Modelling arterial thrombus formation in vitro

High-throughput assessment identifying major platelet Ca2+ entry pathways via tyrosine kinase-linked and G protein-coupled receptors

(2023) Hilaire Yam Fung Cheung et al.   CELL CALCIUM

Developing Biomimetic Hydrogels of the Arterial Wall as a Prothrombotic Substrate for In Vitro Human Thrombosis Models

(2023) Jacob Ranjbar et al.   Gels

High-throughput microfluidic blood testing to phenotype genetically linked platelet disorders: an aid to diagnosis

(2023) Delia I. Fernandez et al.   Blood Advances

Multiparameter platelet function analysis of bleeding patients with a prolonged platelet function analyser closure time

(2022) Floor C. J. I. Heubel‐Moenen et al.   BRITISH JOURNAL OF HAEMATOLOGY

Role of Neutrophils and NETs in Animal Models of Thrombosis

(2022) Estelle Carminita et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cucurbitacins elicit anti-platelet activity via perturbation of the actin cytoskeleton and integrin function.

(2022) Neline Kriek et al.   THROMBOSIS AND HAEMOSTASIS

Anti‐GPVI nanobody blocks collagen‐ and atherosclerotic plaque–induced GPVI clustering, signaling, and thrombus formation

(2022) Natalie J. Jooss et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

CLEC-2 supports platelet aggregation in mouse but not human blood at arterial shear

(2022) Joshua Bourne et al.   THROMBOSIS AND HAEMOSTASIS

Atherothrombosis‐on‐Chip: A Site‐Specific Microfluidic Model for Thrombus Formation and Drug Discovery

(2022) Fahima Akther et al.   Advanced Biology

Ex vivo perfusion of the human placenta to investigate pregnancy pathologies

(2022) Rachel R. Zabel et al.   PLACENTA

Developing human tissue engineered arterial constructs to simulate human in vivo thrombus formation

(2022) Jacob Ranjbar et al.   PLATELETS

In vitro flow‐based assay: From simple toward more sophisticated models for mimicking hemostasis and thrombosis

(2021) Pierre H. Mangin et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

The changing landscape of atherosclerosis

(2021) Peter Libby   NATURE

Identification of the haemodynamic environment permissive for plaque erosion

(2021) Michael McElroy et al.   Scientific Reports

Multiparameter Evaluation of the Platelet-Inhibitory Effects of Tyrosine Kinase Inhibitors Used for Cancer Treatment

(2021) Bibian Tullemans et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Temporal Roles of Platelet and Coagulation Pathways in Collagen- and Tissue Factor-Induced Thrombus Formation

(2021) Stefano Navarro et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Method article: an in vitro blood flow model to advance the study of platelet adhesion utilizing a damaged endothelium

(2021) Alison Leigh Banka et al.   PLATELETS

Anti-platelet properties of Pim kinase inhibition is mediated through disruption of thromboxane A2 receptor signalling

(2020) Amanda J. Unsworth et al.   HAEMATOLOGICA

Glenzocimab does not impact glycoprotein VI-dependent inflammatory haemostasis

(2020) Soumaya Jadoui et al.   HAEMATOLOGICA

Interrelationships between structure and function during the hemostatic response to injury

(2019) Maurizio Tomaiuolo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of Platelet Glycoprotein VI and Tyrosine Kinase Syk in Thrombus Formation on Collagen-Like Surfaces

(2019) Natalie J. Jooss et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Localized endothelial‐based control of platelet aggregation and coagulation under flow: A proof‐of‐principle vessel‐on‐a‐chip study

(2019) Sanne L.N. Brouns et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Oral Bruton tyrosine kinase inhibitors selectively block atherosclerotic plaque–triggered thrombus formation in humans

(2018) Kristina Busygina et al.   BLOOD

Cell free hemoglobin in the fetoplacental circulation: a novel cause of fetal growth restriction?

(2018) Adam Brook et al.   FASEB JOURNAL

High-throughput measurement of human platelet aggregation under flow: application in hemostasis and beyond

(2018) Sanne L. N. Brouns et al.   PLATELETS

High-throughput elucidation of thrombus formation reveals sources of platelet function variability

(2018) Johanna P. van Geffen et al.   HAEMATOLOGICA

Targeting cell adhesion molecules with nanoparticles using in vivo and flow-based in vitro models of atherosclerosis

(2017) Khosrow Khodabandehlou et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Flow chamber and microfluidic approaches for measuring thrombus formation in genetic bleeding disorders

(2017) Rogier M. Schoeman et al.   PLATELETS

Differential integrin activity mediated by platelet collagen receptor engagement under flow conditions

(2017) Ben Maddox et al.   THROMBOSIS AND HAEMOSTASIS

Cigarette smoke extract profoundly suppresses TNFα-mediated proinflammatory gene expression through upregulation of ATF3 in human coronary artery endothelial cells

(2017) Jack E. Teasdale et al.   Scientific Reports

Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis

(2016) Michael A. Gimbrone et al.   CIRCULATION RESEARCH

Bioprinted thrombosis-on-a-chip

(2016) Yu Shrike Zhang et al.   LAB ON A CHIP

Humanizing the Protease-Activated Receptor (PAR) Expression Profile in Mouse Platelets by Knocking PAR1 into the Par3 Locus Reveals PAR1 Expression Is Not Tolerated in Mouse Platelets

(2016) Shauna L. French et al.   PLoS One

Ibrutinib Inhibits Platelet Integrin αIIbβ3Outside-In Signaling and Thrombus Stability But Not Adhesion to CollagenSignificance

(2015) Alexander P. Bye et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Dysregulated flow-mediated vasodilatation in the human placenta in fetal growth restriction

(2015) Sarah Jones et al.   JOURNAL OF PHYSIOLOGY-LONDON

Identification of platelet function defects by multi-parameter assessment of thrombus formation

(2014) Susanne M. de Witt et al.   Nature Communications

Integrin α 6 β 1 Is the Main Receptor for Vascular Laminins and Plays a Role in Platelet Adhesion, Activation, and Arterial Thrombosis

(2013) Mathieu Schaff et al.   CIRCULATION

Thrombus Growth and Embolism on Tissue Factor-Bearing Collagen Surfaces Under Flow

(2012) Thomas V. Colace et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Animal Models of Atherosclerosis

(2012) Godfrey S. Getz et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Monitoringin vitrothrombus formation with novel microfluidic devices

(2012) Erik Westein et al.   PLATELETS

In vitro microvessels for the study of angiogenesis and thrombosis

(2012) Y. Zheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Well plate microfluidic system for investigation of dynamic platelet behavior under variable shear loads

(2011) Carolyn G. Conant et al.   BIOTECHNOLOGY AND BIOENGINEERING

Towards standardization of in vivo thrombosis studies in mice

(2011) C. V. DENIS et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

A microchip flow-chamber system for quantitative assessment of the platelet thrombus formation process

(2011) Kazuya Hosokawa et al.   MICROVASCULAR RESEARCH

Synergism between platelet collagen receptors defined using receptor-specific collagen-mimetic peptide substrata in flowing blood

(2010) N. Pugh et al.   BLOOD

A dual role for integrin-linked kinase in platelets: regulating integrin function and  -granule secretion

(2008) K. L. Tucker et al.   BLOOD

Microfluidic focal thrombosis model for measuring murine platelet deposition and stability: PAR4 signaling enhances shear-resistance of platelet aggregates

(2008) K. B. NEEVES et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Peripheral tachykinins and the neurokinin receptor NK1 are required for platelet thrombus formation

(2007) S. Jones et al.   BLOOD