The role of interferon in the thymus

Impaired thymic AIRE expression underlies autoantibodies against type I IFNs in humans with inborn errors of the alternative NF-κB pathway

(2023) Tom Le Voyer et al.   CLINICAL IMMUNOLOGY

Type III interferon drives thymic B cell activation and regulatory T cell generation

(2023) Ryan J. Martinez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Myasthenia Gravis: An Acquired Interferonopathy?

(2022) Cloé A. Payet et al.   Cells

Thymic epithelial cells co-opt lineage-defining transcription factors to eliminate autoreactive T cells

(2022) Daniel A. Michelson et al.   CELL

Self-reactivity of CD8 T-cell clones determines their differentiation status rather than their responsiveness in infections

(2022) Darina Paprckova et al.   Frontiers in Immunology

Post-Aire Medullary Thymic Epithelial Cells and Hassall’s Corpuscles as Inducers of Tonic Pro-Inflammatory Microenvironment

(2021) Martti Laan et al.   Frontiers in Immunology

Infection-induced type I interferons critically modulate the homeostasis and function of CD8+ naïve T cells

(2021) Mladen Jergović et al.   Nature Communications

Infection-Associated Thymic Atrophy

(2021) Mingli Luo et al.   Frontiers in Immunology

Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths

(2021) Paul Bastard et al.   Science Immunology

Induction of thymic atrophy and loss of thymic output by type-I interferons during chronic viral infection

(2021) Thomas Démoulins et al.   VIROLOGY

Self-reactivity controls functional diversity of naive CD8+ T cells by co-opting tonic type I interferon

(2021) Young-Jun Ju et al.   Nature Communications

Chronic virus infection drives CD8 T cell-mediated thymic destruction and impaired negative selection

(2020) Heidi J. Elsaesser et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

VISTA is a checkpoint regulator for naïve T cell quiescence and peripheral tolerance

(2020) Mohamed A. ElTanbouly et al.   SCIENCE

IFN-λ Enhances Constitutive Expression of MHC Class I Molecules on Thymic Epithelial Cells

(2020) Mohamed Benhammadi et al.   JOURNAL OF IMMUNOLOGY

Autoantibodies against type I IFNs in patients with life-threatening COVID-19

(2020) Paul Bastard et al.   SCIENCE

Differential Activation of the Transcription Factor IRF1 Underlies the Distinct Immune Responses Elicited by Type I and Type III Interferons

(2019) Adriana Forero et al.   IMMUNITY

IL-2 production by self-reactive CD4 thymocytes scales regulatory T cell generation in the thymus

(2019) Saskia Hemmers et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Risk factors associated with myasthenia gravis in thymoma patients: The potential role of thymic germinal centers

(2019) Claire MJ. Lefeuvre et al.   JOURNAL OF AUTOIMMUNITY

Anticytokine autoantibodies in a patient with a heterozygous NFKB2 mutation

(2018) Kesava A. Ramakrishnan et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Type I interferon signaling attenuates regulatory T cell function in viral infection and in the tumor microenvironment

(2018) Arunakumar Gangaplara et al.   PLoS Pathogens

Neutralizing Anti-Cytokine Autoantibodies Against Interferon-α in Immunodysregulation Polyendocrinopathy Enteropathy X-Linked

(2018) Jacob M. Rosenberg et al.   Frontiers in Immunology

Thymic tuft cells promote an IL-4-enriched medulla and shape thymocyte development

(2018) Corey N. Miller et al.   NATURE

Central immune tolerance depends on crosstalk between the classical and alternative NF-κB pathways in medullary thymic epithelial cells

(2017) Marc Riemann et al.   JOURNAL OF AUTOIMMUNITY

Autoantibody Repertoire in APECED Patients Targets Two Distinct Subgroups of Proteins

(2017) Dmytro Fishman et al.   Frontiers in Immunology

AIRE-Deficient Patients Harbor Unique High-Affinity Disease-Ameliorating Autoantibodies

(2016) Steffen Meyer et al.   CELL

Broad and Largely Concordant Molecular Changes Characterize Tolerogenic and Immunogenic Dendritic Cell Maturation in Thymus and Periphery

(2016) Laurence Ardouin et al.   IMMUNITY

Aire Enforces Immune Tolerance by Directing Autoreactive T Cells into the Regulatory T Cell Lineage

(2016) Sven Malchow et al.   IMMUNITY

Type I interferon–mediated monogenic autoinflammation: The type I interferonopathies, a conceptual overview

(2016) Mathieu P. Rodero et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Late stages of T cell maturation in the thymus involve NF-κB and tonic type I interferon signaling

(2016) Yan Xing et al.   NATURE IMMUNOLOGY

Dominant Mutations in the Autoimmune Regulator AIRE Are Associated with Common Organ-Specific Autoimmune Diseases

(2015) Bergithe E. Oftedal et al.   IMMUNITY

The effects of RelB deficiency on lymphocyte development and function

(2015) Nigel Sharfe et al.   JOURNAL OF AUTOIMMUNITY

Broad-spectrum antibodies against self-antigens and cytokines in RAG deficiency

(2015) Jolan E. Walter et al.   JOURNAL OF CLINICAL INVESTIGATION

IFN-α/β Receptor Signaling Promotes Regulatory T Cell Development and Function under Stress Conditions

(2015) Amina Metidji et al.   JOURNAL OF IMMUNOLOGY

Aire controls gene expression in the thymic epithelium with ordered stochasticity

(2015) Matthew Meredith et al.   NATURE IMMUNOLOGY

Thymoma-associated myasthenia gravis: On the search for a pathogen signature

(2014) Perrine Cufi et al.   JOURNAL OF AUTOIMMUNITY

Central role of interferon-beta in thymic events leading to myasthenia gravis

(2014) Perrine Cufi et al.   JOURNAL OF AUTOIMMUNITY

IRF7-Dependent IFN-  Production in Response to RANKL Promotes Medullary Thymic Epithelial Cell Development

(2013) D. C. Otero et al.   JOURNAL OF IMMUNOLOGY

Transcriptome sequencing of neonatal thymic epithelial cells

(2013) Charles St-Pierre et al.   Scientific Reports

Implication of double-stranded RNA signaling in the etiology of autoimmune myasthenia gravis

(2012) Perrine Cufi et al.   ANNALS OF NEUROLOGY

Commensal Bacteria Calibrate the Activation Threshold of Innate Antiviral Immunity

(2012) Michael C. Abt et al.   IMMUNITY

Novel Reporter Mouse Reveals Constitutive and Inflammatory Expression of IFN-  In Vivo

(2009) S. Lienenklaus et al.   JOURNAL OF IMMUNOLOGY

Interferon autoantibodies associated with AIRE deficiency decrease the expression of IFN-stimulated genes

(2008) K. Kisand et al.   BLOOD