Journal
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
Volume 170, Issue -, Pages 144-159Publisher
ELSEVIER
DOI: 10.1016/j.ejpb.2021.11.001
Keywords
Inkjet printing; 3DP; Additive manufacturing; Fast dissolving tablets; Wettability; Clotrimazole; Quinapril; Spray drying
Categories
Funding
- Ministry of Science and Higher Education [SUB.D190.20.004]
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This paper introduces a strategy for formulating fast dissolving tablets using binder jetting technology, demonstrating its effects with model APIs. The proposed printing method can produce model tablets with uniform drug content, excellent mechanical properties, and a highly porous structure.
Increasing access to additive manufacturing technologies utilising easily available desktop devices opened novel ways for formulation of personalized medicines. It is, however, challenging to propose a flexible and robust formulation platform which can be used for fabrication of tailored solid dosage forms composed of APIs with different properties (e.g., hydrophobicity) without extensive optimization. This manuscript presents a strategy for formulation of fast dissolving tablets using binder jetting (BJ) technology. The approach is demonstrated using two model APIs: hydrophilic quinapril hydrochloride (QHCl, logP = 1.4) and hydrophobic clotrimazole (CLO, logP = 5.4). The proposed printing method uses inexpensive, well known, and easily available FDA approved pharmaceutical excipients. The obtained model tablets had uniform content of the drug, excellent mechanical properties, and highly porous structure resulting in short disintegration time and fast dissolution rate. The tablets could be scaled and obtained in predesigned shapes and sizes. The proposed method may find its application in the early stages of drug development where high flexibility of the formulation is required and the amount of available API is limited.
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