GPR146 regulates pulmonary vascular remodeling by promoting pulmonary artery smooth muscle cell proliferation through 5-lipoxygenase

Hypoxia activates GPR146 which participates in pulmonary vascular remodeling by promoting pyroptosis of pulmonary artery endothelial cells

(2023) Yanjiao Jiang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Generation of a GPR146 knockout human induced pluripotent stem cell line (ITXi001-A-1)

(2022) Lise Bray et al.   Stem Cell Research

Orphan GPR146: an alternative therapeutic pathway to achieve cholesterol homeostasis?

(2022) Brendan P. Wilkins et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The mechanism of the imbalance between proliferation and ferroptosis in pulmonary artery smooth muscle cells based on the activation of SLC7A11

(2022) Panpan Hu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Cellular mechanosignaling in pulmonary arterial hypertension

(2021) Ariel Wang et al.   Biophysical Reviews

Structure-Based Virtual Screening for Ligands of G Protein–Coupled Receptors: What Can Molecular Docking Do for You?

(2021) Flavio Ballante et al.   PHARMACOLOGICAL REVIEWS

An Insight into GPCR and G-Proteins as Cancer Drivers

(2021) Preeti Kumari Chaudhary et al.   Cells

Metabolite G-Protein Coupled Receptors in Cardio-Metabolic Diseases

(2021) Derek Strassheim et al.   Cells

Transcriptomic analysis of pulmonary artery smooth muscle cells identifies new potential therapeutic targets for idiopathic pulmonary arterial hypertension

(2020) Matthew W. Gorr et al.   BRITISH JOURNAL OF PHARMACOLOGY

Structural features of activated GPCR signaling complexes

(2020) Jingjing Wang et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Anti-inflammatory signaling through G protein-coupled receptors

(2020) Yun-jun Ge et al.   ACTA PHARMACOLOGICA SINICA

NDUFA4L2 in smooth muscle promotes vascular remodeling in hypoxic pulmonary arterial hypertension

(2020) Yun Liu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Post-Translational Modifications of G Protein–Coupled Receptors Control Cellular Signaling Dynamics in Space and Time

(2020) Anand Patwardhan et al.   PHARMACOLOGICAL REVIEWS

GPCR Signaling Regulation: The Role of GRKs and Arrestins

(2019) Vsevolod V. Gurevich et al.   Frontiers in Pharmacology

ALDH2 (Aldehyde Dehydrogenase 2) Protects Against Hypoxia-Induced Pulmonary Hypertension

(2019) Yu Zhao et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

GPR146 Deficiency Protects against Hypercholesterolemia and Atherosclerosis

(2019) Haojie Yu et al.   CELL

The nature of efficacy at G protein-coupled receptors

(2019) Peishen Zhao et al.   BIOCHEMICAL PHARMACOLOGY

Usefulness of thrombosis and inflammation biomarkers in chronic thromboembolic pulmonary hypertension—sampling plasma and surgical specimens

(2018) Nika Skoro-Sajer et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

G Protein-Coupled Receptors as Targets for Approved Drugs: How Many Targets and How Many Drugs?

(2018) Krishna Sriram et al.   MOLECULAR PHARMACOLOGY

Pulmonary arterial hypertension: pathogenesis and clinical management

(2018) Thenappan Thenappan et al.   BMJ-British Medical Journal

Pulmonary arterial hypertension: pathogenesis and clinical management

(2018) Thenappan Thenappan et al.   BMJ-British Medical Journal

Elimination of GPR146-mediated antiviral function through IRF3/HES1-signalling pathway

(2017) Hongjun Huang et al.   IMMUNOLOGY

Regulation of Pulmonary Vascular Smooth Muscle Contractility in Pulmonary Arterial Hypertension: Implications for Therapy

(2017) Melissa A. Lyle et al.   Frontiers in Physiology

Aldehyde dehydrogenase 2 protects against oxidative stress associated with pulmonary arterial hypertension

(2017) Tao Xu et al.   Redox Biology

Targeting orphan G protein-coupled receptors for the treatment of diabetes and its complications: C-peptide and GPR146

(2016) G. R. Kolar et al.   JOURNAL OF INTERNAL MEDICINE

The protective effect of caffeic acid on global cerebral ischemia-reperfusion injury in rats

(2015) Guojuan Liang et al.   Behavioral and Brain Functions

Characteristics of Pulmonary Arterial Hypertension in Affected Carriers of a Mutation Located in the Cytoplasmic Tail of Bone Morphogenetic Protein Receptor Type 2

(2015) Barbara Girerd et al.   CHEST

Structural mechanism of G protein activation by G protein-coupled receptor

(2015) Nguyen Minh Duc et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Leukotrienes in pulmonary arterial hypertension

(2014) Wen Tian et al.   IMMUNOLOGIC RESEARCH

Ion channels and transporters as therapeutic targets in the pulmonary circulation

(2014) Andrea Olschewski et al.   PHARMACOLOGY & THERAPEUTICS

Recapitulation of Developing Artery Muscularization in Pulmonary Hypertension

(2014) Abdul Q. Sheikh et al.   Cell Reports

Oxidative-Stress Biomarkers in Patients with Pulmonary Hypertension

(2014) Graziela S. Reis et al.   Pulmonary Circulation

Role of vitamin E as a lipid-soluble peroxyl radical scavenger: in vitro and in vivo evidence

(2013) Etsuo Niki   FREE RADICAL BIOLOGY AND MEDICINE

Caffeic Acid Phenethyl Ester and Its Amide Analogue Are Potent Inhibitors of Leukotriene Biosynthesis in Human Polymorphonuclear Leukocytes

(2012) Luc H. Boudreau et al.   PLoS One

Survival in incident and prevalent cohorts of patients with pulmonary arterial hypertension

(2010) M. Humbert et al.   EUROPEAN RESPIRATORY JOURNAL

Hypoxia promotes human pulmonary artery smooth muscle cell proliferation through induction of arginase

(2009) Bernadette Chen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY