Capturing additional genetic risk from family history for improved polygenic risk prediction

Polygenic risk score as a possible tool for identifying familial monogenic causes of complex diseases

(2022) Tianyuan Lu et al.   GENETICS IN MEDICINE

Identification of epigenome-wide DNA methylation differences between carriers of APOE ε4 and APOE ε2 alleles

(2021) Rosie M. Walker et al.   Genome Medicine

The Polygenic Score Catalog as an open database for reproducibility and systematic evaluation

(2021) Samuel A. Lambert et al.   NATURE GENETICS

A polygenic risk score to predict future adult short stature amongst children

(2021) Tianyuan Lu et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Utility of polygenic embryo screening for disease depends on the selection strategy

(2021) Todd Lencz et al.   eLife

Polygenic risk for coronary heart disease acts through atherosclerosis in type 2 diabetes

(2020) Tianyuan Lu et al.   Cardiovascular Diabetology

Liability threshold modeling of case–control status and family history of disease increases association power

(2020) Margaux L. A. Hujoel et al.   NATURE GENETICS

Polygenic and clinical risk scores and their impact on age at onset and prediction of cardiometabolic diseases and common cancers

(2020) Nina Mars et al.   NATURE MEDICINE

Efficient polygenic risk scores for biobank scale data by exploiting phenotypes from inferred relatives

(2020) Buu Truong et al.   Nature Communications

Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci

(2019) A. Mesut Erzurumluoglu et al.   MOLECULAR PSYCHIATRY

Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use

(2019) Mengzhen Liu et al.   NATURE GENETICS

Clinical use of current polygenic risk scores may exacerbate health disparities

(2019) Alicia R. Martin et al.   NATURE GENETICS

Towards clinical utility of polygenic risk scores

(2019) Samuel A Lambert et al.   HUMAN MOLECULAR GENETICS

Rare-variant collapsing analyses for complex traits: guidelines and applications

(2019) Gundula Povysil et al.   NATURE REVIEWS GENETICS

The personal and clinical utility of polygenic risk scores

(2018) Ali Torkamani et al.   NATURE REVIEWS GENETICS

Strongly enhanced colorectal cancer risk stratification by combining family history and genetic risk score

(2018) Korbinian Weigl et al.   Clinical Epidemiology

Meta-analysis of genome-wide association studies for height and body mass index in ∼700000 individuals of European ancestry

(2018) Loic Yengo et al.   HUMAN MOLECULAR GENETICS

Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations

(2018) Amit V. Khera et al.   NATURE GENETICS

The genetic risk of Alzheimer’s disease beyond APOE ε4: systematic review of Alzheimer’s genetic risk scores

(2018) Hannah Stocker et al.   Translational Psychiatry

Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes

(2018) Nasim Mavaddat et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Genomic Risk Prediction of Coronary Artery Disease in 480,000 Adults

(2018) Michael Inouye et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The UK Biobank resource with deep phenotyping and genomic data

(2018) Clare Bycroft et al.   NATURE

An atlas of genetic associations in UK Biobank

(2018) Oriol Canela-Xandri et al.   NATURE GENETICS

Concepts, estimation and interpretation of SNP-based heritability

(2017) Jian Yang et al.   NATURE GENETICS

Association Between Family History, a Genetic Risk Score, and Severity of Coronary Artery Disease in Patients With Premature Acute Coronary SyndromesHighlights

(2016) Waseem Hindieh et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Breast cancer risk prediction using a clinical risk model and polygenic risk score

(2016) Yiwey Shieh et al.   BREAST CANCER RESEARCH AND TREATMENT

Incorporating a Genetic Risk Score Into Coronary Heart Disease Risk EstimatesCLINICAL PERSPECTIVE

(2016) Iftikhar J. Kullo et al.   CIRCULATION

Breast cancer risk prediction using a polygenic risk score in the familial setting: a prospective study from the Breast Cancer Family Registry and kConFab

(2016) Hongyan Li et al.   GENETICS IN MEDICINE

A reference panel of 64,976 haplotypes for genotype imputation

(2016)   NATURE GENETICS

Age at onset and Parkinson disease phenotype

(2016) Gennaro Pagano et al.   NEUROLOGY

Adding genetic risk score to family history identifies twice as many high-risk men for prostate cancer: Results from the prostate cancer prevention trial

(2016) Haitao Chen et al.   PROSTATE

Two-Variance-Component Model Improves Genetic Prediction in Family Datasets

(2015) George Tucker et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Dominance Genetic Variation Contributes Little to the Missing Heritability for Human Complex Traits

(2015) Zhihong Zhu et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A Type 1 Diabetes Genetic Risk Score Can Aid Discrimination Between Type 1 and Type 2 Diabetes in Young Adults

(2015) Richard A. Oram et al.   DIABETES CARE

Genetic variance estimation with imputed variants finds negligible missing heritability for human height and body mass index

(2015) Jian Yang et al.   NATURE GENETICS

Defining the role of common variation in the genomic and biological architecture of adult human height

(2014) Andrew R Wood et al.   NATURE GENETICS

How to interpret a small increase in AUC with an additional risk prediction marker: decision analysis comes through

(2014) Stuart G. Baker et al.   STATISTICS IN MEDICINE

Integrating sequence and array data to create an improved 1000 Genomes Project haplotype reference panel

(2014) Olivier Delaneau et al.   Nature Communications

Cohort Profile: The Avon Longitudinal Study of Parents and Children: ALSPAC mothers cohort

(2012) A. Fraser et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Cohort Profile: The ‘Children of the 90s’—the index offspring of the Avon Longitudinal Study of Parents and Children

(2012) Andy Boyd et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Risk Prediction of Complex Diseases from Family History and Known Susceptibility Loci, with Applications for Cancer Screening

(2011) Hon-Cheong So et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Apolipoprotein E in Alzheimer's disease and other neurological disorders

(2011) Philip B Verghese et al.   LANCET NEUROLOGY

Common SNPs explain a large proportion of the heritability for human height

(2010) Jian Yang et al.   NATURE GENETICS

Family-based genetic risk prediction of multifactorial disease

(2010) Douglas M Ruderfer et al.   Genome Medicine

Predicting human height by Victorian and genomic methods

(2009) Yurii S Aulchenko et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Disclosure ofAPOEGenotype for Risk of Alzheimer's Disease

(2009) Robert C. Green et al.   NEW ENGLAND JOURNAL OF MEDICINE