The transcription factor IRF2 drives interferon-mediated CD8+ T cell exhaustion to restrict anti-tumor immunity
Published 2022 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
The transcription factor IRF2 drives interferon-mediated CD8+ T cell exhaustion to restrict anti-tumor immunity
Authors
Keywords
-
Journal
IMMUNITY
Volume 55, Issue 12, Pages 2369-2385.e10
Publisher
Elsevier BV
Online
2022-11-12
DOI
10.1016/j.immuni.2022.10.020
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- A STING-related prognostic score predicts high-risk patients of colorectal cancer and provides insights into immunotherapy
- (2021) Si-Yuan Chen et al. Annals of Translational Medicine
- In vivo CD8+ T cell CRISPR screening reveals control by Fli1 in infection and cancer
- (2021) Zeyu Chen et al. CELL
- BACH2 enforces the transcriptional and epigenetic programs of stem-like CD8+ T cells
- (2021) Chen Yao et al. NATURE IMMUNOLOGY
- The NF-κB regulator Bcl-3 restricts terminal differentiation and promotes memory cell formation of CD8+ T cells during viral infection
- (2021) Hemant Jaiswal et al. PLoS Pathogens
- CD73 Ectonucleotidase Restrains CD8+ T Cell Metabolic Fitness and Anti-tumoral Activity
- (2021) Pedro Briceño et al. Frontiers in Cell and Developmental Biology
- Integrated analysis of multimodal single-cell data
- (2021) Yuhan Hao et al. CELL
- BATF and IRF4 cooperate to counter exhaustion in tumor-infiltrating CAR T cells
- (2021) Hyungseok Seo et al. NATURE IMMUNOLOGY
- BATF regulates progenitor to cytolytic effector CD8+ T cell transition during chronic viral infection
- (2021) Yao Chen et al. NATURE IMMUNOLOGY
- Dynamic CD4+ T cell heterogeneity defines subset-specific suppression and PD-L1-blockade-driven functional restoration in chronic infection
- (2021) Laura M. Snell et al. NATURE IMMUNOLOGY
- Interferon regulatory factor 1 (IRF-1) and IRF-2 regulate PD-L1 expression in hepatocellular carcinoma (HCC) cells
- (2020) Yihe Yan et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- A Targeted Multi-omic Analysis Approach Measures Protein Expression and Low-Abundance Transcripts on the Single-Cell Level
- (2020) Florian Mair et al. Cell Reports
- Cereblon harnesses Myc-dependent bioenergetics and activity of CD8+ T lymphocytes
- (2020) Rebecca S. Hesterberg et al. BLOOD
- CITED2 limits pathogenic inflammatory gene programs in myeloid cells
- (2020) Hang Pong Ng et al. FASEB JOURNAL
- Opposing Roles of Type I Interferons in Cancer Immunity
- (2020) Giselle M. Boukhaled et al. Annual Review of Pathology-Mechanisms of Disease
- Intratumoral Tcf1+PD-1+CD8+ T Cells with Stem-like Properties Promote Tumor Control in Response to Vaccination and Checkpoint Blockade Immunotherapy
- (2019) Imran Siddiqui et al. IMMUNITY
- Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade
- (2019) Brian C. Miller et al. NATURE IMMUNOLOGY
- NR4A transcription factors limit CAR T cell function in solid tumours
- (2019) Joyce Chen et al. NATURE
- CD8 T Cell Exhaustion During Chronic Viral Infection and Cancer
- (2019) Laura M. McLane et al. Annual Review of Immunology
- Type I interferon signaling, regulation and gene stimulation in chronic virus infection
- (2019) Sabelo Lukhele et al. SEMINARS IN IMMUNOLOGY
- TOX is a critical regulator of tumour-specific T cell differentiation
- (2019) Andrew C. Scott et al. NATURE
- TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion
- (2019) Omar Khan et al. NATURE
- TOX and TOX2 transcription factors cooperate with NR4A transcription factors to impose CD8+ T cell exhaustion
- (2019) Hyungseok Seo et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Peak calling by Sparse Enrichment Analysis for CUT&RUN chromatin profiling
- (2019) Michael P. Meers et al. Epigenetics & Chromatin
- CUT&Tag for efficient epigenomic profiling of small samples and single cells
- (2019) Hatice S. Kaya-Okur et al. Nature Communications
- The ENCODE Blacklist: Identification of Problematic Regions of the Genome
- (2019) Haley M. Amemiya et al. Scientific Reports
- Direct Inhibition of IRF-Dependent Transcriptional Regulatory Mechanisms Associated With Disease
- (2019) Aleksandra Antonczyk et al. Frontiers in Immunology
- Frequent Loss of IRF2 in Cancers Leads to Immune Evasion through Decreased MHC Class I Antigen Presentation and Increased PD-L1 Expression
- (2019) Barry A. Kriegsman et al. JOURNAL OF IMMUNOLOGY
- Identification and dynamic quantification of regulatory elements using total RNA
- (2019) Sascha H. Duttke et al. GENOME RESEARCH
- Interferon γ and Its Important Roles in Promoting and Inhibiting Spontaneous and Therapeutic Cancer Immunity
- (2018) Elise Alspach et al. Cold Spring Harbor Perspectives in Biology
- Plasticity of Type I Interferon-Mediated Responses in Cancer Therapy: From Anti-tumor Immunity to Resistance
- (2018) Megha Budhwani et al. Frontiers in Oncology
- Heavy-tailed prior distributions for sequence count data: removing the noise and preserving large differences
- (2018) Anqi Zhu et al. BIOINFORMATICS
- Chromatin states define tumour-specific T cell dysfunction and reprogramming
- (2017) Mary Philip et al. NATURE
- SCENIC: single-cell regulatory network inference and clustering
- (2017) Sara Aibar et al. NATURE METHODS
- Exhaustion-associated regulatory regions in CD8+tumor-infiltrating T cells
- (2017) Giuliana P. Mognol et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Type I Interferon in Chronic Virus Infection and Cancer
- (2017) Laura M. Snell et al. TRENDS IN IMMUNOLOGY
- Prognostic value of IRF-2 expression in colorectal cancer
- (2017) Zubing Mei et al. Oncotarget
- TFBSTools: an R/bioconductor package for transcription factor binding site analysis
- (2016) Ge Tan et al. BIOINFORMATICS
- T Cell Factor 1-Expressing Memory-like CD8 + T Cells Sustain the Immune Response to Chronic Viral Infections
- (2016) Daniel T. Utzschneider et al. IMMUNITY
- Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy
- (2016) Se Jin Im et al. NATURE
- IL2Rβ-dependent signals drive terminal exhaustion and suppress memory development during chronic viral infection
- (2016) Jean-Christophe Beltra et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- ChIPseeker: an R/Bioconductor package for ChIP peak annotation, comparison and visualization
- (2015) Guangchuang Yu et al. BIOINFORMATICS
- Data-Driven Phenotypic Dissection of AML Reveals Progenitor-like Cells that Correlate with Prognosis
- (2015) Jacob H. Levine et al. CELL
- Genetic absence of PD-1 promotes accumulation of terminally differentiated exhausted CD8+T cells
- (2015) Pamela M. Odorizzi et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Interferons and the Immunogenic Effects of Cancer Therapy
- (2015) Andy J. Minn TRENDS IN IMMUNOLOGY
- Division of labor between IRF1 and IRF2 in regulating different stages of transcriptional activation in cellular antiviral activities
- (2015) Gang Ren et al. Cell and Bioscience
- A Critical Role of IL-21-Induced BATF in Sustaining CD8-T-Cell-Mediated Chronic Viral Control
- (2015) Gang Xin et al. Cell Reports
- The Molecular Signatures Database Hallmark Gene Set Collection
- (2015) Arthur Liberzon et al. Cell Systems
- IRF4 and BATF are critical for CD8+ T-cell function following infection with LCMV
- (2014) M Grusdat et al. CELL DEATH AND DIFFERENTIATION
- The Roles of Interferon Regulatory Factors 1 and 2 in the Progression of Human Pancreatic Cancer
- (2014) Toshitaka Sakai et al. PANCREAS
- Interferon Regulatory Factor (IRF)-1 and IRF-2 are Associated with Prognosis and Tumor Invasion in HCC
- (2012) Yong Yi et al. ANNALS OF SURGICAL ONCOLOGY
- clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters
- (2012) Guangchuang Yu et al. OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY
- Molecular signatures database (MSigDB) 3.0
- (2011) A. Liberzon et al. BIOINFORMATICS
- Genetic Variants in Interferon Regulatory Factor 2 (IRF2) Are Associated with Atopic Dermatitis and Eczema Herpeticum
- (2011) Pei-Song Gao et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- T cell exhaustion
- (2011) E John Wherry NATURE IMMUNOLOGY
- BEDTools: a flexible suite of utilities for comparing genomic features
- (2010) Aaron R. Quinlan et al. BIOINFORMATICS
- Prolonged Interleukin-2Rα Expression on Virus-Specific CD8+ T Cells Favors Terminal-Effector Differentiation In Vivo
- (2010) Vandana Kalia et al. IMMUNITY
- Negative Feedback Regulation of NF- B Action by CITED2 in the Nucleus
- (2010) X. Lou et al. JOURNAL OF IMMUNOLOGY
- A Role for the Transcriptional Repressor Blimp-1 in CD8+ T Cell Exhaustion during Chronic Viral Infection
- (2009) Haina Shin et al. IMMUNITY
- IRF-2 regulates NF-κB activity by modulating the subcellular localization of NF-κB
- (2008) Myounghee Chae et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Negative Feedback Regulation of IFN- Pathway by IFN Regulatory Factor 2 in Esophageal Cancers
- (2008) Y. Wang et al. CANCER RESEARCH
- Model-based Analysis of ChIP-Seq (MACS)
- (2008) Yong Zhang et al. GENOME BIOLOGY
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search