pruim et al.   BIOINFORMATICS

Sclerostin: Current Knowledge and Future Perspectives

(2010) M. J. C. Moester et al.   CALCIFIED TISSUE INTERNATIONAL

Evolutionary evidence of the effect of rare variants on disease etiology

(2010) IP Gorlov et al.   CLINICAL GENETICS

Assessment of fracture risk

(2009) John A. Kanis et al.   EUROPEAN JOURNAL OF RADIOLOGY

BMP signaling negatively regulates bone mass through sclerostin by inhibiting the canonical Wnt pathway

(2008) N. Kamiya et al.   DEVELOPMENT

FRAX™ and the assessment of fracture probability in men and women from the UK

(2008) J. A. Kanis et al.   OSTEOPOROSIS INTERNATIONAL