Apoptosis induction in human prostate cancer cells related to the fatty acid metabolism by wogonin-mediated regulation of the AKT-SREBP1-FASN signaling network

An AKT/PRMT5/SREBP1 axis in lung adenocarcinoma regulates de novo lipogenesis and tumor growth

(2021) Liu Liu et al.   CANCER SCIENCE

Wogonin Induces Cell Cycle Arrest and Apoptosis of Hepatocellular Carcinoma Cells by Activating Hippo Signaling

(2021) Keyan Wu et al.   Anti-Cancer Agents in Medicinal Chemistry

CPT1A-mediated Fat Oxidation, Mechanisms, and Therapeutic Potential

(2020) Isabel R Schlaepfer et al.   ENDOCRINOLOGY

Tumour metabolism and its unique properties in prostate adenocarcinoma

(2020) David A. Bader et al.   Nature Reviews Urology

Fascinating chemo preventive story of wogonin: A chance to hit on the head in cancer treatment

(2020) Rajesh Kumar et al.   CURRENT PHARMACEUTICAL DESIGN

Role of oxidative stress in the pathogenesis of nonalcoholic fatty liver disease

(2020) Ze Chen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oncogenic activation of PI3K-AKT-mTOR signaling suppresses ferroptosis via SREBP-mediated lipogenesis

(2020) Junmei Yi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer statistics, 2019

(2019) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Fatty Acid Synthesis and Degradation Interplay to Regulate the Oxidative Stress in Cancer Cells

(2019) Valeryia Mikalayeva et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Treatment of Advanced Prostate Cancer

(2019) Min Yuen Teo et al.   Annual Review of Medicine

Wogonin attenuates liver fibrosis via regulating hepatic stellate cell activation and apoptosis

(2019) Xiao-Sa Du et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

High glucose augments ROS generation regulates mitochondrial dysfunction and apoptosis via stress signalling cascades in keratinocytes

(2019) Huma Rizwan et al.   LIFE SCIENCES

An important role of SREBP-1 in HBV and HCV co-replication inhibition by PTEN

(2018) Qi Wu et al.   VIROLOGY

Adipocyte Fatty Acid-Binding Protein Promotes Palmitate-Induced Mitochondrial Dysfunction and Apoptosis in Macrophages

(2018) Hui Li et al.   Frontiers in Immunology

Heterogeneity of fatty acid metabolism in breast cancer cells underlies differential sensitivity to palmitate-induced apoptosis

(2018) Seher Balaban et al.   Molecular Oncology

Can All Major Ros Forming Sites of the Respiratory Chain Be Activated by High FADH2 /NADH Ratios?

(2018) Peter Schönfeld   BIOESSAYS

Can All Major ROS Forming Sites of the Respiratory Chain Be Activated By High FADH2 /NADH Ratios?

(2018) Dave Speijer   BIOESSAYS

Isoalantolactone induces apoptosis through ROS-mediated ER stress and inhibition of STAT3 in prostate cancer cells

(2018) Wei Chen et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Wogonin, a plant derived small molecule, exerts potent anti-inflammatory and chondroprotective effects through the activation of ROS/ERK/Nrf2 signaling pathways in human Osteoarthritis chondrocytes

(2017) Nazir M. Khan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Anti-Tumorigenic Potential of a Novel Orlistat-AICAR Combination in Prostate Cancer Cells

(2017) Clayton Wright et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Metabolic Vulnerabilities of Prostate Cancer: Diagnostic and Therapeutic Opportunities

(2017) Giorgia Zadra et al.   Cold Spring Harbor Perspectives in Medicine

TIP30 regulates lipid metabolism in hepatocellular carcinoma by regulating SREBP1 through the Akt/mTOR signaling pathway

(2017) F Yin et al.   Oncogenesis

ROS homeostasis and metabolism: a dangerous liason in cancer cells

(2016) E Panieri et al.   Cell Death & Disease

SREBP-1c overactivates ROS-mediated hepatic NF-κB inflammatory pathway in dairy cows with fatty liver

(2015) Xinwei Li et al.   CELLULAR SIGNALLING

CD147 reprograms fatty acid metabolism in hepatocellular carcinoma cells through Akt/mTOR/SREBP1c and P38/PPARα pathways

(2015) Jibin Li et al.   JOURNAL OF HEPATOLOGY

4-Methylene-2-octyl-5-oxotetrahydrofuran-3-carboxylic Acid (C75), an Inhibitor of Fatty-acid Synthase, Suppresses the Mitochondrial Fatty Acid Synthesis Pathway and Impairs Mitochondrial Function

(2014) Cong Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Wogonin enhances antitumor activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo through ROS-mediated downregulation of cFLIPL and IAP proteins

(2013) Lan Yang et al.   APOPTOSIS

Cellular Fatty Acid Metabolism and Cancer

(2013) Erin Currie et al.   Cell Metabolism

Protein tyrosine phosphatase 1B inhibition ameliorates palmitate-induced mitochondrial dysfunction and apoptosis in skeletal muscle cells

(2013) Gholamreza Taheripak et al.   FREE RADICAL BIOLOGY AND MEDICINE

Fatty Acid Synthase Is a Key Target in Multiple Essential Tumor Functions of Prostate Cancer: Uptake of Radiolabeled Acetate as a Predictor of the Targeted Therapy Outcome

(2013) Yukie Yoshii et al.   PLoS One

Different fatty acid metabolism effects of (−)-Epigallocatechin-3-Gallate and C75 in Adenocarcinoma lung cancer

(2012) Joana Relat et al.   BMC CANCER

Wogonin Induces Reactive Oxygen Species Production and Cell Apoptosis in Human Glioma Cancer Cells

(2012) Cheng-Fang Tsai et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress

(2012) Sang-Min Jeon et al.   NATURE

AMPK Phosphorylates and Inhibits SREBP Activity to Attenuate Hepatic Steatosis and Atherosclerosis in Diet-Induced Insulin-Resistant Mice

(2011) Yu Li et al.   Cell Metabolism

Akt Stimulates Hepatic SREBP1c and Lipogenesis through Parallel mTORC1-Dependent and Independent Pathways

(2011) Jessica L. Yecies et al.   Cell Metabolism

PTEN ameliorates high glucose-induced lipid deposits through regulating SREBP-1/FASN/ACC pathway in renal proximal tubular cells

(2011) Jun Hao et al.   EXPERIMENTAL CELL RESEARCH

Activation of Androgen Receptor, Lipogenesis, and Oxidative Stress Converged by SREBP-1 Is Responsible for Regulating Growth and Progression of Prostate Cancer Cells

(2011) W.-C. Huang et al.   MOLECULAR CANCER RESEARCH

Wogonin induces apoptosis by activation of ERK and p38 MAPKs signaling pathways and generation of reactive oxygen species in human breast cancer cells

(2011) Ji Sun Yu et al.   MOLECULES AND CELLS

Oxygen radicals shaping evolution: Why fatty acid catabolism leads to peroxisomes while neurons do without it

(2010) Dave Speijer   BIOESSAYS

Thiazolidinediones/PPARγ agonists and fatty acid synthase inhibitors as an experimental combination therapy for prostate cancer

(2010) Mansour   INTERNATIONAL JOURNAL OF ONCOLOGY

Subchronic toxicity and plasma pharmacokinetic studies on wogonin, a natural flavonoid, in Beagle dogs

(2009) Jian Peng et al.   JOURNAL OF ETHNOPHARMACOLOGY

EGFR Signaling Through an Akt-SREBP-1-Dependent, Rapamycin-Resistant Pathway Sensitizes Glioblastomas to Antilipogenic Therapy

(2009) D. Guo et al.   Science Signaling

Role of p53, PUMA, and Bax in wogonin-induced apoptosis in human cancer cells

(2008) Dae-Hee Lee et al.   BIOCHEMICAL PHARMACOLOGY

SREBP Activity Is Regulated by mTORC1 and Contributes to Akt-Dependent Cell Growth

(2008) Thomas Porstmann et al.   Cell Metabolism

Toxicological studies of wogonin in experimental animals

(2008) Qi Qi et al.   PHYTOTHERAPY RESEARCH