Smad3 Promotes Cancer‐Associated Fibroblasts Generation via Macrophage–Myofibroblast Transition

AANG: A natural compound formula for overcoming multidrug resistance via synergistic rebalancing the TGF‐β/Smad signalling in hepatocellular carcinoma

(2021) Jeff Yat‐Fai Chung et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

USMB-shMincle: a virus-free gene therapy for blocking M1/M2 polarization of tumor-associated macrophages

(2021) Vivian Weiwen Xue et al.   Molecular Therapy-Oncolytics

Diminished CD68+ Cancer-Associated Fibroblast Subset Induces Treg Infiltration and Predicts Poor Prognosis of Oral Squamous Cell Carcinoma Patients

(2020) Xingxing Zhao et al.   AMERICAN JOURNAL OF PATHOLOGY

Neural transcription factor Pou4f1 promotes renal fibrosis via macrophage–myofibroblast transition

(2020) Patrick Ming-Kuen Tang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Mincle/Syk/NF-κB Signaling Circuit Is Essential for Maintaining the Protumoral Activities of Tumor-Associated Macrophages

(2020) Chunjie Li et al.   Cancer Immunology Research

Reprogramming of tumor-associated macrophages by targeting β-catenin/FOSL2/ARID5A signaling: A potential treatment of lung cancer

(2020) Poonam Sarode et al.   Science Advances

TFEB is a master regulator of tumor-associated macrophages in breast cancer

(2020) Yong Li et al.   Journal for ImmunoTherapy of Cancer

Human Tumor-Associated Macrophage and Monocyte Transcriptional Landscapes Reveal Cancer-Specific Reprogramming, Biomarkers, and Therapeutic Targets

(2019) Luca Cassetta et al.   CANCER CELL

LRNA9884, a Novel Smad3-Dependent LncRNA, Promotes Diabetic Kidney Injury in db/db Mice Via Enhancing MCP-1-Dependent Renal Inflammation

(2019) Ying-ying Zhang et al.   DIABETES

Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39

(2019) Maisa C. Takenaka et al.   NATURE NEUROSCIENCE

Epigenetic SMAD3 repression in tumor-associated fibroblasts impairs fibrosis and response to the antifibrotic drug nintedanib in lung squamous cell carcinoma

(2019) Rafael Ikemori et al.   CANCER RESEARCH

Transition of Macrophages to Fibroblast-Like Cells in Healing Myocardial Infarction

(2019) Nezam Haider et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Fibroblast Heterogeneity and Immunosuppressive Environment in Human Breast Cancer

(2018) Ana Costa et al.   CANCER CELL

Inhibition of Rspo-Lgr4 facilitates checkpoint blockade therapy by switching macrophage polarization

(2018) Binghe Tan et al.   CANCER RESEARCH

Tumor-secreted Pros1 inhibits macrophage M1 polarization to reduce antitumor immune response

(2018) Eric Ubil et al.   JOURNAL OF CLINICAL INVESTIGATION

CD206-positive myeloid cells bind galectin-9 and promote a tumor-supportive microenvironment

(2018) Elizabeth Ann L Enninga et al.   JOURNAL OF PATHOLOGY

The proto-oncogene tyrosine protein kinase Src is essential for macrophage-myofibroblast transition during renal scarring

(2018) Patrick Ming-Kuen Tang et al.   KIDNEY INTERNATIONAL

Single-cell transcriptomics of the mouse kidney reveals potential cellular targets of kidney disease

(2018) Jihwan Park et al.   SCIENCE

RNA velocity of single cells

(2018) Gioele La Manno et al.   NATURE

USP17 mediates macrophage-promoted inflammation and stemness in lung cancer cells by regulating TRAF2/TRAF3 complex formation

(2018) Chih-Hao Lu et al.   ONCOGENE

Macrophages are exploited from an innate wound healing response to facilitate cancer metastasis

(2018) Tamara Muliaditan et al.   Nature Communications

Bone marrow–derived fibroblasts are a functionally distinct stromal cell population in breast cancer

(2018) Yael Raz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Link between tumor-promoting fibrous microenvironment and an immunosuppressive microenvironment in stage I lung adenocarcinoma

(2018) Takashi Sakai et al.   LUNG CANCER

Turning foes to friends: targeting cancer-associated fibroblasts

(2018) Xueman Chen et al.   NATURE REVIEWS DRUG DISCOVERY

Cancer Associated Fibroblasts: Naughty Neighbors That Drive Ovarian Cancer Progression

(2018) Subramanyam Dasari et al.   Cancers

Macrophage-to-Myofibroblast Transition Contributes to Interstitial Fibrosis in Chronic Renal Allograft Injury

(2017) Ying-Ying Wang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The pattern recognition receptor, Mincle, is essential for maintaining the M1 macrophage phenotype in acute renal inflammation

(2017) Lin L. Lv et al.   KIDNEY INTERNATIONAL

Cancer associated fibroblasts: An essential role in the tumor microenvironment

(2017) Leilei Tao et al.   Oncology Letters

Smad3 promotes cancer progression by inhibiting E4BP4-mediated NK cell development

(2017) Patrick Ming-Kuen Tang et al.   Nature Communications

Phenotypic and functional heterogeneity of cancer-associated fibroblast within the tumor microenvironment

(2016) Genichiro Ishii et al.   ADVANCED DRUG DELIVERY REVIEWS

Tumor-associated macrophages drive spheroid formation during early transcoelomic metastasis of ovarian cancer

(2016) Mingzhu Yin et al.   JOURNAL OF CLINICAL INVESTIGATION

Collaboration of cancer-associated fibroblasts and tumour-associated macrophages for neuroblastoma development

(2016) Okito Hashimoto et al.   JOURNAL OF PATHOLOGY

CAFs and TAMs: maestros of the tumour microenvironment

(2016) Yoshihiro Komohara et al.   JOURNAL OF PATHOLOGY

Inflammatory macrophages can transdifferentiate into myofibroblasts during renal fibrosis

(2016) Xiao-Ming Meng et al.   Cell Death & Disease

Tumor-associated macrophages of the M2 phenotype contribute to progression in gastric cancer with peritoneal dissemination

(2015) Takahisa Yamaguchi et al.   Gastric Cancer

Molecular aspects of breast cancer resistance to drugs (Review)

(2015) GLORIA M. CALAF et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

TGF-β/Smad3 signalling regulates the transition of bone marrowderived macrophages into myofibroblasts during tissue fibrosis

(2015) Shuang Wang et al.   Oncotarget

Cancer Associated Fibroblasts in Stage I-IIIA NSCLC: Prognostic Impact and Their Correlations with Tumor Molecular Markers

(2015) Thomas K. Kilvaer et al.   PLoS One

TGF- -induced differentiation into myofibroblasts involves specific regulation of two MKL1 isoforms

(2014) M. A. Scharenberg et al.   JOURNAL OF CELL SCIENCE

Single-cell RNA-seq: advances and future challenges

(2014) Antoine-Emmanuel Saliba et al.   NUCLEIC ACIDS RESEARCH

Single-Cell RNA-Seq Reveals Dynamic, Random Monoallelic Gene Expression in Mammalian Cells

(2014) Q. Deng et al.   SCIENCE

Single-cell transcriptomics reveals bimodality in expression and splicing in immune cells

(2013) Alex K. Shalek et al.   NATURE

Ptpn11 deletion in a novel progenitor causes metachondromatosis by inducing hedgehog signalling

(2013) Wentian Yang et al.   NATURE

Microenvironmental regulation of tumor progression and metastasis

(2013) Daniela F Quail et al.   NATURE MEDICINE

Tumoral Immune Suppression by Macrophages Expressing Fibroblast Activation Protein-  and Heme Oxygenase-1

(2013) J. N. Arnold et al.   Cancer Immunology Research

Suppression of Antitumor Immunity by Stromal Cells Expressing Fibroblast Activation Protein- 

(2010) M. Kraman et al.   SCIENCE

A Transgenic Mouse Model of Inducible Macrophage Depletion

(2009) Itamar Goren et al.   AMERICAN JOURNAL OF PATHOLOGY