The role of copper ions in pathophysiology and fluorescent sensors for the detection thereof

The Ongoing Search for Small Molecules to Study Metal-Associated Amyloid-β Species in Alzheimer’s Disease

(2014) Masha G. Savelieff et al.   ACCOUNTS OF CHEMICAL RESEARCH

The amyloid hypothesis, time to move on: Amyloid is the downstream result, not cause, of Alzheimer's disease

(2014) David A. Drachman   Alzheimers & Dementia

Two-Photon Probe for Cu2+ with an Internal Reference: Quantitative Estimation of Cu2+ in Human Tissues by Two-Photon Microscopy

(2014) Dong Eun Kang et al.   ANALYTICAL CHEMISTRY

Design of intrahepatocyte copper(I) chelators as drug candidates for Wilson's disease

(2014) Christelle Gateau et al.   Annals of the New York Academy of Sciences

A novel fully water-soluble Cu(i) probe for fluorescence live cell imaging

(2014) Maria Laura Giuffrida et al.   CHEMICAL COMMUNICATIONS

Organelle-selective fluorescent Cu2+ ion probes: revealing the endoplasmic reticulum as a reservoir for Cu-overloading

(2014) Yun Hak Lee et al.   CHEMICAL COMMUNICATIONS

Fluorescent Sensors for Measuring Metal Ions in Living Systems

(2014) Kyle P. Carter et al.   CHEMICAL REVIEWS

Biological metals and metal-targeting compounds in major neurodegenerative diseases

(2014) Kevin J. Barnham et al.   CHEMICAL SOCIETY REVIEWS

Wilson Disease Protein ATP7B Utilizes Lysosomal Exocytosis to Maintain Copper Homeostasis

(2014) Elena V. Polishchuk et al.   DEVELOPMENTAL CELL

Insights into the physiological function of the β-amyloid precursor protein: beyond Alzheimer's disease

(2014) Edgar Dawkins et al.   JOURNAL OF NEUROCHEMISTRY

Fluorescence lifetime imaging of physiological free Cu(ii) levels in live cells with a Cu(ii)-selective carbonic anhydrase-based biosensor

(2014) Bryan J. McCranor et al.   Metallomics

Copper is an endogenous modulator of neural circuit spontaneous activity

(2014) Sheel C. Dodani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

On the origin of Alzheimer's disease. Trials and tribulations of the amyloid hypothesis

(2013) Michael A. Castello et al.   AGEING RESEARCH REVIEWS

A highly selective turn-on fluorescent sensor for Cu(ii) based on an NSe2 chelating moiety and its application in living cell imaging

(2013) Cho-Yen Chou et al.   ANALYST

Prions and the Potential Transmissibility of Protein Misfolding Diseases

(2013) Allison Kraus et al.   Annual Review of Microbiology

Origins of amyloid-β

(2013) William G Tharp et al.   BMC GENOMICS

Synthetic fluorescent probes for monovalent copper

(2013) Christoph J Fahrni   CURRENT OPINION IN CHEMICAL BIOLOGY

A Highly Selective Fluorescence “Turn-On” Probe for Cu(II) Based on Reaction and Its Imaging in Living Cells

(2013) Zhaohua Shi et al.   INORGANIC CHEMISTRY

Two-Photon Fluorescent Probes for Metal Ions in Live Tissues

(2013) Avik Ranjan Sarkar et al.   INORGANIC CHEMISTRY

Fenton-like copper redox chemistry revisited: Hydrogen peroxide and superoxide mediation of copper-catalyzed oxidant production

(2013) A. Ninh Pham et al.   JOURNAL OF CATALYSIS

Rational Design of a Structural Framework with Potential Use to Develop Chemical Reagents That Target and Modulate Multiple Facets of Alzheimer’s Disease

(2013) Sanghyun Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Copper pathology in vulnerable brain regions in Parkinson's disease

(2013) Katherine M. Davies et al.   NEUROBIOLOGY OF AGING

Imaging of Tau Pathology in a Tauopathy Mouse Model and in Alzheimer Patients Compared to Normal Controls

(2013) Masahiro Maruyama et al.   NEURON

A 7-nitrobenz-2-oxa-1,3-diazole based highly sensitive and selective turn-on chemosensor for copper(ii) ion with intracellular application without cytotoxicity

(2013) Tarun Mistri et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Alzheimer disease

(2013) Justin M. Nussbaum et al.   Prion

Low Copper and High Manganese Levels in Prion Protein Plaques

(2013) Christopher Johnson et al.   Viruses-Basel

 -Synuclein in Parkinson's Disease

(2013) L. Stefanis   Cold Spring Harbor Perspectives in Medicine

Neurotoxicity of Amyloid  -Protein: Synaptic and Network Dysfunction

(2013) L. Mucke et al.   Cold Spring Harbor Perspectives in Medicine

Role of the P-Type ATPases, ATP7A and ATP7B in brain copper homeostasis

(2013) Jonathon Telianidis et al.   Frontiers in Aging Neuroscience

Ultraviolet-Visible Light (UV–Vis)-Reversible but Fluorescence-Irreversible Chemosensor for Copper in Water and Its Application in Living Cells

(2012) Fang-Jun Huo et al.   ANALYTICAL CHEMISTRY

Ceruloplasmin dysfunction and therapeutic potential for Parkinson disease

(2012) Scott Ayton et al.   ANNALS OF NEUROLOGY

Coordination of Copper to the Membrane-Bound Form of α-Synuclein

(2012) Christopher G. Dudzik et al.   BIOCHEMISTRY

Development of a near-infrared fluorescent probe for imaging of endogenous Cu+ in live cells

(2012) Xiaowei Cao et al.   CHEMICAL COMMUNICATIONS

Werner coordination chemistry and neurodegeneration

(2012) Maria A. Telpoukhovskaia et al.   CHEMICAL SOCIETY REVIEWS

Chelation therapy in Wilson's disease: from d-penicillamine to the design of selective bioinspired intracellular Cu(i) chelators

(2012) Pascale Delangle et al.   DALTON TRANSACTIONS

Dual-function triazole–pyridine derivatives as inhibitors of metal-induced amyloid-β aggregation

(2012) Michael R. Jones et al.   Metallomics

Localization of copper and copper transporters in the human brain

(2012) Katherine M. Davies et al.   Metallomics

High-resolution structure of infectious prion protein: the final frontier

(2012) Rodrigo Diaz-Espinoza et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Near-infrared fluorescent sensor for in vivo copper imaging in a murine Wilson disease model

(2012) T. Hirayama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The challenges of using a copper fluorescent sensor (CS1) to track intracellular distributions of copper in neuronal and glial cells

(2012) Katherine A. Price et al.   Chemical Science

Two-Photon Microscopy for Chemical Neuroscience

(2011) Graham C. R. Ellis-Davies   ACS Chemical Neuroscience

A copper(i)-ion selective two-photon fluorescent probe for in vivo imaging

(2011) Chang Su Lim et al.   CHEMICAL COMMUNICATIONS

Fluorescent Chemosensors Based on Spiroring-Opening of Xanthenes and Related Derivatives

(2011) Xiaoqiang Chen et al.   CHEMICAL REVIEWS

Aluminum, copper, iron and zinc differentially alter amyloid-Aβ1–42 aggregation and toxicity

(2011) Silvia Bolognin et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Zn- and Cu-thioneins: a functional classification for metallothioneins?

(2011) Òscar Palacios et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Chemistry and biology of mammalian metallothioneins

(2011) Milan Vašák et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Copper(II)-Induced Secondary Structure Changes and Reduced Folding Stability of the Prion Protein

(2011) Nadine D. Younan et al.   JOURNAL OF MOLECULAR BIOLOGY

Ceruloplasmin Oxidation, a Feature of Parkinson's Disease CSF, Inhibits Ferroxidase Activity and Promotes Cellular Iron Retention

(2011) S. Olivieri et al.   JOURNAL OF NEUROSCIENCE

A Targetable Fluorescent Sensor Reveals That Copper-DeficientSCO1andSCO2Patient Cells Prioritize Mitochondrial Copper Homeostasis

(2011) Sheel C. Dodani et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Designed To Dissolve: Suppression of Colloidal Aggregation of Cu(I)-Selective Fluorescent Probes in Aqueous Buffer and In-Gel Detection of a Metallochaperone

(2011) M. Thomas Morgan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Molecular-Level Examination of Cu2+Binding Structure for Amyloid Fibrils of 40-Residue Alzheimer’s β by Solid-State NMR Spectroscopy

(2011) Sudhakar Parthasarathy et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Phosphorescent Sensor for Robust Quantification of Copper(II) Ion

(2011) Youngmin You et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Gender differences in Wilson's disease

(2011) T. Litwin et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Alzheimer's disease

(2011) Clive Ballard et al.   LANCET

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

(2011) Eric Karran et al.   NATURE REVIEWS DRUG DISCOVERY

Highly Selective Fluorescence Turn-on Chemodosimeter Based on Rhodamine for Nanomolar Detection of Copper Ions

(2011) Manoj Kumar et al.   ORGANIC LETTERS

Neuronal vulnerability in Parkinson's disease

(2011) Kay L Double   PARKINSONISM & RELATED DISORDERS

Alpha-Synuclein Is a Cellular Ferrireductase

(2011) Paul Davies et al.   PLoS One

Calcium-dependent copper redistributions in neuronal cells revealed by a fluorescent copper sensor and X-ray fluorescence microscopy

(2011) S. C. Dodani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fluorescence turn-on detection of Cu2+ in water samples and living cells based on the unprecedented copper-mediated dihydrorosamine oxidation reaction

(2010) Weiying Lin et al.   CHEMICAL COMMUNICATIONS

Alzheimer Disease

(2010) Rudy J. Castellani et al.   DM DISEASE-A-MONTH

Amyloid oligomers: formation and toxicity of Aβ oligomers

(2010) Masafumi Sakono et al.   FEBS Journal

Ctr1 Is an Apical Copper Transporter in Mammalian Intestinal Epithelial Cellsin VivoThat Is Controlled at the Level of Protein Stability

(2010) Yasuhiro Nose et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interaction between Human Prion Protein and Amyloid-β (Aβ) Oligomers

(2010) Shugui Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Substoichiometric Levels of Cu2+Ions Accelerate the Kinetics of Fiber Formation and Promote Cell Toxicity of Amyloid-β from Alzheimer Disease

(2010) Claire J. Sarell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Copper binding regulates intracellular alpha-synuclein localisation, aggregation and toxicity

(2010) Xiaoyan Wang et al.   JOURNAL OF NEUROCHEMISTRY

Memory Impairment in Transgenic Alzheimer Mice Requires Cellular Prion Protein

(2010) D. A. Gimbel et al.   JOURNAL OF NEUROSCIENCE

Development of Highly Sensitive Fluorescent Probes for Detection of Intracellular Copper(I) in Living Systems

(2010) Masayasu Taki et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Visualizing Ascorbate-Triggered Release of Labile Copper within Living Cells using a Ratiometric Fluorescent Sensor

(2010) Dylan W. Domaille et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Hepatocyte Targeting and Intracellular Copper Chelation by a Thiol-Containing Glycocyclopeptide

(2010) Anaïs M. Pujol et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Axonal prion protein is required for peripheral myelin maintenance

(2010) Juliane Bremer et al.   NATURE NEUROSCIENCE

Insights into prion protein function from atomistic simulations

(2010) Miroslav Hodak et al.   Prion

The eye in Wilson disease

(2010) J. M. Walshe   QJM-AN INTERNATIONAL JOURNAL OF MEDICINE

Highly Sensitive and Selective Colorimetric and Off−On Fluorescent Chemosensor for Cu2+in Aqueous Solution and Living Cells

(2009) Yan Zhao et al.   ANALYTICAL CHEMISTRY

Carbonic anhydrase II-based metal ion sensing: Advances and new perspectives

(2009) Tamiika K. Hurst et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Role of copper and manganese in prion disease progression

(2009) Gerda Mitteregger et al.   BRAIN RESEARCH

Application of Metal Coordination Chemistry To Explore and Manipulate Cell Biology

(2009) Kathryn L. Haas et al.   CHEMICAL REVIEWS

In Situ Imaging of Metals in Cells and Tissues

(2009) Reagan McRae et al.   CHEMICAL REVIEWS

Unique copper-induced oligomers mediate alpha-synuclein toxicity

(2009) Josephine A. Wright et al.   FASEB JOURNAL

β-amyloid oligomers and cellular prion protein in Alzheimer’s disease

(2009) Erik C. Gunther et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Zn(II)- and Cu(II)-induced non-fibrillar aggregates of amyloid-β (1-42) peptide are transformed to amyloid fibrils, both spontaneously and under the influence of metal chelators

(2009) Vello Tõugu et al.   JOURNAL OF NEUROCHEMISTRY

Design, Selection, and Characterization of Thioflavin-Based Intercalation Compounds with Metal Chelating Properties for Application in Alzheimer’s Disease

(2009) Cristina Rodríguez-Rodríguez et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Parkinson's disease

(2009) Andrew J Lees et al.   LANCET

Mapping metals in Parkinson's and normal brain using rapid-scanning x-ray fluorescence

(2009) Bogdan F Gh Popescu et al.   PHYSICS IN MEDICINE AND BIOLOGY

Increasing Cu bioavailability inhibits A  oligomers and tau phosphorylation

(2009) P. J. Crouch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms Underlying Development of Visual Maps and Receptive Fields

(2008) Andrew D. Huberman et al.   Annual Review of Neuroscience

Intracellular copper deficiency increases amyloid-β secretion by diverse mechanisms

(2008) Michael A. Cater et al.   BIOCHEMICAL JOURNAL

Boronic acid-linked fluorescent and colorimetric probes for copper ions

(2008) K. M. K. Swamy et al.   CHEMICAL COMMUNICATIONS

Metals in Neurobiology: Probing Their Chemistry and Biology with Molecular Imaging

(2008) Emily L. Que et al.   CHEMICAL REVIEWS

Highly Sensitive and Fast Responsive Fluorescence Turn-On Chemodosimeter for Cu2+and Its Application in Live Cell Imaging

(2008) Mengxiao Yu et al.   CHEMISTRY-A EUROPEAN JOURNAL

Structural Classification of Toxic Amyloid Oligomers

(2008) Charles G. Glabe   JOURNAL OF BIOLOGICAL CHEMISTRY

Manganese Binding to the Prion Protein

(2008) Marcus W. Brazier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synthetic fluorescent sensors for studying the cell biology of metals

(2008) Dylan W Domaille et al.   Nature Chemical Biology

Rapid Restoration of Cognition in Alzheimer's Transgenic Mice with 8-Hydroxy Quinoline Analogs Is Associated with Decreased Interstitial Aβ

(2008) Paul A. Adlard et al.   NEURON

Neonatal Diagnosis and Treatment of Menkes Disease

(2008) Stephen G. Kaler et al.   NEW ENGLAND JOURNAL OF MEDICINE

Oxidative impairment in scrapie-infected mice is associated with brain metals perturbations and altered antioxidant activities

(2003) Boon-Seng Wong et al.   JOURNAL OF NEUROCHEMISTRY