Transcriptomic analysis of pulmonary artery smooth muscle cells identifies new potential therapeutic targets for idiopathic pulmonary arterial hypertension

Gpr126 (Adgrg6) is expressed in cell types known to be exposed to mechanical stimuli

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Targeting cyclin-dependent kinases for the treatment of pulmonary arterial hypertension

(2019) Astrid Weiss et al.   Nature Communications

Efficacy and safety of ralinepag, a novel oral IP agonist, in PAH patients on mono or dual background therapy Results from a Phase 2 randomized, parallel group, placebo-controlled trial

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Endothelial and Smooth Muscle Cell Interaction via FoxM1 Signaling Mediates Vascular Remodeling and Pulmonary Hypertension

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GPCRs in pulmonary arterial hypertension: tipping the balance

(2018) Jean Iyinikkel et al.   BRITISH JOURNAL OF PHARMACOLOGY

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(2018) Krishna Sriram et al.   MOLECULAR PHARMACOLOGY

FOXM1 promotes pulmonary artery smooth muscle cell expansion in pulmonary arterial hypertension

(2017) Alice Bourgeois et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

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(2017) Edmund M. T. Lau et al.   Nature Reviews Cardiology

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Single-cell profiling reveals heterogeneity and functional patterning of GPCR expression in the vascular system

(2017) H. Kaur et al.   Nature Communications

The prostacyclin pathway in pulmonary arterial hypertension: a clinical review

(2017) R Del Pozo et al.   Expert Review of Respiratory Medicine

The cancer theory of pulmonary arterial hypertension

(2017) Olivier Boucherat et al.   Pulmonary Circulation

Microarray analysis in pulmonary hypertension

(2016) Julia Hoffmann et al.   EUROPEAN RESPIRATORY JOURNAL

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(2016) Nicolas L Bray et al.   NATURE BIOTECHNOLOGY

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Enhanced IL-6 trans-signaling in pulmonary arterial hypertension and its potential role in disease-related systemic damage

(2015) Malgorzata Jasiewicz et al.   CYTOKINE

The Adhesion GPCR GPR126 Has Distinct, Domain-Dependent Functions in Schwann Cell Development Mediated by Interaction with Laminin-211

(2015) Sarah C. Petersen et al.   NEURON

Interleukin-6/interleukin-21 signaling axis is critical in the pathogenesis of pulmonary arterial hypertension

(2015) Takahiro Hashimoto-Kataoka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proinflammatory High-Density Lipoprotein Results from Oxidized Lipid Mediators in the Pathogenesis of Both Idiopathic and Associated Types of Pulmonary Arterial Hypertension

(2015) David J. Ross et al.   Pulmonary Circulation

The Role of Vascular Endothelial Growth Factor in Pulmonary Arterial Hypertension. The Angiogenesis Paradox

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Inflammation and Immunity in the Pathogenesis of Pulmonary Arterial Hypertension

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Pro-proliferative and inflammatory signaling converge on FoxO1 transcription factor in pulmonary hypertension

(2014) Rajkumar Savai et al.   NATURE MEDICINE

Type IV collagen is an activating ligand for the adhesion G protein-coupled receptor GPR126

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17β-Estradiol Attenuates Hypoxic Pulmonary Hypertension via Estrogen Receptor–mediated Effects

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Whole Exome Sequencing to Identify a Novel Gene (Caveolin-1) Associated With Human Pulmonary Arterial Hypertension

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Targeting PDGF pathway in pulmonary arterial hypertension

(2012) Sabina Antonela Antoniu   EXPERT OPINION ON THERAPEUTIC TARGETS

Estrogen Rescues Preexisting Severe Pulmonary Hypertension in Rats

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Pulmonary hypertension in adult Alk1 heterozygous mice due to oxidative stress

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Thrombin activation of proteinase-activated receptor 1 potentiates the myofilament Ca2+ sensitivity and induces vasoconstriction in porcine pulmonary arteries

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Survival in incident and prevalent cohorts of patients with pulmonary arterial hypertension

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Fatty Acid Oxidation and Malonyl-CoA Decarboxylase in the Vascular Remodeling of Pulmonary Hypertension

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RhoA and Rho Kinase Activation in Human Pulmonary Hypertension

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Serum VEGF levels are related to the presence of pulmonary arterial hypertension in systemic sclerosis

(2009) Andriana I Papaioannou et al.   BMC Pulmonary Medicine

Platelet-derived Growth Factor Expression and Function in Idiopathic Pulmonary Arterial Hypertension

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Clinical Outcomes of Pulmonary Arterial Hypertension in Carriers ofBMPR2Mutation

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Insulin resistance in pulmonary arterial hypertension

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