Review of bioactivity and structure-activity relationship on baicalein (5,6,7-trihydroxyflavone) and wogonin (5,7-dihydroxy-8-methoxyflavone) derivatives: Structural modifications inspired from flavonoids in Scutellaria baicalensis

Design, synthesis and evaluation of novel scutellarin and scutellarein-N,N-bis-substituted carbamate-l-amino acid derivatives as potential multifunctional therapeutics for Alzheimer’s disease

(2022) Dirong Wu et al.   BIOORGANIC CHEMISTRY

Synthesis and biological evaluation of scutellarein derivatives as neuroprotective agents via activating Nrf2/HO-1 pathway

(2022) Tong Han et al.   FITOTERAPIA

Promising influences of Scutellaria baicalensis and its two active constituents, baicalin, and baicalein, against metabolic syndrome: A review

(2021) Vafa Baradaran Rahimi et al.   PHYTOTHERAPY RESEARCH

Identification of novel androgen receptor degrading agents to treat advanced prostate cancer

(2021) Hongxi Wu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Baicalein, Baicalin, and Wogonin: Protective Effects against Ischemia-Induced Neurodegeneration in the Brain and Retina

(2021) Li Pan et al.   Oxidative Medicine and Cellular Longevity

Synthesis and Biochemical Evaluation of Baicalein Prodrugs

(2021) Sang-Hyun Son et al.   Pharmaceutics

Regulation of cell signaling pathways by Wogonin in different cancers: Mechanistic review

(2021) Ghazala Butt et al.   CELLULAR AND MOLECULAR BIOLOGY

Anti-SARS-CoV-2 activities in vitro of Shuanghuanglian preparations and bioactive ingredients

(2020) Hai-xia Su et al.   ACTA PHARMACOLOGICA SINICA

Synthesis, pharmacological evaluation and mechanistic study of scutellarin methyl ester -4′-dipeptide conjugates for the treatment of hypoxic-ischemic encephalopathy (HIE) in rat pups

(2020) Tao Li et al.   BIOORGANIC CHEMISTRY

Scutellaria baicalensis Georgi. (Lamiaceae): a review of its traditional uses, botany, phytochemistry, pharmacology and toxicology

(2019) Tiantian Zhao et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Baicalein triazole prevents respiratory tract infection by RSV through suppression of oxidative damage

(2019) Cuicui Zhang et al.   MICROBIAL PATHOGENESIS

Design of wogonin-inspired selective cyclin-dependent kinase 9 (CDK9) inhibitors with potent in vitro and in vivo antitumor activity

(2019) Jubo Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Hybrid molecules of scutellarein and tertramethylpyrazine’s active metabolites for ischemic stroke

(2019) Yongxi Dong et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Repurposing mosloflavone/5,6,7-trimethoxyflavone-resveratrol hybrids: Discovery of novel p38-α MAPK inhibitors as potent interceptors of macrophage-dependent production of proinflammatory mediators

(2019) Ahmed H.E. Hassan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Flavonoid GL-V9 induces apoptosis and inhibits glycolysis of breast cancer via disrupting GSK-3β-modulated mitochondrial binding of HKII

(2019) Yongjian Guo et al.   FREE RADICAL BIOLOGY AND MEDICINE

Biocatalytic Synthesis of Lipophilic Baicalin Derivatives as Antimicrobial Agents

(2019) Xuan Xin et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Synthesis of Novel Baicalein Amino Acid Derivatives and Biological Evaluation as Neuroprotective Agents

(2019) Xiaohui Jia et al.   MOLECULES

Flavone-based arylamides as potential anticancers: Design, synthesis and in vitro cell-based/cell-free evaluations

(2019) Ahmed H.E. Hassan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Current scenario of tetrazole hybrids for antibacterial activity

(2019) Feng Gao et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Structure-activity relationships (SAR) of triazine derivatives: Promising antimicrobial agents

(2019) Hao Liu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

GL-V9 exerts anti-T cell malignancies effects via promoting lysosome-dependent AKT1 degradation and activating AKT1/FOXO3A/BIM axis

(2019) Po Hu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Discovery of novel negletein derivatives as potent anticancer agents for acute myeloid leukemia

(2018) Jianlei Wu et al.   Chemical Biology & Drug Design

Natural or Plant Products for the Treatment of Neurological Disorders: Current Knowledge

(2018) Mohammad Khalid Parvez   CURRENT DRUG METABOLISM

Synthesis and biological evaluation of N-alkyl-1,4-dihydroquinoline prodrugs of scutellarin methyl ester as neuroprotective agents

(2018) Yongxi Dong et al.   MEDICINAL CHEMISTRY RESEARCH

Anti-angiogenic and anticancer effects of baicalein derivatives based on transgenic zebrafish model

(2018) Xueyang Jiang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Discovery of Wogonin-based PROTACs against CDK9 and capable of achieving antitumor activity

(2018) Jinlei Bian et al.   BIOORGANIC CHEMISTRY

Synthesis of scutellarein derivatives with antiproliferative activity and selectivity through the intrinsic pathway

(2018) Tong Han et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Neuroprotective effects of Baicalein in animal models of Parkinson's disease: A Systematic review of experimental studies

(2018) Qi Zhu et al.   PHYTOMEDICINE

Natural products hybrids: 3,5,4′-Trimethoxystilbene-5,6,7-trimethoxyflavone chimeric analogs as potential cytotoxic agents against diverse human cancer cells

(2018) Ahmed H.E. Hassan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and evaluation of scutellarein- O -acetamidoalkylbenzylamines as potential multifunctional agents for the treatment of Alzheimer's disease

(2017) Zhipei Sang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery and synthesis of novel Wogonin derivatives with potent antitumor activity in vitro

(2017) Jubo Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Scutellarin derivatives as apoptosis inducers: Design, synthesis and biological evaluation

(2017) Tong Han et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Strategies to diversify natural products for drug discovery

(2017) Gang Li et al.   MEDICINAL RESEARCH REVIEWS

Novel Tacrine-Scutellarin Hybrids as Multipotent Anti-Alzheimer’s Agents: Design, Synthesis and Biological Evaluation

(2017) Katarina Spilovska et al.   MOLECULES

Discovery and mechanism of action of Novel Baicalein modified derivatives as potent antihepatitis agent

(2017) Ji Ma et al.   VIROLOGY

Synthesis of novel flavone derivatives possessing substituted benzamides and their biological evaluation against human cancer cells

(2016) Bo Hee Yun et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design, Synthesis, and Biological Evaluation of Scutellarein Derivatives Based on Scutellarin Metabolic MechanismIn Vivo

(2016) Ze-Xi Dong et al.   Chemical Biology & Drug Design

Anticancer properties of baicalein: a review

(2016) Ying Gao et al.   MEDICINAL CHEMISTRY RESEARCH

Multifunctional scutellarin–rivastigmine hybrids with cholinergic, antioxidant, biometal chelating and neuroprotective properties for the treatment of Alzheimer’s disease

(2015) Zhipei Sang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design, Synthesis, and Biological Evaluation of Scutellarein Carbamate Derivatives as Potential Multifunctional Agents for the Treatment of Alzheimer's Disease

(2015) Zhi-pei Sang et al.   Chemical Biology & Drug Design

Synthesis and biological evaluation of methylated scutellarein analogs based on metabolic mechanism of scutellarin in vivo

(2015) Zhi-Hao Shi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and evaluation of scutellarein-O-alkylamines as multifunctional agents for the treatment of Alzheimer's disease

(2015) Zhipei Sang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and biological evaluation of novel 7-O-lipophilic substituted baicalein derivatives as potential anticancer agents

(2015) Shao-Hung Wang et al.   MedChemComm

Synthesis and biological evaluation of baicalein derivatives as potent antitumor agents

(2014) Rong Luo et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and Anti-influenza Activities of Novel Baicalein Analogs

(2014) Shu-Ting Chung et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

The ameliorating effects of 5,7-dihydroxy-6-methoxy-2(4-phenoxyphenyl)-4H-chromene-4-one, an oroxylin A derivative, against memory impairment and sensorimotor gating deficit in mice

(2013) Xiaotong Liu et al.   ARCHIVES OF PHARMACAL RESEARCH

5,7-Dihydroxy-6-methoxy-4'-phenoxyflavone, a derivative of oroxylin A improves attention-deficit/hyperactivity disorder (ADHD)-like behaviors in spontaneously hypertensive rats

(2013) Ike C. dela Peña et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Oroxylin A analogs exhibited strong inhibitory activities against iNOS-mediated nitric oxide (NO) production

(2012) Tuan-Ahn. N. Pham et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design, synthesis and biological evaluation of glucose-containing scutellarein derivatives as neuroprotective agents based on metabolic mechanism of scutellarin in vivo

(2012) Nian-Guang Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

4′-Bromo-5,6,7-trimethoxyflavone represses lipopolysaccharide-induced iNOS and COX-2 expressions by suppressing the NF-κB signaling pathway in RAW 264.7 macrophages

(2011) Dong Han Kim et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and biological evaluation of 7-O-modified oroxylin A derivatives

(2011) Wei Fu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Prenylated derivatives of baicalein and 3,7-dihydroxyflavone: Synthesis and study of their effects on tumor cell lines growth, cell cycle and apoptosis

(2011) Marta Perro Neves et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Convulsion-related activities of Scutellaria flavones are related to the 5,7-dihydroxyl structures

(2011) Seo Young Yoon et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Design, Synthesis and Biological Evaluation of Scutellarein Derivatives as Potential Anti-Alzheimers Disease Candidates Based on Metabolic Mechanism

(2011) Shu-Lin Song et al.   Letters in Drug Design & Discovery

Novel synthetic baicalein derivatives caused apoptosis and activated AMP-activated protein kinase in human tumor cells

(2011) Derong Ding et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis and biological evaluation of novel benzyl-substituted flavones as free radical (DPPH) scavengers and α-glucosidase inhibitors

(2010) G. Suresh Kumar et al.   JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

Novel 3α-methoxyserrat-14-en-21β-ol (PJ-1) and 3β-methoxyserrat-14-en-21β-ol (PJ-2)-curcumin, kojic acid, quercetin, and baicalein conjugates as HIV agents

(2009) Reiko Tanaka et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Impacts of baicalein analogs with modification of the 6th position of A ring on the activity toward NF-κB-, AP-1-, or CREB-mediated transcription

(2008) Sheng-Teng Huang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and biological evaluation of novel 8-aminomethylated oroxylin A analogues as α-glucosidase inhibitors

(2008) T. Hari Babu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS