Methyltransferase SMYD3 impairs hypoxia tolerance by augmenting hypoxia signaling independent of its enzymatic activity

Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology

(2022) Helmut Sies et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Heat shock protein-90alpha (Hsp90α) stabilizes hypoxia-inducible factor-1α (HIF-1α) in support of spermatogenesis and tumorigenesis

(2021) Xin Tang et al.   CANCER GENE THERAPY

SMYD3: a regulator of epigenetic and signaling pathways in cancer

(2021) Benjamin J. Bernard et al.   Clinical Epigenetics

PRMT3 promotes tumorigenesis by methylating and stabilizing HIF1α in colorectal cancer

(2021) Xin Zhang et al.   Cell Death & Disease

ZHX2 promotes HIF1α oncogenic signaling in triple-negative breast cancer

(2021) Wentong Fang et al.   eLife

Cellular adaptation to hypoxia through hypoxia inducible factors and beyond

(2020) Pearl Lee et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Bclaf1 is a direct target of HIF-1 and critically regulates the stability of HIF-1α under hypoxia

(2020) Anwen Shao et al.   ONCOGENE

SMYD3: An Oncogenic Driver Targeting Epigenetic Regulation and Signaling Pathways

(2020) Cinzia Bottino et al.   Cancers

SIRT5 impairs aggregation and activation of the signaling adaptor MAVS through catalyzing lysine desuccinylation

(2020) Xing Liu et al.   EMBO JOURNAL

USP37 promotes deubiquitination of HIF2α in kidney cancer

(2020) Kai Hong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxia-inducible factors and diabetes

(2020) Jenny E. Gunton   JOURNAL OF CLINICAL INVESTIGATION

Regulation of glycolysis by the hypoxia‐inducible factor (HIF): implications for cellular physiology

(2020) S. J. Kierans et al.   JOURNAL OF PHYSIOLOGY-LONDON

Oxygen-sensing mechanisms across eukaryotic kingdoms and their roles in complex multicellularity

(2020) Emma U. Hammarlund et al.   SCIENCE

The Role of Hypoxia-Inducible Factor Post-Translational Modifications in Regulating Its Localisation, Stability, and Activity

(2020) Adam Albanese et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Involvement of E3 Ligases and Deubiquitinases in the Control of HIF-α Subunit Abundance

(2019) Kateryna Kubaichuk et al.   Cells

Methylation of hypoxia-inducible factor (HIF)-1α by G9a/GLP inhibits HIF-1 transcriptional activity and cell migration

(2018) Lei Bao et al.   NUCLEIC ACIDS RESEARCH

VHL substrate transcription factor ZHX2 as an oncogenic driver in clear cell renal cell carcinoma

(2018) Jing Zhang et al.   SCIENCE

A pathogen-derived effector modulates host glucose metabolism by arginine GlcNAcylation of HIF-1α protein

(2018) Chenxi Xu et al.   PLoS Pathogens

The role of hypoxia-inducible factors in metabolic diseases

(2018) Frank J. Gonzalez et al.   Nature Reviews Endocrinology

A compendium of proteins that interact with HIF-1α

(2017) Gregg L. Semenza   EXPERIMENTAL CELL RESEARCH

The EGLN-HIF O 2 -Sensing System: Multiple Inputs and Feedbacks

(2017) Mircea Ivan et al.   MOLECULAR CELL

Tet1 facilitates hypoxia tolerance by stabilizing the HIF-α proteins independent of its methylcytosine dioxygenase activity

(2017) Jing Wang et al.   NUCLEIC ACIDS RESEARCH

LSD1 demethylates HIF1α to inhibit hydroxylation and ubiquitin-mediated degradation in tumor angiogenesis

(2017) J-Y Lee et al.   ONCOGENE

Protein lysine methyltransferase SMYD3 is involved in tumorigenesis through regulation of HER2 homodimerization

(2017) Yuichiro Yoshioka et al.   Cancer Medicine

BNIP3 induction by hypoxia stimulates FASN-dependent free fatty acid production enhancing therapeutic potential of umbilical cord blood-derived human mesenchymal stem cells

(2017) Hyun Jik Lee et al.   Redox Biology

Mitochondrial composition and function under the control of hypoxia

(2017) Dominik C. Fuhrmann et al.   Redox Biology

Redox signaling during hypoxia in mammalian cells

(2017) Kimberly A. Smith et al.   Redox Biology

Smyd3 Is a Transcriptional Potentiator of Multiple Cancer-Promoting Genes and Required for Liver and Colon Cancer Development

(2016) Michalis E. Sarris et al.   CANCER CELL

Genetics of human origin and evolution: high-altitude adaptations

(2016) Abigail W Bigham   CURRENT OPINION IN GENETICS & DEVELOPMENT

Forkhead Transcription Factor 3a (FOXO3a) Modulates Hypoxia Signaling via Up-regulation of the von Hippel-Lindau Gene (VHL)

(2016) Xing Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A hypoxia-responsive TRAF6–ATM–H2AX signalling axis promotes HIF1α activation, tumorigenesis and metastasis

(2016) Abdol-Hossein Rezaeian et al.   NATURE CELL BIOLOGY

Major spliceosome defects cause male infertility and are associated with nonobstructive azoospermia in humans

(2016) Hao Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

K63-polyubiquitinated HAUSP deubiquitinates HIF-1α and dictates H3K56 acetylation promoting hypoxia-induced tumour progression

(2016) Han-Tsang Wu et al.   Nature Communications

SMYD3-mediated lysine methylation in the PH domain is critical for activation of AKT1

(2016) Yuichiro Yoshioka et al.   Oncotarget

Novel insights into the oncogenic function of the SMYD3 lysine methyltransferase

(2016) Pawel K. Mazur et al.   Translational Cancer Research

Repression of hypoxia-inducible factor α signaling by Set7-mediated methylation

(2015) Xing Liu et al.   NUCLEIC ACIDS RESEARCH

UCHL1 provides diagnostic and antimetastatic strategies due to its deubiquitinating effect on HIF-1α

(2015) Yoko Goto et al.   Nature Communications

Human high-altitude adaptation: forward genetics meets the HIF pathway

(2014) Abigail W. Bigham et al.   GENES & DEVELOPMENT

EAF2 Suppresses Hypoxia-Induced Factor 1  Transcriptional Activity by Disrupting Its Interaction with Coactivator CBP/p300

(2014) Z. Chen et al.   MOLECULAR AND CELLULAR BIOLOGY

Altitude adaptation in Tibetans caused by introgression of Denisovan-like DNA

(2014) Emilia Huerta-Sánchez et al.   NATURE

Fructose-1,6-bisphosphatase opposes renal carcinoma progression

(2014) Bo Li et al.   NATURE

SMYD3 links lysine methylation of MAP3K2 to Ras-driven cancer

(2014) Pawel K. Mazur et al.   NATURE

A genetic mechanism for Tibetan high-altitude adaptation

(2014) Felipe R Lorenzo et al.   NATURE GENETICS

Admixture facilitates genetic adaptations to high altitude in Tibet

(2014) Choongwon Jeong et al.   Nature Communications

Oxygen Sensing, Hypoxia-Inducible Factors, and Disease Pathophysiology

(2013) Gregg L. Semenza   Annual Review of Pathology-Mechanisms of Disease

CDK1 stabilizes HIF-1α via direct phosphorylation of Ser668 to promote tumor growth

(2013) Noel A Warfel et al.   CELL CYCLE

HIF1α deubiquitination by USP8 is essential for ciliogenesis in normoxia

(2013) Albino Troilo et al.   EMBO REPORTS

Sirtuin-7 Inhibits the Activity of Hypoxia-inducible Factors

(2013) Maimon E. Hubbi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of Hypoxia-Inducible Factor Prolyl Hydroxylase Domain Oxygen Sensors: Tricking the Body into Mounting Orchestrated Survival and Repair Responses

(2013) Michael H. Rabinowitz   JOURNAL OF MEDICINAL CHEMISTRY

Smyd3 regulates cancer cell phenotypes and catalyzes histone H4 lysine 5 methylation

(2012) Glenn S. Van Aller et al.   Epigenetics

Hypoxia-inducible factors: Crosstalk between inflammation and metabolism

(2012) Jessica E.S. Shay et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

SIRT3 Opposes Reprogramming of Cancer Cell Metabolism through HIF1α Destabilization

(2011) Lydia W.S. Finley et al.   CANCER CELL

NRF2 Blockade Suppresses Colon Tumor Angiogenesis by Inhibiting Hypoxia-Induced Activation of HIF-1 

(2011) T.-H. Kim et al.   CANCER RESEARCH

Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1

(2011) Weibo Luo et al.   CELL

HDAC4 Protein Regulates HIF1α Protein Lysine Acetylation and Cancer Cell Response to Hypoxia

(2011) Hao Geng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ubiquitin-specific Protease 19 (USP19) Regulates Hypoxia-inducible Factor 1α (HIF-1α) during Hypoxia

(2011) Mikael Altun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis via Hif1α

(2010) Lei Zhong et al.   CELL

Plk3 Functions as an Essential Component of the Hypoxia Regulatory Pathway by Direct Phosphorylation of HIF-1α

(2010) Dazhong Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Casein kinase 1 regulates human hypoxia-inducible factor HIF-1

(2010) A. Kalousi et al.   JOURNAL OF CELL SCIENCE

Sirtuin 1 Modulates Cellular Responses to Hypoxia by Deacetylating Hypoxia-Inducible Factor 1α

(2010) Ji-Hong Lim et al.   MOLECULAR CELL

Hypoxia-Inducible Factors and the Response to Hypoxic Stress

(2010) Amar J. Majmundar et al.   MOLECULAR CELL

Requirement of Histone Methyltransferase SMYD3 for Estrogen Receptor-mediated Transcription

(2009) Hyunjung Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Hypoxia-Inducible Factor 2  Signaling by the Stress-Responsive Deacetylase Sirtuin 1

(2009) E. M. Dioum et al.   SCIENCE

Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway

(2008) William G. Kaelin et al.   MOLECULAR CELL