Fighting drug-resistant lung cancer by induction of NAD(P)H:quinone oxidoreductase 1 (NQO1)-mediated ferroptosis

Ferroptosis in cancer therapy: a novel approach to reversing drug resistance

(2022) Chen Zhang et al.   Molecular Cancer

Targeting NQO1/GPX4-mediated ferroptosis by plumbagin suppresses in vitro and in vivo glioma growth

(2022) Sheng Zhan et al.   BRITISH JOURNAL OF CANCER

Discovery of Small Molecules Simultaneously Targeting NAD(P)H:Quinone Oxidoreductase 1 and Nicotinamide Phosphoribosyltransferase: Treatment of Drug-Resistant Non-small-Cell Lung Cancer

(2022) Kuojun Zhang et al.   JOURNAL OF MEDICINAL CHEMISTRY

A novel strategy for glioblastoma treatment by induction of noptosis, an NQO1-dependent necrosis

(2021) Bingling Zhong et al.   FREE RADICAL BIOLOGY AND MEDICINE

The diverse functionality of NQO1 and its roles in redox control

(2021) David Ross et al.   Redox Biology

Challenge and countermeasures for EGFR targeted therapy in non-small cell lung cancer

(2021) Xueli Tian et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

2-Methoxy-6-acetyl-7-methyljuglone (MAM) induced programmed necrosis in glioblastoma by targeting NAD(P)H: Quinone oxidoreductase 1 (NQO1)

(2020) Jie Yu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Multicenter phase 1/2 Trial of napabucasin and pembrolizumab in patients with metastatic colorectal cancer (EPOC1503/SCOOP Trial)

(2020) Akihito Kawazoe et al.   CLINICAL CANCER RESEARCH

Targeting Ferroptosis to Iron Out Cancer

(2019) Behrouz Hassannia et al.   CANCER CELL

The role of necroptosis in cancer biology and therapy

(2019) Yitao Gong et al.   Molecular Cancer

NQO1: A target for the treatment of cancer and neurological diseases, and a model to understand loss of function disease mechanisms

(2019) Sarah K. Beaver et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

NAD(P)H:Quinone Oxidoreductase 1 (NQO1) as a Therapeutic and Diagnostic Target in Cancer

(2018) Kuojun Zhang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Inhibition of lung cancer by 2-methoxy-6-acetyl-7-methyljuglone (MAM) through induction of necroptosis by targeting receptor-interacting protein 1 (RIP1)

(2018) Wen Sun et al.   ANTIOXIDANTS & REDOX SIGNALING

NAD(P)H quinone oxidoreductase (NQO1): an enzyme which needs just enough mobility, in just the right places

(2018) Angel L. Pey et al.   BIOSCIENCE REPORTS

Phase 1 study of ARQ 761, a β-lapachone analogue that promotes NQO1-mediated programmed cancer cell necrosis

(2018) David E. Gerber et al.   BRITISH JOURNAL OF CANCER

Discovery of Nonquinone Substrates for NAD(P)H: Quinone Oxidoreductase 1 (NQO1) as Effective Intracellular ROS Generators for the Treatment of Drug-Resistant Non-Small-Cell Lung Cancer

(2018) Xingsen Wu et al.   JOURNAL OF MEDICINAL CHEMISTRY

2-Substituted 3,7,8-trimethylnaphtho[1,2- b ]furan-4,5-diones as specific L-shaped NQO1-mediated redox modulators for the treatment of non-small cell lung cancer

(2017) Xiaojin Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Inhibition of the Ras/Raf interaction and repression of renal cancer xenografts in vivo by an enantiomeric iridium(iii) metal-based compound

(2017) Li-Juan Liu et al.   Chemical Science

Predictors of chemotherapy efficacy in non-small-cell lung cancer: a challenging landscape

(2016) K. A. Olaussen et al.   ANNALS OF ONCOLOGY

Induction of ferroptotic cell death for overcoming cisplatin resistance of head and neck cancer

(2016) Jong-Lyel Roh et al.   CANCER LETTERS

2-Methoxy-6-acetyl-7-methyljuglone (MAM), a natural naphthoquinone, induces NO-dependent apoptosis and necroptosis by H 2 O 2 -dependent JNK activation in cancer cells

(2016) Wen Sun et al.   FREE RADICAL BIOLOGY AND MEDICINE

Characterization of osimertinib (AZD9291)-resistant non-small cell lung cancer NCI-H1975/OSIR cell line

(2016) Zheng-Hai Tang et al.   Oncotarget

Implications of NQO1 in cancer therapy

(2015) Eun-Taex Oh et al.   BMB Reports

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR

(2014) Randall M. Chin et al.   NATURE

An NQO1 Substrate with Potent Antitumor Activity That Selectively Kills by PARP1-Induced Programmed Necrosis

(2012) X. Huang et al.   CANCER RESEARCH

A bioluminescent cytotoxicity assay for assessment of membrane integrity using a proteolytic biomarker

(2008) Ming-Hsuang Cho et al.   TOXICOLOGY IN VITRO