A catalog of genetic loci associated with kidney function from analyses of a million individuals

Integrated Functional Genomic Analysis Enables Annotation of Kidney Genome-Wide Association Study Loci

(2019) Karsten B. Sieber et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Genome-Wide Association Study of Renal Function Traits: Results from the Japan Multi-Institutional Collaborative Cohort Study

(2018) Asahi Hishida et al.   AMERICAN JOURNAL OF NEPHROLOGY

Using an atlas of gene regulation across 44 human tissues to inform complex disease- and trait-associated variation

(2018) Eric R. Gamazon et al.   NATURE GENETICS

Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases

(2018) Masahiro Kanai et al.   NATURE GENETICS

Genome-wide association analysis identifies multiple loci associated with kidney disease-related traits in Korean populations

(2018) Jeonghwan Lee et al.   PLoS One

An eQTL Landscape of Kidney Tissue in Human Nephrotic Syndrome

(2018) Christopher E. Gillies et al.   AMERICAN JOURNAL OF HUMAN GENETICS

An atlas of genetic associations in UK Biobank

(2018) Oriol Canela-Xandri et al.   NATURE GENETICS

Sequential recruitment of study participants may inflate genetic heritability estimates

(2017) Damia Noce et al.   HUMAN GENETICS

Trans-ethnic meta-regression of genome-wide association studies accounting for ancestry increases power for discovery and improves fine-mapping resolution

(2017) Reedik Mägi et al.   HUMAN MOLECULAR GENETICS

Changes in ceramide metabolism are essential in Madin-Darby canine kidney cell differentiation

(2017) Lucila Gisele Pescio et al.   JOURNAL OF LIPID RESEARCH

Global kidney health 2017 and beyond: a roadmap for closing gaps in care, research, and policy

(2017) Adeera Levin et al.   LANCET

Genetic effects on gene expression across human tissues

(2017) François Aguet et al.   NATURE

Voltage-gated calcium channels: Novel targets for cancer therapy

(2017) Nam Nhut Phan et al.   Oncology Letters

Trans-ethnic Fine Mapping Highlights Kidney-Function Genes Linked to Salt Sensitivity

(2016) Anubha Mahajan et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Novel regulations of MEF2-A, MEF2-D, and CACNA1S in the functional incompetence of adipose-derived mesenchymal stem cells by induced indoxyl sulfate in chronic kidney disease

(2016) Duyen Thi Do et al.   CYTOTECHNOLOGY

Million Veteran Program: A mega-biobank to study genetic influences on health and disease

(2016) John Michael Gaziano et al.   JOURNAL OF CLINICAL EPIDEMIOLOGY

SOS2andACP1Loci Identified through Large-Scale Exome Chip Analysis Regulate Kidney Development and Function

(2016) Man Li et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Combination of mouse models and genomewide association studies highlights novel genes associated with human kidney function

(2016) Jiaojiao Jing et al.   KIDNEY INTERNATIONAL

Genomics is failing on diversity

(2016) Alice B. Popejoy et al.   NATURE

A reference panel of 64,976 haplotypes for genotype imputation

(2016)   NATURE GENETICS

Insights into kidney diseases from genome-wide association studies

(2016) Matthias Wuttke et al.   Nature Reviews Nephrology

GenToS: Use of Orthologous Gene Information to Prioritize Signals from Human GWAS

(2016) Anselm S. Hoppmann et al.   PLoS One

Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

(2016) Cristian Pattaro et al.   Nature Communications

Chronic kidney disease and cardiovascular risk in six regions of the world (ISN-KDDC): a cross-sectional study

(2016) Bogdan Ene-Iordache et al.   Lancet Global Health

The LIFE-Adult-Study: objectives and design of a population-based cohort study with 10,000 deeply phenotyped adults in Germany

(2015) Markus Loeffler et al.   BMC PUBLIC HEALTH

Dissecting the genetics of the human transcriptome identifies novel trait-relatedtrans-eQTLs and corroborates the regulatory relevance of non-protein coding loci

(2015) Holger Kirsten et al.   HUMAN MOLECULAR GENETICS

The Cooperative Health Research in South Tyrol (CHRIS) study: rationale, objectives, and preliminary results

(2015) Cristian Pattaro et al.   Journal of Translational Medicine

Autosomal dominant tubulointerstitial kidney disease: diagnosis, classification, and management—A KDIGO consensus report

(2015) Kai-Uwe Eckardt et al.   KIDNEY INTERNATIONAL

Partitioning heritability by functional annotation using genome-wide association summary statistics

(2015) Hilary K Finucane et al.   NATURE GENETICS

An atlas of genetic correlations across human diseases and traits

(2015) Brendan Bulik-Sullivan et al.   NATURE GENETICS

Gene expression analysis identifies global gene dosage sensitivity in cancer

(2015) Rudolf S N Fehrmann et al.   NATURE GENETICS

LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

(2015) Brendan K Bulik-Sullivan et al.   NATURE GENETICS

Genome-Wide Association Study with Targeted and Non-targeted NMR Metabolomics Identifies 15 Novel Loci of Urinary Human Metabolic Individuality

(2015) Johannes Raffler et al.   PLoS Genetics

Second-generation PLINK: rising to the challenge of larger and richer datasets

(2015) Christopher C Chang et al.   GigaScience

Comparison and integration of deleteriousness prediction methods for nonsynonymous SNVs in whole exome sequencing studies

(2015) C. Dong et al.   HUMAN MOLECULAR GENETICS

MCMC Methods for Multi-Response Generalized Linear Mixed Models: TheMCMCglmmRPackage

(2015) Jarrod D. Hadfield   Journal of Statistical Software

SNiPA: an interactive, genetic variant-centered annotation browser

(2014) Matthias Arnold et al.   BIOINFORMATICS

Shroom3contributes to the maintenance of the glomerular filtration barrier integrity

(2014) Nan Cher Yeo et al.   GENOME RESEARCH

Rare mutations associating with serum creatinine and chronic kidney disease

(2014) Gardar Sveinbjornsson et al.   HUMAN MOLECULAR GENETICS

Decline in Estimated Glomerular Filtration Rate and Subsequent Risk of End-Stage Renal Disease and Mortality

(2014) Josef Coresh et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Common Variants in UMOD Associate with Urinary Uromodulin Levels: A Meta-Analysis

(2014) M. Olden et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

A general framework for estimating the relative pathogenicity of human genetic variants

(2014) Martin Kircher et al.   NATURE GENETICS

A Gene Variant in CERS2 Is Associated with Rate of Increase in Albuminuria in Patients with Diabetes from ONTARGET and TRANSCEND

(2014) Dov Shiffman et al.   PLoS One

Bayesian Test for Colocalisation between Pairs of Genetic Association Studies Using Summary Statistics

(2014) Claudia Giambartolomei et al.   PLoS Genetics

Organic Cation Transporter OCTs (SLC22) and MATEs (SLC47) in the Human Kidney

(2013) Hideyuki Motohashi et al.   AAPS Journal

The Landscape of Clinical Trials in Nephrology: A Systematic Review of ClinicalTrials.gov

(2013) Jula K. Inrig et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

A New Equation to Estimate Glomerular Filtration Rate

(2013) Andrew S. Levey et al.   ANNALS OF INTERNAL MEDICINE

Genetic Variants Associated With Glycine Metabolism and Their Role in Insulin Sensitivity and Type 2 Diabetes

(2013) W. Xie et al.   DIABETES

Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality

(2013) Ilkka Seppälä et al.   EUROPEAN HEART JOURNAL

Common Variants in Mendelian Kidney Disease Genes and Their Association with Renal Function

(2013) A. Parsa et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Chronic kidney disease: global dimension and perspectives

(2013) Vivekanand Jha et al.   LANCET

Evolving importance of kidney disease: from subspecialty to global health burden

(2013) Kai-Uwe Eckardt et al.   LANCET

Systematic identification of trans eQTLs as putative drivers of known disease associations

(2013) Harm-Jan Westra et al.   NATURE GENETICS

Estimating the Glomerular Filtration Rate in the General Population Using Different Equations: Effects on Classification and Association

(2013) Cristian Pattaro et al.   NEPHRON CLINICAL PRACTICE

Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function

(2012) Daniel I. Chasman, Christian Fuchsberger, Cristian Pattaro, Alexander Teumer, Carsten A. Böger, Karlhans Endlich, Matthias Olden, Ming-Huei Chen, Adrienne Tin, Daniel Taliun, Man Li, Xiaoyi Gao, Mathias Gorski, Qiong Yang, Claudia Hundertmark, Meredith C. Foster, Conall M. O'Seaghdha, Nicole Glazer, Aaron Isaacs, Ching-Ti Liu, Albert V. Smith, Jeffrey R. O'Connell, Maksim Struchalin, Toshiko Tanaka, Guo Li, Andrew D. Johnson, Hinco J. Gierman, Mary F. Feitosa, Shih-Jen Hwang, Elizabeth J. Atkinson, Kurt Lohman, Marilyn C. Cornelis, Åsa Johansson, Anke Tönjes, Abbas Dehghan, Jean-Charles Lambert, Elizabeth G. Holliday, Rossella Sorice, Zoltan Kutalik, Terho Lehtimäki, Tõnu Esko, Harshal Deshmukh, Sheila Ulivi, Audrey Y. Chu, Federico Murgia, Stella Trompet, Medea Imboden, Stefan Coassin, Giorgio Pistis, Tamara B. Harris, Lenore J. Launer, Thor Aspelund, Gudny Eiriksdottir, Braxton D. Mitchell, Eric Boerwinkle, Helena Schmidt, Margherita Cavalieri, Madhumathi Rao, Frank Hu, Ayse Demirkan, Ben A. Oostra, Mariza de Andrade, Stephen T. Turner, Jingzhong Ding, Jeanette S. Andrews, Barry I. Freedman, Franco Giulianini, Wolfgang Koenig, Thomas Illig, Christa Meisinger, Christian Gieger, Lina Zgaga, Tatijana Zemunik, Mladen Boban, Cosetta Minelli, Heather E. Wheeler, Wilmar Igl, Ghazal Zaboli, Sarah H. Wild, Alan F. Wright, Harry Campbell, David Ellinghaus, Ute Nöthlings, Gunnar Jacobs, Reiner Biffar, Florian Ernst, Georg Homuth, Heyo K. Kroemer, Matthias Nauck, Sylvia Stracke, Uwe Völker, Henry Völzke, Peter Kovacs, Michael Stumvoll, Reedik Mägi, Albert Hofman, Andre G. Uitterlinden, Fernando Rivadeneira, Yurii S. Aulchenko, Ozren Polasek, Nick Hastie, Veronique Vitart, Catherine Helmer, Jie Jin Wang, Bénédicte Stengel, Daniela Ruggiero, Sven Bergmann, Mika Kähönen, Jorma Viikari, Tiit Nikopensius, Michael Province, Shamika Ketkar, Helen Colhoun, Alex Doney, Antonietta Robino, Bernhard K. Krämer, Laura Portas, Ian Ford, Brendan M. Buckley, Martin Adam, Gian-Andri Thun, Bernhard Paulweber, Margot Haun, Cinzia Sala, Paul Mitchell, Marina Ciullo, Stuart K. Kim, Peter Vollenweider, Olli Raitakari, Andres Metspalu, Colin Palmer, Paolo Gasparini, Mario Pirastu, J. Wouter Jukema, Nicole M. Probst-Hensch, Florian Kronenberg, Daniela Toniolo, Vilmundur Gudnason, Alan R. Shuldiner, Josef Coresh, Reinhold Schmidt, Luigi Ferrucci, David S. Siscovick, Cornelia M. van Duijn, Ingrid B. Borecki, Sharon L.R. Kardia, Yongmei Liu, Gary C. Curhan, Igor Rudan, Ulf Gyllensten, James F. Wilson, Andre Franke, Peter P. Pramstaller, Rainer Rettig, Inga Prokopenko et al.   HUMAN MOLECULAR GENETICS

Improved equations estimating GFR in children with chronic kidney disease using an immunonephelometric determination of cystatin C

(2012) George J. Schwartz et al.   KIDNEY INTERNATIONAL

An integrated map of genetic variation from 1,092 human genomes

(2012)   NATURE

Meta-analysis identifies multiple loci associated with kidney function–related traits in east Asian populations

(2012) Yukinori Okada et al.   NATURE GENETICS

Genome-wide association analyses identify 18 new loci associated with serum urate concentrations

(2012) Anna Köttgen et al.   NATURE GENETICS

Genome-Wide Association and Functional Follow-Up Reveals New Loci for Kidney Function

(2012) Cristian Pattaro et al.   PLoS Genetics

Novel Loci for Adiponectin Levels and Their Influence on Type 2 Diabetes and Metabolic Traits: A Multi-Ethnic Meta-Analysis of 45,891 Individuals

(2012) Zari Dastani et al.   PLoS Genetics

GWAtoolbox: an R package for fast quality control and handling of genome-wide association studies meta-analysis data

(2011) Christian Fuchsberger et al.   BIOINFORMATICS

The German Chronic Kidney Disease (GCKD) study: design and methods

(2011) K.-U. Eckardt et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Rationale and Design of the Leipzig (LIFE) Heart Study: Phenotyping and Cardiovascular Characteristics of Patients with Coronary Artery Disease

(2011) Frank Beutner et al.   PLoS One

Trans-eQTLs Reveal That Independent Genetic Variants Associated with a Complex Phenotype Converge on Intermediate Genes, with a Major Role for the HLA

(2011) Rudolf S. N. Fehrmann et al.   PLoS Genetics

GCTA: A Tool for Genome-wide Complex Trait Analysis

(2010) Jian Yang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Deriving the consequences of genomic variants with the Ensembl API and SNP Effect Predictor

(2010) William McLaren et al.   BIOINFORMATICS

METAL: fast and efficient meta-analysis of genomewide association scans

(2010) C. J. Willer et al.   BIOINFORMATICS

New loci associated with kidney function and chronic kidney disease

(2010) Anna Köttgen et al.   NATURE GENETICS

Genetic loci influencing kidney function and chronic kidney disease

(2010) John C Chambers et al.   NATURE GENETICS

Genetics and Beyond – The Transcriptome of Human Monocytes and Disease Susceptibility

(2010) Tanja Zeller et al.   PLoS One

Contribution of Organic Cation Transporter 2 (OCT2) to Cisplatin-Induced Nephrotoxicity

(2009) K K Filipski et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Adult Ceramide Synthase 2 (CERS2)-deficient Mice Exhibit Myelin Sheath Defects, Cerebellar Degeneration, and Hepatocarcinomas

(2009) Silke Imgrund et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeted Disruption of the Multidrug and Toxin Extrusion 1 (Mate1) Gene in Mice Reduces Renal Secretion of Metformin

(2009) M. Tsuda et al.   MOLECULAR PHARMACOLOGY

Multiple loci associated with indices of renal function and chronic kidney disease

(2009) Anna Köttgen et al.   NATURE GENETICS

Bayes factors for genome-wide association studies: comparison withP-values

(2008) Jon Wakefield   GENETIC EPIDEMIOLOGY