Branched-chain amino acid biosynthesis in fungi

High-level Production of Isoleucine and Fusel alcohol by expression of the Feedback Inhibition-insensitive Threonine deaminase in Saccharomyces cerevisiae

(2022) Shota Isogai et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Regulation of the Leucine Metabolism in Mortierella alpina

(2022) Robin Sonnabend et al.   Journal of Fungi

Acetolactate synthases regulatory subunit and catalytic subunit genes VdILVs are involved in BCAA biosynthesis, microscletotial and conidial formation and virulence in Verticillium dahliae

(2022) ShengNan Shao et al.   FUNGAL GENETICS AND BIOLOGY

Duplication and Functional Divergence of Branched-Chain Amino Acid Biosynthesis Genes in Aspergillus nidulans

(2021) Joel T. Steyer et al.   mBio

Triazolopyrimidine herbicides are potent inhibitors of Aspergillus fumigatus acetohydroxyacid synthase and potential antifungal drug leads

(2021) Y. S. Low et al.   Scientific Reports

Host-induced gene silencing of the acetolactate synthases VdILV2 and VdILV6 confers resistance to Verticillium wilt in cotton (Gossypium hirsutum L.)

(2020) Chunyan Wei et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

In Kluyveromyces lactis a Pair of Paralogous Isozymes Catalyze the First Committed Step of Leucine Biosynthesis in Either the Mitochondria or the Cytosol

(2020) Beatriz Aguirre-López et al.   Frontiers in Microbiology

Fungal iron homeostasis with a focus on Aspergillus fumigatus

(2020) Matthias Misslinger et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Metabolic regulatory mechanisms and physiological roles of functional amino acids and their applications in yeast

(2019) Hiroshi Takagi   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

FgIlv3a is crucial in branched-chain amino acid biosynthesis, vegetative differentiation, and virulence in Fusarium graminearum

(2019) Xin Liu et al.   JOURNAL OF MICROBIOLOGY

Leucine biosynthesis is required for infection-related morphogenesis and pathogenicity in the rice blast fungus Magnaporthe oryzae

(2019) Yawei Que et al.   CURRENT GENETICS

High-level production of valine by expression of the feedback inhibition-insensitive acetohydroxyacid synthase in Saccharomyces cerevisiae

(2018) Natthaporn Takpho et al.   METABOLIC ENGINEERING

Commercial AHAS-inhibiting herbicides are promising drug leads for the treatment of human fungal pathogenic infections

(2018) Mario D. Garcia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Zn2Cys6-type transcription factor LeuB cross-links regulation of leucine biosynthesis and iron acquisition in Aspergillus fumigatus

(2018) Nanbiao Long et al.   PLoS Genetics

Diversification of Transcriptional Regulation Determines Subfunctionalization of Paralogous Branched Chain Aminotransferases in the YeastSaccharomyces cerevisiae

(2017) James González et al.   GENETICS

Diversification of Transcriptional Regulation Determines Subfunctionalization of Paralogous Branched Chain Aminotransferases in the YeastSaccharomyces cerevisiae

(2017) James González et al.   GENETICS

New Aspercryptins, Lipopeptide Natural Products, Revealed by HDAC Inhibition in Aspergillus nidulans

(2016) Matthew T. Henke et al.   ACS Chemical Biology

Thiamine synthesis regulates the fermentation mechanisms in the fungusAspergillus nidulans

(2016) Motoyuki Shimizu et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Two FgLEU2 Genes with Different Roles in Leucine Biosynthesis and Infection-Related Morphogenesis in Fusarium graminearum

(2016) Xin Liu et al.   PLoS One

Development of Genetic Dereplication Strains in Aspergillus nidulans Results in the Discovery of Aspercryptin

(2015) Yi-Ming Chiang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Diversification of Paralogous α-Isopropylmalate Synthases by Modulation of Feedback Control and Hetero-Oligomerization in Saccharomyces cerevisiae

(2015) Geovani López et al.   EUKARYOTIC CELL

Functional roles of a predicted branched chain aminotransferase encoded by the LkBAT1 gene of the yeast Lachancea kluyveri

(2015) Javier Montalvo-Arredondo et al.   FUNGAL GENETICS AND BIOLOGY

Leu1 plays a role in iron metabolism and is required for virulence in Cryptococcus neoformans

(2015) Eunsoo Do et al.   FUNGAL GENETICS AND BIOLOGY

Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway

(2015) R. A. Saxton et al.   SCIENCE

Sestrin2 is a leucine sensor for the mTORC1 pathway

(2015) R. L. Wolfson et al.   SCIENCE

Acetohydroxyacid synthase FgIlv2 and FgIlv6 are involved in BCAA biosynthesis, mycelial and conidial morphogenesis and full virulence in Fusarium graminearum

(2015) Xin Liu et al.   Scientific Reports

Branched-Chain Aminotransferases Control TORC1 Signaling in Saccharomyces cerevisiae

(2015) Joanne M. Kingsbury et al.   PLoS Genetics

Phytotoxin production in Aspergillus terreus is regulated by independent environmental signals

(2015) Markus Gressler et al.   eLife

Prevalence of transcription factors in ascomycete and basidiomycete fungi

(2014) Richard B Todd et al.   BMC GENOMICS

Threonine deaminase MoIlv1 is important for conidiogenesis and pathogenesis in the rice blast fungus Magnaporthe oryzae

(2014) Yan Du et al.   FUNGAL GENETICS AND BIOLOGY

FgIlv5 is required for branched-chain amino acid biosynthesis and full virulence in Fusarium graminearum

(2014) X. Liu et al.   MICROBIOLOGY-SGM

Dual DNA binding and coactivator functions ofAspergillus nidulans TamA, a Zn(II)2Cys6 transcription factor

(2014) Damien J. Downes et al.   MOLECULAR MICROBIOLOGY

Identification and Evaluation of Novel Acetolactate Synthase Inhibitors as Antifungal Agents

(2013) Daryl L. Richie et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Regulation of the NADP-glutamate dehydrogenase gene gdhA in Aspergillus nidulans by the Zn(II)2Cys6 transcription factor LeuB

(2013) D. J. Downes et al.   MICROBIOLOGY-SGM

Acetolactate synthases MoIlv2 and MoIlv6 are required for infection-related morphogenesis inMagnaporthe oryzae

(2013) Yan Du et al.   MOLECULAR PLANT PATHOLOGY

Sulfonylureas Have Antifungal Activity and Are Potent Inhibitors of Candida albicans Acetohydroxyacid Synthase

(2012) Yu-Ting Lee et al.   JOURNAL OF MEDICINAL CHEMISTRY

Comparative proteome analysis of Aspergillus oryzae 3.042 and A. oryzae 100–8 strains: Towards the production of different soy sauce flavors

(2012) Guozhong Zhao et al.   Journal of Proteomics

HapX-Mediated Iron Homeostasis Is Essential for Rhizosphere Competence and Virulence of the Soilborne Pathogen Fusarium oxysporum

(2012) M. S. Lopez-Berges et al.   PLANT CELL

The Aspergillus fumigatus Dihydroxyacid Dehydratase Ilv3A/IlvC Is Required for Full Virulence

(2012) Jason D. Oliver et al.   PLoS One

An Iron Homeostasis Regulatory Circuit with Reciprocal Roles in Candida albicans Commensalism and Pathogenesis

(2011) Changbin Chen et al.   Cell Host & Microbe

Saccharomyces cerevisiae Bat1 and Bat2 Aminotransferases Have Functionally Diverged from the Ancestral-Like Kluyveromyces lactis Orthologous Enzyme

(2011) Maritrini Colón et al.   PLoS One

Mechanism of De Novo Branched-Chain Amino Acid Synthesis as an Alternative Electron Sink in Hypoxic Aspergillus nidulans Cells

(2010) M. Shimizu et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Two Origins for the Gene Encoding α-Isopropylmalate Synthase in Fungi

(2010) Erica M. Larson et al.   PLoS One

Iron Regulation through the Back Door: Iron-Dependent Metabolite Levels Contribute to Transcriptional Adaptation to Iron Deprivation in Saccharomyces cerevisiae

(2009) Jessica Ihrig et al.   EUKARYOTIC CELL

Cytocidal amino acid starvation of Saccharomyces cerevisiae and Candida albicans acetolactate synthase (ilv2 ) mutants is influenced by the carbon source and rapamycin

(2009) J. M. Kingsbury et al.   MICROBIOLOGY-SGM

Dissecting individual steps of nitrogen transcription factor cooperation in theAspergillus nidulansnitrate cluster

(2008) Harald Berger et al.   MOLECULAR MICROBIOLOGY