Developments in oral enterotoxigenic Escherichia coli vaccines

Safety and immunogenicity of ETVAX®, an oral inactivated vaccine against enterotoxigenic Escherichia coli diarrhoea: a double-blinded, randomized, placebo-controlled trial amongst Finnish travellers to Benin, West Africa

(2023) Anu Kantele et al.   JOURNAL OF TRAVEL MEDICINE

Evaluation of the Safety, Tolerability and Immunogenicity of ShigETEC, an Oral Live Attenuated Shigella-ETEC Vaccine in Placebo-Controlled Randomized Phase 1 Trial

(2022) Petra Girardi et al.   Vaccines

Vaccine Candidate Double Mutant Variants of Enterotoxigenic Escherichia coli Heat-Stable Toxin

(2022) Ephrem Debebe Zegeye et al.   Vaccines

Preclinical characterization of immunogenicity and efficacy against diarrhea from MecVax, a multivalent enterotoxigenic E. coli vaccine candidate

(2021) Hyesuk Seo et al.   INFECTION AND IMMUNITY

Enterotoxigenic Escherichia coli (ETEC) vaccines: Priority activities to enable product development, licensure, and global access

(2021) Ibrahim Khalil et al.   VACCINE

A Systems Biology Approach Identifies B Cell Maturation Antigen (BCMA) as a Biomarker Reflecting Oral Vaccine Induced IgA Antibody Responses in Humans

(2021) Lynda Mottram et al.   Frontiers in Immunology

Mucosal immune responses against an oral ETEC vaccine evaluated in clinical trials

(2021) Ann-Mari Svennerholm et al.   JOURNAL OF INFECTIOUS DISEASES

Safety and immunogenicity of intramuscularly administered CS6 subunit vaccine with a modified heat-labile enterotoxin from enterotoxigenic Escherichia coli

(2021) Tida Lee et al.   VACCINE

Enterotoxigenic Escherichia coli Degrades the Host MUC2 Mucin Barrier To Facilitate Critical Pathogen-Enterocyte Interactions in Human Small Intestine

(2021) Alaullah Sheikh et al.   INFECTION AND IMMUNITY

Induction of mucosal and systemic immune responses against the common O78 antigen of an oral inactivated ETEC vaccine in Bangladeshi children and infants

(2021) Ann-Mari Svennerholm et al.   VACCINE

A bivalent vaccine confers immunogenicity and protection against Shigella flexneri and enterotoxigenic Escherichia coli infections in mice

(2020) Pedro Henrique Q. S. Medeiros et al.   npj Vaccines

Evaluation of the Immunogenicity and Protective Efficacy of an Enterotoxigenic Escherichia coli CFA/I Adhesin–Heat-Labile Toxin Chimera

(2020) Aisling O'Dowd et al.   INFECTION AND IMMUNITY

A first in human clinical trial assessing the safety and immunogenicity of transcutaneously delivered enterotoxigenic Escherichia coli fimbrial tip adhesin with heat-labile enterotoxin with mutation R192G

(2020) Mark S. Riddle et al.   VACCINE

Characterization of ShigETEC, a Novel Live Attenuated Combined Vaccine against Shigellae and ETEC

(2020) Shushan Harutyunyan et al.   Vaccines

Colonization factors among enterotoxigenic Escherichia coli isolates from children with moderate-to-severe diarrhea and from matched controls in the Global Enteric Multicenter Study (GEMS)

(2019) Roberto M. Vidal et al.   PLoS Neglected Tropical Diseases

Burden of enterotoxigenic Escherichia coli and shigella non-fatal diarrhoeal infections in 79 low-income and lower middle-income countries: a modelling analysis

(2019) John D Anderson et al.   Lancet Global Health

A roadmap for enterotoxigenic Escherichia coli vaccine development based on volunteer challenge studies

(2019) Myron M. Levine et al.   Human Vaccines & Immunotherapeutics

Live attenuated enterotoxigenic Escherichia coli (ETEC) vaccine with dmLT adjuvant protects human volunteers against virulent experimental ETEC challenge

(2019) Clayton Harro et al.   VACCINE

Intradermal or sublingual delivery and heat-labile enterotoxin (LT) proteins shape immunologic outcomes to CFA/I fimbriae-derived subunit antigen vaccine against enterotoxigenic E. coli

(2019) Milton Maciel et al.   INFECTION AND IMMUNITY

Safety and immunogenicity of the oral, inactivated, enterotoxigenic Escherichia coli vaccine ETVAX in Bangladeshi children and infants: a double-blind, randomised, placebo-controlled phase 1/2 trial

(2019) Firdausi Qadri et al.   LANCET INFECTIOUS DISEASES

Development of an enterotoxigenic Escherichia coli vaccine based on the heat-stable toxin

(2018) Ephrem Debebe Zegeye et al.   Human Vaccines & Immunotherapeutics

The Mucosal Vaccine Adjuvant LT(R192G/L211A) or dmLT

(2018) John D. Clements et al.   mSphere

Evaluation of the safety and immunogenicity of the oral inactivated multivalent enterotoxigenic Escherichia coli vaccine ETVAX in Bangladeshi adults in a double-blind, randomized, placebo-controlled Phase I trial using electrochemiluminescence and ELISA assays for immunogenicity analyses

(2018) Marjahan Akhtar et al.   VACCINE

A Phase 1 dose escalating study of double mutant heat-labile toxin LTR192G/L211A (dmLT) from Enterotoxigenic Escherichia coli (ETEC) by sublingual or oral immunization

(2018) David I. Bernstein et al.   VACCINE

Prophylactic Efficacy of Hyperimmune Bovine Colostral Antiadhesin Antibodies Against Enterotoxigenic Escherichia coli Diarrhea: A Randomized, Double-Blind, Placebo-Controlled, Phase 1 Trial

(2017) Stephen J. Savarino et al.   JOURNAL OF INFECTIOUS DISEASES

Etiology of travellers’ diarrhea

(2017) Z.D. Jiang et al.   JOURNAL OF TRAVEL MEDICINE

Kinetics of antibody-secreting cell and fecal IgA responses after oral cholera vaccination in different age groups in a cholera endemic country

(2017) Marjahan Akhtar et al.   VACCINE

Cross-reactivity and avidity of antibody responses induced in humans by the oral inactivated multivalent enterotoxigenic Escherichia coli (ETEC) vaccine ETVAX

(2017) Susannah Leach et al.   VACCINE

Immunogenicity and Protective Efficacy against Enterotoxigenic Escherichia coli Colonization following Intradermal, Sublingual, or Oral Vaccination with EtpA Adhesin

(2016) Qingwei Luo et al.   Clinical and Vaccine Immunology

Combined Oral and Intravenous Immunization Stimulates Strong IgA Responses in Both Systemic and Mucosal Compartments

(2016) Zhe Yang et al.   PLoS One

Induction of long term mucosal immunological memory in humans by an oral inactivated multivalent enterotoxigenic Escherichia coli vaccine

(2016) Anna Lundgren et al.   VACCINE

An assessment of enterotoxigenic Escherichia coli and Shigella vaccine candidates for infants and children

(2015) Richard I. Walker   VACCINE

Identification of enterotoxigenic Escherichia coli (ETEC) clades with long-term global distribution

(2014) Astrid von Mentzer et al.   NATURE GENETICS

Safety and immunogenicity of an improved oral inactivated multivalent enterotoxigenic Escherichia coli (ETEC) vaccine administered alone and together with dmLT adjuvant in a double-blind, randomized, placebo-controlled Phase I study

(2014) Anna Lundgren et al.   VACCINE

Efficacy and safety of a patch vaccine containing heat-labile toxin from Escherichia coli against travellers' diarrhoea: a phase 3, randomised, double-blind, placebo-controlled field trial in travellers from Europe to Mexico and Guatemala

(2013) Ronald H Behrens et al.   LANCET INFECTIOUS DISEASES

Clinical trial to evaluate safety and immunogenicity of an oral inactivated enterotoxigenic Escherichia coli prototype vaccine containing CFA/I overexpressing bacteria and recombinantly produced LTB/CTB hybrid protein

(2013) A. Lundgren et al.   VACCINE

Development and preclinical evaluation of safety and immunogenicity of an oral ETEC vaccine containing inactivated E. coli bacteria overexpressing colonization factors CFA/I, CS3, CS5 and CS6 combined with a hybrid LT/CT B subunit antigen, administered alone and together with dmLT adjuvant

(2013) J. Holmgren et al.   VACCINE

Strategies to overexpress enterotoxigenic Escherichia coli (ETEC) colonization factors for the construction of oral whole-cell inactivated ETEC vaccine candidates

(2012) Joshua Tobias et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Recent progress toward an enterotoxigenicEscherichia colivaccine

(2012) Ann-Mari Svennerholm et al.   Expert Review of Vaccines

Construction of non-toxic Escherichia coli and Vibrio cholerae strains expressing high and immunogenic levels of enterotoxigenic E. coli colonization factor I fimbriae

(2008) Joshua Tobias et al.   VACCINE