NAD(P)H quinone oxidoreductase (NQO1): an enzyme which needs just enough mobility, in just the right places

Development of novel amino-quinoline-5,8-dione derivatives as NAD(P)H:quinone oxidoreductase 1 (NQO1) inhibitors with potent antiproliferative activities

(2018) Yong Ling et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Biophysical and functional perturbation analyses at cancer-associated P187 and K240 sites of the multifunctional NADP(H):quinone oxidoreductase 1

(2018) Angel L. Pey   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Redox modulation of NQO1

(2018) David Siegel et al.   PLoS One

Evolutionary Divergent Suppressor Mutations in Conformational Diseases

(2018) Noel Mesa-Torres et al.   Genes

A mechanism for cancer-associated inactivation of NQO1 due to P187S and its reactivation by the consensus mutation H80R

(2017) Inés G. Muñoz et al.   FEBS LETTERS

Enhanced vulnerability of human proteins towards disease-associated inactivation through divergent evolution

(2017) Encarnación Medina-Carmona et al.   HUMAN MOLECULAR GENETICS

Functions of NQO1 in Cellular Protection and CoQ10 Metabolism and its Potential Role as a Redox Sensitive Molecular Switch

(2017) David Ross et al.   Frontiers in Physiology

Site-to-site interdomain communication may mediate different loss-of-function mechanisms in a cancer-associated NQO1 polymorphism

(2017) Encarnación Medina-Carmona et al.   Scientific Reports

Natural Small Molecules as Stabilizers and Activators of Cancer-Associated NQO1 Polymorphisms

(2016) Angel L. Pey et al.   CURRENT DRUG TARGETS

Recognition of enzymes lacking bound cofactor by protein quality control

(2016) Adrián Martínez-Limón et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conformational dynamics is key to understanding loss-of-function of NQO1 cancer-associated polymorphisms and its correction by pharmacological ligands

(2016) Encarnación Medina-Carmona et al.   Scientific Reports

Implications of NQO1 in cancer therapy

(2015) Eun-Taex Oh et al.   BMB Reports

A Mutually Inhibitory Feedback Loop between the 20S Proteasome and Its Regulator, NQO1

(2015) Oren Moscovitz et al.   MOLECULAR CELL

FAD binding overcomes defects in activity and stability displayed by cancer-associated variants of human NQO1

(2014) Angel L. Pey et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

On the preferred structure of dicoumarol and implications for enzyme binding: A quantum chemical analysis

(2014) Bilal M. Hussain et al.   CHEMICAL PHYSICS LETTERS

2-Substituted 3-methylnaphtho[1,2-b]furan-4,5-diones as novel L-shaped ortho-quinone substrates for NAD(P)H:quinone oxidoreductase (NQO1)

(2014) Jinlei Bian et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Collapse of the native structure caused by a single amino acid exchange in human NAD(P)H:quinone oxidoreductase1

(2014) Wolf-Dieter Lienhart et al.   FEBS Journal

The two common polymorphic forms of human NRH-quinone oxidoreductase 2 (NQO2) have different biochemical properties

(2014) Clare F. Megarity et al.   FEBS LETTERS

TheSaccharomyces cerevisiaequinone oxidoreductase Lot6p: stability, inhibition and cooperativity

(2014) Clare F. Megarity et al.   FEMS YEAST RESEARCH

Structural and biochemical characterization of MdaB from cariogenicStreptococcus mutansreveals an NADPH-specific quinone oxidoreductase

(2014) Zixi Wang et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Assessment of the contribution of NAD(P)H-dependent quinone oxidoreductase 1 (NQO1) to the reduction of vitamin K in wild-type and NQO1-deficient mice

(2013) Brian O. Ingram et al.   BIOCHEMICAL JOURNAL

The NQO1 polymorphism C609T (Pro187Ser) and cancer susceptibility: a comprehensive meta-analysis

(2013) B Lajin et al.   BRITISH JOURNAL OF CANCER

Ensembl 2013

(2012) Paul Flicek et al.   NUCLEIC ACIDS RESEARCH

Functional study of the vitamin K cycle in mammalian cells

(2011) J.-K. Tie et al.   BLOOD

NAD(P)H:Quinone Oxidoreductase 1 and its Potential Protective Role in Cardiovascular Diseases and Related Conditions

(2011) Hong Zhu et al.   Cardiovascular Toxicology

NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1), a multifunctional antioxidant enzyme and exceptionally versatile cytoprotector

(2010) Albena T. Dinkova-Kostova et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Pharmacological inhibitors of NAD(P)H quinone oxidoreductase, NQO1: Structure/activity relationships and functional activity in tumour cells

(2010) Karen Ann Nolan et al.   BIOCHEMICAL PHARMACOLOGY

Inhibitors of NQO1: Identification of compounds more potent than dicoumarol without associated off-target effects

(2010) Katherine Ann Scott et al.   BIOCHEMICAL PHARMACOLOGY

Cooperation of NAD(P)H:quinone oxidoreductase 1 and UDP-glucuronosyltransferases reduces menadione cytotoxicity in HEK293 cells

(2009) Takahito Nishiyama et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Synthesis and Biological Evaluation of Coumarin-Based Inhibitors of NAD(P)H: Quinone Oxidoreductase-1 (NQO1)†

(2009) Karen A. Nolan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Induction of the Phase II Detoxification Enzyme NQO1 in Hepatocarcinoma Cells by Lignans from the Fruit ofSchisandra chinensisthrough Nuclear Accumulation of Nrf2

(2009) Saet Lee et al.   PLANTA MEDICA

Allosteric regulation and catalysis emerge via a common route

(2008) Nina M Goodey et al.   Nature Chemical Biology

The NADPH quinone reductase MdaB confers oxidative stress resistance to Helicobacter hepaticus

(2007) Yang Hong et al.   MICROBIAL PATHOGENESIS