Intestinal proteases

Next Generation of Fluorometric Protease Assays: 7‐Nitrobenz‐2‐oxa‐1,3‐diazol‐4‐yl‐amides (NBD‐Amides) as Class‐Spanning Protease Substrates

(2023) Hannah Maus et al.   CHEMISTRY-A EUROPEAN JOURNAL

Imaging of proteases using activity-based probes

(2023) Mikolaj Zmudzinski et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Mice expressing fluorescent PAR2 reveal that endocytosis mediates colonic inflammation and pain

(2022) Rocco Latorre et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Effect of Serine Protease Inhibitors on Visceral Pain in Different Rodent Models With an Intestinal Insult

(2022) Hannah Ceuleers et al.   Frontiers in Pharmacology

Gut microbial β-glucuronidases regulate host luminal proteases and are depleted in irritable bowel syndrome

(2022) Adam L. Edwinson et al.   Nature Microbiology

Identification of a Distinct Platelet Phenotype in the Elderly: ADP Hypersensitivity Coexists With Platelet PAR (Protease-Activated Receptor)-1 and PAR-4–Mediated Thrombin Resistance

(2022) Sonali R. Gnanenthiran et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Efficacy of Fecal Microbiota Transplantation for Patients With Irritable Bowel Syndrome at 3 Years After Transplantation

(2022) Magdy El-Salhy et al.   GASTROENTEROLOGY

Biogeographic Variation and Functional Pathways of the Gut Microbiota in Celiac Disease

(2022) Marco Constante et al.   GASTROENTEROLOGY

Epithelial production of elastase is increased in inflammatory bowel disease and causes mucosal inflammation

(2021) Jean-Paul Motta et al.   Mucosal Immunology

Matrix Metalloproteinase MMP-12 promotes macrophage transmigration across intestinal epithelial tight junctions and increases severity of experimental colitis

(2021) Meghali Nighot et al.   Journal of Crohns & Colitis

Matrix metalloproteinase-2 on activated platelets triggers endothelial PAR-1 initiating atherosclerosis

(2021) Stefania Momi et al.   EUROPEAN HEART JOURNAL

Local Colonic Administration of a Serine Protease Inhibitor Improves Post-Inflammatory Visceral Hypersensitivity in Rats

(2021) Nikita Hanning et al.   Pharmaceutics

The deubiquitinase OTUD1 inhibits colonic inflammation by suppressing RIPK1-mediated NF-κB signaling

(2021) Bo Wu et al.   Cellular & Molecular Immunology

Prostaglandin E2, Produced by Mast Cells in Colon Tissues from Patients with Irritable Bowel Syndrome, Contributes to Visceral Hypersensitivity in Mice

(2020) Gintautas Grabauskas et al.   GASTROENTEROLOGY

Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense

(2020) Min Zheng et al.   CELL

Clinical efficacy and safety of ketotifen in treating irritable bowel syndrome with diarrhea

(2020) Jing Wang et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Mast Cell Tryptase Promotes Inflammatory Bowel Disease–Induced Intestinal Fibrosis

(2020) Bin Liu et al.   INFLAMMATORY BOWEL DISEASES

Gluten Degrading Enzymes for Treatment of Celiac Disease

(2020) Guoxian Wei et al.   Nutrients

Novel fecal biomarkers that precede clinical diagnosis of ulcerative colitis.

(2020) Heather J. Galipeau et al.   GASTROENTEROLOGY

Increased Mucosal Thrombin is Associated with Crohn’s Disease and Causes Inflammatory Damage through Protease-activated Receptors Activation

(2020) Jean-Paul Motta et al.   Journal of Crohns & Colitis

Influence of the Treatment Used in Inflammatory Bowel Disease on the Protease Activities

(2020) Ewa Dudzińska et al.   International Journal of General Medicine

Duodenal bacterial proteolytic activity determines sensitivity to dietary antigen through protease-activated receptor-2

(2019) Alberto Caminero et al.   Nature Communications

Serine proteases as luminal mediators of intestinal barrier dysfunction and symptom severity in IBS

(2019) Shoko Edogawa et al.   GUT

Application of a chemical probe to detect neutrophil elastase activation during inflammatory bowel disease

(2019) Bethany M. Anderson et al.   Scientific Reports

Efficacy of faecal microbiota transplantation for patients with irritable bowel syndrome in a randomised, double-blind, placebo-controlled study

(2019) Magdy El-Salhy et al.   GUT

Newly developed serine protease inhibitors decrease visceral hypersensitivity in a post-inflammatory rat model for irritable bowel syndrome.

(2018) Hannah Ceuleers et al.   BRITISH JOURNAL OF PHARMACOLOGY

Protease-activated receptor 1 is implicated in irritable bowel syndrome mediators–induced signaling to thoracic human sensory neurons

(2018) Cleo Desormeaux et al.   PAIN

Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome

(2018) Nestor N. Jimenez-Vargas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional Proteomic Profiling of Secreted Serine Proteases in Health and Inflammatory Bowel Disease

(2018) Alexandre Denadai-Souza et al.   Scientific Reports

Epithelial expression and function of trypsin-3 in irritable bowel syndrome

(2017) Claire Rolland-Fourcade et al.   GUT

Cortical forces and CDC-42 control clustering of PAR proteins for Caenorhabditis elegans embryonic polarization

(2017) Shyi-Chyi Wang et al.   NATURE CELL BIOLOGY

Downregulation of mucosal mast cell activation and immune response in diarrhoea-irritable bowel syndrome by oral disodium cromoglycate: A pilot study

(2017) Beatriz Lobo et al.   United European Gastroenterology Journal

PAR2-dependent activation of GSK3β regulates the survival of colon stem/progenitor cells

(2016) Imen Nasri et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Protease inhibition as new therapeutic strategy for GI diseases

(2016) Nathalie Vergnolle   GUT

Intestinal Microbiota Modulates Gluten-Induced Immunopathology in Humanized Mice

(2015) Heather J. Galipeau et al.   AMERICAN JOURNAL OF PATHOLOGY

Novel Role of the Serine Protease Inhibitor Elafin in Gluten-Related Disorders

(2014) Heather J Galipeau et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY