Biochemical Basis of the Antimicrobial Activity of Quinazolinone Derivatives in the Light of Insights into the Features of the Chemical Structure and Ways of Binding to Target Molecules. A Review

Quinazolinones, the Winning Horse in Drug Discovery

(2023) Aishah M. Alsibaee et al.   MOLECULES

Exploration of structural requirements for azole chemicals towards human aromatase CYP19A1 activity: Classification modeling, structure-activity relationships and read-across study

(2022) Ana Y. Caballero Alfonso et al.   TOXICOLOGY IN VITRO

Pseudomonas aeruginosa efflux pump superfamily (review of literature)

(2022) Mikhail Eduardovich Ivanov et al.   Klinichescheskaya Laboratornaya Diagnostika

Screening studies of antimicrobial activity of pyrimidine derivative

(2022) A. A. Tsibizova et al.   Sibirskii nauchnyi meditsinskii zhurnal

Two-Stage Activation of lux Regulon of Psychrophilic Marine Luminescent Bacteria Aliivibrio logei

(2022) S. V. Bazhenov et al.   RUSSIAN JOURNAL OF GENETICS

Virtual screening, optimization and molecular dynamics analyses highlighting a pyrrolo[1,2-a]quinazoline derivative as a potential inhibitor of DNA gyrase B of Mycobacterium tuberculosis

(2022) Juan Marcelo Carpio Arévalo et al.   Scientific Reports

Solution structure of the type I polyketide synthase Pks13 from Mycobacterium tuberculosis

(2022) Cécile Bon et al.   BMC BIOLOGY

Potent DNA gyrase inhibitors bind asymmetrically to their target using symmetrical bifurcated halogen bonds

(2021) Anja Kolarič et al.   Nature Communications

Sorting out the Superbugs: Potential of Sortase A Inhibitors among Other Antimicrobial Strategies to Tackle the Problem of Antibiotic Resistance

(2021) Nikita Zrelovs et al.   Antibiotics-Basel

Physiological Functions of Bacterial “Multidrug” Efflux Pumps

(2021) Peter J. F. Henderson et al.   CHEMICAL REVIEWS

Diversity and Functions of Type II Topoisomerases

(2021) Dmitry A. Sutormin et al.   Acta Naturae

An Experimental Toolbox for Structure‐Based Hit Discovery for P .  aeruginosa FabF, a Promising Target for Antibiotics

(2021) Ludvik Olai Espeland et al.   ChemMedChem

Impact of FtsZ Inhibition on the Localization of the Penicillin Binding Proteins in Methicillin-Resistant Staphylococcus aureus

(2021) Edgar Ferrer-González et al.   JOURNAL OF BACTERIOLOGY

Chemical Biology of Sortase A Inhibition: A Gateway to Anti-infective Therapeutic Agents

(2021) Rachit Sapra et al.   JOURNAL OF MEDICINAL CHEMISTRY

Non-β-Lactam Allosteric Inhibitors Target Methicillin-Resistant Staphylococcus aureus: An In Silico Drug Discovery Study

(2021) Mahmoud A. A. Ibrahim et al.   Antibiotics-Basel

ANTIMICROBIAL ACTIVITY STUDY OF NEW QUINAZOLIN-4(3H)-ONES AGAINST STAPHYLOCOCCUS AUREUS AND STREPTOCOCCUS PNEUMONIAE

(2021) M. A. Samotrueva et al.   Pharmacy & Pharmacology-Farmatsiya i Farmakologiya

Identification of Novel Antistaphylococcal Hit Compounds Targeting Sortase A

(2021) Galyna Volynets et al.   MOLECULES

Revisiting Antibiotic Resistance: Mechanistic Foundations to Evolutionary Outlook

(2021) Chowdhury M. Hasan et al.   Antibiotics-Basel

Two-component signal transduction systems in the human pathogen, Streptococcus agalactiae

(2020) Lamar Thomas et al.   INFECTION AND IMMUNITY

Functional and Structural Roles of the Major Facilitator Superfamily Bacterial Multidrug Efflux Pumps

(2020) Sanath Kumar et al.   Microorganisms

Identification of an ethyl 5,6-dihydropyrazolo[1,5-c]quinazoline-1-carboxylate as a catalytic inhibitor of DNA gyrase

(2020) Arturo L. Aguirre et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Novel N-(Substituted) Thioacetamide Quinazolinone Benzenesulfonamides as Antimicrobial Agents

(2020) Mostafa M Ghorab et al.   International Journal of Nanomedicine

Exploration of the Structural Space in 4(3H)-Quinazolinone Antibacterials

(2020) Yuanyuan Qian et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure of a proton-dependent lipid transporter involved in lipoteichoic acids biosynthesis

(2020) Bing Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

PhoQ is an unsaturated fatty acid receptor that fine-tunes Salmonella pathogenic traits

(2020) María Ayelén Carabajal et al.   Science Signaling

Recent advances in DNA gyrase-targeted antimicrobial agents

(2020) Satish N. Dighe et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis, molecular docking study, and antibacterial evaluation of some new fluoroquinolone analogues bearing a quinazolinone moiety

(2020) Maryam Norouzbahari et al.   DARU-Journal of Pharmaceutical Sciences

Progress Overview of Bacterial Two-Component Regulatory Systems as Potential Targets for Antimicrobial Chemotherapy

(2020) Hidetada Hirakawa et al.   Antibiotics-Basel

Synthesis and biofilm inhibition studies of 2-(2-amino-6-arylpyrimidin-4-yl)quinazolin-4(3H)-ones

(2020) Sivappa Rasapalli et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Novel quinazolinone inhibitors of the Pseudomonas aeruginosa quorum sensing transcriptional regulator PqsR

(2020) Scott Grossman et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Genetic Diversity of norA, Coding for a Main Efflux Pump of Staphylococcus aureus

(2019) Sofia Santos Costa et al.   Frontiers in Genetics

Astilbin Inhibits the Activity of Sortase A from Streptococcus mutans

(2019) Junxian Wang et al.   MOLECULES

Design, synthesis and molecular docking studies of quinazolin-4-ones linked to 1,2,3-triazol hybrids as Mycobacterium tuberculosis H37Rv inhibitors besides antimicrobial activity

(2019) Narendra Kumar Maddali et al.   MEDICINAL CHEMISTRY RESEARCH

Staphylococcus aureus Lipoteichoic Acid Damages the Skin Barrier through an IL-1 mediated Pathway

(2019) Anne M. Brauweiler et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Two Component Regulatory Systems and Antibiotic Resistance in Gram-Negative Pathogens

(2019) Anjali Y. Bhagirath et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mechanisms of Incorporation for D-Amino Acid Probes That Target Peptidoglycan Biosynthesis

(2019) Erkin Kuru et al.   ACS Chemical Biology

Quinazoline-Based Antivirulence Compounds Selectively Target Salmonella PhoP/PhoQ Signal Transduction System

(2019) María Ayelén Carabajal et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Targeting Bacterial Sortase A with Covalent Inhibitors: 27 New Starting Points for Structure-Based Hit-to-Lead Optimization

(2019) Kristaps Jaudzems et al.   ACS Infectious Diseases

Structural analysis of mycobacterial homoserine transacetylases central to methionine biosynthesis reveals druggable active site

(2019) Catherine T. Chaton et al.   Scientific Reports

DNA gyrase inhibitors: Progress and synthesis of potent compounds as antibacterial agents

(2018) Tabassum Khan et al.   BIOMEDICINE & PHARMACOTHERAPY

Synthesis and molecular docking of N,N′-disubstituted thiourea derivatives as novel aromatase inhibitors

(2018) Ratchanok Pingaew et al.   BIOORGANIC CHEMISTRY

Recent progress in the discovery and development of DNA gyrase B inhibitors

(2018) Michaela Barančoková et al.   Future Medicinal Chemistry

Role of bacterial efflux pumps in biofilm formation

(2018) Ilyas Alav et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Pseudomonas aeruginosa Quorum Sensing Systems as Drug Discovery Targets: Current Position and Future Perspectives.

(2018) Fadi Soukarieh et al.   JOURNAL OF MEDICINAL CHEMISTRY

Characterization of Long-Chain Fatty Acid as N-(4-Aminomethylphenyl) Pyridinium Derivative by MALDI LIFT-TOF/TOF Mass Spectrometry

(2018) Cheryl Frankfater et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

One-pot synthesis of triazines as potential agents affecting cell differentiation

(2018) Thomas Linder et al.   MONATSHEFTE FUR CHEMIE

Multidrug efflux pumps: structure, function and regulation

(2018) Dijun Du et al.   NATURE REVIEWS MICROBIOLOGY

Lipoteichoic Acid Inhibits Staphylococcus aureus Biofilm Formation

(2018) Ki Bum Ahn et al.   Frontiers in Microbiology

Efflux pump inhibition by 11H-pyrido[2,1-b]quinazolin-11-one analogues in mycobacteria

(2018) Tejosmita Sen et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Targeting the Pseudomonas quinolone signal quorum sensing system for the discovery of novel anti-infective pathoblockers

(2018) Christian Schütz et al.   Beilstein Journal of Organic Chemistry

Design, synthesis, antimicrobial and anti-biofilm evaluation, and molecular docking of new substituted fluoroquinazolinones

(2018) Mohamed F. Zayed et al.   Medicinal Chemistry

Characterization of H-box region mutants of WalK inert to the action of waldiomycin in Bacillus subtilis

(2017) Akinori Kato et al.   JOURNAL OF GENERAL AND APPLIED MICROBIOLOGY

Two-Component Signal Transduction Systems of Pathogenic Bacteria As Targets for Antimicrobial Therapy: An Overview

(2017) Sandeep Tiwari et al.   Frontiers in Microbiology

Regulation of bacterial cell wall growth

(2016) Alexander J. F. Egan et al.   FEBS Journal

Quorum Signal Inhibitors and Their Potential Use against Fish Diseases

(2016) Weihua Chu et al.   JOURNAL OF AQUATIC ANIMAL HEALTH

Insights on Antimicrobial Resistance, Biofilms and the Use of Phytochemicals as New Antimicrobial Agents

(2015) Anabela Borges et al.   CURRENT MEDICINAL CHEMISTRY

Molecular features of the sortase enzyme family

(2015) William J. Bradshaw et al.   FEBS Journal

Benzofuran as a promising scaffold for the synthesis of antimicrobial and antibreast cancer agents: A review

(2015) Ghadamali Khodarahmi et al.   Journal of Research in Medical Sciences

Synthesis, Anti-microbial and Molecular Docking Studies of Quinazolin-4(3H)-one Derivatives

(2014) Yahia Mabkhot et al.   MOLECULES

Fatty acids and early detection of pathogens

(2013) Justin W Walley et al.   CURRENT OPINION IN PLANT BIOLOGY

Synthesis and biological evaluation of cationic fullerene quinazolinone conjugates and their binding mode with modeled Mycobacterium tuberculosis hypoxanthine-guanine phosphoribosyltransferase enzyme

(2013) Manishkumar B. Patel et al.   JOURNAL OF MOLECULAR MODELING

Antituberculosis thiophenes define a requirement for Pks13 in mycolic acid biosynthesis

(2013) Regina Wilson et al.   Nature Chemical Biology

Small molecule inhibitor of lipoteichoic acid synthesis is an antibiotic for Gram-positive bacteria

(2013) Stefan G. Richter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bacterial Cell Wall Compounds as Promising Targets of Antimicrobial Agents I. Antimicrobial Peptides and Lipopolyamines

(2012) Guillermo Martinez de Tejada et al.   CURRENT DRUG TARGETS

Synthesis, characterization, and pharmacological evaluation of 1-[2-(6-nitro-4-oxo-2-phenyl-4H-quinazolin-3-yl)-ethyl]-3-phenyl ureas

(2012) Aniruddhasinh M. Rana et al.   MEDICINAL CHEMISTRY RESEARCH

An Original Deal for New Molecule: Reversal of Efflux Pump Activity, A Rational Strategy to Combat Gram-Negative Resistant Bacteria

(2011) J.-M. Pages et al.   CURRENT MEDICINAL CHEMISTRY

β-Lactone natural products and derivatives inactivate homoserine transacetylase, a target for antimicrobial agents

(2011) Gianfranco De Pascale et al.   JOURNAL OF ANTIBIOTICS

Sortase enzymes in Gram-positive bacteria

(2011) Thomas Spirig et al.   MOLECULAR MICROBIOLOGY

Synthesis and antimicrobial activity of novel quinazolinone–thiazolidine–quinoline compounds

(2011) N.C. Desai et al.   Journal of Saudi Chemical Society

Novel antibacterial compounds specifically targeting the essential WalR response regulator

(2010) Yasuhiro Gotoh et al.   JOURNAL OF ANTIBIOTICS

Ciprofloxacin: review on developments in synthetic, analytical, and medicinal aspects

(2010) Prabodh Chander Sharma et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

The anti-inflammatory non-antibiotic helper compound diclofenac: an antibacterial drug target

(2009) K. Mazumdar et al.   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

QS-type bacterial signal molecules of nonpeptide origin

(2009) A. O. Shpakov   MICROBIOLOGY