Long noncoding RNA AI662270 promotes kidney fibrosis through enhancing METTL3‐mediated m6A modification of CTGF mRNA

Dynamic control of chromatin-associated m6A methylation regulates nascent RNA synthesis

(2022) Wenqi Xu et al.   MOLECULAR CELL

Inhibition of METTL3 attenuates renal injury and inflammation by alleviating TAB3 m6A modifications via IGF2BP2-dependent mechanisms

(2022) Jia-nan Wang et al.   Science Translational Medicine

m6A-independent genome-wide METTL3 and METTL14 redistribution drives the senescence-associated secretory phenotype

(2021) Pingyu Liu et al.   NATURE CELL BIOLOGY

m6A RNA methylation regulates promoter- proximal pausing of RNA polymerase II

(2021) Junaid Akhtar et al.   MOLECULAR CELL

Long noncoding RNA growth arrest‐specific transcript 5 alleviates renal fibrosis in diabetic nephropathy by downregulating matrix metalloproteinase 9 through recruitment of enhancer of zeste homolog 2

(2020) Lei Zhang et al.   FASEB JOURNAL

N6-methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcription

(2020) Jun Liu et al.   SCIENCE

N6-methyladenosine regulates glycolysis of cancer cells through PDK4

(2020) Zihan Li et al.   Nature Communications

DsbA-L mediated renal tubulointerstitial fibrosis in UUO mice

(2020) Xiaozhou Li et al.   Nature Communications

Upregulated long noncoding RNA LOC105375913 induces tubulointerstitial fibrosis in focal segmental glomerulosclerosis

(2019) Runhong Han et al.   Scientific Reports

Upregulation of HER2 in tubular epithelial cell drives fibroblast activation and renal fibrosis.

(2019) Huanan Li et al.   KIDNEY INTERNATIONAL

The RNA N6-methyladenosine modification landscape of human fetal tissues

(2019) Shan Xiao et al.   NATURE CELL BIOLOGY

Mettl3-mediated mRNA m6A methylation promotes dendritic cell activation

(2019) Huamin Wang et al.   Nature Communications

A catalog of genetic loci associated with kidney function from analyses of a million individuals

(2019) Matthias Wuttke et al.   NATURE GENETICS

Fibroblast growth factor 1 ameliorates diabetic nephropathy by an anti-inflammatory mechanism

(2018) Guang Liang et al.   KIDNEY INTERNATIONAL

TGF-β Mediates Renal Fibrosis via the Smad3-Erbb4-IR Long Noncoding RNA Axis

(2018) Min Feng et al.   MOLECULAR THERAPY

The SMAD2/3 interactome reveals that TGFβ controls m6A mRNA methylation in pluripotency

(2018) Alessandro Bertero et al.   NATURE

m6A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer

(2018) Jun Liu et al.   NATURE CELL BIOLOGY

LNMAT1 promotes lymphatic metastasis of bladder cancer via CCL2 dependent macrophage recruitment

(2018) Changhao Chen et al.   Nature Communications

Long noncoding RNA lnc-TSI inhibits renal fibrogenesis by negatively regulating the TGF-β/Smad3 pathway

(2018) Peng Wang et al.   Science Translational Medicine

Trans-ethnic kidney function association study reveals putative causal genes and effects on kidney-specific disease aetiologies

(2018) Andrew P. Morris et al.   Nature Communications

m 6 A mRNA modifications are deposited in nascent pre-mRNA and are not required for splicing but do specify cytoplasmic turnover

(2017) Shengdong Ke et al.   GENES & DEVELOPMENT

Chronic Kidney Disease

(2017) Angela C Webster et al.   LANCET

Promoter-bound METTL3 maintains myeloid leukaemia by m6A-dependent translation control

(2017) Isaia Barbieri et al.   NATURE

Long noncoding RNA Tug1 regulates mitochondrial bioenergetics in diabetic nephropathy

(2016) Jianyin Long et al.   JOURNAL OF CLINICAL INVESTIGATION

The global burden of chronic kidney disease: estimates, variability and pitfalls

(2016) Richard J. Glassock et al.   Nature Reviews Nephrology

Whole-transcriptome analysis of UUO mouse model of renal fibrosis reveals new molecular players in kidney diseases

(2016) Eleni Arvaniti et al.   Scientific Reports

Long Noncoding RNA Arid2-IR Is a Novel Therapeutic Target for Renal Inflammation

(2015) Qin Zhou et al.   MOLECULAR THERAPY

MEG3 long noncoding RNA regulates the TGF-β pathway genes through formation of RNA–DNA triplex structures

(2015) Tanmoy Mondal et al.   Nature Communications

LongTarget: a tool to predict lncRNA DNA-binding motifs and binding sites via Hoogsteen base-pairing analysis

(2014) Sha He et al.   BIOINFORMATICS

Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase

(2014) Xiao-Li Ping et al.   CELL RESEARCH

LincRNA-p21 Activates p21 In cis to Promote Polycomb Target Gene Expression and to Enforce the G1/S Checkpoint

(2014) Nadya Dimitrova et al.   MOLECULAR CELL

N6-methyladenosine modification destabilizes developmental regulators in embryonic stem cells

(2014) Yang Wang et al.   NATURE CELL BIOLOGY

A perspective on anti-CCN2 therapy for chronic kidney disease

(2014) L. L. Falke et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Perturbation of m6A Writers Reveals Two Distinct Classes of mRNA Methylation at Internal and 5′ Sites

(2014) Schraga Schwartz et al.   Cell Reports

A METTL3–METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation

(2013) Jianzhao Liu et al.   Nature Chemical Biology

CTGF induces monocyte chemoattractant protein-1 expression to enhance monocyte migration in human synovial fibroblasts

(2012) Shan-Chi Liu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Targeting the TGFβ signalling pathway in disease

(2012) Rosemary J. Akhurst et al.   NATURE REVIEWS DRUG DISCOVERY

CTGF/CCN2 activates canonical Wnt signalling in mesangial cells through LRP6: Implications for the pathogenesis of diabetic nephropathy

(2011) Brian Rooney et al.   FEBS LETTERS

TGF- /Smad3 Signaling Promotes Renal Fibrosis by Inhibiting miR-29

(2011) W. Qin et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Genomic Maps of Long Noncoding RNA Occupancy Reveal Principles of RNA-Chromatin Interactions

(2011) Ci Chu et al.   MOLECULAR CELL

Involvement of Connective Tissue Growth Factor in Human and Experimental Hypertensive Nephrosclerosis

(2010) Yasuhiko Ito et al.   NEPHRON EXPERIMENTAL NEPHROLOGY

Advanced Glycation End-Products Induce Tubular CTGF via TGF- -Independent Smad3 Signaling

(2009) A. C.K. Chung et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

CTGF Promotes Inflammatory Cell Infiltration of the Renal Interstitium by Activating NF- B

(2009) E. Sanchez-Lopez et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Posttranscriptional Regulation of Chicken ccn2 Gene Expression by Nucleophosmin/B23 during Chondrocyte Differentiation

(2008) Y. Mukudai et al.   MOLECULAR AND CELLULAR BIOLOGY