The role of IFN-γ-signalling in response to immune checkpoint blockade therapy

Tissue-specific abundance of interferon-gamma drives regulatory T cells to restrain DC1-mediated priming of cytotoxic T cells against lung cancer

(2023) Maria Zagorulya et al.   IMMUNITY

Targeting TBK1 to overcome resistance to cancer immunotherapy

(2023) Yi Sun et al.   NATURE

IFNγ signaling in cytotoxic T cells restricts anti-tumor responses by inhibiting the maintenance and diversity of intra-tumoral stem-like T cells

(2023) Julie M. Mazet et al.   Nature Communications

Cancer cells resistant to immune checkpoint blockade acquire interferon-associated epigenetic memory to sustain T cell dysfunction

(2023) Jingya Qiu et al.   Nature Cancer

Prior anti-CTLA-4 therapy impacts molecular characteristics associated with anti-PD-1 response in advanced melanoma

(2023) Katie M. Campbell et al.   CANCER CELL

Mutations in IFN-γ signaling genes sensitize tumors to immune checkpoint blockade

(2023) Eric Song et al.   CANCER CELL

TGFβ Antagonizes IFNγ-Mediated Adaptive Immune Evasion via Activation of the AKT–Smad3–SHP1 Axis in Lung Adenocarcinoma

(2023) Fan Ye et al.   CANCER RESEARCH

IFNγ-induced stem-like state of cancer cells as a driver of metastatic progression following immunotherapy

(2023) Laurent Beziaud et al.   Cell Stem Cell

Genomic and transcriptomic analysis of checkpoint blockade response in advanced non-small cell lung cancer

(2023) Arvind Ravi et al.   NATURE GENETICS

The molecular and functional landscape of resistance to immune checkpoint blockade in melanoma

(2023) Su Yin Lim et al.   Nature Communications

EHBP1L1 Drives Immune Evasion in Renal Cell Carcinoma through Binding and Stabilizing JAK1

(2023) Yihui Pan et al.   Advanced Science

Disrupting the phase separation of KAT8–IRF1 diminishes PD-L1 expression and promotes antitumor immunity

(2023) Yuanzhong Wu et al.   Nature Cancer

An adverse tumor-protective effect of IDO1 inhibition

(2023) Juliana C.N. Kenski et al.   Cell Reports Medicine

Lymph node colonization induces tumor-immune tolerance to promote distant metastasis

(2022) Nathan E. Reticker-Flynn et al.   CELL

The interferon-stimulated gene RIPK1 regulates cancer cell intrinsic and extrinsic resistance to immune checkpoint blockade

(2022) Lisa Cucolo et al.   IMMUNITY

In vivo CRISPR screens reveal the landscape of immune evasion pathways across cancer

(2022) Juan Dubrot et al.   NATURE IMMUNOLOGY

Selective suppression of melanoma lacking IFN-γ pathway by JAK inhibition depends on T cells and host TNF signaling

(2022) Hongxing Shen et al.   Nature Communications

N-glycosylation Regulates Intrinsic IFN-γ Resistance in Colorectal Cancer: Implications for Immunotherapy

(2022) Julia Krug et al.   GASTROENTEROLOGY

The transcription factor IRF2 drives interferon-mediated CD8+ T cell exhaustion to restrict anti-tumor immunity

(2022) Sabelo Lukhele et al.   IMMUNITY

Meta-analysis of tumor- and T cell-intrinsic mechanisms of sensitization to checkpoint inhibition

(2021) Kevin Litchfield et al.   CELL

Interferon-γ induces tumor resistance to anti-PD-1 immunotherapy by promoting YAP phase separation

(2021) Man Yu et al.   MOLECULAR CELL

Down-regulation of A20 promotes immune escape of lung adenocarcinomas

(2021) Kristina Breitenecker et al.   Science Translational Medicine

Tumor heterogeneity and clonal cooperation influence the immune selection of IFN-γ-signaling mutant cancer cells

(2020) Jason B. Williams et al.   Nature Communications

Tim-3 finds its place in the cancer immunotherapy landscape

(2020) Nandini Acharya et al.   Journal for ImmunoTherapy of Cancer

Conserved Interferon-γ Signaling Drives Clinical Response to Immune Checkpoint Blockade Therapy in Melanoma

(2020) Catherine S. Grasso et al.   CANCER CELL

Uncoupling interferon signaling and antigen presentation to overcome immunotherapy resistance due to JAK1 loss in melanoma

(2020) Anusha Kalbasi et al.   Science Translational Medicine

The Challenges of Tumor Mutational Burden as an Immunotherapy Biomarker

(2020) Denis L. Jardim et al.   CANCER CELL

Distinct Immune Cell Populations Define Response to Anti-PD-1 Monotherapy and Anti-PD-1/Anti-CTLA-4 Combined Therapy

(2019) Tuba N. Gide et al.   CANCER CELL

Low-dose IFN-γ induces tumor cell stemness in the tumor microenvironment of non-small cell lung cancer

(2019) Mengjia Song et al.   CANCER RESEARCH

Augmenting Immunotherapy Impact by Lowering Tumor TNF Cytotoxicity Threshold

(2019) David W. Vredevoogd et al.   CELL

LNK suppresses interferon signaling in melanoma

(2019) Ling-Wen Ding et al.   Nature Communications

Opposing Functions of Interferon Coordinate Adaptive and Innate Immune Responses to Cancer Immune Checkpoint Blockade

(2019) Joseph L. Benci et al.   CELL

JAK–STAT inhibition impairs K‐RAS‐driven lung adenocarcinoma progression

(2019) Julian Mohrherr et al.   INTERNATIONAL JOURNAL OF CANCER

Epacadostat plus pembrolizumab versus placebo plus pembrolizumab in patients with unresectable or metastatic melanoma (ECHO-301/KEYNOTE-252): a phase 3, randomised, double-blind study

(2019) Georgina V Long et al.   LANCET ONCOLOGY

Integrative molecular and clinical modeling of clinical outcomes to PD1 blockade in patients with metastatic melanoma

(2019) David Liu et al.   NATURE MEDICINE

Genomic Features of Response to Combination Immunotherapy in Patients with Advanced Non-Small-Cell Lung Cancer

(2018) Matthew D. Hellmann et al.   CANCER CELL

Interferon-Gamma at the Crossroads of Tumor Immune Surveillance or Evasion

(2018) Flávia Castro et al.   Frontiers in Immunology

TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells

(2018) Sanjeev Mariathasan et al.   NATURE

IFN-r-induced IFIT5 promotes epithelial-to-mesenchymal transition in prostate cancer via microRNA processing

(2018) U-Ging Lo et al.   CANCER RESEARCH

Leukemia inhibitory factor functions in parallel with interleukin-6 to promote ovarian cancer growth

(2018) Karen McLean et al.   ONCOGENE

LAG3 (CD223) as a cancer immunotherapy target

(2017) Lawrence P. Andrews et al.   IMMUNOLOGICAL REVIEWS

The Dark Side of IFN-γ: Its Role in Promoting Cancer Immunoevasion

(2017) Marija Mojic et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

IFN-γ–related mRNA profile predicts clinical response to PD-1 blockade

(2017) Mark Ayers et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification of essential genes for cancer immunotherapy

(2017) Shashank J. Patel et al.   NATURE

Tumour ischaemia by interferon-γ resembles physiological blood vessel regression

(2017) Thomas Kammertoens et al.   NATURE

In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target

(2017) Robert T. Manguso et al.   NATURE

Integrated molecular analysis of tumor biopsies on sequential CTLA-4 and PD-1 blockade reveals markers of response and resistance

(2017) Whijae Roh et al.   Science Translational Medicine

IFN-γ is required for cytotoxic T cell-dependent cancer genome immunoediting

(2017) Kazuyoshi Takeda et al.   Nature Communications

Resistance to checkpoint blockade therapy through inactivation of antigen presentation

(2017) Moshe Sade-Feldman et al.   Nature Communications

Loss of IFN-γ Pathway Genes in Tumor Cells as a Mechanism of Resistance to Anti-CTLA-4 Therapy

(2016) Jianjun Gao et al.   CELL

Tumor Interferon Signaling Regulates a Multigenic Resistance Program to Immune Checkpoint Blockade

(2016) Joseph L. Benci et al.   CELL

Genomic and Transcriptomic Features of Response to Anti-PD-1 Therapy in Metastatic Melanoma

(2016) Willy Hugo et al.   CELL

Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma

(2016) Jesse M. Zaretsky et al.   NEW ENGLAND JOURNAL OF MEDICINE

Primary Resistance to PD-1 Blockade Mediated by JAK1/2 Mutations

(2016) Daniel Sanghoon Shin et al.   Cancer Discovery

T Cell Intrinsic USP15 Deficiency Promotes Excessive IFN-γ Production and an Immunosuppressive Tumor Microenvironment in MCA-Induced Fibrosarcoma

(2015) Qiang Zou et al.   Cell Reports

Interferon-γ-induced activation of JAK1 and JAK2 suppresses tumor cell susceptibility to NK cells through upregulation of PD-L1 expression

(2015) Roberto Bellucci et al.   OncoImmunology

Anti-proliferation Effects of Interferon-gamma on Gastric Cancer Cells

(2014) Ying-Hui Zhao et al.   Asian Pacific Journal of Cancer Prevention

RIPK1 Blocks Early Postnatal Lethality Mediated by Caspase-8 and RIPK3

(2014) Christopher P. Dillon et al.   CELL

Inhibition of Tumor Angiogenesis by Interferon-γ by Suppression of Tumor-Associated Macrophage Differentiation

(2014) Tao Sun et al.   ONCOLOGY RESEARCH

Cyclooxygenase-2-prostaglandin E2-eicosanoid receptor inflammatory axis: a key player in Kaposi's sarcoma-associated herpes virus associated malignancies

(2013) Arun George Paul et al.   Translational Research

I B  augments IL-12- and IL-18-mediated IFN-  production in human NK cells

(2011) Y. Kannan et al.   BLOOD

Dichotomous Effects of IFN-  on Dendritic Cell Function Determine the Extent of IL-12-Driven Antitumor T Cell Immunity

(2011) J. L. Harden et al.   JOURNAL OF IMMUNOLOGY

Induction of metastatic cancer stem cells from the NK/LAK-resistant floating, but not adherent, subset of the UP-LN1 carcinoma cell line by IFN-γ

(2011) Hung-Chang Chen et al.   LABORATORY INVESTIGATION

NF- B Protects Cells from Gamma Interferon-Induced RIP1-Dependent Necroptosis

(2011) R. J. Thapa et al.   MOLECULAR AND CELLULAR BIOLOGY

Interferon-γ links ultraviolet radiation to melanomagenesis in mice

(2011) M. Raza Zaidi et al.   NATURE

Inflammation driven by tumour-specific Th1 cells protects against B-cell cancer

(2011) Ole Audun Werner Haabeth et al.   Nature Communications

Interferon   limits the effectiveness of melanoma peptide vaccines

(2010) H.-I. Cho et al.   BLOOD

Indoleamine 2,3-dioxygenase-expressing mature human monocyte-derived dendritic cells expand potent autologous regulatory T cells

(2009) D. J. Chung et al.   BLOOD

Interferon- -triggered indoleamine 2,3-dioxygenase competence in human monocyte-derived dendritic cells induces regulatory activity in allogeneic T cells

(2009) B. Jurgens et al.   BLOOD

Interferon-γ reverses the immunosuppressive and protumoral properties and prevents the generation of human tumor-associated macrophages

(2009) Dorothée Duluc et al.   INTERNATIONAL JOURNAL OF CANCER