Deletion of prolyl hydroxylase domain-containing enzyme 3 (phd3) in zebrafish facilitates hypoxia tolerance

VBP1 negatively regulates CHIP and selectively inhibits the activity of hypoxia-inducible factor (HIF)-1α but not HIF-2α

(2023) Yiming Yue et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transcriptome Analysis Reveals Molecular Underpinnings of Common Carp (Cyprinus carpio) Under Hypoxia Stress

(2022) Ning Suo et al.   Frontiers in Genetics

Methyltransferase SMYD3 impairs hypoxia tolerance by augmenting hypoxia signaling independent of its enzymatic activity

(2022) Zixuan Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Histone H3 proline 16 hydroxylation regulates mammalian gene expression

(2022) Xijuan Liu et al.   NATURE GENETICS

Breakthrough Science: Hypoxia-Inducible Factors, Oxygen Sensing, and Disorders of Hematopoiesis

(2021) Gregg L. Semenza   BLOOD

Heritable disorders of oxygen sensing

(2021) Gregg L. Semenza   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

High-altitude adaptation: Role of genetic and epigenetic factors

(2021) Nipa Basak et al.   JOURNAL OF BIOSCIENCES

Cellular adaptation to hypoxia through hypoxia inducible factors and beyond

(2020) Pearl Lee et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Genomics and Genetics of Oxygen Homeostasis

(2020) Gregg L. Semenza   Annual Review of Genomics and Human Genetics

Gene transcription and chromatin regulation in hypoxia

(2020) Michael Batie et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Zebrafish phd3 Negatively Regulates Antiviral Responses via Suppression of Irf7 Transactivity Independent of Its Prolyl Hydroxylase Activity

(2020) Guangqing Yu et al.   JOURNAL OF IMMUNOLOGY

Fish response to hypoxia stress: growth, physiological, and immunological biomarkers

(2019) Mohsen Abdel-Tawwab et al.   FISH PHYSIOLOGY AND BIOCHEMISTRY

Purification and Characterization of Prolyl Hydroxylase 3/Pyruvate Kinase Isoform 2 Protein Complex

(2019) Sunil Kumar et al.   MOLECULAR BIOTECHNOLOGY

Deletion of the fih gene encoding an inhibitor of hypoxia-inducible factors increases hypoxia tolerance in zebrafish

(2018) Wuhan Xiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PHD3 is a transcriptional coactivator of HIF-1α in nucleus pulposus cells independent of the PKM2-JMJD5 axis

(2017) Zachary R. Schoepflin et al.   FASEB JOURNAL

Gain-of-function EGLN1 prolyl hydroxylase (PHD2 D4E:C127S) in combination with EPAS1 (HIF-2α) polymorphism lowers hemoglobin concentration in Tibetan highlanders

(2017) Tsewang Tashi et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

The EGLN-HIF O 2 -Sensing System: Multiple Inputs and Feedbacks

(2017) Mircea Ivan et al.   MOLECULAR CELL

Tet1 facilitates hypoxia tolerance by stabilizing the HIF-α proteins independent of its methylcytosine dioxygenase activity

(2017) Jing Wang et al.   NUCLEIC ACIDS RESEARCH

HRGFish: A database of hypoxia responsive genes in fishes

(2017) Iliyas Rashid et al.   Scientific Reports

Transcriptional events co-regulated by hypoxia and cold stresses in Zebrafish larvae

(2015) Yong Long et al.   BMC GENOMICS

Genome-wide mapping of Hif-1α binding sites in zebrafish

(2015) David Greenald et al.   BMC GENOMICS

Exploring the HIFs, buts and maybes of hypoxia signalling in disease: lessons from zebrafish models

(2015) P. M. Elks et al.   Disease Models & Mechanisms

Human high-altitude adaptation: forward genetics meets the HIF pathway

(2014) Abigail W. Bigham et al.   GENES & DEVELOPMENT

Genetic Convergence in the Adaptation of Dogs and Humans to the High-Altitude Environment of the Tibetan Plateau

(2014) Guo-Dong Wang et al.   Genome Biology and Evolution

Population Variation Revealed High-Altitude Adaptation of Tibetan Mastiffs

(2014) Yan Li et al.   MOLECULAR BIOLOGY AND EVOLUTION

Altitude adaptation in Tibetans caused by introgression of Denisovan-like DNA

(2014) Emilia Huerta-Sánchez et al.   NATURE

Hypoxia-Inducible Factor 3 Is an Oxygen-Dependent Transcription Activator and Regulates a Distinct Transcriptional Response to Hypoxia

(2014) Peng Zhang et al.   Cell Reports

Oxygen Sensing, Hypoxia-Inducible Factors, and Disease Pathophysiology

(2013) Gregg L. Semenza   Annual Review of Pathology-Mechanisms of Disease

Zebrafish erythropoiesis and the utility of fish as models of anemia

(2013) Kasem Kulkeaw et al.   Stem Cell Research & Therapy

A Zebrafish Model to Study and Therapeutically Manipulate Hypoxia Signaling in Tumorigenesis

(2012) Kirankumar Santhakumar et al.   CANCER RESEARCH

Expression of Prolyl Hydroxylases (PHDs) Is Selectively Controlled by HIF-1 and HIF-2 Proteins in Nucleus Pulposus Cells of the Intervertebral Disc

(2012) Nobuyuki Fujita et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1

(2011) Weibo Luo et al.   CELL

Genetic Evidence for High-Altitude Adaptation in Tibet

(2010) T. S. Simonson et al.   SCIENCE

Identifying Signatures of Natural Selection in Tibetan and Andean Populations Using Dense Genome Scan Data

(2010) Abigail Bigham et al.   PLoS Genetics

Zebrafish mutants in the von Hippel-Lindau tumor suppressor display a hypoxic response and recapitulate key aspects of Chuvash polycythemia

(2009) E. van Rooijen et al.   BLOOD

Role and regulation of prolyl hydroxylase domain proteins

(2008) G-H Fong et al.   CELL DEATH AND DIFFERENTIATION

Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway

(2008) William G. Kaelin et al.   MOLECULAR CELL

PHD2Mutation and Congenital Erythrocytosis with Paraganglioma

(2008) Charline Ladroue et al.   NEW ENGLAND JOURNAL OF MEDICINE

Regulation of adult erythropoiesis by prolyl hydroxylase domain proteins

(2007) K. Takeda et al.   BLOOD

Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure

(2007) Y. A. Minamishima et al.   BLOOD