Sorting out the Superbugs: Potential of Sortase A Inhibitors among Other Antimicrobial Strategies to Tackle the Problem of Antibiotic Resistance

Defeating Antibiotic-Resistant Bacteria: Exploring Alternative Therapies for a Post-Antibiotic Era

(2020) Chih-Hung Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Management of Streptococcus mutans-Candida spp. Oral Biofilms’ Infections: Paving the Way for Effective Clinical Interventions

(2020) Bahare Salehi et al.   Journal of Clinical Medicine

Alternatives to antibiotics in a One Health context and the role genomics can play in reducing antimicrobial use

(2020) J. Pollock et al.   CLINICAL MICROBIOLOGY AND INFECTION

Antimicrobial Resistance in ESKAPE Pathogens

(2020) David M. P. De Oliveira et al.   CLINICAL MICROBIOLOGY REVIEWS

Tideglusib and Its Analogues As Inhibitors of Staphylococcus aureus SrtA

(2020) Teng Yang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Advanced engineering of third-generation lysins and formulation strategies for clinical applications

(2020) Vincent De Maesschalck et al.   CRITICAL REVIEWS IN MICROBIOLOGY

Design and Synthesis of Small Molecules as Potent Staphylococcus aureus Sortase A Inhibitors

(2020) Min Woo Ha et al.   Antibiotics-Basel

Rutin reduces the pathogenicity of Streptococcus agalactiae to tilapia by inhibiting the activity of sortase A

(2020) Jing Dong et al.   AQUACULTURE

Quantifying the Interactions between Biomolecules: Guidelines for Assay Design and Data Analysis

(2019) Peter J Tonge   ACS Infectious Diseases

Astilbin Inhibits the Activity of Sortase A from Streptococcus mutans

(2019) Junxian Wang et al.   MOLECULES

A comprehensive in silico analysis of sortase superfamily

(2019) Adeel Malik et al.   JOURNAL OF MICROBIOLOGY

Engineered bacteriophages for treatment of a patient with a disseminated drug-resistant Mycobacterium abscessus

(2019) Rebekah M. Dedrick et al.   NATURE MEDICINE

Alternatives to Conventional Antibiotics in the Era of Antimicrobial Resistance

(2019) Chandradhish Ghosh et al.   TRENDS IN MICROBIOLOGY

Recent Advances in Anti-virulence Therapeutic Strategies With a Focus on Dismantling Bacterial Membrane Microdomains, Toxin Neutralization, Quorum-Sensing Interference and Biofilm Inhibition

(2019) Osmel Fleitas Martínez et al.   Frontiers in Cellular and Infection Microbiology

Antibiotics versus biofilm: an emerging battleground in microbial communities

(2019) Divakar Sharma et al.   Antimicrobial Resistance and Infection Control

Novel Antibiotics for Multidrug-Resistant Gram-Positive Microorganisms

(2019) Koulenti et al.   Microorganisms

Discovery and development of substituted thiadiazoles as inhibitors of Staphylococcus aureus Sortase A

(2019) Patrick M. Wehrli et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Targeting Bacterial Sortase A with Covalent Inhibitors: 27 New Starting Points for Structure-Based Hit-to-Lead Optimization

(2019) Kristaps Jaudzems et al.   ACS Infectious Diseases

Oligopeptide Targeting Sortase A as Potential Anti-infective Therapy for Staphylococcus aureus

(2018) Jianfeng Wang et al.   Frontiers in Microbiology

Thousands of Novel Endolysins Discovered in Uncultured Phage Genomes

(2018) Iris Fernández-Ruiz et al.   Frontiers in Microbiology

Interference in Bacterial Quorum Sensing: A Biopharmaceutical Perspective

(2018) Benjamin Rémy et al.   Frontiers in Pharmacology

Emergence of Antibiotic Resistance in Listeria monocytogenes Isolated from Food Products: A Comprehensive Review

(2018) Amin N. Olaimat et al.   COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY

Erianin against Staphylococcus aureus Infection via Inhibiting Sortase A

(2018) Ping Ouyang et al.   Toxins

A Review: The Fate of Bacteriocins in the Human Gastro-Intestinal Tract: Do They Cross the Gut–Blood Barrier?

(2018) Leon M. T. Dicks et al.   Frontiers in Microbiology

Technologies to address antimicrobial resistance

(2018) Stephen J. Baker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A review of Listeria monocytogenes : An update on outbreaks, virulence, dose-response, ecology, and risk assessments

(2017) Robert L. Buchanan et al.   FOOD CONTROL

Recently approved antibacterials for methicillin-resistant Staphylococcus aureus (MRSA) and other Gram-positive pathogens: the shock of the new

(2017) Michael Z. David et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Molecular Docking and Screening Studies of New Natural Sortase A Inhibitors

(2017) Georgiana Nitulescu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Update on Antimicrobial Resistance in Clostridium difficile: Resistance Mechanisms and Antimicrobial Susceptibility Testing

(2017) Zhong Peng et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Different drugs for bad bugs: antivirulence strategies in the age of antibiotic resistance

(2017) Seth W. Dickey et al.   NATURE REVIEWS DRUG DISCOVERY

Alternative therapeutics for self-limiting infections—An indirect approach to the antibiotic resistance challenge

(2017) Kristofer Wollein Waldetoft et al.   PLOS BIOLOGY

From endolysins to Artilysin(R)s: novel enzyme-based approaches to kill drug-resistant bacteria

(2016) H. Gerstmans et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Beyond Antibiotics: New Therapeutic Approaches for Bacterial Infections

(2016) Alan R. Hauser et al.   CLINICAL INFECTIOUS DISEASES

Emerging bacterial pathogens: the past and beyond

(2016) M. Vouga et al.   CLINICAL MICROBIOLOGY AND INFECTION

Antimicrobial peptides

(2016) Ling-juan Zhang et al.   CURRENT BIOLOGY

Alternatives to antibiotics—a pipeline portfolio review

(2016) Lloyd Czaplewski et al.   LANCET INFECTIOUS DISEASES

Alternatives to overcoming bacterial resistances: State-of-the-art

(2016) Alessandra C. Rios et al.   MICROBIOLOGICAL RESEARCH

Discovery of a New Class of Sortase A Transpeptidase Inhibitors to Tackle Gram-Positive Pathogens: 2-(2-Phenylhydrazinylidene)alkanoic Acids and Related Derivatives

(2016) Benedetta Maggio et al.   MOLECULES

Targeting Staphylococcus aureus Toxins: A Potential form of Anti-Virulence Therapy

(2016) Cin Kong et al.   Toxins

Antimicrobial Peptides: An Emerging Category of Therapeutic Agents

(2016) Margit Mahlapuu et al.   Frontiers in Cellular and Infection Microbiology

Nanotechnology: A Valuable Strategy to Improve Bacteriocin Formulations

(2016) Hazem A. Fahim et al.   Frontiers in Microbiology

Engineered nanoparticles mimicking cell membranes for toxin neutralization

(2015) Ronnie H. Fang et al.   ADVANCED DRUG DELIVERY REVIEWS

Streptococcus mutans sortase A inhibitory metabolites from the flowers of Sophora japonica

(2015) Woo-Young Yang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Evolving Resistance Among Gram-positive Pathogens

(2015) Jose M. Munita et al.   CLINICAL INFECTIOUS DISEASES

Staphylococcus aureus Infections: Epidemiology, Pathophysiology, Clinical Manifestations, and Management

(2015) Steven Y. C. Tong et al.   CLINICAL MICROBIOLOGY REVIEWS

APD3: the antimicrobial peptide database as a tool for research and education

(2015) Guangshun Wang et al.   NUCLEIC ACIDS RESEARCH

Alexander Fleming (1881–1955): Discoverer of penicillin

(2015) SY Tan et al.   SINGAPORE MEDICAL JOURNAL

The therapeutic effect of chlorogenic acid against Staphylococcus aureus infection through sortase A inhibition

(2015) Lin Wang et al.   Frontiers in Microbiology

Discovery and structure–activity relationship studies of irreversible benzisothiazolinone-based inhibitors against Staphylococcus aureus sortase A transpeptidase

(2014) Dmitrijs Zhulenkovs et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Virtual screening of LPXTG competitive SrtA inhibitors targeting signal transduction mechanism inBacillus anthracis: a combined experimental and theoretical study

(2014) Chandrabose Selvaraj et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Targeting virulence: can we make evolution-proof drugs?

(2014) Richard C. Allen et al.   NATURE REVIEWS MICROBIOLOGY

Antiinfective therapy with a small molecule inhibitor ofStaphylococcus aureussortase

(2014) Jie Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of bacterial biofilms in chronic infections

(2013) Thomas Bjarnsholt   APMIS

Curcumin Inhibits the Sortase A Activity of the Streptococcus mutans UA159

(2013) Ping Hu et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Learning from our mistakes: The ‘unknown knowns’ in fragment screening

(2013) Ben J. Davis et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Sortase A inhibitory metabolites from the roots of Pulsatilla koreana

(2013) Sooryun Lee et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery ofStaphylococcus aureusSortase A Inhibitors Using Virtual Screening and the Relaxed Complex Scheme

(2013) Albert H. Chan et al.   Chemical Biology & Drug Design

Beta-carboline alkaloids derived from the ascidian Synoicum sp.

(2012) Tae Hyung Won et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Brominated Aromatic Furanones and Related Esters from the Ascidian Synoicum sp.

(2012) Tae Hyung Won et al.   JOURNAL OF NATURAL PRODUCTS

Bacteriocins — a viable alternative to antibiotics?

(2012) Paul D. Cotter et al.   NATURE REVIEWS MICROBIOLOGY

Crystallization and preliminary X-ray diffraction studies of sortase A fromStreptococcus pneumoniae

(2011) Anurag Misra et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

In vitro sortase a inhibitory and antimicrobial activity of flavonoids isolated from the roots of Sophora flavescens

(2011) Ikhoon Oh et al.   ARCHIVES OF PHARMACAL RESEARCH

Sesterterpenes from the Tropical SpongeCoscinodermasp.

(2011) Jaemin Bae et al.   JOURNAL OF NATURAL PRODUCTS

Architects at the bacterial surface — sortases and the assembly of pili with isopeptide bonds

(2011) Antoni P. A. Hendrickx et al.   NATURE REVIEWS MICROBIOLOGY

Therapeutic effect of (Z)-3-(2,5-dimethoxyphenyl)-2-(4-methoxyphenyl) acrylonitrile (DMMA) against Staphylococcus aureus infection in a murine model

(2010) Ki-Bong Oh et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Synthetic analogs of indole-containing natural products as inhibitors of sortase A and isocitrate lyase

(2010) Yeon-Ju Lee et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and structure activity relationship studies of novel Staphylococcus aureus Sortase A inhibitors

(2010) Bala Chandra Chenna et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Functional microdomains in bacterial membranes

(2010) D. Lopez et al.   GENES & DEVELOPMENT

Discorhabdins from the Korean Marine SpongeSceptrellasp.

(2010) Ju-eun Jeon et al.   JOURNAL OF NATURAL PRODUCTS

Discovery and structure–activity relationship analysis of Staphylococcus aureus sortase A inhibitors

(2009) Nuttee Suree et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The Structure of theStaphylococcus aureusSortase-Substrate Complex Reveals How the Universally Conserved LPXTG Sorting Signal Is Recognized

(2009) Nuttee Suree et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of novel inhibitors of bacterial surface enzyme Staphylococcus aureus Sortase A

(2007) Bala Chandra Chenna et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Disruption of srtA gene in Streptococcus suis results in decreased interactions with endothelial cells and extracellular matrix proteins

(2007) G. Vanier et al.   VETERINARY MICROBIOLOGY