Review
Pharmacology & Pharmacy
Atabak Ghanizadeh Tabriz, Hannah Kuofie, James Scoble, Sam Boulton, Dennis Douroumis
Summary: Three-dimensional printing, particularly selective laser sintering (SLS), has revolutionized pharmaceutical manufacturing by allowing personalized dosage forms with improved clinical outcomes. SLS has the technological features to overcome manufacturing challenges and introduce new supply chain models, paving the way for decentralization and customization of medicines.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Daniel Moldenhauer, Doan Chau Yen Nguyen, Lisa Jescheck, Franz Hack, Dagmar Fischer, Achim Schneeberger
Summary: This study utilized three-dimensional screen printing to fabricate oral dosage forms of different shapes and sizes, demonstrating high uniformity in size and mass of the tablets, as well as showing that drug release rate depends on the surface-area-to-volume ratio. The results indicate the potential of 3D screen printing for producing complex oral dosage forms with high reproducibility in mass production settings.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Review
Instruments & Instrumentation
Rabinarayan Parhi, Goutam Kumar Jena
Summary: Digital-based three-dimensional printing (3DP) is a powerful tool for fabricating personalized medicine by creating 3D printed pharmaceutical dosage forms with variable geometry. It has a significant impact on tailoring drug delivery systems for different patients and special populations.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Review
Pharmacology & Pharmacy
Prasanna Kumar Desu, Balaji Maddiboyina, K. Vanitha, Koteswara G. S. N. Rao, R. Anusha, Vikas Jhawat
Summary: 3D printing technology is a promising method for quick prototyping and manufacturing of various materials, with significant implications for the pharmaceutical industry. It has the potential to produce personalized medications and novel dosage forms, demonstrating great possibilities for development. However, there are still many challenges in the correct utilization of 3D printing technology in the pharmaceutical field.
CURRENT DRUG TARGETS
(2021)
Article
Pharmacology & Pharmacy
Aikaterini-Theodora Chatzitaki, Emmanouela Mystiridou, Nikolaos Bouropoulos, Christos Ritzoulis, Christina Karavasili, Dimitrios G. Fatouros
Summary: This study describes the fabrication of starch-based soft dosage forms using semi-solid extrusion (SSE) 3D printing, and evaluates their physicochemical properties and texture characteristics. The results show that this method can produce dosage forms with good resolution and high dose accuracy, while also having a soft texture and highly porous microstructure that are suitable for pediatric patients.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Dilawar Khan, Daniel Kirby, Simon Bryson, Maryam Shah, Afzal Rahman Mohammed
Summary: This article discusses the factors affecting the safety, toxicity, and efficacy of pediatric drug delivery systems, as well as the anatomical and physiological differences between children and adults. It evaluates the advantages, limitations, and acceptability of current pediatric dosage forms, and explores techniques to overcome barriers associated with non-adherence to pediatric medications.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Review
Pharmacology & Pharmacy
Magdalena Janczura, Szymon Sip, Judyta Cielecka-Piontek
Summary: This article introduces the development of innovative forms of combination drugs and the application of various formulation technologies, including bilayer system, multilayer tablet, active film coating, hot-melt extrusion, and 3D printing. It also discusses the technological issues and challenges in the development of combination drugs, and summarizes the range of dosage forms made using these technologies over the past 30 years.
Review
Instruments & Instrumentation
Siying Pan, Sheng Ding, Xuhui Zhou, Ning Zheng, Meng Zheng, Juan Wang, Qingliang Yang, Gensheng Yang
Summary: Oral administration is the most commonly used form of treatment due to its advantages, but traditional oral solid preparation processes have several defects. 3D printing technology can greatly reduce or eliminate these disadvantages and enable continuous production for small-scale personalized manufacturing.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Syed M. Kawish, Shwetakshi Sharma, Waleed H. Almalki, Saad Alghamdi, Obaid Afzal, Imran Kazmi, Abdulmalik S. A. Altamimi, Fahad A. Al-Abbasi, Sarwar Beg, Farhan J. Ahmad
Summary: The pharmaceutical industry is advancing towards personalized medicine through innovation in drug development. Three-dimensional printing technology has enabled the manufacturing of personalized dosage forms, opening up new possibilities for discovering compounds and technologies.
CURRENT DRUG METABOLISM
(2022)
Article
Pharmacology & Pharmacy
Martina Olsson, Rydvikha Govender, Ana Diaz, Mirko Holler, Andreas Menzel, Susanna Abrahmsen-Alami, Matthew Sadd, Anette Larsson, Aleksandar Matic, Marianne Liebi
Summary: This paper presents a correlative, multiscale imaging methodology combining PXCT and S/WAXS to visualize and quantify the morphology of solid dosage forms. The method allows characterization of structures from the nanometre to millimetre regime. The methodology is demonstrated using a hot-melt extruded solid dispersion of carbamazepine in ethyl cellulose. The 3D morphology was visualized through PXCT, revealing an oriented structure of crystalline drug domains. Scanning S/WAXS showed similarity in the nanostructure across the cross section of the extruded filament.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Review
Pharmacology & Pharmacy
Khater AL-Japairai, Samah Hamed Almurisi, Abd Almonem Doolaanea, Syed Mahmood, Fawaz Alheibshy, Ahmed Alobaida, Nadiya Abdul-Halim, Bappaditya Chatterjee
Summary: Taste refers to the perception of sensations through taste buds, and the unpleasant taste of drugs can lead to refusal of medication in pediatric patients. The acceptability of pharmaceutical products is influenced by a variety of factors, including swallowability, palatability, appearance, ease of administration, and patient characteristics. Multiparticulate dosage forms provide a solution for pediatric patients who struggle with swallowing and the unpleasant taste of medications. This review provides insights into the considerations for preparing taste masked multiparticulate dosage forms for pediatric use.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Review
Pharmacology & Pharmacy
Ji Hoon Kim, Kyeongjin Kim, Hyo-Eon Jin
Summary: This article introduces the application of 3D printing technology in the pharmaceutical industry, covering five common printing technologies and four oral pharmaceutical dosage forms. 3D printing technologies are suitable for preparing drugs in oral dosage forms and can develop patient-friendly 3D-printed drugs based on factors influencing drug release.
JOURNAL OF PHARMACEUTICAL INVESTIGATION
(2022)
Article
Pharmacology & Pharmacy
Vineet R. Kulkarni, Jaidev Chakka, Faez Alkadi, Mohammed Maniruzzaman
Summary: 3D printing of pharmaceuticals aims to create personalized medication for patients on demand. The study resolves the printing lag time and manual interventions in the current FDM-based processes by using the dynamic z-axis to continuously print drug-loaded printlets.
Article
Engineering, Manufacturing
Hong Liu, Ting Lei, Fan Peng
Summary: Binder jetting additive manufacturing technology plays an important role in the manufacturing of complex casting sand molds, and the permeation and migration of the liquid binder significantly affect the performance of the produced sand mold. Desired dimensional accuracy, strength, and formability can be achieved by adjusting the droplet amount of the liquid binder at different positions.
JOURNAL OF MANUFACTURING PROCESSES
(2023)
Review
Chemistry, Multidisciplinary
Liam Krueger, Jared A. Miles, Amirali Popat
Summary: 3D printing is rapidly expanding in the pharmaceutical and healthcare fields, allowing for precise control of dosage and multiple aesthetic features of dosage forms. The development of hybrid materials is gaining momentum, particularly in the context of FDM technology.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Pharmacology & Pharmacy
Aikaterini-Theodora Chatzitaki, Emmanouela Mystiridou, Nikolaos Bouropoulos, Christos Ritzoulis, Christina Karavasili, Dimitrios G. Fatouros
Summary: This study describes the fabrication of starch-based soft dosage forms using semi-solid extrusion (SSE) 3D printing, and evaluates their physicochemical properties and texture characteristics. The results show that this method can produce dosage forms with good resolution and high dose accuracy, while also having a soft texture and highly porous microstructure that are suitable for pediatric patients.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2022)
Article
Materials Science, Biomaterials
Konstantina Chachlioutaki, Christina Karavasili, Elisavet Adamoudi, Nikolaos Bouropoulos, Dimitrios Tzetzis, Athina Bakopoulou, Dimitrios G. Fatouros
Summary: Silk sericin-PLGA composite scaffolds with sustained anti-inflammatory action and favorable compatibility were investigated. The composite scaffolds showed improved hydrophilicity and mechanical properties compared to plain PLGA scaffolds, and promoted attachment and proliferation of human gingival fibroblasts. The study suggests that silk sericin-PLGA composite scaffolds have potential application in the treatment of periodontal diseases.
BIOMATERIALS ADVANCES
(2022)
Article
Medicine, Research & Experimental
Ioannis I. Andreadis, Christina Karavasili, Angelos Thomas, Anastasia Komnenou, Manolis Tzimtzimis, Dimitrios Tzetzis, Dimitrios Andreadis, Nikolaos Bouropoulos, Dimitrios G. Fatouros
Summary: Intraocular pressure reduction regimens for glaucoma often involve eye drops, which have limitations such as short residence time and reduced patient compliance. In situ gelling nanofiber films were developed for ocular delivery of timolol maleate, showing sustained IOP-lowering effects and improved drug release compared to conventional eye drops.
MOLECULAR PHARMACEUTICS
(2022)
Article
Pharmacology & Pharmacy
Nikoleta F. Theodoroula, Christina Karavasili, Manos C. Vlasiou, Alexandra Primikyri, Christia Nicolaou, Alexandra V. Chatzikonstantinou, Aikaterini-Theodora Chatzitaki, Christos Petrou, Nikolaos Bouropoulos, Constantinos K. Zacharis, Eleftheria Galatou, Yiannis Sarigiannis, Dimitrios G. Fatouros, Ioannis S. Vizirianakis
Summary: The NGIWY-amide pentapeptide derived from sea cucumber can self-assemble into a stiff hydrogel with a high content of beta-sheet structures, forming filamentous fibers with a helical-twisted morphology. It serves as a versatile vector for delivering hydrophobic and hydrophilic compounds of different molecular weights. In addition, the peptide demonstrates cytocompatibility and potential applications in cell growth, drug delivery, and 3D bioprinting tissue engineering.
Article
Biochemical Research Methods
Vasileios Tsamis, Eleni Tsanaktsidou, Christina Karavasili, Constantinos K. Zacharis, Nikolaos Bouropoulos, Dimitrios G. Fatouros, Catherine K. Markopoulou
Summary: The production quality of controlled-release tablets and rectal suppositories of sulfasalazine (SLF) and hydrocortisone 21-acetate (HA) can be effectively evaluated using a High-Performance Liquid Chromatography method with a gradient elution mobile phase.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2022)
Article
Materials Science, Biomaterials
Konstantina Chachlioutaki, Christina Karavasili, Elisavet Adamoudi, Anestis Tsitsos, Vangelis Economou, Charis Beltes, Nikolaos Bouropoulos, Orestis L. Katsamenis, Regan Doherty, Athina Bakopoulou, Dimitrios G. Fatouros
Summary: A fast-disintegrating nanofibrous film was developed for the intracanal coadministration of antimicrobial and anti-inflammatory agents to address the treatment failure of endodontic infections. The film was found to eliminate microbial infection and inflammation, making it a promising therapeutic option for nonvital infected teeth in endodontic therapy.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2022)
Article
Pharmacology & Pharmacy
Afroditi Kapourani, Konstantina Chachlioutaki, Eleftherios G. Andriotis, Dimitrios G. Fatouros, Panagiotis Barmpalexis
Summary: This article extends previous studies by examining the processes and mechanisms involved in the preparation of HDASDs using in situ thermal crosslinking. ATR-FTIR spectroscopy revealed that the crosslinking reaction follows a different pattern at different temperatures. TGA results were consistent with the ATR-FTIR findings regarding crosslinking density and annealing temperature, but they disagreed on the progress of the annealing process. Additionally, the rheological behavior and elastic mechanical properties of the systems were investigated using molecular dynamics simulation models.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Konstantina Chachlioutaki, Christos Gioumouxouzis, Christina Karavasili, Dimitrios G. Fatouros
Summary: Medication errors during drug manipulations in pediatric care pose significant challenges to patient safety and optimal medication management. The observed prevalence of medication errors and manipulations underscores the importance of addressing these issues to enhance patient safety and improve medication outcomes in pediatric care. Overall, the development of age-appropriate formulations and the dissemination of comprehensive clinical guidelines are essential steps toward improving medication safety and minimizing manipulations in pediatric healthcare settings.
EXPERT OPINION ON DRUG DELIVERY
(2023)
Article
Pharmacology & Pharmacy
Afroditi Kapourani, Katerina Kirimkiroglou, Konstantina Chachlioutaki, Maria Koromili, Christos Ritzoulis, Andreana N. Assimopoulou, Dimitrios A. Andreadis, Dimitrios G. Fatouros, Panagiotis Barmpalexis
Summary: Buccally administrated pilocarpine can be effectively controlled for xerostomia management by using in situ thermoresponsive hydrogel. The optimized sol-gel formulations formed a strong gel at temperatures in the buccal cavity, demonstrating good drug release and mucoadhesion properties.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Medicinal
Konstantina Chachlioutaki, Anastasia Iordanopoulou, Nikolaos Bouropoulos, Thomas Meikopoulos, Helen Gika, Christos Ritzoulis, Dimitrios Andreadis, Christina Karavasili, Dimitrios G. Fatouros
Summary: Buccal foams containing omeprazole have been developed as a potential drug delivery system for individuals with swallowing difficulties. The foams are formulated with different polymers to optimize their properties and enhance drug delivery. The study found that the foam composed of hydroxypropyl methylcellulose and alginate exhibited moderate hardness and high mucoadhesion, resulting in increased drug permeability across porcine buccal tissue.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Engineering, Biomedical
Christina Karavasili, Sahab Babaee, Shruti Kutty, Jacqueline N. Chu, Seokkee Min, Nina Fitzgerald, Joshua Morimoto, Nicoletta Inverardi, Giovanni Traverso
Summary: Simplification of complex medication regimens through a modular titratable polypill approach that allows for personalized drug dosing and combination significantly improves treatment adherence and reduces costs. This approach involves assembling modular units containing different drugs at adjustable doses into a single polypill, enabling flexibility in dose adjustment for each drug. Cost-effectiveness analysis shows that this variable dose strategy is more cost-effective than fixed-dose combination (FDC) drug products and offers greater efficacy and cost savings compared to standard of care. The use of variable dose polypills can reduce pill burden, improve treatment adherence, and provide potential cost-saving benefits.
ADVANCED HEALTHCARE MATERIALS
(2023)
Meeting Abstract
Plant Sciences
C. Karavasili, C. Gioumouxouzis, G. Eleftheriadis, D. Fatouros
Article
Pharmacology & Pharmacy
Greta Camilla Magnano, Marika Quadri, Elisabetta Palazzo, Roberta Lotti, Francesca Loschi, Stefano Dall'Acqua, Michela Abrami, Francesca Larese Filon, Alessandra Marconi, Dritan Hasa
Summary: This study aimed to investigate the loading of sildenafil citrate in three commercial transdermal vehicles using 3D full-thickness skin equivalent and compare the results with permeability experiments using porcine skin. The results showed that the results obtained using the 3D skin equivalent were comparable to those obtained using porcine skin, suggesting that the 3D skin model can be a valid alternative for ex-vivo skin absorption experiments.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
Article
Pharmacology & Pharmacy
James W. Mckeage, Andrew Z. H. Tan, Andrew J. Taberner
Summary: Needle-free jet injection is a promising alternative drug delivery technique that offers rapid, non-invasive, and large-volume injections. The study presents a prototype multi-orifice nozzle and a computational fluid dynamic model to demonstrate the feasibility and effectiveness of this technology.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
