STAT6 contributes to renal fibrosis by modulating PPARα-mediated tubular fatty acid oxidation

The m6A Reader IGF2BP2 Regulates Macrophage Phenotypic Activation and Inflammatory Diseases by Stabilizing TSC1 and PPAR γ

(2021) Xia Wang et al.   Advanced Science

Tumor-derived microparticles promote the progression of triple-negative breast cancer via PD-L1-associated immune suppression

(2021) Cong Li et al.   CANCER LETTERS

Functional Comparison of IFN‐α Subtypes Reveals Potent HBV Suppression by a Concerted Action of IFN‐α and ‐γ Signaling

(2020) Jieliang Chen et al.   HEPATOLOGY

Interleukin-4 stimulates lipogenesis in meibocytes by activating the STAT6/PPARγ signaling pathway

(2020) Ikhyun Jun et al.   Ocular Surface

Kidney Single-Cell Atlas Reveals Myeloid Heterogeneity in Progression and Regression of Kidney Disease

(2020) Bryan R. Conway et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

China Kidney Disease Network (CK-NET) 2016 Annual Data Report

(2020) Luxia Zhang et al.   Kidney International Supplements

Bixin Protects Against Kidney Interstitial Fibrosis Through Promoting STAT6 Degradation

(2020) Jianzhong Li et al.   Frontiers in Cell and Developmental Biology

Tubular GM-CSF Promotes Late MCP-1/CCR2-Mediated Fibrosis and Inflammation after Ischemia/Reperfusion Injury

(2019) Leyuan Xu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Inhibition of 4E-BP1 phosphorylation promotes tubular cell escaping from G2/M arrest and ameliorates kidney fibrosis

(2019) Xiaoli Sun et al.   CELLULAR SIGNALLING

Activation of the IL-4/STAT6 Signaling Pathway Promotes Lung Cancer Progression by Increasing M2 Myeloid Cells

(2019) Cuiping Fu et al.   Frontiers in Immunology

Molecular actions of PPARα in lipid metabolism and inflammation

(2018) Nadia Bougarne et al.   ENDOCRINE REVIEWS

Targeting the Stat6 pathway in tumor-associated macrophages reduces tumor growth and metastatic niche formation in breast cancer

(2018) Karin Binnemars-Postma et al.   FASEB JOURNAL

Impairment of PPARαand the Fatty Acid Oxidation Pathway Aggravates Renal Fibrosis during Aging

(2018) Ki Wung Chung et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Renal tubule injury: a driving force toward chronic kidney disease

(2018) Bi-Cheng Liu et al.   KIDNEY INTERNATIONAL

Renal fibrosis: Primacy of the proximal tubule

(2018) Leslie S. Gewin   MATRIX BIOLOGY

Cellular and molecular mechanisms of kidney fibrosis

(2018) Sonja Djudjaj et al.   MOLECULAR ASPECTS OF MEDICINE

STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets

(2018) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

STAT6 degradation and ubiquitylated TRIML2 are essential for activation of human oncogenic herpesvirus

(2018) Feng Gu et al.   PLoS Pathogens

Pharmacologic Approaches to Improve Mitochondrial Function in AKI and CKD

(2017) Hazel H. Szeto   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

IL-4/IL-13–mediated polarization of renal macrophages/dendritic cells to an M2a phenotype is essential for recovery from acute kidney injury

(2017) Ming-Zhi Zhang et al.   KIDNEY INTERNATIONAL

CD36 in chronic kidney disease: novel insights and therapeutic opportunities

(2017) Xiaochun Yang et al.   Nature Reviews Nephrology

The next generation of therapeutics for chronic kidney disease

(2016) Matthew D. Breyer et al.   NATURE REVIEWS DRUG DISCOVERY

JAK3/STAT6 Stimulates Bone Marrow-Derived Fibroblast Activation in Renal Fibrosis

(2015) J. Yan et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Rictor/mTORC2 signaling mediates TGFβ1-induced fibroblast activation and kidney fibrosis

(2015) Jianzhong Li et al.   KIDNEY INTERNATIONAL

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Defective fatty acid oxidation in renal tubular epithelial cells has a key role in kidney fibrosis development

(2014) Hyun Mi Kang et al.   NATURE MEDICINE

Altered renal lipid metabolism and renal lipid accumulation in human diabetic nephropathy

(2013) Michal Herman-Edelstein et al.   JOURNAL OF LIPID RESEARCH

Origin and function of myofibroblasts in kidney fibrosis

(2013) Valerie S LeBleu et al.   NATURE MEDICINE

STAT6 promotes bi-directional modulation of PKM2 in liver and adipose inflammatory cells in Rosiglitazone-treated mice

(2013) Tatjana Sajic et al.   Scientific Reports

The contribution of chronic kidney disease to the global burden of major noncommunicable diseases

(2012) Keng-Thye Woo et al.   KIDNEY INTERNATIONAL

Signal transducer and activator of transcription-6 (STAT6) inhibition suppresses renal cyst growth in polycystic kidney disease

(2011) E. E. Olsan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IL-4/STAT6 immune axis regulates peripheral nutrient metabolism and insulin sensitivity

(2010) R. R. Ricardo-Gonzalez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA