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Chemistry, Multidisciplinary
Kai Xia, Wei-Jin Qi, Xiao-Qiang Wu, Yu-Yang Song, Jun-Jie Zhu, Yi Ai, Zhen Cui, Zheng-Ping Zhang, Shu-Ai Tang, Yu-Ting Gui, Yue Yuan, Lu Wang, Hang Zhong
Summary: Blumeatin, isolated from Blumea balsamifera, is a compound with hydroxyl groups at C3' and C5' of ring B. However, the traditional isolation procedure for blumeatin is time-consuming and costly. This study presents a new method for efficient preparation of optically pure blumeatin and its R-isomer through Lewis acid-catalyzed ring closure and chiral resolution via Schiff base intermediates. Moreover, a structure revision of putative blumeatin based on logical synthesis and NMR spectroscopic analysis suggests that the reported blumeatin structure is misassigned as sterubin. Ear-swelling test results demonstrate that synthetic (+/-)-blumeatin and (+/-)-sterubin show moderate anti-inflammatory activity, which is lower than that of (-)-sterubin.
Article
Chemistry, Multidisciplinary
Kai Xia, Wei-Jin Qi, Xiao-Qiang Wu, Yu-Yang Song, Jun-Jie Zhu, Yi Ai, Zhen Cui, Zheng-Ping Zhang, Shu-Ai Tang, Yu-Ting Gui, Yue Yuan, Lu Wang, Hang Zhong
Summary: Blumeatin, isolated from Blumea balsamifera, a traditional Chinese medicine, possesses two hydroxyl groups at C3' and C5' of ring B. However, the current isolation method for blumeatin from plants is time-consuming and expensive. In this study, a Lewis acid-catalyzed ring closure and chiral resolution procedure utilizing Schiff base intermediates was developed for the efficient preparation of optically pure blumeatin and its R-isomer. Furthermore, a structure revision of putative blumeatin was conducted based on a logically synthetic procedure and NMR spectroscopic analysis, which revealed that the reported blumeatin structure corresponds to sterubin instead. The synthetic (+/-)-blumeatin and (+/-)-sterubin exhibited moderate anti-inflammatory activity, though lower than that of (-)-sterubin, as demonstrated by the ear-swelling test.
Review
Medicine, Research & Experimental
Ji Cai, Hongli Wen, He Zhou, Dan Zhang, Dongfeng Lan, Songpo Liu, Chunyang Li, Xiaofang Dai, Tao Song, Xianyao Wang, Yuqi He, Zhixu He, Jun Tan, Jidong Zhang
Summary: Although inflammation and infection are crucial to major diseases, current medications have side effects, leading to the need for alternative treatments. Naringenin, a flavonoid derived from plants, has been used to treat inflammation and infections caused by bacteria or viruses. However, its usage is limited due to lack of clinical data and poor solubility and stability.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Biochemistry & Molecular Biology
Jiahua Cui, Jinping Jia
Summary: COX-2 is a key enzyme in the inflammatory process, and natural COX-2 inhibitors have been reported to have anti-inflammatory effects and benefits against cell injury. Understanding the characteristics of natural COX-2 inhibitors paves the way for the development of more potent and selective inhibitors in the future.
CURRENT MEDICINAL CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Vinay Bharadwaj Tatipamula, Biljana Kukavica
Summary: Phenolic compounds, found in plants, have antioxidant and pro-oxidative properties that protect against degenerative disorders. Despite limitations in bioactivity due to physico-chemical properties, encapsulation technologies can be used to deliver phenolic compounds effectively while maintaining their activity.
CELL BIOCHEMISTRY AND FUNCTION
(2021)
Review
Medicine, Research & Experimental
Allah Rakha, Nehal Umar, Roshina Rabail, Masood Sadiq Butt, Marek Kieliszek, Abdo Hassoun, Rana Muhammad Aadil
Summary: Chronic inflammation plays a crucial role in chronic diseases, and flavonoids in diet have the potential to regulate inflammation and display anti-inflammatory properties.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biotechnology & Applied Microbiology
Shadi Dashtbanei, Zahra Keshtmand
Summary: This study investigated the protective effects of Iranian probiotics against cadmium-induced tissue injury in the small intestine and lungs. The results showed that probiotic-treated rats exhibited antioxidative and anti-inflammatory effects, reducing tissue damage caused by cadmium.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2023)
Review
Biochemistry & Molecular Biology
Coralia Cotoraci, Alina Ciceu, Alciona Sasu, Eftimie Miutescu, Anca Hermenean
Summary: The use of biologically active compounds for the treatment of leukemia shows promise in improving therapeutic options for patients, targeting different types of leukemia cells. This review serves as a basis for further research in developing new alternative therapies in the fight against leukemia, a deadly hematological cancer.
Article
Biochemistry & Molecular Biology
Eleonora Cremonini, Elena Daveri, Dario E. Iglesias, Jiye Kang, Ziwei Wang, Russell Gray, Angela Mastaloudis, Colin D. Kay, Shelly N. Hester, Steven M. Wood, Cesar G. Fraga, Patricia Oteiza
Summary: This study investigated the effects of a cyanidin-and delphinidin-rich extract on the postprandial dysmetabolism, inflammation, and insulin signaling triggered by a high fat meal. The results showed that the extract reduced the negative effects associated with postprandial dysmetabolism and regulated glycemia and lipidemia.
Article
Plant Sciences
Leandro Ferrini, Juan Pablo Rodriguez, Juan Pablo Melana Colavita, Gabriela Olea, Gonzalo Adrian Ojeda, Gabriela Ricciardi, Ana Maria Torres, Maria Victoria Aguirre
Summary: The ethanolic extract of Nectandra angustifolia has a high content of flavonoids and possesses antioxidant and anti-inflammatory properties as demonstrated by multiparametric analyses from in vitro assays and an in vivo model of inflammation.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Plant Sciences
Marcello Nicoletti
Summary: The therapeutic story of European mistletoe has had ups and downs. In ancient times, it was considered a panacea, but recent concerns about its toxicity led to doubts about its medicinal value. However, its selective action on tumor cells has brought back medical interest in mistletoe.
Article
Chemistry, Multidisciplinary
Zhuo-Ya Tang, Run-Zhu Fan, Ai-Ping Yin, Di-Kai Tang, Abrar Ahmed, Jin Cao, Sheng Yin, Rong Pu, Gui-Hua Tang
Summary: The stem and root barks of Daphne giraldii Nitsche, also known as Zushima, contain 26 flavonoids, including some new flavonoids, which have shown significant anti-inflammatory properties. This traditional Chinese medicine has great potential for treating various diseases and could be a promising candidate for drug development.
ARABIAN JOURNAL OF CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Shanoo Suroowan, Eulogio Jose Llorent-Martinez, Gokhan Zengin, Stefano Dall'Acqua, Stefania Sut, Kalaivani Buskaran, Sharida Fakurazi, Bao Le Van, Mohnad Abdalla, Ashraf N. Abdalla, Asaad Khalid, Mohamad Fawzi Mahomoodally
Summary: In this study, the phytochemical and pharmacological properties of Ravenala madagascariensis were investigated. The aqueous extract showed prominent antioxidant activity, while the methanolic extract exhibited the best antioxidant potential and acetylcholinesterase inhibition. The extracts also demonstrated activity against alpha-amylase, alpha-glucosidase enzymes, and cytotoxicity against HT29 cells.
Article
Plant Sciences
Shuqi Chen, Jixin Chen, Yifan Xu, Xinhua Wang, Jing Li
Summary: The genus Elsholtzia, a member of the Labiaceae family, is an important source of traditional Chinese medicine used for treating cold, fever, and pneumonia. It has been found to have antibacterial, antiviral, and anti-inflammatory properties mainly due to its flavonoids and terpenoids content.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Alessandro De Stefano, Sabrina Caporali, Nicola Di Daniele, Valentina Rovella, Carmine Cardillo, Francesca Schinzari, Marilena Minieri, Massimo Pieri, Eleonora Candi, Sergio Bernardini, Manfredi Tesauro, Alessandro Terrinoni
Summary: Flavonoids, particularly luteolin-7-O-glucoside (LUT-7G), have been shown to exhibit antioxidant and anti-inflammatory effects in endothelial cells, inhibiting the STAT3 pathway and reducing ROS generation. These properties contribute to the potential cardiovascular benefits and demonstrate the molecular pathway underlying the protective effects of flavonoids in cardiovascular and circulatory diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)