Unveiling the structural and functional consequences of the p.D109G pathogenic mutation in human αB-Crystallin responsible for restrictive cardiomyopathy and skeletal myopathy

Investigating the role of double mutations R12C/P20R, and R12C/R69C on structure, chaperone-like activity, and amyloidogenic properties of human αB-crystallin

(2023) Seyed Hossein Khaleghinejad et al.   International Journal of Biological Macromolecules

Increased chaperone activity of human α‌B-crystallin with incomplete oxidation as a new defense mechanism against oxidative stress

(2022) Maryam Ghahramani et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

An AFM Approach Applied in a Study of α-Crystallin Membrane Association: New Insights into Lens Hardening and Presbyopia Development

(2022) Nawal K. Khadka et al.   Membranes

Elucidation of the mechanism of subunit exchange in αB crystallin oligomers

(2021) Rintaro Inoue et al.   Scientific Reports

The biochemical association between R157H mutation in human αB-crystallin and development of cardiomyopathy: Structural and functional analyses of the mutant protein

(2021) Parto Nasiri et al.   BIOCHIMIE

The congenital cataract‐causing mutations P20R and A171T are associated with important changes in the amyloidogenic feature, structure and chaperone‐like activity of human αB‐crystallin

(2020) Maryam Ghahramani et al.   BIOPOLYMERS

Amyloid formation of bovine insulin is retarded in moderately acidic pH and by addition of short-chain alcohols

(2020) David Bernson et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Neuromuscular Diseases Due to Chaperone Mutations: A Review and Some New Results

(2020) Jaakko Sarparanta et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Alpha B-Crystallin Overexpression Protects Oligodendrocyte Precursor Cells Against Oxidative Stress-Induced Apoptosis Through the Akt Pathway

(2020) Ji Young Kim et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Interaction of the chaperones alpha B-crystallin and CHIP with fibrillar alpha-synuclein: Effects on internalization by cells and identification of interacting interfaces

(2020) Maya Bendifallah et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Structural and Functional Peculiarities of α-Crystallin

(2020) Olga M. Selivanova et al.   Biology-Basel

Peak Fitting Applied to Fourier Transform Infrared and Raman Spectroscopic Analysis of Proteins

(2020) Azin Sadat et al.   Applied Sciences-Basel

Crosstalk Between Chaperone-Mediated Protein Disaggregation and Proteolytic Pathways in Aging and Disease

(2019) Diogo R. Feleciano et al.   Frontiers in Aging Neuroscience

The coming of age of chaperone-mediated autophagy

(2018) Susmita Kaushik et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Macroautophagy and Chaperone-Mediated Autophagy in Heart Failure: The Known and the Unknown

(2018) Rajeshwary Ghosh et al.   Oxidative Medicine and Cellular Longevity

HSPB5 engages multiple states of a destabilized client to enhance chaperone activity in a stress-dependent manner.

(2018) Scott P. Delbecq et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The novel αB-crystallin (CRYAB ) mutation p.D109G causes restrictive cardiomyopathy

(2017) Andreas Brodehl et al.   HUMAN MUTATION

Evaluation of structure, chaperone-like activity and protective ability of peroxynitrite modified human α-Crystallin subunits against copper-mediated ascorbic acid oxidation

(2016) Maryam Ghahramani et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

The impact of Hydrogen peroxide on structure, stability and functional properties of Human R12C mutant αA-crystallin: The imperative insights into pathomechanism of the associated congenital cataract incidence

(2015) Kazem Khoshaman et al.   FREE RADICAL BIOLOGY AND MEDICINE

Upregulation of alphaB-crystallin expression in the substantia nigra of patients with Parkinson's disease

(2015) Yingjun Liu et al.   NEUROBIOLOGY OF AGING

Missense Mutations in CRYAB Are Liable for Recessive Congenital Cataracts

(2015) Xiaodong Jiaox et al.   PLoS One

Interplay of LRRK2 with chaperone-mediated autophagy

(2013) Samantha J Orenstein et al.   NATURE NEUROSCIENCE

The specificity of the interaction between  B-crystallin and desmin filaments and its impact on filament aggregation and cell viability

(2013) J. L. Elliott et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Human resistin, a proinflammatory cytokine, shows chaperone-like activity

(2013) M. Suragani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cataract-Causing Defect of a Mutant γ-Crystallin Proceeds through an Aggregation Pathway Which Bypasses Recognition by the α-Crystallin Chaperone

(2012) Kate L. Moreau et al.   PLoS One

A novel CRYAB mutation resulting in multisystemic disease

(2011) Sabrina Sacconi et al.   NEUROMUSCULAR DISORDERS

The Interaction of αB-Crystallin with Mature α-Synuclein Amyloid Fibrils Inhibits Their Elongation

(2010) Christopher A. Waudby et al.   BIOPHYSICAL JOURNAL

Abnormal interaction of motor neuropathy-associated mutant HspB8 (Hsp22) forms with the RNA helicase Ddx20 (gemin3)

(2010) Xiankui Sun et al.   CELL STRESS & CHAPERONES

Altered Chaperone-like Activity of α-Crystallins Promotes Cataractogenesis

(2010) Catherine Cheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lens aging: Effects of crystallins

(2009) K. Krishna Sharma et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Modulation of α-crystallin chaperone activity: A target to prevent or delay cataract?

(2009) Pasupulati Anil Kumar et al.   IUBMB LIFE

Mechanism of Insolubilization by a Single-Point Mutation in αA-Crystallin Linked with Hereditary Human Cataracts†

(2008) Usha P. Andley et al.   BIOCHEMISTRY

Genetics of crystallins: Cataract and beyond

(2008) Jochen Graw   EXPERIMENTAL EYE RESEARCH

Effect of Phosphorylation on αB-crystallin: Differences in Stability, Subunit Exchange and Chaperone Activity of Homo and Mixed Oligomers of αB-Crystallin and its Phosphorylation-mimicking Mutant

(2007) Md. Faiz Ahmad et al.   JOURNAL OF MOLECULAR BIOLOGY