Native and Non-Native aggregation pathways of antibodies anticipated by cold-accelerated studies

In Situ Monitoring of Protein Unfolding/Structural States under Cold High-Pressure Stress

(2021) Diana C. Gomes et al.   MOLECULAR PHARMACEUTICS

Long-term stability predictions of therapeutic monoclonal antibodies in solution using Arrhenius-based kinetics

(2021) Drago Kuzman et al.   Scientific Reports

Stability of Protein Formulations at Subzero Temperatures by Isochoric Cooling

(2019) Cátia Correia et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

The Molecular Interaction Process

(2019) Thomas M. Laue et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Freezing of Biologicals Revisited: Scale, Stability, Excipients, and Degradation Stresses

(2019) Jean-Rene Authelin et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Chemical and physical instabilities in manufacturing and storage of therapeutic proteins

(2019) Mary E Krause et al.   CURRENT OPINION IN BIOTECHNOLOGY

Protein aggregation – Mechanisms, detection, and control

(2018) Wei Wang et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Connecting high-temperature and low-temperature protein stability and aggregation

(2017) Mónica Rosa et al.   PLoS One

Pre-study and in-study validation of a size-exclusion chromatography method with different detection modes for the analysis of monoclonal antibody aggregates

(2016) Alexis Oliva et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Mechanism of Reversible Self-Association of a Monoclonal Antibody: Role of Electrostatic and Hydrophobic Interactions

(2015) Reza Esfandiary et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Non-Arrhenius Protein Aggregation

(2013) Wei Wang et al.   AAPS Journal

Measuring and Modeling Hemoglobin Aggregation below the Freezing Temperature

(2013) Mónica Rosa et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Evaluation of a Non-Arrhenius Model for Therapeutic Monoclonal Antibody Aggregation

(2011) Veysel Kayser et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Predicting accelerated aggregation rates for monoclonal antibody formulations, and challenges for low-temperature predictions

(2011) Rebecca K. Brummitt et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Cold denaturation of monoclonal antibodies

(2010) Kristi L. Lazar et al.   mAbs

Aggregation-Prone Motifs in Human Immunoglobulin G

(2009) Naresh Chennamsetty et al.   JOURNAL OF MOLECULAR BIOLOGY

Conformational Implications of an Inversed pH-Dependent Antibody Aggregation

(2008) Natalie Perico et al.   JOURNAL OF PHARMACEUTICAL SCIENCES