STAT6 promoting oxalate crystal deposition-induced renal fibrosis by mediating macrophage-to-myofibroblast transition via inhibiting fatty acid oxidation

Germline STAT6 gain-of-function variants cause severe allergy

(2023) Motoi Yamashita et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

STAT6 contributes to renal fibrosis by modulating PPARα-mediated tubular fatty acid oxidation

(2022) Jianzhong Li et al.   Cell Death & Disease

STAT6 Blockade Abrogates Aspergillus-Induced Eosinophilic Chronic Rhinosinusitis and Asthma, A Model of Unified Airway Disease

(2022) Hua Sun et al.   Frontiers in Immunology

Ketone body β-hydroxybutyrate ameliorates colitis by promoting M2 macrophage polarization through the STAT6-dependent signaling pathway

(2022) Chongyang Huang et al.   BMC Medicine

CXCR4 inhibition attenuates calcium oxalate crystal deposition-induced renal fibrosis

(2022) Zehua Ye et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

PARP14 is a novel target in STAT6 mutant follicular lymphoma

(2022) Michael Mentz et al.   LEUKEMIA

P2Y12 inhibitor clopidogrel inhibits renal fibrosis by blocking macrophage-to-myofibroblast transition

(2022) Junzhe Chen et al.   MOLECULAR THERAPY

STAT6 inhibits ferroptosis and alleviates acute lung injury via regulating P53/SLC7A11 pathway

(2022) Youjing Yang et al.   Cell Death & Disease

Pharmacological Inhibition of STING/TBK1 Signaling Attenuates Myeloid Fibroblast Activation and Macrophage to Myofibroblast Transition in Renal Fibrosis

(2022) Haimei Zeng et al.   Frontiers in Pharmacology

The phase changes of M1/M2 phenotype of microglia/macrophage following oxygen-induced retinopathy in mice

(2021) Jia Li et al.   INFLAMMATION RESEARCH

Total Glucosides of Paeony Ameliorate Pristane-Induced Lupus Nephritis by Inducing PD-1 ligands+ Macrophages via Activating IL-4/STAT6/PD-L2 Signaling

(2021) Chun-Ling Liang et al.   Frontiers in Immunology

Smad3 Promotes Cancer‐Associated Fibroblasts Generation via Macrophage–Myofibroblast Transition

(2021) Philip Chiu‐Tsun Tang et al.   Advanced Science

Construction and Analysis of Immune Infiltration-Related ceRNA Network for Kidney Stones

(2021) Yuqi Xia et al.   Frontiers in Genetics

Enhanced lipid accumulation and metabolism are required for the differentiation and activation of tumor-associated macrophages

(2020) Pan Su et al.   CANCER RESEARCH

Neural transcription factor Pou4f1 promotes renal fibrosis via macrophage–myofibroblast transition

(2020) Patrick Ming-Kuen Tang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kidney Single-Cell Atlas Reveals Myeloid Heterogeneity in Progression and Regression of Kidney Disease

(2020) Bryan R. Conway et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Macrophages: versatile players in renal inflammation and fibrosis

(2019) Patrick Ming-Kuen Tang et al.   Nature Reviews Nephrology

CPT1a downregulation protects against cholesterol-induced fibrosis in tubular epithelial cells by downregulating TGFβ-1 and inflammasome

(2019) Priscila Calle et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mitochondrial Damage and Activation of the STING Pathway Lead to Renal Inflammation and Fibrosis

(2019) Ki Wung Chung et al.   Cell Metabolism

The potential and controversy of targeting STAT family members in cancer

(2019) Yannick Verhoeven et al.   SEMINARS IN CANCER BIOLOGY

Impairment of PPARαand the Fatty Acid Oxidation Pathway Aggravates Renal Fibrosis during Aging

(2018) Ki Wung Chung et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets

(2018) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Macrophage-to-Myofibroblast Transition Contributes to Interstitial Fibrosis in Chronic Renal Allograft Injury

(2017) Ying-Ying Wang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

STAT6 deficiency ameliorates Graves’ disease severity by suppressing thyroid epithelial cell hyperplasia

(2016) Xuechao Jiang et al.   Cell Death & Disease

Kidney stones

(2016) Saeed R. Khan et al.   Nature Reviews Disease Primers

JAK3/STAT6 Stimulates Bone Marrow-Derived Fibroblast Activation in Renal Fibrosis

(2015) J. Yan et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Diverse origins of the myofibroblast—implications for kidney fibrosis

(2015) Lucas L. Falke et al.   Nature Reviews Nephrology

TGF-β/Smad3 signalling regulates the transition of bone marrowderived macrophages into myofibroblasts during tissue fibrosis

(2015) Shuang Wang et al.   Oncotarget

Medical Management to Prevent Recurrent Nephrolithiasis in Adults: A Systematic Review for an American College of Physicians Clinical Guideline

(2013) Howard A. Fink et al.   ANNALS OF INTERNAL MEDICINE

Slowing progression of chronic kidney disease

(2013) Paul E. Drawz et al.   Kidney International Supplements

Fibrosis and evidence for epithelial-mesenchymal transition in the kidneys of patients with staghorn calculi

(2011) Chanchai Boonla et al.   BJU INTERNATIONAL

Chronic Kidney Disease in Kidney Stone Formers

(2011) A. D. Rule et al.   Clinical Journal of the American Society of Nephrology

IL-4/STAT6 immune axis regulates peripheral nutrient metabolism and insulin sensitivity

(2010) R. R. Ricardo-Gonzalez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Novel STAT6 Inhibitor AS1517499 Ameliorates Antigen-Induced Bronchial Hypercontractility in Mice

(2009) Yoshihiko Chiba et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY