Challenges associated with using extracellular vesicles as biomarkers in neurodegenerative disease

Myelin Basic Protein in Oligodendrocyte-Derived Extracellular Vesicles as a Diagnostic and Prognostic Biomarker in Multiple Sclerosis: A Pilot Study

(2023) Cristina Agliardi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Brain-enriched miR-128: Reduced in exosomes from Parkinson’s patient plasma, improves synaptic integrity, and prevents 6-OHDA mediated neuronal apoptosis

(2023) Pallabi Bhattacharyya et al.   Frontiers in Cellular Neuroscience

Development of a Novel Electrochemiluminescence ELISA for Quantification of α-Synuclein Phosphorylated at Ser129 in Biological Samples

(2023) Suman Dutta et al.   ACS Chemical Neuroscience

C1q is increased in cerebrospinal fluid‐derived extracellular vesicles in Alzheimer's disease: A multi‐cohort proteomics and immuno‐assay validation study

(2023) Madhurima Chatterjee et al.   Alzheimers & Dementia

MicroRNA expression in extracellular vesicles as a novel blood‐based biomarker for Alzheimer's disease

(2023) Ashish Kumar et al.   Alzheimers & Dementia

Protein corona and exosomes: new challenges and prospects

(2023) Morteza Heidarzadeh et al.   Cell Communication and Signaling

Saliva and Saliva Extracellular Vesicles for Biomarker Candidate Identification—Assay Development and Pilot Study in Amyotrophic Lateral Sclerosis

(2023) Sebastian Sjoqvist et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Bioinformatic analysis of the SPs and NFTs proteomes unravel putative biomarker candidates for Alzheimer's disease

(2023) Maria J. Cardoso Ferreira et al.   PROTEOMICS

L1CAM immunocapture generates a unique extracellular vesicle population with a reproducible miRNA fingerprint

(2023) Rachael Anne Dunlop et al.   RNA Biology

Small RNA sequencing of circulating small extracellular vesicles microRNAs in patients with amyotrophic lateral sclerosis

(2023) Jin-Ah Kim et al.   Scientific Reports

Aβ1-42-containing platelet-derived extracellular vesicle is associated with cognitive decline in Parkinson’s disease

(2023) Ziyu Wang et al.   Frontiers in Aging Neuroscience

Improved isolation of extracellular vesicles by removal of both free proteins and lipoproteins

(2023) Dmitry Ter-Ovanesyan et al.   eLife

Meaningful Clinical Changes in Alzheimer Disease Measured With the iADRS and Illustrated Using the Donanemab TRAILBLAZER-ALZ Study Findings

(2023) Alette M. Wessels et al.   Neurology-Clinical Practice

Fluorescence-tagged salivary small extracellular vesicles as a nanotool in early diagnosis of Parkinson’s disease

(2023) Simran Rastogi et al.   BMC Medicine

Brain and immune system-derived extracellular vesicles mediate regulation of complement system, extracellular matrix remodeling, brain repair and antigen tolerance in Multiple sclerosis

(2023) Gabriel Torres Iglesias et al.   BRAIN BEHAVIOR AND IMMUNITY

Assessment of technical and clinical utility of a bead-based flow cytometry platform for multiparametric phenotyping of CNS-derived extracellular vesicles

(2023) Alexandra Brahmer et al.   Cell Communication and Signaling

Antibody Content against Epstein–Barr Virus in Blood Extracellular Vesicles Correlates with Disease Activity and Brain Volume in Patients with Relapsing–Remitting Multiple Sclerosis

(2023) Mireya Fernández-Fournier et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Extracellular Vesicles for the Diagnosis of Parkinson's Disease: Systematic Review and Meta‐Analysis

(2023) Mary Xylaki et al.   MOVEMENT DISORDERS

Dual role of peripheral B cells in multiple sclerosis: emerging remote players in demyelination and novel diagnostic biomarkers

(2023) Gabriel Torres Iglesias et al.   Frontiers in Immunology

α-Synuclein-carrying astrocytic extracellular vesicles in Parkinson pathogenesis and diagnosis

(2023) Pan Wang et al.   Translational Neurodegeneration

Differential Expression of Serum Extracellular Vesicle miRNAs in Multiple Sclerosis: Disease-Stage Specificity and Relevance to Pathophysiology

(2022) Nagiua Cuomo-Haymour et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cysteine String Protein Controls Two Routes of Export for Misfolded Huntingtin

(2022) Desmond Pink et al.   Frontiers in Neuroscience

Neurodegenerative Disease-Associated TDP-43 Fragments Are Extracellularly Secreted with CASA Complex Proteins

(2022) Elena Casarotto et al.   Cells

CNS endothelial derived extracellular vesicles are biomarkers of active disease in multiple sclerosis

(2022) Michael Mazzucco et al.   Fluids and Barriers of the CNS

Migrasomes, new vescicles as Hansel and Gretel white pebbles?

(2022) Arianna Di Daniele et al.   Biology Direct

Extracellular vesicles with diagnostic and therapeutic potential for prion diseases

(2022) Arun Khadka et al.   CELL AND TISSUE RESEARCH

Huntingtin Co-Isolates with Small Extracellular Vesicles from Blood Plasma of TgHD and KI-HD Pig Models of Huntington’s Disease and Human Blood Plasma

(2022) Hanadi Ananbeh et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Alteration of miRNAs in Small Neuron-Derived Extracellular Vesicles of Alzheimer's Disease Patients and the Effect of Extracellular Vesicles on Microglial Immune Responses

(2022) Devrim Yagmur Durur et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Novel Exosome Biomarker Candidates for Alzheimer’s Disease Unravelled Through Mass Spectrometry Analysis

(2022) Tânia Soares Martins et al.   MOLECULAR NEUROBIOLOGY

Serum metabolome associated with severity of acute traumatic brain injury

(2022) Ilias Thomas et al.   Nature Communications

β-Amyloid in blood neuronal-derived extracellular vesicles is elevated in cognitively normal adults at risk of Alzheimer’s disease and predicts cerebral amyloidosis

(2022) Tao-Ran Li et al.   Alzheimers Research & Therapy

Biosensing Extracellular Vesicle Subpopulations in Neurodegenerative Disease Conditions

(2022) Yacine Mazouzi et al.   ACS Sensors

Blood extracellular vesicles carrying synaptic function‐ and brain‐related proteins as potential biomarkers for Alzheimer's disease

(2022) Chen Tian et al.   Alzheimers & Dementia

A pilot study using proximity extension assay of cerebrospinal fluid and its extracellular vesicles identifies novel amyotrophic lateral sclerosis biomarker candidates

(2022) Sebastian Sjoqvist et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Detection of neuron-derived pathological α-synuclein in blood

(2022) Annika Kluge et al.   BRAIN

Characterization of protein complexes in extracellular vesicles by intact extracellular vesicle crosslinking mass spectrometry (iEVXL)

(2022) Julia Bauzá‐Martinez et al.   Journal of Extracellular Vesicles

miRNA extracted from extracellular vesicles is a robust biomarker of amyotrophic lateral sclerosis

(2022) Sandra Anne Banack et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Association of Donanemab Treatment With Exploratory Plasma Biomarkers in Early Symptomatic Alzheimer Disease

(2022) Michael J. Pontecorvo et al.   JAMA Neurology

The Prevalence of Comorbidities and Associated Factors among Patients with Dementia in the Indian Setting: Meta-analysis of Observational Studies

(2022) Biji P. Varkey et al.   Indian Journal of Psychological Medicine

Spreading of alpha-synuclein between different cell types

(2022) Wolfgang P. Ruf et al.   BEHAVIOURAL BRAIN RESEARCH

Oligomeric α-synuclein and tau aggregates in NDEVs differentiate Parkinson's disease from atypical parkinsonisms

(2022) Mario Meloni et al.   NEUROBIOLOGY OF DISEASE

Lecanemab in Early Alzheimer’s Disease

(2022) Christopher H. van Dyck et al.   NEW ENGLAND JOURNAL OF MEDICINE

CSF extracellular vesicles and risk of disease activity after a first demyelinating event

(2021) Gloria Dalla Costa et al.   Multiple Sclerosis Journal

Extracellular Vesicles in Liquid Biopsies: Potential for Disease Diagnosis

(2021) Jialing Liu et al.   Biomed Research International

Validation of α‐Synuclein in L1CAM ‐Immunocaptured Exosomes as a Biomarker for the Stratification of Parkinsonian Syndromes

(2021) Cheng Jiang et al.   MOVEMENT DISORDERS

α‐Synuclein in Plasma‐Derived Extracellular Vesicles Is a Potential Biomarker of Parkinson's Disease

(2021) Anne Stuendl et al.   MOVEMENT DISORDERS

Plasma Extracellular Vesicle α-Synuclein Level in Patients with Parkinson’s Disease

(2021) Chen-Chih Chung et al.   Biomolecules

Biomarkers for neurodegenerative diseases

(2021) Oskar Hansson   NATURE MEDICINE

L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma

(2021) Maia Norman et al.   NATURE METHODS

Proteome profiling of neuron-derived exosomes in Alzheimer's disease reveals hemoglobin as a potential biomarker

(2021) Burak Ibrahim Arioz et al.   NEUROSCIENCE LETTERS

Decreased Exosomal Acetylcholinesterase Activity in the Plasma of Patients With Parkinson’s Disease

(2021) Kyu Hwan Shim et al.   Frontiers in Aging Neuroscience

Cerebrospinal Fluid of Patients With Alzheimer’s Disease Contains Increased Percentages of Synaptophysin-Bearing Microvesicles

(2021) Janine Utz et al.   Frontiers in Aging Neuroscience

Extracellular Vesicles in Multiple Sclerosis: Role in the Pathogenesis and Potential Usefulness as Biomarkers and Therapeutic Tools

(2021) Marianna D’Anca et al.   Cells

Molecular evaluation of five different isolation methods for extracellular vesicles reveals different clinical applicability and subcellular origin

(2021) Rosanne E. Veerman et al.   Journal of Extracellular Vesicles

Formation of a protein corona on the surface of extracellular vesicles in blood plasma

(2021) Eszter Á. Tóth et al.   Journal of Extracellular Vesicles

Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets

(2021) Qin Zhang et al.   NATURE CELL BIOLOGY

Extracellular Vesicles in Serum and Central Nervous System Tissues Contain microRNA Signatures in Sporadic Amyotrophic Lateral Sclerosis

(2021) Ting-wen Lo et al.   Frontiers in Molecular Neuroscience

Updating MISEV: Evolving the minimal requirements for studies of extracellular vesicles

(2021) Kenneth W Witwer et al.   Journal of Extracellular Vesicles

Profiling of Plasma Extracellular Vesicle Transcriptome Reveals That circRNAs Are Prevalent and Differ between Multiple Sclerosis Patients and Healthy Controls

(2021) Leire Iparraguirre et al.   Biomedicines

Discriminating α-synuclein strains in Parkinson’s disease and multiple system atrophy

(2020) Mohammad Shahnawaz et al.   NATURE

Extracellular vesicle-mediated amyloid transfer to neural progenitor cells: implications for RAGE and HIV infection

(2020) Ibolya E. András et al.   Molecular Brain

A Pilot Study of Urinary Exosomes in Alzheimer’s Disease

(2020) Ruihua Sun et al.   Neurodegenerative Diseases

Imaging biomarkers in neurodegeneration: current and future practices

(2020) Peter N. E. Young et al.   Alzheimers Research & Therapy

Detection of Pathognomonic Biomarker PrPSc and the Contribution of Cell Free-Amplification Techniques to the Diagnosis of Prion Diseases

(2020) Hasier Eraña et al.   Biomolecules

Extracellular vesicle biomarkers of Alzheimer's disease associated with sub‐clinical cognitive decline in late middle age

(2020) Erden Eren et al.   Alzheimers & Dementia

Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers

(2020) Ayuko Hoshino et al.   CELL

Extracellular Vesicles of Alzheimer’s Disease Patients as a Biomarker for Disease Progression

(2020) Anat Aharon et al.   MOLECULAR NEUROBIOLOGY

An miRNA fingerprint using neural-enriched extracellular vesicles from blood plasma: towards a biomarker for amyotrophic lateral sclerosis/motor neuron disease

(2020) Sandra Anne Banack et al.   Open Biology

TDP-43 Is Efficiently Transferred Between Neuron-Like Cells in a Manner Enhanced by Preservation of Its N-Terminus but Independent of Extracellular Vesicles

(2020) Christopher Sackmann et al.   Frontiers in Neuroscience

Elevated matrix metalloproteinase‐9 levels in neuronal extracellular vesicles in Alzheimer’s disease

(2020) Dongmei Gu et al.   Annals of Clinical and Translational Neurology

Zeta Potential of Extracellular Vesicles: Toward Understanding the Attributes that Determine Colloidal Stability

(2020) Getnet Midekessa et al.   ACS Omega

Novel Blood-Derived Extracellular Vesicle-Based Biomarkers in Alzheimer’s Disease Identified by Proximity Extension Assay

(2020) Jonas Ellegaard Nielsen et al.   Biomedicines

Development of a Simple and Rapid Method for In Situ Vesicle Detection in Cultured Media

(2020) Kenichi Kawano et al.   JOURNAL OF MOLECULAR BIOLOGY

Raman spectroscopy reveals biochemical differences in plasma derived extracellular vesicles from sporadic Amyotrophic Lateral Sclerosis patients

(2020) Carlo F. Morasso et al.   Nanomedicine-Nanotechnology Biology and Medicine

CSF extracellular vesicle proteomics demonstrates altered protein homeostasis in amyotrophic lateral sclerosis

(2020) Alexander G. Thompson et al.   Clinical Proteomics

Proteomic Profiling of Extracellular Vesicles Derived from Cerebrospinal Fluid of Alzheimer’s Disease Patients: A Pilot Study

(2020) Satoshi Muraoka et al.   Cells

Oligomeric α-Syn and SNARE complex proteins in peripheral extracellular vesicles of neural origin are biomarkers for Parkinson's disease

(2020) Cristina Agliardi et al.   NEUROBIOLOGY OF DISEASE

Mitochondrial RNA in Alzheimer’s Disease Circulating Extracellular Vesicles

(2020) Kyoung Mi Kim et al.   Frontiers in Cell and Developmental Biology

Altered Insulin Receptor Substrate 1 Phosphorylation in Blood Neuron-Derived Extracellular Vesicles From Patients With Parkinson’s Disease

(2020) Szu-Yi Chou et al.   Frontiers in Cell and Developmental Biology

CNS-derived extracellular vesicles from superoxide dismutase 1 (SOD1)G93A ALS mice originate from astrocytes and neurons and carry misfolded SOD1

(2019) Judith M. Silverman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intercellular Vesicular Transfer by Exosomes, Microparticles and Oncosomes - Implications for Cancer Biology and Treatments

(2019) Ritu Jaiswal et al.   Frontiers in Oncology

Extracellular Vesicle as a Source of Alzheimer’s Biomarkers: Opportunities and Challenges

(2019) Seongju Lee et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Proteomics characterization of extracellular vesicles sorted by flow cytometry reveals a disease-specific molecular cross-talk from cerebrospinal fluid and tears in multiple sclerosis

(2019) Damiana Pieragostino et al.   Journal of Proteomics

CSF and blood biomarkers for Parkinson's disease

(2019) Lucilla Parnetti et al.   LANCET NEUROLOGY

Proteomic analysis of urinary extracellular vesicles reveal biomarkers for neurologic disease

(2019) Shijie Wang et al.   EBioMedicine

­Domain-specific quantification of prion protein in cerebrospinal fluid by targeted mass spectrometry

(2019) Eric Vallabh Minikel et al.   MOLECULAR & CELLULAR PROTEOMICS

Propagation of Tau via Extracellular Vesicles

(2019) Mar Pérez et al.   Frontiers in Neuroscience

Extracellular vesicles or exosomes? On primacy, precision, and popularity influencing a choice of nomenclature

(2019) Kenneth W. Witwer et al.   Journal of Extracellular Vesicles

Raman profiling of circulating extracellular vesicles for the stratification of Parkinson’s patients

(2019) Alice Gualerzi et al.   Nanomedicine-Nanotechnology Biology and Medicine

miR-212 and miR-132 Are Downregulated in Neurally Derived Plasma Exosomes of Alzheimer’s Patients

(2019) Diana J. Cha et al.   Frontiers in Neuroscience

Exploratory study on microRNA profiles from plasma-derived extracellular vesicles in Alzheimer’s disease and dementia with Lewy bodies

(2019) Ana Gámez-Valero et al.   Translational Neurodegeneration

Biomarker definitions and their applications

(2018) Robert M Califf   EXPERIMENTAL BIOLOGY AND MEDICINE

Technical challenges of working with extracellular vesicles

(2018) Marcel I. Ramirez et al.   Nanoscale

Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation

(2018) Haiying Zhang et al.   NATURE CELL BIOLOGY

Identification of new biomarkers to promote personalised treatment of patients with inflammatory rheumatic disease: protocol for an open cohort study

(2018) Tina Marie Kringelbach et al.   BMJ Open

Platelet-derived extracellular vesicles in Huntington’s disease

(2018) Hélèna L. Denis et al.   JOURNAL OF NEUROLOGY

Classification of amyloid PET images using novel features for early diagnosis of Alzheimer’s disease and mild cognitive impairment conversion

(2018) Yu Yan et al.   NUCLEAR MEDICINE COMMUNICATIONS

Quantification of brain-derived extracellular vesicles in plasma as a biomarker to diagnose Parkinson's and related diseases

(2018) Takuma Ohmichi et al.   PARKINSONISM & RELATED DISORDERS

α-Synuclein in salivary extracellular vesicles as a potential biomarker of Parkinson’s disease

(2018) Zhentang Cao et al.   NEUROSCIENCE LETTERS

Portrait of blood-derived extracellular vesicles in patients with Parkinson’s disease

(2018) Jérôme Lamontagne-Proulx et al.   NEUROBIOLOGY OF DISEASE

Multiple sclerosis: Serum-derived exosomes express myelin proteins

(2017) Grazyna Galazka et al.   Multiple Sclerosis Journal

Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer

(2017) Sushrut Kamerkar et al.   NATURE

Clinical validity of cerebrospinal fluid Aβ42, tau, and phospho-tau as biomarkers for Alzheimer's disease in the context of a structured 5-phase development framework

(2017) Niklas Mattsson et al.   NEUROBIOLOGY OF AGING

Transitional changes in the CRP structure lead to the exposure of proinflammatory binding sites

(2017) David Braig et al.   Nature Communications

Multiple sclerosis: Serum-derived exosomes express myelin proteins

(2017) Grazyna Galazka et al.   Multiple Sclerosis Journal

Exosomes as Carriers of Alzheimer's Amyloid-ß

(2017) Kohei Yuyama et al.   Frontiers in Neuroscience

Sulfatides in extracellular vesicles isolated from plasma of multiple sclerosis patients

(2016) Ana Lis Moyano et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Detailed Analysis of Protein Topology of Extracellular Vesicles–Evidence of Unconventional Membrane Protein Orientation

(2016) Aleksander Cvjetkovic et al.   Scientific Reports

Chemical Biology Probes for Extracellular Vesicles Facilitate Studies of Neuroinflammation

(2015) Lei Yan et al.   ACS Chemical Neuroscience

Induction of α-synuclein aggregate formation by CSF exosomes from patients with Parkinson’s disease and dementia with Lewy bodies

(2015) Anne Stuendl et al.   BRAIN

Improving the Quality of Biomarker Discovery Research: The Right Samples and Enough of Them

(2015) M. S. Pepe et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Quantification of mutant huntingtin protein in cerebrospinal fluid from Huntington’s disease patients

(2015) Edward J. Wild et al.   JOURNAL OF CLINICAL INVESTIGATION

Large oncosomes contain distinct protein cargo and represent a separate functional class of tumor-derived extracellular vesicles

(2015) Valentina R. Minciacchi et al.   Oncotarget

TDP-43 pathology and neuronal loss in amyotrophic lateral sclerosis spinal cord

(2014) Johannes Brettschneider et al.   ACTA NEUROPATHOLOGICA

Discovery of the migrasome, an organelle mediating release of cytoplasmic contents during cell migration

(2014) Liang Ma et al.   CELL RESEARCH

A type 2 biomarker separates relapsing-remitting from secondary progressive multiple sclerosis

(2014) A. M. Dickens et al.   NEUROLOGY

Accuracy of the Clinical Diagnosis of Alzheimer Disease at National Institute on Aging Alzheimer Disease Centers, 2005–2010

(2012) Thomas G. Beach et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Exosomal cell-to-cell transmission of alpha synuclein oligomers

(2012) Karin M Danzer et al.   Molecular Neurodegeneration

Prostasomes are mediators of intercellular communication: from basic research to clinical implications

(2011) G. Ronquist   JOURNAL OF INTERNAL MEDICINE

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

(2011) Lydia Alvarez-Erviti et al.   NATURE BIOTECHNOLOGY

Oncosome Formation in Prostate Cancer: Association with a Region of Frequent Chromosomal Deletion in Metastatic Disease

(2009) Dolores Di Vizio et al.   CANCER RESEARCH

Age-dependent high-density clustering of GM1 ganglioside at presynaptic neuritic terminals promotes amyloid β-protein fibrillogenesis

(2008) Naoki Yamamoto et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Enrichment of prion protein in exosomes derived from ovine cerebral spinal fluid

(2008) Laura J. Vella et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY