In Situ Monitoring of Protein Unfolding/Structural States under Cold High-Pressure Stress

Combining Unfolding Reversibility Studies and Molecular Dynamics Simulations to Select Aggregation-Resistant Antibodies

(2021) Carolin Berner et al.   MOLECULAR PHARMACEUTICS

A New Perspective on Scale-down Strategies for Freezing of Biopharmaceutics by means of Computational Fluid Dynamics

(2020) Vitor Geraldes et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

High-pressure small-angle X-ray scattering cell for biological solutions and soft materials

(2020) Durgesh K. Rai et al.   JOURNAL OF APPLIED CRYSTALLOGRAPHY

High Pressure Small Angle Neutron Scattering for Food Studies

(2019) Susana C.M. Teixeira   CURRENT OPINION IN COLLOID & INTERFACE SCIENCE

Advancing Therapeutic Protein Discovery and Development through Comprehensive Computational and Biophysical Characterization

(2019) Lorenzo Gentiluomo et al.   MOLECULAR PHARMACEUTICS

Characterization of the NISTmAb Reference Material using small-angle scattering and molecular simulation

(2018) Maria Monica Castellanos et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Characterization of the NISTmAb Reference Material using small-angle scattering and molecular simulation

(2018) Maria Monica Castellanos et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Parallel chromatography and in situ scattering to interrogate competing protein aggregation pathways

(2018) Diana Gomes et al.   PROTEIN SCIENCE

Freezing of aqueous solutions and chemical stability of amorphous pharmaceuticals: water clusters hypothesis

(2018) Evgenyi Shalaev et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Submicron Aggregation of Chemically Denatured Monoclonal Antibody

(2018) Jacob B. Rowe et al.   MOLECULAR PHARMACEUTICS

Thermally induced conformational changes and protein–protein interactions of bovine serum albumin in aqueous solution under different pH and ionic strengths as revealed by SAXS measurements

(2017) Dmitry Molodenskiy et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Monitoring protein folding through high pressure NMR spectroscopy

(2017) Julien Roche et al.   PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY

Investigating Structure and Dynamics of Proteins in Amorphous Phases Using Neutron Scattering

(2017) Maria Monica Castellanos et al.   Computational and Structural Biotechnology Journal

Continuous Paranematic Ordering of Rigid and Semiflexible Amyloid-Fe3O4 Hybrid Fibrils in an External Magnetic Field

(2016) Jianguo Zhao et al.   BIOMACROMOLECULES

Cold denaturation as a tool to measure protein stability

(2016) Domenico Sanfelice et al.   BIOPHYSICAL CHEMISTRY

Acetate- and Citrate-Specific Ion Effects on Unfolding and Temperature-Dependent Aggregation Rates of Anti-Streptavidin IgG1

(2016) Gregory V. Barnett et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Application of a High-Throughput Relative Chemical Stability Assay to Screen Therapeutic Protein Formulations by Assessment of Conformational Stability and Correlation to Aggregation Propensity

(2015) Joseph M. Rizzo et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Specific-Ion Effects on the Aggregation Mechanisms and Protein–Protein Interactions for Anti-streptavidin Immunoglobulin Gamma-1

(2015) Gregory V. Barnett et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Evolutionarily Conserved Pattern of Interactions in a Protein Revealed by Local Thermal Expansion Properties

(2015) Mariano Dellarole et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

High-pressure SANS and fluorescence unfolding study of calmodulin

(2014) Gabriel Gibrat et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Cooperative Cold Denaturation: The Case of the C-Terminal Domain of Ribosomal Protein L9

(2013) Bowu Luan et al.   BIOCHEMISTRY

The importance of heat flow direction for reproducible and homogeneous freezing of bulk protein solutions

(2013) Miguel A. Rodrigues et al.   BIOTECHNOLOGY PROGRESS

Role of the N-Terminal Amphiphilic Region of Ovalbumin during Heat-Induced Aggregation and Gelation

(2013) Yuki Kawachi et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Measuring and Modeling Hemoglobin Aggregation below the Freezing Temperature

(2013) Mónica Rosa et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Accurate assessment of mass, models and resolution by small-angle scattering

(2013) Robert P. Rambo et al.   NATURE

Impact of deglycosylation and thermal stress on conformational stability of a full length murine igG2a monoclonal antibody: Observations from molecular dynamics simulations

(2013) Xiaoling Wang et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Aggregation of anti-streptavidin immunoglobulin gamma‐1 involves Fab unfolding and competing growth pathways mediated by pH and salt concentration

(2012) Nayoung Kim et al.   BIOPHYSICAL CHEMISTRY

A Delicate Interplay of Structure, Dynamics, and Thermodynamics for Function: A High Pressure NMR Study of Outer Surface Protein A

(2012) Ryo Kitahara et al.   BIOPHYSICAL JOURNAL

How Random are Intrinsically Disordered Proteins? A Small Angle Scattering Perspective

(2012) Veronique Receveur-Brechot et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Role of Hydrophobic Hydration in Protein Stability: A 3D Water-Explicit Protein Model Exhibiting Cold and Heat Denaturation

(2012) Silvina Matysiak et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Proteins under pressure

(2012) B. W. Matthews   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterizing flexible and intrinsically unstructured biological macromolecules by SAS using the Porod-Debye law

(2011) Robert P. Rambo et al.   BIOPOLYMERS

Nonnative Aggregation of an IgG1 Antibody in Acidic Conditions: Part 1. Unfolding, Colloidal Interactions, and Formation of High-Molecular-Weight Aggregates

(2011) Rebecca K. Brummitt et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Predicting accelerated aggregation rates for monoclonal antibody formulations, and challenges for low-temperature predictions

(2011) Rebecca K. Brummitt et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

In SituMeasurement of Reaction Volume and Calculation of pH of Weak Acid Buffer Solutions Under High Pressure

(2011) Stephen K. Min et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Frozen State Storage Instability of a Monoclonal Antibody: Aggregation as a Consequence of Trehalose Crystallization and Protein Unfolding

(2011) Satish K. Singh et al.   PHARMACEUTICAL RESEARCH

Effect of Freezing Rate and Dendritic Ice Formation on Concentration Profiles of Proteins Frozen in Cylindrical Vessels

(2010) Miguel A. Rodrigues et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Protein−Protein Interactions in Ovalbumin Solutions Studied by Small-Angle Scattering: Effect of Ionic Strength and the Chemical Nature of Cations

(2010) Luca Ianeselli et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Cold denaturation of monoclonal antibodies

(2010) Kristi L. Lazar et al.   mAbs

Increasing protein stability: Importance of ΔCp and the denatured state

(2010) Hailong Fu et al.   PROTEIN SCIENCE

Impact of freezing on pH of buffered solutions and consequences for monoclonal antibody aggregation

(2009) Parag Kolhe et al.   BIOTECHNOLOGY PROGRESS

Multi-variate approach to global protein aggregation behavior and kinetics: Effects of pH, NaCl, and temperature for α-chymotrypsinogen A

(2009) Yi Li et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Current Perspectives on Stability of Protein Drug Products during Formulation, Fill and Finish Operations

(2008) N. Rathore et al.   BIOTECHNOLOGY PROGRESS

High hydrostatic pressure small-angle X-ray scattering cell for protein solution studies featuring diamond windows and disposable sample cells

(2008) Nozomi Ando et al.   JOURNAL OF APPLIED CRYSTALLOGRAPHY