Enterotoxigenic Escherichia coli (ETEC) vaccines: Priority activities to enable product development, licensure, and global access

A bivalent vaccine confers immunogenicity and protection against Shigella flexneri and enterotoxigenic Escherichia coli infections in mice

(2020) Pedro Henrique Q. S. Medeiros et al.   npj Vaccines

Etiology of Diarrhea Requiring Hospitalization in Bangladesh by Quantitative Polymerase Chain Reaction, 2014–2018

(2020) Mami Taniuchi et al.   CLINICAL INFECTIOUS DISEASES

Child malnutrition and COVID-19: the time to act is now

(2020) Henrietta H Fore et al.   LANCET

Epidemiology and associated microbiota changes in deployed military personnel at high risk of traveler's diarrhea

(2020) William A. Walters et al.   PLoS One

Incidence and etiology of clinically-attended, antibiotic-treated diarrhea among children under five years of age in low- and middle-income countries: Evidence from the Global Enteric Multicenter Study

(2020) Joseph A. Lewnard et al.   PLoS Neglected Tropical Diseases

Measuring antibiotic use in children: piecing together the puzzle

(2020) Julia Anna Bielicki et al.   Lancet Global Health

Rapid isothermal amplification and portable detection system for SARS-CoV-2

(2020) Anurup Ganguli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multi-omics analysis reveals the influence of genetic and environmental risk factors on developing gut microbiota in infants at risk of celiac disease

(2020) Maureen M. Leonard et al.   Microbiome

Characterization of ShigETEC, a Novel Live Attenuated Combined Vaccine against Shigellae and ETEC

(2020) Shushan Harutyunyan et al.   Vaccines

Colonization factors among enterotoxigenic Escherichia coli isolates from children with moderate-to-severe diarrhea and from matched controls in the Global Enteric Multicenter Study (GEMS)

(2019) Roberto M. Vidal et al.   PLoS Neglected Tropical Diseases

Genome and Functional Characterization of Colonization Factor Antigen I- and CS6-Encoding Heat-Stable Enterotoxin-Only Enterotoxigenic Escherichia coli Reveals Lineage and Geographic Variation

(2019) Tracy H. Hazen et al.   mSystems

Burden of enterotoxigenic Escherichia coli and shigella non-fatal diarrhoeal infections in 79 low-income and lower middle-income countries: a modelling analysis

(2019) John D Anderson et al.   Lancet Global Health

Live attenuated enterotoxigenic Escherichia coli (ETEC) vaccine with dmLT adjuvant protects human volunteers against virulent experimental ETEC challenge

(2019) Clayton Harro et al.   VACCINE

Effects of child and maternal Histo Blood Group Antigen status on symptomatic and asymptomatic enteric infections in early childhood

(2019) Josh M Colston et al.   JOURNAL OF INFECTIOUS DISEASES

The incidence, aetiology, and adverse clinical consequences of less severe diarrhoeal episodes among infants and children residing in low-income and middle-income countries: a 12-month case-control study as a follow-on to the Global Enteric Multicenter Study (GEMS)

(2019) Karen L Kotloff et al.   Lancet Global Health

Intradermal or sublingual delivery and heat-labile enterotoxin (LT) proteins shape immunologic outcomes to CFA/I fimbriae-derived subunit antigen vaccine against enterotoxigenic E. coli

(2019) Milton Maciel et al.   INFECTION AND IMMUNITY

Technical product attributes in development of an oral enteric vaccine for infants

(2019) Jessica A. White et al.   VACCINE

Vaccines Against Shigella and Enterotoxigenic Escherichia coli: A summary of the 2018 VASE Conference

(2019) Eileen Barry et al.   VACCINE

Interrogation of a live-attenuated enterotoxigenic Escherichia coli vaccine highlights features unique to wild-type infection

(2019) Subhra Chakraborty et al.   npj Vaccines

Safety and immunogenicity of the oral, inactivated, enterotoxigenic Escherichia coli vaccine ETVAX in Bangladeshi children and infants: a double-blind, randomised, placebo-controlled phase 1/2 trial

(2019) Firdausi Qadri et al.   LANCET INFECTIOUS DISEASES

Conservation and global distribution of non-canonical antigens in Enterotoxigenic Escherichia coli

(2019) F. Matthew Kuhlmann et al.   PLoS Neglected Tropical Diseases

Exploring the relationship between environmental enteric dysfunction and oral vaccine responses

(2018) James A Church et al.   Future Microbiology

Causes of impaired oral vaccine efficacy in developing countries

(2018) Edward PK Parker et al.   Future Microbiology

Critical Role of Zinc in a New Murine Model of Enterotoxigenic Escherichia coli Diarrhea

(2018) D. T. Bolick et al.   INFECTION AND IMMUNITY

Enterotoxigenic Escherichia coli–blood group A interactions intensify diarrheal severity

(2018) Pardeep Kumar et al.   JOURNAL OF CLINICAL INVESTIGATION

Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis

(2018) Evelina Tacconelli et al.   LANCET INFECTIOUS DISEASES

Use of mathematical modelling to assess the impact of vaccines on antibiotic resistance

(2018) Katherine E Atkins et al.   LANCET INFECTIOUS DISEASES

Global disability-adjusted life-year estimates of long-term health burden and undernutrition attributable to diarrhoeal diseases in children younger than 5 years

(2018) Christopher Troeger et al.   Lancet Global Health

Estimates of the global, regional, and national morbidity, mortality, and aetiologies of diarrhoea in 195 countries: a systematic analysis for the Global Burden of Disease Study 2016

(2018) Christopher Troeger et al.   LANCET INFECTIOUS DISEASES

Comparison of stool collection and storage on Whatman FTA Elute cards versus frozen stool for enteropathogen detection using the TaqMan Array Card PCR assay

(2018) Tahaniyat Lalani et al.   PLoS One

Evaluation of a conjugate vaccine platform against enterotoxigenic Escherichia coli (ETEC), Campylobacter jejuni and Shigella

(2018) Renee M. Laird et al.   VACCINE

A Novel Shigella Proteome Microarray Discriminates Targets of Human Antibody Reactivity following Oral Vaccination and Experimental Challenge

(2018) Esther Ndungo et al.   mSphere

Evaluation of the safety and immunogenicity of the oral inactivated multivalent enterotoxigenic Escherichia coli vaccine ETVAX in Bangladeshi adults in a double-blind, randomized, placebo-controlled Phase I trial using electrochemiluminescence and ELISA assays for immunogenicity analyses

(2018) Marjahan Akhtar et al.   VACCINE

The Euvichol story – Development and licensure of a safe, effective and affordable oral cholera vaccine through global public private partnerships

(2018) Lina Odevall et al.   VACCINE

Use of quantitative molecular diagnostic methods to assess the aetiology, burden, and clinical characteristics of diarrhoea in children in low-resource settings: a reanalysis of the MAL-ED cohort study

(2018) James A Platts-Mills et al.   Lancet Global Health

Perspective: What Does Stunting Really Mean? A Critical Review of the Evidence

(2018) Jef L Leroy et al.   Advances in Nutrition

Correlates of protection for enteric vaccines

(2017) Jan Holmgren et al.   VACCINE

Cross-reactivity and avidity of antibody responses induced in humans by the oral inactivated multivalent enterotoxigenic Escherichia coli (ETEC) vaccine ETVAX

(2017) Susannah Leach et al.   VACCINE

Combination vaccine strategies to prevent enteric infections

(2017) Richard Walker et al.   VACCINE

Passive antibodies derived from intramuscularly immunized toxoid fusion 3xSTa N12S -dmLT protect against STa+ enterotoxigenic Escherichia coli (ETEC) diarrhea in a pig model

(2017) Rahul M. Nandre et al.   VACCINE

Impact of CD4+ T Cell Responses on Clinical Outcome following Oral Administration of Wild-Type Enterotoxigenic Escherichia coli in Humans

(2017) Monica A. McArthur et al.   PLoS Neglected Tropical Diseases

Causal Pathways from Enteropathogens to Environmental Enteropathy: Findings from the MAL-ED Birth Cohort Study

(2017) Margaret N. Kosek et al.   EBioMedicine

FUT2 non-secretor status is associated with altered susceptibility to symptomatic enterotoxigenic Escherichia coli infection in Bangladeshis

(2017) Lynda Mottram et al.   Scientific Reports

Breastfeeding in the 21st century: epidemiology, mechanisms, and lifelong effect

(2016) Cesar G Victora et al.   LANCET

Status of vaccine research and development for enterotoxigenic Escherichia coli

(2016) A. Louis Bourgeois et al.   VACCINE

Recommendations regarding the development of combined enterotoxigenic Eschericha coli and Shigella vaccines for infants

(2015) Richard I. Walker et al.   VACCINE

Pathogen-specific burdens of community diarrhoea in developing countries: a multisite birth cohort study (MAL-ED)

(2015) James A Platts-Mills et al.   Lancet Global Health

Novel antigens for enterotoxigenicEscherichia colivaccines

(2014) James Fleckenstein et al.   Expert Review of Vaccines

Identification of enterotoxigenic Escherichia coli (ETEC) clades with long-term global distribution

(2014) Astrid von Mentzer et al.   NATURE GENETICS

Safety and immunogenicity of an improved oral inactivated multivalent enterotoxigenic Escherichia coli (ETEC) vaccine administered alone and together with dmLT adjuvant in a double-blind, randomized, placebo-controlled Phase I study

(2014) Anna Lundgren et al.   VACCINE

Burden and aetiology of diarrhoeal disease in infants and young children in developing countries (the Global Enteric Multicenter Study, GEMS): a prospective, case-control study

(2013) Karen L Kotloff et al.   LANCET

Development and preclinical evaluation of safety and immunogenicity of an oral ETEC vaccine containing inactivated E. coli bacteria overexpressing colonization factors CFA/I, CS3, CS5 and CS6 combined with a hybrid LT/CT B subunit antigen, administered alone and together with dmLT adjuvant

(2013) J. Holmgren et al.   VACCINE

Progress and hurdles in the development of vaccines against enterotoxigenicEscherichia coliin humans

(2012) Weiping Zhang et al.   Expert Review of Vaccines

The impoverished gut—a triple burden of diarrhoea, stunting and chronic disease

(2012) Richard L. Guerrant et al.   Nature Reviews Gastroenterology & Hepatology

Induction of Increased Permeability of Polarized Enterocyte Monolayers by Enterotoxigenic Escherichia coli Heat-Labile Enterotoxin

(2011) Roderick B. Kreisberg et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Breastfeeding and the risk for diarrhea morbidity and mortality

(2011) Laura M Lamberti et al.   BMC PUBLIC HEALTH

Volunteer Challenge With Enterotoxigenic Escherichia coli That Express Intestinal Colonization Factor Fimbriae CS17 and CS19

(2011) R. McKenzie et al.   JOURNAL OF INFECTIOUS DISEASES

A systematic review of ETEC epidemiology focusing on colonization factor and toxin expression

(2011) S.D. Isidean et al.   VACCINE

The Epidemiology of Rotavirus Diarrhea in Countries in the Eastern Mediterranean Region

(2010) Mark A. Malek et al.   JOURNAL OF INFECTIOUS DISEASES

Toxin-Mediated Effects on the Innate Mucosal Defenses: Implications for Enteric Vaccines

(2009) G. M. Glenn et al.   INFECTION AND IMMUNITY

Molecular mechanisms of enterotoxigenic Escherichia coli infection

(2009) James M. Fleckenstein et al.   MICROBES AND INFECTION

Vaccines against enterotoxigenicEscherichia coli

(2008) Ann-Mari Svennerholm et al.   Expert Review of Vaccines

The EtpA Exoprotein of Enterotoxigenic Escherichia coli Promotes Intestinal Colonization and Is a Protective Antigen in an Experimental Model of Murine Infection

(2008) K. Roy et al.   INFECTION AND IMMUNITY

Enteric infections, diarrhea, and their impact on function and development

(2008) William A. Petri et al.   JOURNAL OF CLINICAL INVESTIGATION