Improved prediction of fracture risk leveraging a genome-wide polygenic risk score

BMD-related genetic risk scores predict site-specific fractures as well as trabecular and cortical bone microstructure

(2020) Maria Nethander et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

U1 snRNP regulates cancer cell migration and invasion in vitro

(2020) Jung-Min Oh et al.   Nature Communications

Polygenic and clinical risk scores and their impact on age at onset and prediction of cardiometabolic diseases and common cancers

(2020) Nina Mars et al.   NATURE MEDICINE

Development of a polygenic risk score to improve screening for fracture risk: A genetic risk prediction study

(2020) Vincenzo Forgetta et al.   PLOS MEDICINE

Clinical use of current polygenic risk scores may exacerbate health disparities

(2019) Alicia R. Martin et al.   NATURE GENETICS

Genetic risk factors identified in populations of European descent do not improve the prediction of osteoporotic fracture and bone mineral density in Chinese populations

(2019) Yu-Mei Li et al.   Scientific Reports

Screening for Osteoporosis to Prevent Fractures

(2018) et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations

(2018) Amit V. Khera et al.   NATURE GENETICS

Identification of 613 new loci associated with heel bone mineral density and a polygenic risk score for bone mineral density, osteoporosis and fracture

(2018) Stuart K. Kim   PLoS One

Assessment of the genetic and clinical determinants of fracture risk: genome wide association and mendelian randomisation study

(2018) Katerina Trajanoska et al.   BMJ-British Medical Journal

Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes

(2018) Nasim Mavaddat et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The UK Biobank resource with deep phenotyping and genomic data

(2018) Clare Bycroft et al.   NATURE

An atlas of genetic influences on osteoporosis in humans and mice

(2018) John A. Morris et al.   NATURE GENETICS

Falls Predict Fractures Independently of FRAX Probability: A Meta-Analysis of the Osteoporotic Fractures in Men (MrOS) Study

(2017) Nicholas C Harvey et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Low Serum DHEAS Predicts Increased Fracture Risk in Older Men: The MrOS Sweden Study

(2017) Claes Ohlsson et al.   JOURNAL OF BONE AND MINERAL RESEARCH

DNA sequencing at 40: past, present and future

(2017) Jay Shendure et al.   NATURE

UK clinical guideline for the prevention and treatment of osteoporosis

(2017) J. Compston et al.   Archives of Osteoporosis

Prediction of Bone Mineral Density and Fragility Fracture by Genetic Profiling

(2016) Thao P Ho-Le et al.   JOURNAL OF BONE AND MINERAL RESEARCH

A reference panel of 64,976 haplotypes for genotype imputation

(2016)   NATURE GENETICS

A systematic review of intervention thresholds based on FRAX

(2016) John A. Kanis et al.   Archives of Osteoporosis

PRROC: computing and visualizing precision-recall and receiver operating characteristic curves in R

(2015) Jan Grau et al.   BIOINFORMATICS

Genetic Risk Scores Implicated in Adult Bone Fragility Associate With Pediatric Bone Density

(2015) Jonathan A Mitchell et al.   JOURNAL OF BONE AND MINERAL RESEARCH

A global reference for human genetic variation

(2015) Richard A. Gibbs et al.   NATURE

Predictive ability of heel quantitative ultrasound for incident fractures: an individual-level meta-analysis

(2015) E. V. McCloskey et al.   OSTEOPOROSIS INTERNATIONAL

Surgery for Hip Fracture Yields Societal Benefits That Exceed the Direct Medical Costs

(2014) Qian Gu et al.   CLINICAL ORTHOPAEDICS AND RELATED RESEARCH

Limited Clinical Utility of a Genetic Risk Score for the Prediction of Fracture Risk in Elderly Subjects

(2014) Joel Eriksson et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Clinician’s Guide to Prevention and Treatment of Osteoporosis

(2014) F. Cosman et al.   OSTEOPOROSIS INTERNATIONAL

Multiple gene polymorphisms can improve prediction of nonvertebral fracture in postmenopausal women

(2013) Seung Hun Lee et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture

(2012) Karol Estrada et al.   NATURE GENETICS

pROC: an open-source package for R and S+ to analyze and compare ROC curves

(2011) Xavier Robin et al.   BMC BIOINFORMATICS

Osteoporosis Canada 2010 Guidelines for the Assessment of Fracture Risk

(2011) Brian Lentle et al.   CANADIAN ASSOCIATION OF RADIOLOGISTS JOURNAL-JOURNAL DE L ASSOCIATION CANADIENNE DES RADIOLOGISTES

PredictABEL: an R package for the assessment of risk prediction models

(2011) Suman Kundu et al.   EUROPEAN JOURNAL OF EPIDEMIOLOGY

China Kadoorie Biobank of 0.5 million people: survey methods, baseline characteristics and long-term follow-up

(2011) Z. Chen et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

The heritability of bone mineral density, ultrasound of the calcaneus and hip axis length: A study of postmenopausal twins

(2010) N.K. Arden et al.   JOURNAL OF BONE AND MINERAL RESEARCH

FRAX™ and the assessment of fracture probability in men and women from the UK

(2008) J. A. Kanis et al.   OSTEOPOROSIS INTERNATIONAL

Case finding for the management of osteoporosis with FRAX®—assessment and intervention thresholds for the UK

(2008) J. A. Kanis et al.   OSTEOPOROSIS INTERNATIONAL