Wogonin, as a potent anticancer compound: From chemistry to cellular interactions

Wogonin inhibits inflammation and apoptosis through STAT3 signal pathway to promote the recovery of spinal cord injury

(2022) Wenbo Shao et al.   BRAIN RESEARCH

Wogonin and its analogs for the prevention and treatment of cancer: A systematic review

(2022) Kishore Banik et al.   PHYTOTHERAPY RESEARCH

The Role of Diet in Prognosis among Cancer Survivors: A Systematic Review and Meta-Analysis of Dietary Patterns and Diet Interventions

(2022) Carlota Castro-Espin et al.   Nutrients

Effects of wogonin on the growth and metastasis of colon cancer through the Hippo signaling pathway

(2022) Wenli You et al.   Bioengineered

Green synthesized Ag-nanoparticles using Scutellaria multicaulis stem extract and their selective cytotoxicity against breast cancer

(2022) Zahra Gharari et al.   ANALYTICAL BIOCHEMISTRY

Apoptosis induction in human prostate cancer cells related to the fatty acid metabolism by wogonin-mediated regulation of the AKT-SREBP1-FASN signaling network

(2022) Yuening Sun et al.   FOOD AND CHEMICAL TOXICOLOGY

Wogonin Restrains the Malignant Progression of Lung Cancer through Modulating MMP1 and PI3K/AKT Signaling Pathway

(2022) Zhi Zhao et al.   PROTEIN AND PEPTIDE LETTERS

Emergence of nutrigenomics and dietary components as a complementary therapy in cancer prevention

(2022) Shambhavi Srivastava et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Review of bioactivity and structure-activity relationship on baicalein (5,6,7-trihydroxyflavone) and wogonin (5,7-dihydroxy-8-methoxyflavone) derivatives: Structural modifications inspired from flavonoids in Scutellaria baicalensis

(2022) Zefeng Zhao et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Wogonin increases gemcitabine sensitivity in pancreatic cancer by inhibiting Akt pathway

(2022) Tianli Zhang et al.   Frontiers in Pharmacology

Synergistically Anti-Multiple Myeloma Effects: Flavonoid, Non-Flavonoid Polyphenols, and Bortezomib

(2022) Kaixi Ding et al.   Biomolecules

Immunotoxicity and Anti-Inflammatory Characterizations of Prenylated Flavonoids—The Lipophilic 7-O-Terpenylated Wogonin

(2022) Jin-Yi Wu et al.   Life-Basel

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2021) Hyuna Sung et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Pharmacologic targeting of the P-TEFb complex as a therapeutic strategy for chronic myeloid leukemia

(2021) Yingjie Qing et al.   Cell Communication and Signaling

Investigating the Mechanism of Scutellariae barbata Herba in the Treatment of Colorectal Cancer by Network Pharmacology and Molecular Docking

(2021) Xiangjun Qi et al.   Evidence-based Complementary and Alternative Medicine

The Therapeutic Potential of Wogonin Observed in Preclinical Studies

(2021) Javad Sharifi-Rad et al.   Evidence-based Complementary and Alternative Medicine

Regulation of cell signaling pathways by Wogonin in different cancers: Mechanistic review

(2021) Ghazala Butt et al.   CELLULAR AND MOLECULAR BIOLOGY

FV-429 enhances the efficacy of paclitaxel in NSCLC by reprogramming HIF-1α-modulated FattyAcid metabolism

(2021) Yongjian Guo et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Wogonin inhibits the growth of HT144 melanoma via regulating hedgehog signaling-mediated inflammation and glycolysis

(2021) Ling Li et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Effects and mechanisms of dietary bioactive compounds on breast cancer prevention

(2021) Ganesan Kumar et al.   PHARMACOLOGICAL RESEARCH

Wogonin inhibits cell cycle progression by activating the glycogen synthase kinase-3 beta in hepatocellular carcinoma

(2020) Ming Hong et al.   PHYTOMEDICINE

Fascinating chemo preventive story of wogonin: A chance to hit on the head in cancer treatment

(2020) Rajesh Kumar et al.   CURRENT PHARMACEUTICAL DESIGN

Wogonin induces cellular senescence in breast cancer via suppressing TXNRD2 expression

(2020) Dawei Yang et al.   ARCHIVES OF TOXICOLOGY

Garcinol Exhibits Anti-Neoplastic Effects by Targeting Diverse Oncogenic Factors in Tumor Cells

(2020) Vaishali Aggarwal et al.   Biomedicines

Wogonin pre-treatment attenuates cisplatin-induced nephrotoxicity in rats: Impact on PPAR-γ, inflammation, apoptosis and Wnt/β-catenin pathway

(2019) Alaa M. Badawy et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Wogonin Increases Cisplatin Sensitivity in Ovarian Cancer Cells Through Inhibition of the Phosphatidylinositol 3-Kinase (PI3K)/Akt Pathway

(2019) Feng Xing et al.   MEDICAL SCIENCE MONITOR

Tumor angiogenesis: causes, consequences, challenges and opportunities

(2019) Roberta Lugano et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Anti-Proliferative Effect of Wogonin on Ovary Cancer Cells Involves Activation of Apoptosis and Cell Cycle Arrest

(2019) Qingyang Zhao et al.   MEDICAL SCIENCE MONITOR

Wogonin Suppresses the Activity of Matrix Metalloproteinase-9 and Inhibits Migration and Invasion in Human Hepatocellular Carcinoma

(2018) Ming Hong et al.   MOLECULES

Selective Anti-tumor Activity of wogonin targeting the Warburg Effect through stablizing p53

(2018) Yikai Zhao et al.   PHARMACOLOGICAL RESEARCH

Prevention of Wogonin on Colorectal Cancer Tumorigenesis by Regulating p53 Nuclear Translocation

(2018) Qian Feng et al.   Frontiers in Pharmacology

Discovery and synthesis of novel Wogonin derivatives with potent antitumor activity in vitro

(2017) Jubo Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A Practical and Efficient Approach to the Preparation of Bioactive Natural Product Wogonin

(2017) Tinghan Li et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Therapy Effects of Wogonin on Ovarian Cancer Cells

(2017) Jiang Ruibin et al.   Biomed Research International

Apoptosis Induction and Imaging of Cadmium-Telluride Quantum Dots with Wogonin in Multidrug-Resistant Leukemia K562/A02 Cell

(2016) Bin Huang et al.   JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY

Wogonin Induced Mitochondrial Dysfunction and Endoplasmic Reticulum Stress in Human Malignant Neuroblastoma Cells Via IRE1α-Dependent Pathway

(2015) Wenliang Ge et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Molecular aspects of melatonin (MLT)-mediated therapeutic effects

(2015) Hardeep Singh Tuli et al.   LIFE SCIENCES

Wogonin induces apoptosis and endoplasmic reticulum stress in HL-60 leukemia cells through inhibition of the PI3K-AKT signaling pathway

(2015) CHENGJUN HU et al.   ONCOLOGY REPORTS

Pharmacokinetics, Tissue Distribution, Excretion and Plasma Protein Binding Studies of Wogonin in Rats

(2014) Amer Talbi et al.   MOLECULES

NF-κB and Nrf2 signaling pathways contribute to wogonin-mediated inhibition of inflammation-associated colorectal carcinogenesis

(2014) J Yao et al.   Cell Death & Disease

Wogonin enhances antitumor activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo through ROS-mediated downregulation of cFLIPL and IAP proteins

(2013) Lan Yang et al.   APOPTOSIS

Enhanced 5-fluorouracil cytotoxicity in high COX-2 expressing hepatocellular carcinoma cells by wogonin via the PI3K/Akt pathway

(2013) Li Zhao et al.   Biochemistry and Cell Biology

Wogonin induced G1 cell cycle arrest by regulating Wnt/β-catenin signaling pathway and inactivating CDK8 in human colorectal cancer carcinoma cells

(2013) Licheng He et al.   TOXICOLOGY

GSK3β/β-catenin signaling is correlated with the differentiation of glioma cells induced by wogonin

(2013) Yajing Wang et al.   TOXICOLOGY LETTERS

Wogonin Induces Reactive Oxygen Species Production and Cell Apoptosis in Human Glioma Cancer Cells

(2012) Cheng-Fang Tsai et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Wogonin potentiates cisplatin-induced cancer cell apoptosis through accumulation of intracellular reactive oxygen species

(2012) FAN HE et al.   ONCOLOGY REPORTS

Anti-tumor and anti-metastatic actions of wogonin isolated from Scutellaria baicalensis roots through anti-lymphangiogenesis

(2012) Yoshiyuki Kimura et al.   PHYTOMEDICINE

Wogonin induces apoptosis and down-regulates survivin in human breast cancer MCF-7 cells by modulating PI3K–AKT pathway

(2011) K.F. Huang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Wogonin, an active ingredient of Chinese herb medicine Scutellaria baicalensis, inhibits the mobility and invasion of human gallbladder carcinoma GBC-SD cells by inducing the expression of maspin

(2011) Ping Dong et al.   JOURNAL OF ETHNOPHARMACOLOGY

Wogonin induces apoptosis by activation of ERK and p38 MAPKs signaling pathways and generation of reactive oxygen species in human breast cancer cells

(2011) Ji Sun Yu et al.   MOLECULES AND CELLS

Wogonin potentiates the antitumor action of etoposide and ameliorates its adverse effects

(2010) Riyo Enomoto et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Inhibition of P-Glycoprotein by Wogonin Is Involved with the Potentiation of Etoposide-Induced Apoptosis in Cancer Cells

(2009) Eibai Lee et al.   Annals of the New York Academy of Sciences

Molecular crosstalk between TRAIL and natural antioxidants in the treatment of cancer

(2009) Stuart A Rushworth et al.   BRITISH JOURNAL OF PHARMACOLOGY

Reactive oxygen species up-regulate p53 and Puma; a possible mechanism for apoptosis during combined treatment with TRAIL and wogonin

(2009) Dae-Hee Lee et al.   BRITISH JOURNAL OF PHARMACOLOGY

The global burden of cancer: priorities for prevention

(2009) M. J. Thun et al.   CARCINOGENESIS

Wogonin, an active compound in Scutellaria baicalensis, induces apoptosis and reduces telomerase activity in the HL-60 leukemia cells

(2009) Sheng-Teng Huang et al.   PHYTOMEDICINE

Wogonin, a bioactive flavonoid in herbal tea, inhibits inflammatory cyclooxygenase-2 gene expression in human lung epithelial cancer cells

(2008) Lih-Geeng Chen et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Toxicological studies of wogonin in experimental animals

(2008) Qi Qi et al.   PHYTOTHERAPY RESEARCH