Polyamine metabolism controls B-to-Z DNA transition to orchestrate DNA sensor cGAS activity

Spermine enhances antiviral and anticancer responses by stabilizing DNA binding with the DNA sensor cGAS

(2023) Lina Wang et al.   IMMUNITY

Noncanonical DNA structures are drivers of genome evolution

(2023) Kateryna D. Makova et al.   TRENDS IN GENETICS

Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity

(2023) Yuanjiu Lei et al.   CELL

The Z-nucleic acid sensor ZBP1 in health and disease

(2023) Jonathan Maelfait et al.   JOURNAL OF EXPERIMENTAL MEDICINE

ADAR1 masks the cancer immunotherapeutic promise of ZBP1-driven necroptosis

(2022) Ting Zhang et al.   NATURE

Spermidine activates mitochondrial trifunctional protein and improves antitumor immunity in mice

(2022) Muna Al-Habsi et al.   SCIENCE

Phosphorylation and chromatin tethering prevent cGAS activation during mitosis

(2021) Tuo Li et al.   SCIENCE

Metabolic modeling of single Th17 cells reveals regulators of autoimmunity

(2021) Allon Wagner et al.   CELL

Polyamine metabolism is a central determinant of helper T cell lineage fidelity

(2021) Daniel J. Puleston et al.   CELL

Cytoplasmic DNA: sources, sensing, and role in aging and disease

(2021) Karl N. Miller et al.   CELL

Z-form extracellular DNA is a structural component of the bacterial biofilm matrix

(2021) John R. Buzzo et al.   CELL

Nonalternating purine pyrimidine sequences can form stable left-handed DNA duplex by strong topological constraint

(2021) Lin Li et al.   NUCLEIC ACIDS RESEARCH

Influenza Virus Z-RNAs Induce ZBP1-Mediated Necroptosis

(2020) Ting Zhang et al.   CELL

Molecular mechanisms and cellular functions of cGAS–STING signalling

(2020) Karl-Peter Hopfner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Excessive Polyamine Generation in Keratinocytes Promotes Self-RNA Sensing by Dendritic Cells in Psoriasis

(2020) Fangzhou Lou et al.   IMMUNITY

Polyamines and Kynurenines at the Intersection of Immune Modulation

(2020) Elisa Proietti et al.   TRENDS IN IMMUNOLOGY

cGAS in action: Expanding roles in immunity and inflammation

(2019) Andrea Ablasser et al.   SCIENCE

Polyamines and eIF5A Hypusination Modulate Mitochondrial Respiration and Macrophage Activation

(2019) Daniel J. Puleston et al.   Cell Metabolism

DNA sensing by the cGAS–STING pathway in health and disease

(2019) Mona Motwani et al.   NATURE REVIEWS GENETICS

Regulation of cGAS- and RLR-mediated immunity to nucleic acids

(2019) Andrea Ablasser et al.   NATURE IMMUNOLOGY

Manganese Increases the Sensitivity of the cGAS-STING Pathway for Double-Stranded DNA and Is Required for the Host Defense against DNA Viruses

(2018) Chenguang Wang et al.   IMMUNITY

DNA-induced liquid phase condensation of cGAS activates innate immune signaling

(2018) Mingjian Du et al.   SCIENCE

Spermidine in health and disease

(2018) Frank Madeo et al.   SCIENCE

USP1–UAF1 deubiquitinase complex stabilizes TBK1 and enhances antiviral responses

(2017) Zhongxia Yu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

cGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein–DNA ladders

(2017) Liudmila Andreeva et al.   NATURE

Sequence-specific activation of the DNA sensor cGAS by Y-form DNA structures as found in primary HIV-1 cDNA

(2015) Anna-Maria Herzner et al.   NATURE IMMUNOLOGY

Structural mechanism of cytosolic DNA sensing by cGAS

(2013) Filiz Civril et al.   NATURE

The polyamine analogueN1,N11-diethylnorspermine can induce chondrocyte apoptosis independently of its ability to alter metabolism and levels of natural polyamines

(2008) Ivana Stanic' et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The crystal structure of the second Z-DNA binding domain of human DAI (ZBP1) in complex with Z-DNA reveals an unusual binding mode to Z-DNA

(2008) S. C. Ha et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA