Hypoxia activates GPR146 which participates in pulmonary vascular remodeling by promoting pyroptosis of pulmonary artery endothelial cells

Caspase-8 Promotes Pulmonary Hypertension by Activating Macrophage-Associated Inflammation and IL-1β (Interleukin 1β) Production

(2022) Wuwei Rong et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Caspase-4/11–Mediated Pulmonary Artery Endothelial Cell Pyroptosis Contributes to Pulmonary Arterial Hypertension

(2022) Yusi Wu et al.   HYPERTENSION

Endothelial Dysfunction in Pulmonary Hypertension: Cause or Consequence?

(2021) Kondababu Kurakula et al.   Biomedicines

Circular RNA Calm4 Regulates Hypoxia-Induced Pulmonary Arterial Smooth Muscle Cells Pyroptosis via the Circ-Calm4/miR-124-3p/PDCD6 Axis

(2021) Yuan Jiang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Endothelial Cells in the Pathogenesis of Pulmonary Arterial Hypertension

(2021) Colin E. Evans et al.   EUROPEAN RESPIRATORY JOURNAL

Punicalin Ameliorates Cell Pyroptosis Induced by LPS/ATP Through Suppression of ROS/NLRP3 Pathway

(2021) Ruiting Shen et al.   Journal of Inflammation Research

The lncRNA PAHRF functions as a competing endogenous RNA to regulate MST1 expression by sponging miR-23a-3p in pulmonary arterial hypertension

(2021) Yun Liu et al.   VASCULAR PHARMACOLOGY

Cigarette smoke induces the pyroptosis of urothelial cells through ROS/NLRP3/caspase‐1 signaling pathway

(2020) Zonglong Wu et al.   NEUROUROLOGY AND URODYNAMICS

Overexpression of microRNA-340-5p inhibits pulmonary arterial hypertension induced by acute pulmonary embolism by down-regulating Interleukin-1β and Interleukin-6

(2020) Minghui Ou et al.   Molecular Therapy-Nucleic Acids

Minocycline alleviates NLRP3 inflammasome-dependent pyroptosis in monosodium glutamate-induced depressive rats

(2020) Feng Yang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

NLRP3 inflammasome in endothelial dysfunction

(2020) Baochen Bai et al.   Cell Death & Disease

Perivascular Inflammation in Pulmonary Arterial Hypertension

(2020) Yijie Hu et al.   Cells

MicroRNA-221 promotes proliferation and migration of pulmonary arterial smooth muscle cells (PASMCs) by targeting tissue inhibitor of metalloproteinases-3 (TIMP3)

(2020) Yan Yan et al.   Cardiovascular Diagnosis and Therapy

NDUFA4L2 in smooth muscle promotes vascular remodeling in hypoxic pulmonary arterial hypertension

(2020) Yun Liu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Galectin-3: A Harbinger of Reactive Oxygen Species, Fibrosis and Inflammation in Pulmonary Arterial Hypertension

(2019) David Fulton et al.   ANTIOXIDANTS & REDOX SIGNALING

Puerarin protects pulmonary arteries from hypoxic injury through the BMPRII and PPARγ signaling pathways in endothelial cells

(2019) Tianyi Yuan et al.   Pharmacological Reports

Focus on Early Events: Pathogenesis of Pulmonary Arterial Hypertension Development

(2019) Olga Rafikova et al.   ANTIOXIDANTS & REDOX SIGNALING

Long non-coding RNA and mRNA profile analysis of metformin to reverse the pulmonary hypertension vascular remodeling induced by monocrotaline

(2019) Zengxian Sun et al.   BIOMEDICINE & PHARMACOTHERAPY

DAMPs, PAMPs, and LAMPs in Immunity and Sterile Inflammation

(2019) Joel Zindel et al.   Annual Review of Pathology-Mechanisms of Disease

Melatonin alleviates cigarette smoke-induced endothelial cell pyroptosis through inhibiting ROS/NLRP3 axis

(2019) Xuebin Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

GPR146 Deficiency Protects against Hypercholesterolemia and Atherosclerosis

(2019) Haojie Yu et al.   CELL

Intrauterine Growth Restriction Programs Intergenerational Transmission of Pulmonary Arterial Hypertension and Endothelial Dysfunction via Sperm Epigenetic Modifications

(2019) Ziming Zhang et al.   HYPERTENSION

Endothelial cell pyroptosis plays an important role in Kawasaki disease via HMGB1/RAGE/cathespin B signaling pathway and NLRP3 inflammasome activation

(2019) Chang Jia et al.   Cell Death & Disease

Programmed death-ligand 1 triggers PASMCs pyroptosis and pulmonary vascular fibrosis in pulmonary hypertension

(2019) Min Zhang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

GPR146 is a potential new therapeutic target for lipid lowering

(2019) Irene Fernández-Ruiz   Nature Reviews Cardiology

GPCRs in pulmonary arterial hypertension: tipping the balance

(2018) Jean Iyinikkel et al.   BRITISH JOURNAL OF PHARMACOLOGY

Role of Redox Homeostasis and Inflammation in the Pathogenesis of Pulmonary Arterial Hypertension

(2018) Adriane Bello-Klein et al.   CURRENT MEDICINAL CHEMISTRY

Nicotine promotes atherosclerosis via ROS-NLRP3-mediated endothelial cell pyroptosis

(2018) Xianxian Wu et al.   Cell Death & Disease

Rho-Kinase Inhibition Ameliorates Dasatinib-Induced Endothelial Dysfunction and Pulmonary Hypertension

(2018) Csilla Fazakas et al.   Frontiers in Physiology

Reprogramming G protein coupled receptor structure and function

(2018) D Keri et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Bone morphogenetic protein-7 inhibits endothelial-mesenchymal transition in pulmonary artery endothelial cell under hypoxia

(2017) Hongyue Zhang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

FOXM1 promotes pulmonary artery smooth muscle cell expansion in pulmonary arterial hypertension

(2017) Alice Bourgeois et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Pulmonary endothelial cell DNA methylation signature in pulmonary arterial hypertension

(2017) Aurélie Hautefort et al.   Oncotarget

Peroxisome Proliferator–Activated Receptor γ and microRNA 98 in Hypoxia-Induced Endothelin-1 Signaling

(2016) Bum-Yong Kang et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Transforming growth factor-beta1 upregulation triggers pulmonary artery smooth muscle cell proliferation and apoptosis imbalance in rats with hypoxic pulmonary hypertension via the PTEN/AKT pathways

(2016) Yun Liu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

H2S inhibits pulmonary arterial endothelial cell inflammation in rats with monocrotaline-induced pulmonary hypertension

(2016) Shasha Feng et al.   LABORATORY INVESTIGATION

Estradiol improves right ventricular function in rats with severe angioproliferative pulmonary hypertension: effects of endogenous and exogenous sex hormones

(2015) Andrea L. Frump et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Molecular pathogenesis and current pathology of pulmonary hypertension

(2015) Vinicio A. de Jesus Perez   HEART FAILURE REVIEWS

Interleukin 18 accelerates the hepatic cell proliferation in rat liver regeneration after partial hepatectomy

(2014) Jihong Zhang et al.   GENE

Inflammation in Pulmonary Arterial Hypertension

(2012) Laura C. Price et al.   CHEST

NLRP3/Caspase-1-Independent IL-1  Production Mediates Diesel Exhaust Particle-Induced Pulmonary Inflammation

(2011) S. Provoost et al.   JOURNAL OF IMMUNOLOGY

Nitric oxide, oxidative stress and inflammation in pulmonary arterial hypertension

(2010) Patrick Crosswhite et al.   JOURNAL OF HYPERTENSION

The Caspase-1 Inflammasome: A Pilot of Innate Immune Responses

(2008) Hong Bing Yu et al.   Cell Host & Microbe