Small patients, big challenges: navigating pediatric drug manipulations to prevent medication errors - a comprehensive review

Direct cyclodextrin based powder extrusion 3D printing of budesonide loaded mini-tablets for the treatment of eosinophilic colitis in paediatric patients

(2023) Monica Pistone et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Paper Charts

(2023) Emma D. Frost et al.   JOURNAL OF NERVOUS AND MENTAL DISEASE

Impact of compounded drugs on the caregivers’ burden of home therapy management in pediatric palliative care: A descriptive study

(2023) Francesca Burlo et al.   PALLIATIVE MEDICINE

For children admitted to hospital, what interventions improve medication safety on ward rounds? A systematic review

(2023) Charlotte King et al.   ARCHIVES OF DISEASE IN CHILDHOOD

Anti-malarial drug use, appropriateness and associated factors among children under-five with febrile illnesses presenting to a tertiary health facility: a cross sectional study

(2023) Richard Nyeko et al.   MALARIA JOURNAL

Ibuprofen dosing measurement accuracy using infants’ versus children’s ibuprofen: a randomized crossover comparison

(2023) Emily R. Leibovitch et al.   PEDIATRIC RESEARCH

Development of Paediatric Formulation of Baclofen for Improved Safety and Palatability

(2023) Kiran Shetty et al.   Journal of Pharmaceutical Innovation

Potentially inappropriate prescribing in hospitalised children: a retrospective, cross-sectional study at a tertiary children’s hospital in China

(2023) Siyu Li et al.   BMJ Open

Potentiality of algorithms and artificial intelligence adoption to improve medication management in primary care: a systematic review

(2023) Gianfranco Damiani et al.   BMJ Open

Prevalence, Risk, and Challenges of Extemporaneous Preparation for Pediatric Patients in Developing Nations: A Review

(2023) Sri Hartati Yuliani et al.   Pharmaceutics

Medication errors and associated factors among pediatric inpatients in public hospitals of gamo zone, southern Ethiopia

(2023) Agegnehu Bante et al.   Heliyon

Are pediatrics taking the prescribed tablet dosage form? Practices of off-label tablet modification in pediatric wards: A prospective observational study

(2023) Asmamaw Emagn Kasahun et al.   Heliyon

Medication errors in children visiting pediatric emergency departments

(2023) Garrido-Corro Beatriz et al.   FARMACIA HOSPITALARIA

Putting children first: Understanding caregivers’ and children’s perspectives on the usability of oral and respiratory administration devices for paediatric medication

(2023) Elisa Alessandrini et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

3D printed mucoadhesive orodispersible films manufactured by direct powder extrusion for personalized clobetasol propionate based paediatric therapies

(2023) Giuseppe Francesco Racaniello et al.   International Journal of Pharmaceutics

AiRDose

(2022) Temima Waltuch et al.   PEDIATRIC EMERGENCY CARE

3D Printing of Pediatric Medication: The End of Bad Tasting Oral Liquids?—A Scoping Review

(2022) Iris Lafeber et al.   Pharmaceutics

Medication Errors in Pediatrics: Proposals to Improve the Quality and Safety of Care Through Clinical Risk Management

(2022) Stefano D'Errico et al.   Frontiers in Medicine

Opportunities for enteral drug delivery for neonates, infants, and toddlers: a critical exploration

(2022) Nicole Sheena Kaneria et al.   Expert Opinion on Drug Delivery

Reducing Pediatric Emergency Department Prescription Errors

(2022) Veena Devarajan et al.   PEDIATRICS

Nurses should not always be blamed for medication administration errors in pediatric inpatient care

(2022) Ling-ling Zhu et al.   Journal of Pediatric Nursing-Nursing Care of Children & Families

Development of a Hospital Compounded, Taste-Masked, Temozolomide Oral Suspension and 5-Year Real-Life Experience in Treating Paediatric Patients

(2022) Maxime Annereau et al.   Pharmaceuticals

Impact of pharmacist medication review for paediatric patients: an observational study

(2022) Marine Solano et al.   INTERNATIONAL JOURNAL OF PHARMACY PRACTICE

“I don’t hesitate to use the left-over antibiotics for my child” practices and experiences with antibiotic use among caregivers of paediatric patients at Zomba central hospital in Malawi

(2022) Redson Biswick Machongo et al.   BMC Pediatrics

Quality control evaluation of paediatric chocolate-based dosage forms: 3D printing vs mold-casting method

(2022) Konstantina Chachlioutaki et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Personalized insulin dose manipulation attack and its detection using interval-based temporal patterns and machine learning algorithms

(2022) Tamar Levy-Loboda et al.   JOURNAL OF BIOMEDICAL INFORMATICS

Improving Caregiver Understanding of Liquid Acetaminophen Administration at Primary Care Visits

(2022) Sean M. Cullen et al.   PEDIATRICS

A Survey of Prescription Errors in Paediatric Outpatients in Multi-Primary Care Settings: The Implementation of an Electronic Pre-Prescription System

(2022) Lu Tan et al.   Frontiers in Pediatrics

Acceptability of Prednisolone in an Open-Label Randomised Cross-Over Study—Focus on Formulation in Children

(2022) Sissel Sundell Haslund-Krog et al.   Children-Basel

Prevalence, Causes and Severity of Medication Administration Errors in the Neonatal Intensive Care Unit: A Systematic Review and Meta-Analysis

(2022) Josephine Henry Basil et al.   DRUG SAFETY

Existing and emerging mitigation strategies for the prevention of accidental overdose from oral pharmaceutical products

(2022) Mubtasim Murshed et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

The Role of Pharmaceutical Compounding in Promoting Medication Adherence

(2022) Maria Carvalho et al.   Pharmaceuticals

Medicine manipulation: An alternative to mitigate therapeutic gaps in the Brazilian Unified Health System?

(2022) Gabriel Gonçalves Okamoto et al.   PLoS One

Acceptability of Multiparticulate Dosing Using Sympfiny® Delivery System with Children (Age 1–12)

(2022) Kate Abeln et al.   Pharmaceutics

Manipulated Oral and Rectal Drugs in a Paediatric Swedish University Hospital, a Registry-Based Study Comparing Two Study-Years, Ten Years Apart

(2022) Åsa C. Andersson et al.   Pharmaceuticals

Pharmacist clinical interventions: Five years' experience of an efficient, low-cost, and future-proofed tool

(2022) Monica Sajogo et al.   Research in Social & Administrative Pharmacy

Optimising paediatric medicines development in the EU through pragmatic approaches

(2021) Winona Rei Bolislis et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Patent landscape of paediatric-friendly oral dosage forms and administration devices

(2021) Christina Karavasili et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Neonatal and pediatric oral drug delivery: Hopes and hurdles

(2021) Kwadwo Amanor Mfoafo et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

3D Printing of Mini Tablets for Pediatric Use

(2021) Julius Krause et al.   Pharmaceuticals

Children’s Preferences for Oral Dosage Forms and Their Involvement in Formulation Research via EPTRI (European Paediatric Translational Research Infrastructure)

(2021) Elisa Alessandrini et al.   Pharmaceutics

Acceptability of small-sized oblong tablets in comparison to syrup and mini-tablets in infants and toddlers: A randomized controlled trial

(2021) Juliane Münch et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Semi-solid extrusion 3D printing of starch-based soft dosage forms for the treatment of paediatric latent tuberculosis infection

(2021) Aikaterini-Theodora Chatzitaki et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Interventions to Reduce Medication Dispensing, Administration, and Monitoring Errors in Pediatric Professional Healthcare Settings: A Systematic Review

(2021) Joachim A. Koeck et al.   Frontiers in Pediatrics

Personalised Tasted Masked Chewable 3D Printed Fruit-Chews for Paediatric Patients

(2021) Atabak Ghanizadeh Tabriz et al.   Pharmaceutics

Accuracy of Dose Administered to Children Using Off-Labelled or Unlicensed Oral Dosage Forms

(2021) Guillaume Binson et al.   Pharmaceutics

Physiologic Monitor Alarm Burden and Nurses’ Subjective Workload in a Children’s Hospital

(2021) Irit R. Rasooly et al.   Hospital pediatrics

Manipulations and age-appropriateness of oral medications in pediatric oncology patients in Sweden: Need for personalized dosage forms

(2021) Jenny Johannesson et al.   BIOMEDICINE & PHARMACOTHERAPY

Binder jetting 3D printing of challenging medicines: From low dose tablets to hydrophobic molecules

(2021) Marta Kozakiewicz-Latała et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

A Systematic Review of the Stability of Extemporaneous Pediatric Oral Formulations

(2021) Anteneh Belayneh et al.   TheScientificWorldJOURNAL

Quality of FDM 3D Printed Medicines for Pediatrics: Considerations for Formulation Development, Filament Extrusion, Printing Process and Printer Design

(2021) Julian Quodbach et al.   Therapeutic Innovation & Regulatory Science

Manipulations of Oral Medications in Paediatric Neurology and Oncology Care at a Swedish University Hospital: Health Professionals’ Attitudes and Sources of Information

(2021) Rania Kader et al.   Pharmaceutics

Co-administration of Paediatric Medicines with Food and Drinks in the Context of Their Physicochemical Properties—a Global Perspective on Practices and Recommendations

(2020) Joana Martir et al.   AAPS Journal

Off‐label use of prescription analgesics among hospitalized children in the United States

(2020) Mary Carmack et al.   PHARMACOEPIDEMIOLOGY AND DRUG SAFETY

A Focus Group Study about Oral Drug Administration Practices at Hospital Wards—Aspects to Consider in Drug Development of Age-Appropriate Formulations for Children

(2020) Maria Rautamo et al.   Pharmaceutics

Rational dispensing of oral dosage forms of medicines to children at a teaching hospital in Sri Lanka

(2020) Abarna Nadeshkumar et al.   BMC HEALTH SERVICES RESEARCH

The demoralisation of nurses and medical doctors working in the emergency department: A qualitative descriptive study

(2020) Elizabeth Elder et al.   International Emergency Nursing

Impact of Food and Drink Administration Vehicles on Paediatric Formulation Performance: Part 1—Effects on Solubility of Poorly Soluble Drugs

(2020) J. Martir et al.   AAPS PHARMSCITECH

Manipulation of Medicinal Products for Oral Administration to Paediatric Patients at a German University Hospital: An Observational Study

(2020) Julia Zahn et al.   Pharmaceutics

Medicines Acceptability in Hospitalized Children: An Ongoing Need for Age-Appropriate Formulations

(2020) Thibault Vallet et al.   Pharmaceutics

Retrospective survey of compounded medications for children in Japan

(2020) Jumpei Saito et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Vat photopolymerization 3D printing for advanced drug delivery and medical device applications

(2020) Xiaoyan Xu et al.   JOURNAL OF CONTROLLED RELEASE

Palatability of Crushed Over-the-Counter Medications

(2020) Amanda G. Lovell et al.   JOURNAL OF PAIN AND SYMPTOM MANAGEMENT

Impact of Oscillating Positive Expiratory Pressure Device Use on Post-Discharge Hospitalizations: A Retrospective Cohort Study Comparing Patients with COPD or Chronic Bronchitis Using the Aerobika® and Acapella® Devices

(2020) Jenny Tse et al.   International Journal of Chronic Obstructive Pulmonary Disease

Manipulation of oral medication for children by parents and nurses occurs frequently and is often not supported by instructions

(2019) Anna C. van der Vossen et al.   ACTA PAEDIATRICA

Liquid Drug Dosage Measurement Errors with Different Dosing Devices

(2019) Pradnya Joshi et al.   INDIAN JOURNAL OF PEDIATRICS

Global Pediatric Drug Development

(2019) Mette Due Theilade Thomsen   CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL

Prevalence of Medication Errors Among Paediatric Inpatients: Systematic Review and Meta-Analysis

(2019) Peter J. Gates et al.   DRUG SAFETY

Prevalence, severity, and nature of preventable patient harm across medical care settings: systematic review and meta-analysis

(2019) Maria Panagioti et al.   BMJ-British Medical Journal

Adjusting the dose in paediatric care: dispersing four different aspirin tablets and taking a proportion

(2019) Jørgen Brustugun et al.   European Journal of Hospital Pharmacy-Science and Practice

Towards Printed Pediatric Medicines in Hospital Pharmacies: Comparison of 2D and 3D-Printed Orodispersible Warfarin Films with Conventional Oral Powders in Unit Dose Sachets

(2019) Heidi Öblom et al.   Pharmaceutics

Prevalence and Nature of Medication Errors and Preventable Adverse Drug Events in Paediatric and Neonatal Intensive Care Settings: A Systematic Review

(2019) Anwar A. Alghamdi et al.   DRUG SAFETY

Identifying medication errors in neonatal intensive care units: a two-center study

(2019) Kaveh Eslami et al.   BMC Pediatrics

Innovations in Pediatric Drug Formulations and Administration Technologies for Low Resource Settings

(2019) Stephen E. Gerrard et al.   Pharmaceutics

Mapping the prevalence and nature of drug related problems among hospitalised children in the United Kingdom: a systematic review

(2019) Adam Sutherland et al.   BMC Pediatrics

Parent Dosing Tool Use, Beliefs, and Access: A Health Literacy Perspective

(2019) Tiffany A. Williams et al.   JOURNAL OF PEDIATRICS

Errors detected in pediatric oral liquid medication doses prepared in an automated workflow management system

(2018) Sarah Bledsoe et al.   AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY

Cost of Prescription Drug–Related Morbidity and Mortality

(2018) Jonathan H. Watanabe et al.   ANNALS OF PHARMACOTHERAPY

Off-label use and manipulations of antiepileptic drugs in children: Analysis of the outpatient prescriptions in a tertiary center

(2018) Mathieu Kuchenbuch et al.   EPILEPSY & BEHAVIOR

How close is the dose? Manipulation of 10 mg hydrocortisone tablets to provide appropriate doses to children

(2018) Cameron Watson et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Safety and Efficacy of Off-label and Unlicensed Medicines in Children

(2018) Ji-Hyun Lee et al.   JOURNAL OF KOREAN MEDICAL SCIENCE

Drug dosing errors in outpatient paediatric patients at primary health-care centres in Nablus: a cross-sectional study

(2018) Rowa' Al-Ramahi et al.   LANCET

Pediatric Medication Safety in the Emergency Department

(2018) Lee Benjamin et al.   PEDIATRICS

3D Printed “Starmix” Drug Loaded Dosage Forms for Paediatric Applications

(2018) Nicolaos Scoutaris et al.   PHARMACEUTICAL RESEARCH

Preventable Adverse Drug Events Among Inpatients: A Systematic Review

(2018) Peter J. Gates et al.   PEDIATRICS

Pediatric Oral Formulations: An Updated Review of Commercially Available Pediatric Oral Formulations Since 2007

(2018) Robert G. Strickley   JOURNAL OF PHARMACEUTICAL SCIENCES

Medication errors with tramadol drops in children

(2017) Florence Moulis et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

A systematic review of the use of dosage form manipulation to obtain required doses to inform use of manipulation in paediatric practice

(2017) Roberta H. Richey et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

3D printed orodispersible films with Aripiprazole

(2017) Witold Jamróz et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Standardization of compounded oral liquids for pediatric patients in Michigan

(2016) M. J. Engels et al.   AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY

Oral dosage form administration practice in children under 6 years of age: A survey study of paediatric nurses

(2016) A.C. Walch et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Oral drug dosage forms administered to hospitalized children: Analysis of 117,665 oral administrations in a French paediatric hospital over a 1-year period.

(2016) A. Lajoinie et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Off-label and unlicensed medicines to hospitalised children in Norway

(2016) Arna Teigen et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Errors and Nonadherence in Pediatric Oral Chemotherapy Use

(2016) Kathleen Walsh et al.   ONCOLOGY

Liquid Medication Errors and Dosing Tools: A Randomized Controlled Experiment

(2016) H. S. Yin et al.   PEDIATRICS

Risk of medication error administering ciprofloxacin oral suspension in children

(2015) Audrey Lajoinie et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Determination of formulation factors that affect oral medicines acceptability in a domiciliary paediatric population

(2015) Rebecca Venables et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Metric Units and the Preferred Dosing of Orally Administered Liquid Medications

(2015)   PEDIATRICS

Problems with oral formulations prescribed to children: a focus group study of healthcare professionals

(2015) Rebecca Venables et al.   International Journal of Clinical Pharmacy

Impact of Interventions Designed to Reduce Medication Administration Errors in Hospitals: A Systematic Review

(2014) Richard N. Keers et al.   DRUG SAFETY

Medication errors in hospitalised children

(2014) Elizabeth Manias et al.   JOURNAL OF PAEDIATRICS AND CHILD HEALTH

Adherence to Label and Device Recommendations for Over-the-Counter Pediatric Liquid Medications

(2014) D. S. Budnitz et al.   PEDIATRICS

Manipulation of drugs to achieve the required dose is intrinsic to paediatric practice but is not supported by guidelines or evidence

(2013) Roberta H Richey et al.   BMC Pediatrics

Evaluation of Oral Medication Delivery Devices Provided by Community Pharmacies

(2013) Brooke L. Honey et al.   CLINICAL PEDIATRICS

Multisite Parent-Centered Risk Assessment to Reduce Pediatric Oral Chemotherapy Errors

(2013) Kathleen E. Walsh et al.   Journal of Oncology Practice

Accurately administering oral medication to children isn't child's play

(2012) Victoria L Beckett et al.   ARCHIVES OF DISEASE IN CHILDHOOD

Reported medication events in a paediatric emergency research network: sharing to improve patient safety

(2012) Kathy N Shaw et al.   EMERGENCY MEDICINE JOURNAL

Novel formulation and drug delivery strategies for the treatment of pediatric poverty-related diseases

(2012) Alejandro Sosnik et al.   Expert Opinion on Drug Delivery

A benefit/risk approach towards selecting appropriate pharmaceutical dosage forms – An application for paediatric dosage form selection

(2012) Tom Sam et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

A Severe Valproate Overdose With Complete Recovery in a Newborn

(2012) Anna Grynnerup et al.   JOURNAL OF CHILD NEUROLOGY

Effectiveness of Education Programs About Oral Antibiotic Suspensions in Pediatric Outpatient Services

(2012) Hsin Hu et al.   Pediatrics and Neonatology

Estimating the requirement for manipulation of medicines to provide accurate doses for children

(2012) Anthony Nunn et al.   European Journal of Hospital Pharmacy-Science and Practice

Unintentional Oral Beta Agonist Overdose: Case Report and Review of the Literature

(2011) Miguel Marcelo Glatstein et al.   AMERICAN JOURNAL OF THERAPEUTICS

Delivery devices for the administration of paediatric formulations: Overview of current practice, challenges and recent developments

(2011) Jennifer Walsh et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Development of a classification system for drug-related problems in the hospital setting (APS-Doc) and assessment of the inter-rater reliability

(2011) C. Hohmann et al.   JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS

Extrapolation of Adult Data and Other Data in Pediatric Drug-Development Programs

(2011) J. Dunne et al.   PEDIATRICS

Extemporaneous Compounding of Oral Liquid Dosage Formulations and Alternative Drug Delivery Methods for Anticancer Drugs

(2011) Masha S. H Lam   PHARMACOTHERAPY

Medication Administration Errors Involving Paediatric In-Patients in a Hospital in Ethiopia

(2011) Y Feleke et al.   TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH

Medication errors involving oral chemotherapy

(2010) Saul N. Weingart et al.   CANCER

Specific aspects of gastro-intestinal transit in children for drug delivery design

(2010) Alexandra Bowles et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Parental calculation of pediatric paracetamol dose: a randomized trial comparing the Parental Analgesia Slide with product information leaflets

(2010) RICHARD HIXSON et al.   PEDIATRIC ANESTHESIA

Educational strategy to reduce medication errors in a neonatal intensive care unit

(2009) Ainara Campino et al.   ACTA PAEDIATRICA

Medication Errors in Pediatric Inpatients: Prevalence and Results of a Prevention Program

(2008) P. Otero et al.   PEDIATRICS

Accuracy of Oral Liquid Measuring Devices: Comparison of Dosing Cup and Oral Dosing Syringe

(2007) Parisa Sobhani et al.   ANNALS OF PHARMACOTHERAPY

Pediatric Drugs-A Review of Commercially Available Oral Formulations

(2007) Robert G. Strickley et al.   JOURNAL OF PHARMACEUTICAL SCIENCES