High-altitude adaptation: Role of genetic and epigenetic factors

DNA Methylation Changes Are Associated With an Incremental Ascent to High Altitude

(2019) Ainash Childebayeva et al.   Frontiers in Genetics

Selection scan reveals three new loci related to high altitude adaptation in Native Andeans

(2018) Vanessa C. Jacovas et al.   Scientific Reports

LINE-1 and EPAS1 DNA methylation associations with high-altitude exposure

(2018) Ainash Childebayeva et al.   Epigenetics

The earliest human occupation of the high-altitude Tibetan Plateau 40 thousand to 30 thousand years ago

(2018) X. L. Zhang et al.   SCIENCE

The genetic prehistory of the Andean highlands 7000 years BP though European contact

(2018) John Lindo et al.   Science Advances

Epigenomics and human adaptation to high altitude

(2017) Colleen G. Julian   JOURNAL OF APPLIED PHYSIOLOGY

Gain-of-function EGLN1 prolyl hydroxylase (PHD2 D4E:C127S) in combination with EPAS1 (HIF-2α) polymorphism lowers hemoglobin concentration in Tibetan highlanders

(2017) Tsewang Tashi et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Genetic signatures of high-altitude adaptation in Tibetans

(2017) Jian Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epigenetic Editing of Ascl1 Gene in Neural Stem Cells by Optogenetics

(2017) Chiao-Ling Lo et al.   Scientific Reports

Genetics of human origin and evolution: high-altitude adaptations

(2016) Abigail W Bigham   CURRENT OPINION IN GENETICS & DEVELOPMENT

Chronic Mountain Sickness: Clinical Aspects, Etiology, Management, and Treatment

(2016) Francisco C. Villafuerte et al.   HIGH ALTITUDE MEDICINE & BIOLOGY

CRISPR-dCas9 mediated TET1 targeting for selective DNA demethylation at BRCA1 promoter

(2016) Samrat Roy Choudhury et al.   Oncotarget

Optogenetic regulation of site-specific subtelomeric DNA methylation

(2016) Samrat Roy Choudhury et al.   Oncotarget

Perinatal hypoxia increases susceptibility to high-altitude polycythemia and attendant pulmonary vascular dysfunction

(2015) Colleen Glyde Julian et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Unique DNA Methylation Patterns in Offspring of Hypertensive Pregnancy

(2015) Colleen G. Julian et al.   CTS-Clinical and Translational Science

Altitude Adaptation: A Glimpse Through Various Lenses

(2015) Tatum S. Simonson   HIGH ALTITUDE MEDICINE & BIOLOGY

A Novel Candidate Region for Genetic Adaptation to High Altitude in Andean Populations

(2015) Guido Valverde et al.   PLoS One

Endothelin receptor B, a candidate gene from human studies at high altitude, improves cardiac tolerance to hypoxia in genetically engineered heterozygote mice

(2015) Tsering Stobdan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Genetic Basis of Chronic Mountain Sickness

(2014) Roy Ronen et al.   PHYSIOLOGY

The Andean Adaptive Toolkit to Counteract High Altitude Maladaptation: Genome-Wide and Phenotypic Analysis of the Collas

(2014) Christina A. Eichstaedt et al.   PLoS One

Paleoindian settlement of the high-altitude Peruvian Andes

(2014) Kurt Rademaker et al.   SCIENCE

Admixture facilitates genetic adaptations to high altitude in Tibet

(2014) Choongwon Jeong et al.   Nature Communications

Whole genome sequencing of Ethiopian highlanders reveals conserved hypoxia tolerance genes

(2014) Nitin Udpa et al.   GENOME BIOLOGY

Genetic Evidence of Paleolithic Colonization and Neolithic Expansion of Modern Humans on the Tibetan Plateau

(2013) Xuebin Qi et al.   MOLECULAR BIOLOGY AND EVOLUTION

Genetic Signatures Reveal High-Altitude Adaptation in a Set of Ethiopian Populations

(2013) Emilia Huerta-Sánchez et al.   MOLECULAR BIOLOGY AND EVOLUTION

The Genetic Architecture of Adaptations to High Altitude in Ethiopia

(2012) Gorka Alkorta-Aranburu et al.   PLoS Genetics

Genetic adaptation to high altitude in the Ethiopian highlands

(2012) Laura B Scheinfeldt et al.   GENOME BIOLOGY

Peopling the Tibetan Plateau: Insights from Archaeology

(2011) Mark Aldenderfer   HIGH ALTITUDE MEDICINE & BIOLOGY

The human side of hypoxia-inducible factor

(2010) Thomas G. Smith et al.   BRITISH JOURNAL OF HAEMATOLOGY

A Genome-Wide Search for Signals of High-Altitude Adaptation in Tibetans

(2010) S. Xu et al.   MOLECULAR BIOLOGY AND EVOLUTION

Genetic Variations in Tibetan Populations and High-Altitude Adaptation at the Himalayas

(2010) Y. Peng et al.   MOLECULAR BIOLOGY AND EVOLUTION

Natural selection on EPAS1 (HIF2 ) associated with low hemoglobin concentration in Tibetan highlanders

(2010) C. M. Beall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic Evidence for High-Altitude Adaptation in Tibet

(2010) T. S. Simonson et al.   SCIENCE

Sequencing of 50 Human Exomes Reveals Adaptation to High Altitude

(2010) X. Yi et al.   SCIENCE

Human DNA methylomes at base resolution show widespread epigenomic differences

(2009) Ryan Lister et al.   NATURE