Role of aberrant phase separation in pathological protein aggregation

Heterotypic electrostatic interactions control complex phase separation of tau and prion into multiphasic condensates and co-aggregates

(2023) Sandeep K. Rai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Determining the Physico‐Chemical Composition of Biomolecular Condensates from Spatially‐Resolved NMR

(2023) Christian F. Pantoja et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Domain-specific modulatory effects of phosphomimetic substitutions on liquid-liquid phase separation of tau protein

(2023) Solomiia Boyko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Spontaneous nucleation and fast aggregate-dependent proliferation of α-synuclein aggregates within liquid condensates at neutral pH

(2023) Samuel T. Dada et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The implications of physiological biomolecular condensates in amyotrophic lateral sclerosis

(2023) Hana Fakim et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

FUS fibrillation occurs through a nucleation-based process below the critical concentration required for liquid–liquid phase separation

(2023) Emilie Bertrand et al.   Scientific Reports

Disease‐linked TDP‐43 hyperphosphorylation suppresses TDP‐43 condensation and aggregation

(2022) Lara A Gruijs da Silva et al.   EMBO JOURNAL

α‐Synuclein phase separation and amyloid aggregation are modulated by C‐terminal truncations

(2022) Shuai Huang et al.   FEBS LETTERS

Ubiquitination of Alzheimer's-related tau protein affects liquid-liquid phase separation in a site- and cofactor-dependent manner

(2022) Francesca Parolini et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Tauopathies: new perspectives and challenges

(2022) Yi Zhang et al.   Molecular Neurodegeneration

Sirtuin-1 sensitive lysine-136 acetylation drives phase separation and pathological aggregation of TDP-43

(2022) Jorge Garcia Morato et al.   Nature Communications

Spatiotemporal modulations in heterotypic condensates of prion and α-synuclein control phase transitions and amyloid conversion

(2022) Aishwarya Agarwal et al.   Nature Communications

A conceptual framework for understanding phase separation and addressing open questions and challenges

(2022) Tanja Mittag et al.   MOLECULAR CELL

Phase separation of the microtubule-associated protein tau

(2022) Pijush Chakraborty et al.   Essays in Biochemistry

Condensed-phase signaling can expand kinase specificity and respond to macromolecular crowding

(2022) Dajun Sang et al.   MOLECULAR CELL

Interplay between tau and α‐synuclein LLPS

(2021) Anna Siegert et al.   PROTEIN SCIENCE

FUS and TDP-43 Phases in Health and Disease

(2021) Bede Portz et al.   TRENDS IN BIOCHEMICAL SCIENCES

Biomolecular condensates at the nexus of cellular stress, protein aggregation disease and ageing

(2021) Simon Alberti et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

TDP-43 condensation properties specify its RNA-binding and regulatory repertoire

(2021) Martina Hallegger et al.   CELL

Co-factor-free aggregation of tau into seeding-competent RNA-sequestering amyloid fibrils

(2021) Pijush Chakraborty et al.   Nature Communications

Specific RNA interactions promote TDP‐43 multivalent phase separation and maintain liquid properties

(2021) Zachary R Grese et al.   EMBO REPORTS

Molecular interactions contributing to FUS SYGQ LC-RGG phase separation and co-partitioning with RNA polymerase II heptads

(2021) Anastasia C. Murthy et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

α-Synuclein aggregation nucleates through liquid–liquid phase separation

(2020) Soumik Ray et al.   Nature Chemistry

Liquid-liquid phase separation induces pathogenic tau conformations in vitro

(2020) Nicholas M. Kanaan et al.   Nature Communications

Phase Separation and Neurodegenerative Diseases: A Disturbance in the Force

(2020) Aurélie Zbinden et al.   DEVELOPMENTAL CELL

Regulatory mechanisms of tau protein fibrillation under the conditions of liquid–liquid phase separation

(2020) Solomiia Boyko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA Binding Antagonizes Neurotoxic Phase Transitions of TDP-43

(2019) Jacob R. Mann et al.   NEURON

Detection of TAR DNA-binding protein 43 (TDP-43) oligomers as initial intermediate species during aggregate formation

(2019) Rachel L. French et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of liquid-liquid phase separation in aggregation of the TDP-43 low complexity domain

(2019) W. Michael Babinchak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lewy pathology in Parkinson’s disease consists of crowded organelles and lipid membranes

(2019) Sarah H. Shahmoradian et al.   NATURE NEUROSCIENCE

Biomolecular condensation of the microtubule-associated protein tau

(2019) Tina Ukmar-Godec et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Lysine/RNA-interactions drive and regulate biomolecular condensation

(2019) Tina Ukmar-Godec et al.   Nature Communications

Stress granules and neurodegeneration

(2019) Benjamin Wolozin et al.   NATURE REVIEWS NEUROSCIENCE

The physical forces mediating self-association and phase-separation in the C-terminal domain of TDP-43

(2018) Hao-Ru Li et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Tau protein liquid–liquid phase separation can initiate tau aggregation

(2018) Susanne Wegmann et al.   EMBO JOURNAL

Acetylation Disfavors Tau Phase Separation

(2018) Josephine Ferreon et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

RNA buffers the phase separation behavior of prion-like RNA binding proteins

(2018) Shovamayee Maharana et al.   SCIENCE

Biomolecular condensates: organizers of cellular biochemistry

(2017) Salman F. Banani et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Liquid–liquid phase separation of the microtubule-binding repeats of the Alzheimer-related protein Tau

(2017) Susmitha Ambadipudi et al.   Nature Communications

Local Nucleation of Microtubule Bundles through Tubulin Concentration into a Condensed Tau Phase

(2017) Amayra Hernández-Vega et al.   Cell Reports

RNA stores tau reversibly in complex coacervates

(2017) Xuemei Zhang et al.   PLOS BIOLOGY

Toxic gain of function from mutant FUS protein is crucial to trigger cell autonomous motor neuron loss

(2016) Jelena Scekic‐Zahirovic et al.   EMBO JOURNAL

ALS Mutations Disrupt Phase Separation Mediated by α-Helical Structure in the TDP-43 Low-Complexity C-Terminal Domain

(2016) Alexander E. Conicella et al.   STRUCTURE

ALS-associated mutant FUS induces selective motor neuron degeneration through toxic gain of function

(2016) Aarti Sharma et al.   Nature Communications

A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation

(2015) Avinash Patel et al.   CELL

ALS/FTD Mutation-Induced Phase Transition of FUS Liquid Droplets and Reversible Hydrogels into Irreversible Hydrogels Impairs RNP Granule Function

(2015) Tetsuro Murakami et al.   NEURON

 -Synuclein in Parkinson's Disease

(2013) L. Stefanis   Cold Spring Harbor Perspectives in Medicine

Biochemistry and Cell Biology of Tau Protein in Neurofibrillary Degeneration

(2013) E.-M. Mandelkow et al.   Cold Spring Harbor Perspectives in Medicine

Misregulated RNA processing in amyotrophic lateral sclerosis

(2012) Magdalini Polymenidou et al.   BRAIN RESEARCH

TDP-43 and FUS in amyotrophic lateral sclerosis and frontotemporal dementia

(2010) Ian RA Mackenzie et al.   LANCET NEUROLOGY