TLR4/ MyD88/NF-κB signaling pathway involved in the protective effect of diacerein against lung fibrosis in rats

Targeting Oxidative Stress as a Therapeutic Approach for Idiopathic Pulmonary Fibrosis

(2022) Cristina Estornut et al.   Frontiers in Pharmacology

Aprepitant exerts anti-fibrotic effect via inhibition of TGF-β/Smad3 pathway in bleomycin-induced pulmonary fibrosis in rats

(2022) Mervat Z. Mohamed et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Trichlorocarban induces developmental and immune toxicity to zebrafish (Danio rerio) by targeting TLR4/MyD88/NF-κB signaling pathway

(2021) Jiaqi Xu et al.   ENVIRONMENTAL POLLUTION

Sodium Houttuyfonate Inhibits Bleomycin Induced Pulmonary Fibrosis in Mice

(2021) Yun-hui Shen et al.   Frontiers in Pharmacology

Diacerein ameliorates kidney injury induced by cisplatin in rats by activation of Nrf2/Ho-1 pathway and Bax down-regulation

(2021) Nashwa Barakat et al.   SAUDI JOURNAL OF BIOLOGICAL SCIENCES

Diacerein ameliorates testosterone-induced benign prostatic hyperplasia in rats: Effect on oxidative stress, inflammation and apoptosis

(2021) Mohamed El-Sherbiny et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

TLR4/MyD88/NF-κB-Mediated Inflammation Contributes to Cardiac Dysfunction in Rats of PTSD

(2020) Moujie Liu et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Inflammatory Role of TLR-MyD88 Signaling in Multiple Sclerosis

(2020) Chao Zheng et al.   Frontiers in Molecular Neuroscience

Zingerone ameliorates oxidative stress and inflammation in bleomycin-induced pulmonary fibrosis: modulation of the expression of TGF-β1 and iNOS

(2020) Huseyin Gungor et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Vinpocetine Protects Against Cerebral Ischemia-Reperfusion Injury by Targeting Astrocytic Connexin43 via the PI3K/AKT Signaling Pathway

(2020) Mingming Zhao et al.   Frontiers in Neuroscience

Asiaticoside might attenuate bleomycin‐induced pulmonary fibrosis by activating cAMP and Rap1 signalling pathway assisted by A2AR

(2020) Jing Luo et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The cross-talk of NLRP3 inflammasome activation and necroptotic hepatocyte death in acetaminophen-induced mice acute liver injury

(2020) L Li et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Bixin attenuates carbon tetrachloride induced oxidative stress, inflammation and fibrosis in kidney by regulating the Nrf2/TLR4/MyD88 and PPAR-γ/TGF-β1/Smad3 pathway

(2020) Jie-Qiong Ma et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Diacerein protects rats with liver ischemia/reperfusion damage: Down-regulation of TLR4/ NFκ-B signaling pathway

(2020) Mohamed Abdellah Ibrahim et al.   BIOMEDICINE & PHARMACOTHERAPY

Efficacy of diacerein in reducing liver steatosis and fibrosis in patients with type 2 diabetes and non-alcoholic fatty liver disease: A randomized, placebo-controlled trial

(2019) Nathalie C. Leite et al.   DIABETES OBESITY & METABOLISM

Epicatechin protective effects on bleomycin-induced pulmonary oxidative stress and fibrosis in mice

(2019) Saeedeh Shariati et al.   BIOMEDICINE & PHARMACOTHERAPY

Diacerein protects against glycerol-induced acute kidney injury: Modulating oxidative stress, inflammation, apoptosis and necroptosis

(2019) Rania Nagi Abd-Ellatif et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Oxidant/Antioxidant Disequilibrium in Idiopathic Pulmonary Fibrosis Pathogenesis

(2019) Paolo Cameli et al.   INFLAMMATION

Diacerein Downregulates NLRP3/Caspase-1/IL-1β and IL-6/STAT3 Pathways of Inflammation and Apoptosis in a Rat Model of Cadmium Testicular Toxicity

(2019) Amr A. Fouad et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Pulmonary Fibrosis in Children

(2019) Nathan et al.   Journal of Clinical Medicine

Galangin Activates Nrf2 Signaling and Attenuates Oxidative Damage, Inflammation, and Apoptosis in a Rat Model of Cyclophosphamide-Induced Hepatotoxicity

(2019) Aladaileh et al.   Biomolecules

MyD88 mediates colorectal cancer cell proliferation, migration and invasion via NF‑κB/AP‑1 signaling pathway

(2019) Guangwei Zhu et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Aloin Preconditioning Attenuates Hepatic Ischemia/Reperfusion Injury via Inhibiting TLR4/MyD88/NF-κB Signal Pathway In Vivo and In Vitro

(2019) Yichao Du et al.   Oxidative Medicine and Cellular Longevity

Identification of ANXA2 (annexin A2) as a specific bleomycin target to induce pulmonary fibrosis by impeding TFEB-mediated autophagic flux

(2018) Kui Wang et al.   Autophagy

Protective effect of hydroxysafflor yellow A on bleomycin- induced pulmonary inflammation and fibrosis in rats

(2018) Ming Jin et al.   Chinese Journal of Integrative Medicine

Atorvastatin and diacerein reduce insulin resistance and increase disease tolerance in rats with sepsis

(2018) K. L. C. da Silva et al.   Journal of Inflammation-London

Effect of Diacerein on Metabolic Control and Inflammatory Markers in Patients with Type 2 Diabetes Using Antidiabetic Agents: A Randomized Controlled Trial

(2018) Glaucia S. Tres et al.   Journal of Diabetes Research

Mechanism mediating the protective effect of diacerein in ischemia-reperfusion-induced testicular injury in rats

(2018) Seham A. Abdel-Gaber et al.   LIFE SCIENCES

Pharmacological Inhibition of Toll-Like Receptor-4 Signaling by TAK242 Prevents and Induces Regression of Experimental Organ Fibrosis

(2018) Swati Bhattacharyya et al.   Frontiers in Immunology

Aucubin Alleviates Bleomycin-Induced Pulmonary Fibrosis in a Mouse Model

(2017) Yong Zhou et al.   INFLAMMATION

Thyroid hormone inhibits lung fibrosis in mice by improving epithelial mitochondrial function

(2017) Guoying Yu et al.   NATURE MEDICINE

Amelioration of bleomycin-induced lung fibrosis in rats by valproic acid and butyrate: Role of nuclear factor kappa-B, proinflammatory cytokines and oxidative stress

(2016) Ahmed M. Kabel et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Development and Pharmacokinetic Evaluation of New Oral Formulations of Diacerein

(2016) Sagar D. Mandawgade et al.   Current Drug Delivery

Toll-like receptor 4 promotes fibrosis in bleomycin-induced lung injury in mice

(2015) X.X. Li et al.   GENETICS AND MOLECULAR RESEARCH

Diacerein reduces joint damage, pain behavior and inhibits transient receptor potential vanilloid 1, matrix metalloproteinase and glial cells in rat spinal cord

(2015) Morgana Duarte da Silva et al.   International Journal of Rheumatic Diseases

Bleomycin in the setting of lung fibrosis induction: From biological mechanisms to counteractions

(2015) Veronica Della Latta et al.   PHARMACOLOGICAL RESEARCH

The pathogenesis of bleomycin-induced lung injury in animals and its applicability to human idiopathic pulmonary fibrosis

(2014) James D. Williamson et al.   EXPERIMENTAL LUNG RESEARCH

Epithelial–mesenchymal transition involved in pulmonary fibrosis induced by multi-walled carbon nanotubes via TGF-beta/Smad signaling pathway

(2014) Tian Chen et al.   TOXICOLOGY LETTERS

Development of Lipid Nanoparticles of Diacerein, an Antiosteoarthritic Drug for Enhancement in Bioavailability and Reduction in its Side Effects

(2013) Achint Jain et al.   Journal of Biomedical Nanotechnology

Diacerein decreases visceral pain through inhibition of glutamatergic neurotransmission and cytokine signaling in mice

(2012) Vinícius Maria Gadotti et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Modeling pulmonary fibrosis with bleomycin

(2011) Marios A. Mouratis et al.   CURRENT OPINION IN PULMONARY MEDICINE

Effects of diacerein at the molecular level in the osteoarthritis disease process

(2010) Johanne Martel-Pelletier et al.   Therapeutic Advances in Musculoskeletal Disease

Determinants of initiation and progression of idiopathic pulmonary fibrosis

(2009) Robert Matthew KOTTMANN et al.   RESPIROLOGY